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Q61762

- KCNA5_MOUSE

UniProt

Q61762 - KCNA5_MOUSE

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Protein
Potassium voltage-gated channel subfamily A member 5
Gene
Kcna5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation.1 Publication

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. outward rectifier potassium channel activity Source: Ensembl
  3. potassium channel inhibitor activity Source: MGI
  4. protein binding Source: MGI
  5. voltage-gated potassium channel activity Source: MGI
  6. voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. membrane hyperpolarization Source: Ensembl
  2. negative regulation of cytosolic calcium ion concentration Source: Ensembl
  3. negative regulation of potassium ion transport Source: MGI
  4. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  5. positive regulation of myoblast proliferation Source: Ensembl
  6. potassium ion export Source: Ensembl
  7. potassium ion homeostasis Source: Ensembl
  8. potassium ion transport Source: MGI
  9. protein homooligomerization Source: InterPro
  10. regulation of atrial cardiac muscle cell membrane repolarization Source: Ensembl
  11. regulation of heart rate by cardiac conduction Source: Ensembl
  12. regulation of membrane potential Source: MGI
  13. regulation of vasoconstriction Source: MGI
  14. response to hypoxia Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 5
Alternative name(s):
Voltage-gated potassium channel subunit Kv1.5
Short name:
KV1-5
Gene namesi
Name:Kcna5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96662. Kcna5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei242 – 26019Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Transmembranei316 – 33621Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Transmembranei347 – 36822Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Transmembranei387 – 40822Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Transmembranei423 – 44422Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Transmembranei484 – 50522Helical; Name=Segment S6; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. Z disc Source: Ensembl
  3. endoplasmic reticulum Source: Ensembl
  4. integral component of plasma membrane Source: MGI
  5. intercalated disc Source: MGI
  6. intracellular canaliculus Source: Ensembl
  7. membrane Source: MGI
  8. membrane raft Source: Ensembl
  9. perinuclear region of cytoplasm Source: Ensembl
  10. plasma membrane Source: MGI
  11. voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. The action potential in myocytes is not prolonged by low concentrations of 4-aminopyridine, contrary to the situation in wild-type.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602Potassium voltage-gated channel subfamily A member 5
PRO_0000053986Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi44 – 441N-linked (GlcNAc...) Reviewed prediction
Modified residuei81 – 811Phosphoserine; by CK2 and PKA Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi181 – 1811N-linked (GlcNAc...) Reviewed prediction
Cross-linki212 – 212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...) Reviewed prediction
Lipidationi337 – 3371S-palmitoyl cysteine Reviewed prediction
Cross-linki525 – 525Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Modified residuei535 – 5351Phosphoserine; by PKA Reviewed prediction
Modified residuei546 – 5461Phosphoserine; by PKA Reviewed prediction
Modified residuei569 – 5691Phosphoserine; by PKA Reviewed prediction

Post-translational modificationi

Sumoylated on Lys-212, and Lys-525, preferentially with SUMO3. Sumoylation regulates the voltage sensitivity of the channel By similarity.

Keywords - PTMi

Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ61762.
PRIDEiQ61762.

PTM databases

PhosphoSiteiQ61762.

Expressioni

Tissue specificityi

Highly expressed in heart and moderately in brain. Low levels in thymus, skeletal muscle and spleen. Not expressed in liver, lung or kidney.

Gene expression databases

BgeeiQ61762.
GenevestigatoriQ61762.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins. Interacts with DLG1, which enhances channel currents. Forms a ternary complex with DLG1 and CAV3 By similarity. Interacts with UBE2I By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055673.

Structurei

3D structure databases

ProteinModelPortaliQ61762.
SMRiQ61762. Positions 111-516.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi469 – 4746Selectivity filter By similarity
Motifi600 – 6023PDZ-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi373 – 3764Poly-Gly

Domaini

The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments By similarity.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00740000115291.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiQ9Z1R6.
KOiK04878.
OMAiGGELQCP.
OrthoDBiEOG7M0NRD.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004052. K_chnl_volt-dep_Kv1.5.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF25. PTHR11537:SF25. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01512. KV15CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q61762-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEISLVPMEN GSAMTLRGGG EAGASCVQSP RGECGCPPTA GLNNQSKETS    50
PRRRATHEDA GQGGRPLPPM PQELPQPRRP SAEDEEGEGD PGLGTVEEDQ 100
APQDSGSLHH QRVLINISGL RFETQLGTLA QFPNTLLGDP VKRLRYFDPL 150
RNEYFFDRNR PSFDGILYYY QSGGRLRRPV NVSLDVFADE IRFYQLGDEA 200
MERFREDEGF IKEEEKPLPR NEFQRQVWLI FEYPESSGSA RAIAIVSVLV 250
ILISIITFCL ETLPEFRDER ELLRHPPVPP QPPAPAPGAN GSGSGVLSSG 300
PTVAPLLPRT LADPFFIVET TCVIWFTFEL LVRFFACPSK AEFSRNIMNI 350
IDIVAIFPYF ITLGTELAEQ QPGGGGQNGQ QAMSLAILRV IRLVRVFRIF 400
KLSRHSKGLQ ILGKTLQASM RELGLLIFFL FIGVILFSSA VYFAEADNQG 450
SHFSSIPDAF WWAVVTMTTV GYGDMRPITV GGKIVGSLCA IAGVLTIALP 500
VPVIVSNFNY FYHRETDHEE QAALKEEQGI QRRESGLDTG GQRKVSCSKA 550
SFCKTGGPLE STDSIRRGSC PLEKCHLKAK SNVDLRRSLY ALCLDTSRET 600
DL 602
Length:602
Mass (Da):66,580
Last modified:July 27, 2011 - v2
Checksum:i02926E85DC022DDA
GO
Isoform 2 (identifier: Q61762-2) [UniParc]FASTAAdd to Basket

Also known as: 5'

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: Missing.

