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Protein

Keratin, type I cuticular Ha1

Gene

Krt31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei305Stutter1

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha1
Alternative name(s):
HKA-1
Hair keratin, type I Ha1
Keratin-31
Short name:
K31
Gene namesi
Name:Krt31
Synonyms:Hka1, Krt1-1, Krtha1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1309993 Krt31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636851 – 416Keratin, type I cuticular Ha1Add BLAST416

Proteomic databases

MaxQBiQ61765
PaxDbiQ61765
PeptideAtlasiQ61765
PRIDEiQ61765

PTM databases

iPTMnetiQ61765
PhosphoSitePlusiQ61765
SwissPalmiQ61765

Expressioni

Gene expression databases

BgeeiENSMUSG00000048981
CleanExiMM_KRT31
GenevisibleiQ61765 MM

Interactioni

Protein-protein interaction databases

BioGridi201016, 1 interactor
STRINGi10090.ENSMUSP00000007318

Structurei

3D structure databases

ProteinModelPortaliQ61765
SMRiQ61765
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 367IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 56HeadAdd BLAST55
Regioni57 – 91Coil 1AAdd BLAST35
Regioni92 – 102Linker 1Add BLAST11
Regioni103 – 203Coil 1BAdd BLAST101
Regioni204 – 219Linker 12Add BLAST16
Regioni220 – 363Coil 2Add BLAST144
Regioni364 – 416TailAdd BLAST53

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P Eukaryota
ENOG410YK2A LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ61765
KOiK07604
OMAiNPCVSRT
OrthoDBiEOG091G087I
PhylomeDBiQ61765
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q61765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNCCLPAL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VGNCNWFCEG
60 70 80 90 100
SFNGNEKETM QFLNDRLASY MEKVRQLERE NAELECRIQE RNQQQDPLVC
110 120 130 140 150
PAYQAYFRTI EELQQKILCS KSENARLVVQ IDNAKLAADD FRTKYETELG
160 170 180 190 200
LRQLVESDIN GLRRILDELT LCKSDLEAQV ESLKEELLCL KRNHEEEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNRVLNETRC QYEAMVETNR REVEEWFTTQ
260 270 280 290 300
TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH CMRNSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQCLITN VESQLGEIRA DLERQNQEYQ VLLDVKARLE
360 370 380 390 400
CEINTYRGLL ESEDCKLPCN PCATSNACGK PIGPCVSNPC VPCPPPAPCT
410
PCVPRPRCGP CNSFVR
Length:416
Mass (Da):47,117
Last modified:January 20, 2009 - v2
Checksum:i1ABE55EAA4CA3BCC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153 – 154QL → HV in AAA39372 (PubMed:2461417).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27734 mRNA Translation: AAA39372.1
AL592545 Genomic DNA No translation available.
CCDSiCCDS25405.1
PIRiA46559
A61404
RefSeqiNP_034789.2, NM_010659.2
UniGeneiMm.439673

Genome annotation databases

EnsembliENSMUST00000007318; ENSMUSP00000007318; ENSMUSG00000048981
GeneIDi16660
KEGGimmu:16660
UCSCiuc007lkd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiK1H1_MOUSE
AccessioniPrimary (citable) accession number: Q61765
Secondary accession number(s): A2A5Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 20, 2009
Last modified: May 23, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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