Reviewed,
UniProtKB/Swiss-Prot Q61754 (K1B24_MOUSE)
Last modified
May 26, 2009.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Kallikrein 1-related peptidase b24 EC=3.4.21.35 Alternative name(s): Glandular kallikrein K24 Short name=mGK-24 Tissue kallikrein 24 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 263 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. |
| Catalytic activity | Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. |
| Sequence similarities | Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain. |
Ontologies
| Keywords | |
|---|---|
| Domain | Signal |
| Molecular function | Hydrolase Protease Serine protease |
| PTM | Disulfide bond Glycoprotein Zymogen |
| Gene Ontology (GO) | |
| Biological process | proteolysis Ref.1 Non-traceable author statement. Source: UniProtKB |
| Molecular function | serine-type endopeptidase activity Ref.1 Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 17 | 17 | Potential | ||||||||
| Propeptide | 18 – 24 | 7 | Activation peptide By similarity UniProtKB P36368 | PRO_0000027991 | |||||||
| Chain | 25 – 263 | 239 | Kallikrein 1-related peptidase b24 | PRO_0000027992 | |||||||
Regions | |||||||||||
| Domain | 25 – 260 | 236 | Peptidase S1 | ||||||||
Sites | |||||||||||
| Active site | 65 | 1 | Charge relay system By similarity UniProtKB P36368 | ||||||||
| Active site | 122 | 1 | Charge relay system By similarity UniProtKB P36368 | ||||||||
| Active site | 215 | 1 | Charge relay system By similarity UniProtKB P36368 | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 69 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 105 | 1 | N-linked (GlcNAc...) Potential UniProtKB P36368 | ||||||||
| Glycosylation | 185 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 31 ↔ 175 | By similarity UniProtKB P36368 | |||||||||
| Disulfide bond | 50 ↔ 66 | By similarity UniProtKB P36368 | |||||||||
| Disulfide bond | 154 ↔ 221 | By similarity UniProtKB P36368 | |||||||||
| Disulfide bond | 186 ↔ 200 | By similarity UniProtKB P36368 | |||||||||
| Disulfide bond | 211 ↔ 236 | By similarity UniProtKB P36368 | |||||||||
Sequences
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References
| [1] | "Cloning and characterization of mouse Klk27, a novel tissue kallikrein expressed in testicular Leydig cells and exhibiting chymotrypsin-like specificity." Matsui H., Moriyama A., Takahashi T. Eur. J. Biochem. 267:6858-6865(2000) [PubMed: 11082197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Testis. |
| [2] | "Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus." Evans B.A., Drinkwater C.C., Richards R.I. J. Biol. Chem. 262:8027-8034(1987) [PubMed: 3036794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 17-54 AND 73-124. Strain: BALB/c. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB039277 mRNA. Translation: BAA92320.1. M18619, M18599 Genomic DNA. Translation: AAG11390.1. | |
| IPI | IPI00124804. |
| PIR | I70016. I70017. |
| RefSeq | NP_034773.1. |
| UniGene | Mm.444308 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1SGF based on UniProtKB P00757. |
| SMR | Q61754. Positions 25-262. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUSG00000063713. Mus musculus. [Contig view] |
| GeneID | 16617. |
| KEGG | mmu:16617. |
Organism-specific databases | |
| MGI | MGI:892021. Klk1b24. |
Phylogenomic databases | |
| HOVERGEN | Q61754. |
| OMA | Q61754. CVNINIL. |
Enzyme and pathway databases | |
| BRENDA | 3.4.21.35. 244. |
Gene expression databases | |
| ArrayExpress | Q61754. |
| Bgee | Q61754. |
| CleanEx | MM_KLK1B24. |
| GermOnline | ENSMUSG00000063713. Mus musculus. |
Family and domain databases | |
| InterPro | IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. [Graphical view] |
| Pfam | PF00089. Trypsin. 1 hit. [Graphical view] |
| PRINTS | PR00722. CHYMOTRYPSIN. |
| SMART | SM00020. Tryp_SPc. 1 hit. [Graphical view] |
| PROSITE | PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 290215. |
| SOURCE | Search... |
Entry information
| Entry name | K1B24_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q61754 Secondary accession number(s): Q61755, Q9JM69 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

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