Q61759Q61760Q9JM70K1B21_MOUSEKallikrein 1-related peptidase b213.4.21.35Glandular kallikrein K21mGK-21Tissue kallikrein 21Klk1b21Klk-21Klk21Mus musculusMouseEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMusCloning and characterization of mouse Klk27, a novel tissue kallikrein expressed in testicular Leydig cells and exhibiting chymotrypsin-like specificity.NUCLEOTIDE SEQUENCEMouse testicular Leydig cells express Klk21, a tissue kallikrein that cleaves fibronectin and IGF-binding protein-3.NUCLEOTIDE SEQUENCEFUNCTIONACTIVITY REGULATIONTISSUE SPECIFICITYDEVELOPMENTAL STAGEINDUCTIONThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus.NUCLEOTIDE SEQUENCE OF 17-54 AND 70-122Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Displays trypsin-like substrate specificity and shows activity towards casein, gelatin, fibronectin and IGFBP3.Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.Inhibited by protease inhibitors diisopropylfluorophosphate, leupeptin, antipain, benzamidine, phenylmethylsulfonyl fluoride and soybean trypsin inhibitor.Expressed in testis and submaxillary gland. In the testis, expression localized specifically to Leydig cells in the interstitial tissues.Detectable in testis 4 weeks after birth, becoming more prominent thereafter.By T protein.Belongs to the peptidase S1 family. Kallikrein subfamily.Disulfide bondGlycoproteinHydrolaseProteaseReference proteomeSerine proteaseSignalZymogenMRFLILFLALSLGEIDAAPPVQSRIVGGFNCEKNSQPWHVAVFRYNKYICGGVLLNPNWVLTAAHCYGNQYNVWLGKNKLFQHESSAQHRLVSKSFPHPDYNMSLMNDHTPHPEDDYSNDLMLLRLSKPADITDAVKPIDLPTEEPKLGSTCLASGWGSITPTKWQIPNDLQCGFIKPLPNENCAKAYIHKVTDVMLCAGEMGGGKDTCAGDSGGPLICDGVLQGITSWGSIPCAKPNAPAIYTKLIKFTSWIKDTMAKNP
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