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Protein

Keratin, type I cuticular Ha1

Gene

Krt31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei305Stutter1

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha1
Alternative name(s):
HKA-1
Hair keratin, type I Ha1
Keratin-31
Short name:
K31
Gene namesi
Name:Krt31
Synonyms:Hka1, Krt1-1, Krtha1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1309993. Krt31.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636851 – 416Keratin, type I cuticular Ha1Add BLAST416

Proteomic databases

MaxQBiQ61765.
PaxDbiQ61765.
PeptideAtlasiQ61765.
PRIDEiQ61765.

PTM databases

iPTMnetiQ61765.
PhosphoSitePlusiQ61765.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048981.
CleanExiMM_KRT31.
GenevisibleiQ61765. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007318.

Structurei

3D structure databases

ProteinModelPortaliQ61765.
SMRiQ61765.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 56HeadAdd BLAST55
Regioni57 – 363RodAdd BLAST307
Regioni57 – 91Coil 1AAdd BLAST35
Regioni92 – 102Linker 1Add BLAST11
Regioni103 – 203Coil 1BAdd BLAST101
Regioni204 – 219Linker 12Add BLAST16
Regioni220 – 363Coil 2Add BLAST144
Regioni364 – 416TailAdd BLAST53

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ61765.
KOiK07604.
OMAiITSPCTM.
OrthoDBiEOG091G087I.
PhylomeDBiQ61765.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNCCLPAL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VGNCNWFCEG
60 70 80 90 100
SFNGNEKETM QFLNDRLASY MEKVRQLERE NAELECRIQE RNQQQDPLVC
110 120 130 140 150
PAYQAYFRTI EELQQKILCS KSENARLVVQ IDNAKLAADD FRTKYETELG
160 170 180 190 200
LRQLVESDIN GLRRILDELT LCKSDLEAQV ESLKEELLCL KRNHEEEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNRVLNETRC QYEAMVETNR REVEEWFTTQ
260 270 280 290 300
TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH CMRNSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQCLITN VESQLGEIRA DLERQNQEYQ VLLDVKARLE
360 370 380 390 400
CEINTYRGLL ESEDCKLPCN PCATSNACGK PIGPCVSNPC VPCPPPAPCT
410
PCVPRPRCGP CNSFVR
Length:416
Mass (Da):47,117
Last modified:January 20, 2009 - v2
Checksum:i1ABE55EAA4CA3BCC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153 – 154QL → HV in AAA39372 (PubMed:2461417).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27734 mRNA. Translation: AAA39372.1.
AL592545 Genomic DNA. Translation: CAM22481.1.
CCDSiCCDS25405.1.
PIRiA46559.
A61404.
RefSeqiNP_034789.2. NM_010659.2.
UniGeneiMm.439673.

Genome annotation databases

EnsembliENSMUST00000007318; ENSMUSP00000007318; ENSMUSG00000048981.
GeneIDi16660.
KEGGimmu:16660.
UCSCiuc007lkd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27734 mRNA. Translation: AAA39372.1.
AL592545 Genomic DNA. Translation: CAM22481.1.
CCDSiCCDS25405.1.
PIRiA46559.
A61404.
RefSeqiNP_034789.2. NM_010659.2.
UniGeneiMm.439673.

3D structure databases

ProteinModelPortaliQ61765.
SMRiQ61765.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007318.

PTM databases

iPTMnetiQ61765.
PhosphoSitePlusiQ61765.

Proteomic databases

MaxQBiQ61765.
PaxDbiQ61765.
PeptideAtlasiQ61765.
PRIDEiQ61765.

Protocols and materials databases

DNASUi16660.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007318; ENSMUSP00000007318; ENSMUSG00000048981.
GeneIDi16660.
KEGGimmu:16660.
UCSCiuc007lkd.1. mouse.

Organism-specific databases

CTDi3881.
MGIiMGI:1309993. Krt31.

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ61765.
KOiK07604.
OMAiITSPCTM.
OrthoDBiEOG091G087I.
PhylomeDBiQ61765.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ61765.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048981.
CleanExiMM_KRT31.
GenevisibleiQ61765. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1H1_MOUSE
AccessioniPrimary (citable) accession number: Q61765
Secondary accession number(s): A2A5Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 20, 2009
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.