Show »
Length:402
Mass (Da):44,539
Checksum:i6BB846FB2409473D
GO
Isoform 3 (identifier: Q61762-3) [UniParc]FASTAAdd to Basket

Also known as: 3'

The sequence of this isoform differs from the canonical sequence as follows:
     515-602: Missing.

Note: Inactive. Inhibits expression of isoform 1 and isoform 2.

Show »
Length:514
Mass (Da):56,871
Checksum:i9A047A2DE9D6DC7B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 200200Missing in isoform 2.
VSP_000961Add
BLAST
Alternative sequencei515 – 60288Missing in isoform 3.
VSP_000962Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81M → T in AAA39365. 1 Publication
Sequence conflicti23 – 231G → V in AAA39365. 1 Publication
Sequence conflicti61 – 611G → A in AAA39365. 1 Publication
Sequence conflicti127 – 1271G → D in AAA39365. 1 Publication
Sequence conflicti130 – 1301A → V in AAA39365. 1 Publication
Sequence conflicti135 – 1351T → N in AAA39365. 1 Publication
Sequence conflicti249 – 2491L → S in AAA39365. 1 Publication
Sequence conflicti268 – 2692DE → VD in AAA39365. 1 Publication
Sequence conflicti274 – 2741R → L in AAA39365. 1 Publication
Sequence conflicti289 – 2913ANG → TNA in AAA39365. 1 Publication
Sequence conflicti301 – 3011P → T in AAA39365. 1 Publication
Sequence conflicti452 – 4532HF → QL in AAA39365. 1 Publication
Sequence conflicti553 – 5531C → H in AAA39365. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22218 mRNA. Translation: AAA39365.1.
AF108659 mRNA. Translation: AAD13779.1.
AF302768 Genomic DNA. Translation: AAG40241.1.
AK146843 mRNA. Translation: BAE27474.1.
CH466523 Genomic DNA. Translation: EDK99840.1.
BC021787 mRNA. Translation: AAH21787.1.
CCDSiCCDS20554.1. [Q61762-1]
PIRiA49507.
RefSeqiNP_666095.1. NM_145983.2. [Q61762-1]
UniGeneiMm.222831.

Genome annotation databases

EnsembliENSMUST00000060972; ENSMUSP00000055673; ENSMUSG00000045534. [Q61762-1]
GeneIDi16493.
KEGGimmu:16493.
UCSCiuc009dva.2. mouse. [Q61762-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22218 mRNA. Translation: AAA39365.1 .
AF108659 mRNA. Translation: AAD13779.1 .
AF302768 Genomic DNA. Translation: AAG40241.1 .
AK146843 mRNA. Translation: BAE27474.1 .
CH466523 Genomic DNA. Translation: EDK99840.1 .
BC021787 mRNA. Translation: AAH21787.1 .
CCDSi CCDS20554.1. [Q61762-1 ]
PIRi A49507.
RefSeqi NP_666095.1. NM_145983.2. [Q61762-1 ]
UniGenei Mm.222831.

3D structure databases

ProteinModelPortali Q61762.
SMRi Q61762. Positions 111-516.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000055673.

PTM databases

PhosphoSitei Q61762.

Proteomic databases

PaxDbi Q61762.
PRIDEi Q61762.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060972 ; ENSMUSP00000055673 ; ENSMUSG00000045534 . [Q61762-1 ]
GeneIDi 16493.
KEGGi mmu:16493.
UCSCi uc009dva.2. mouse. [Q61762-1 ]

Organism-specific databases

CTDi 3741.
MGIi MGI:96662. Kcna5.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00740000115291.
HOGENOMi HOG000231015.
HOVERGENi HBG052230.
InParanoidi Q9Z1R6.
KOi K04878.
OMAi GGELQCP.
OrthoDBi EOG7M0NRD.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 289799.
PROi Q61762.
SOURCEi Search...

Gene expression databases

Bgeei Q61762.
Genevestigatori Q61762.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004052. K_chnl_volt-dep_Kv1.5.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
PTHR11537:SF25. PTHR11537:SF25. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01512. KV15CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel."
    Attali B., Lesage F., Ziliani P., Guillemare E., Honore E., Waldmann R., Hugnot J.-P., Mattei M.-G., Lazdunski M., Barhanin J.
    J. Biol. Chem. 268:24283-24289(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: Swiss.
    Tissue: Heart.
  2. "Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K,slow) and resistance to drug-induced qt prolongation."
    London B., Guo W., Pan X., Lee J.S., Shusterman V., Rocco C.J., Logothetis D.A., Nerbonne J.M., Hill J.A.
    Circ. Res. 88:940-946(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE, FUNCTION.
    Strain: 129/Sv.
  3. "Cloning and functional expression of mouse heart K+ channel alpha-subunits, Kv1.5, Kv4.2, and Kv4.3."
    Tanaka H., Janzen K., Winkfein R.J., Fiset C., Clark B., Giles W.R.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Stomach.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiKCNA5_MOUSE
AccessioniPrimary (citable) accession number: Q61762
Secondary accession number(s): Q9Z1R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi