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Protein
Submitted name:

Ki-67 protein

Gene

Mki67

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: MGI
  • cholangiocyte proliferation Source: MGI
  • hepatocyte proliferation Source: MGI
  • meiotic nuclear division Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Ki-67 proteinImported
Gene namesi
Name:Mki67Imported
Synonyms:Ki-67Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:106035. Mki67.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric region Source: MGI
  • condensed chromosome Source: MGI
  • cytoplasm Source: MGI
  • membrane Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiQ61769.
PRIDEiQ61769.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ61769. 2 interactions.
MINTiMINT-4109797.

Structurei

3D structure databases

ProteinModelPortaliQ61769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 7650FHAInterPro annotationAdd
BLAST

Phylogenomic databases

HOGENOMiHOG000113223.
HOVERGENiHBG006213.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR012568. K167R.
IPR029334. PP1-bd.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF08065. K167R. 15 hits.
PF15276. PP1_bind. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
SM01295. K167R. 14 hits.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSAHLVTI KRSGDDGAHF PLSLSSCLFG RSIECDIRIQ LPVVSQRHCP
60 70 80 90 100
IVVQEQEAIL YNFSSTNPTQ VNGVTIDEPV RLRHGDIITI IDRSFRYEDG
110 120 130 140 150
NHEDGSKPTE FPGKSLGKEP SRRASRDSFC ADPDGEGQDT KASKMTASRR
160 170 180 190 200
SFVYAKGLSA DSPASDGSKN SVSQDSSGHV EQHTGRNIVE PTSGGSLLRS
210 220 230 240 250
PGLQGAVTGN RSLLPTQSLS NSNEKESPFE KLYQSMKEEL DVKSQKSCRK
260 270 280 290 300
SEPQPDRAAE ESRETQLLVS GRARAKSSGS TPVTAASSPK VGKIWTERWR
310 320 330 340 350
GGMVPVQTST ETAKMKTPVR HSQQLKDEDS RVTGRRHSVN LDEGGSAQAV
360 370 380 390 400
HKTVTPGKLA TRNQTPVEAG DVGSPADTPE HSSSPQRSIP AKVEAPSAET
410 420 430 440 450
QNRLSLTQRL VPGEKKTPKG SFSKPEKLAT AAEQTCSGLP GLSSVDISNF
460 470 480 490 500
GDSINKSEGM PMKRRRVSFG GHLRPELFDE NLPPNTPLKR GETPTKRKSL
510 520 530 540 550
GTHSPAVLKT IIKERPQSPG KQESPGITPP RTNDQRRRSG RTSSGSNFLC
560 570 580 590 600
ETDIPKKAGR KSGNLPAKRA SISRSQHGIL QMICSKRRSG ASEANLIVAK
610 620 630 640 650
SWADVVKLGV KQTQTKVAKH VPPKQTSKRQ RRPSTPKKPT SNLHNQFTTG
660 670 680 690 700
HANSPCTIVV GRAQIEKVSV PARPYKMLNN LMLNRKVDFS EDLSGLTEMF
710 720 730 740 750
KTPVKEKQQQ MSDTGSVLSN SANLSERQLQ VTNSGDIPEP ITTEILGEKV
760 770 780 790 800
LSSTRNAAKQ QSDRYSASPT LRRRSIKHEN TVQTPKNVHN ITDLEKKTPV
810 820 830 840 850
SETEPLKTAS SVSKLRRSRE LRHTLVETMN EKTEAVLAEN TTARHLRGTF
860 870 880 890 900
REQKVDQQVQ DNENAPQRCK ESGELSEGSE KTSARRSSAR KQKPTKDLLG
910 920 930 940 950
SQMVTQTADY AEELLSQGQG TIQNLEESMH MQNTSISEDQ GITEKKVNII
960 970 980 990 1000
VYATKEKHSP KTPGKKAQPL EGPAGLKEHF ETPNPKDKPI TEDRTRVLCK
1010 1020 1030 1040 1050
SPQVTTENIT TNTKPQTSTS GKKVDMKEES SALTKRIHMP GESRHNPKIL
1060 1070 1080 1090 1100
KLECEDIKAL KQSENEMLTS TVNGSKRTLG KSKKKAQPLE DLTCFQELFI
1110 1120 1130 1140 1150
SPVPTNIIKK IPSKSPHTQP VRTPASTKRL SKTGLSKVDV RQEPSTLGKR
1160 1170 1180 1190 1200
TKSPGRAPGT PAPVQEENDC TAYMETPKQK LESIENLTGL RKQSRTPKDI
1210 1220 1230 1240 1250
TGFQDSFQIP DHANGPLVVV KTKKMFFNSP QPESAITRKS RERQSRASIS
1260 1270 1280 1290 1300
KIDVKEELLE SEEHLQLGEG VDTFQVSTNK VIRSSRKPAK RKLDSTAGMP
1310 1320 1330 1340 1350
NSKRMRCSSK DNTPCLEDLN GFQELFQMPG YANDSLTTGI STMLARSPQL
1360 1370 1380 1390 1400
GPVRTQINKK SLPKIILRKM DVTEEISGLW KQSLGRVHTT QEQEDNAIKA
1410 1420 1430 1440 1450
IMEIPKETLQ TAADGTRLTR QPQTPKEKVQ PLEDHSVFQE LFQTSRYCSD
1460 1470 1480 1490 1500
PLIGNKQTRM SLRSPQPGFV RTPRTSKRLA KTSVGNIAVR EKISPVSLPQ
1510 1520 1530 1540 1550
CATGEVVHIP IGPEDDTENK GVKESTPQTL DSSASRTVSK RQQGAHEERP
1560 1570 1580 1590 1600
QFSGDLFHPQ ELFQTPASGK DPVTVDETTK IALQSPQPGH IINPASMKRQ
1610 1620 1630 1640 1650
SNMSLRKDMR EFSILEKQTQ SRGRDAGTPA PMQEENGTTA IMETPKQKLD
1660 1670 1680 1690 1700
FIGNSTGHKR RPRTPKNRAQ PLEDLDGFQE LFQTPAGASD PVSVEESAKI
1710 1720 1730 1740 1750
SLASSQAEPV RTPASTKRRS KTGLSKVDVR QEPSTLGKRM KSLGRAPGTP
1760 1770 1780 1790 1800
APVQEENDST AFMETPKQKL DFTGNSSGHK RRPQTPKIRA QPLEDLDGFQ
1810 1820 1830 1840 1850
ELFQTPAGAN DSVTVEESVK MSLESSQAEP VKTPASTKRL SKTGLSKVDV
1860 1870 1880 1890 1900
REDPSILEKK TKSPGTPAPV QEENDCTAFM ETPKQKLDFT GNSSGHKRRP
1910 1920 1930 1940 1950
RTPKIRAQPL EDLDGFQELF QTPAGASDSV TVEESAKMSL ESSQAKPVKT
1960 1970 1980 1990 2000
PASTKRLSKT GLSKVDVRED PSTLGKKTKS PGRAPGTPAP VQEENDSTAF
2010 2020 2030 2040 2050
METPKQKLDF AENSSGSKRR SRTSKNRSQP LEDLDGFQEL FQTPAGASNP
2060 2070 2080 2090 2100
VSVEESAKIS LESSQAEPVR TRASTKRLSK TGLNKMDVRE GHSPLSKSSC
2110 2120 2130 2140 2150
ASQKVMQTLT LGEDHGRETK DGKVLLAQKL EPAIYVTRGK RQQRSCKKRS
2160 2170 2180 2190 2200
QSPEDLSGVQ EVFQTSGHNK DSVTVDNLAK LPSSSPPLEP TDTSVTSRRQ
2210 2220 2230 2240 2250
ARTGLRKVHV KNELSGGIMH PQISGEIVDL PREPEGEGKV IKTRKQSVKR
2260 2270 2280 2290 2300
KLDTEVNVPR SKRQRITRAE KTLEDLPGFQ ELCQAPSLVM DSVIVEKTPK
2310 2320 2330 2340 2350
MPDKSPEPVD TTSETQARRR LRRLVVTEEP IPQRKTTRVV RQTRNTQKEP
2360 2370 2380 2390 2400
ISDNQGMEEF KESSVQKQDP SVSLTGRRNQ PRTVKEKTQP LEELTSFQEE
2410 2420 2430 2440 2450
TAKRISSKSP QPEEKETLAG LKRQLRIQLI NDGVKEEPTA QRKQPSRETR
2460 2470 2480 2490 2500
NTLKEPVGDS INVEEVKKST KQKIDPVASV PVSKRPRRVP KEKAQALELA
2510 2520 2530 2540 2550
GLKGPIQTLG HTDESASDKG PTQMPCNSLQ PEQVDSFQSS PRRPRTRRGK
2560 2570 2580 2590 2600
VEADEEPSAV RKTVSTSRQT MRSRKVPEIG NNGTQVSKAS IKQTLDTVAK
2610 2620 2630 2640 2650
VTGSRRQLRT HKGWGSTLLK LLGDSKEITQ ISDHSEKLAH DTSILKSTQQ
2660 2670 2680 2690 2700
QKPDSVKPLR TCRRVLRASK EVPKEVLVDT RDHATLQSKS NPLLSPKRKS
2710 2720 2730 2740 2750
ARDGSIVRTR ALRSLAPKQE ATDEKPVPEK KRAASSKRYV SPEPVKMKHL
2760 2770 2780 2790 2800
KIVSNKLESV EEQVSTVMKT EEMEAKRENP VTPDQNSRYR KKTNVKQPRP
2810 2820 2830 2840 2850
KFDASAENVG IKKNEKTMKT ASQETELQNP DDGAKKSTSR GQVSGKRTCL
2860 2870 2880 2890 2900
RSRGTTEMPQ PCEAEEKTSK PAAEILIKPQ EEKGVSGESD VRCLRSRKTR
2910 2920 2930
VALDSEPKPR VTRGTKKDAK TLKEDEDIVC TKKLRTRS
Length:2,938
Mass (Da):324,429
Last modified:November 1, 1996 - v1
Checksum:iF8D798EDE9AA675D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82786 mRNA. Translation: CAA58026.1.
PIRiT30249.
UniGeneiMm.4078.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82786 mRNA. Translation: CAA58026.1.
PIRiT30249.
UniGeneiMm.4078.

3D structure databases

ProteinModelPortaliQ61769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61769. 2 interactions.
MINTiMINT-4109797.

Proteomic databases

PeptideAtlasiQ61769.
PRIDEiQ61769.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:106035. Mki67.

Phylogenomic databases

HOGENOMiHOG000113223.
HOVERGENiHBG006213.

Miscellaneous databases

ChiTaRSiMki67. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR012568. K167R.
IPR029334. PP1-bd.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF08065. K167R. 15 hits.
PF15276. PP1_bind. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
SM01295. K167R. 14 hits.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ61769_MOUSE
AccessioniPrimary (citable) accession number: Q61769
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.