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Q61754

- K1B24_MOUSE

UniProt

Q61754 - K1B24_MOUSE

Protein

Kallikrein 1-related peptidase b24

Gene

Klk1b24

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.Curated

    Catalytic activityi

    Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay systemBy similarity
    Active sitei122 – 1221Charge relay systemBy similarity
    Active sitei215 – 2151Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: UniProtKB

    GO - Biological processi

    1. proteolysis Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

    Protein family/group databases

    MEROPSiS01.069.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein 1-related peptidase b24 (EC:3.4.21.35)
    Alternative name(s):
    Glandular kallikrein K24
    Short name:
    mGK-24
    Tissue kallikrein 24
    Gene namesi
    Name:Klk1b24
    Synonyms:Klk-24, Klk24
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:892021. Klk1b24.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 247Activation peptideBy similarityPRO_0000027991
    Chaini25 – 263239Kallikrein 1-related peptidase b24PRO_0000027992Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 175By similarityPROSITE-ProRule annotation
    Disulfide bondi50 ↔ 66By similarityPROSITE-ProRule annotation
    Glycosylationi69 – 691N-linked (GlcNAc...)Curated
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi154 ↔ 221By similarityPROSITE-ProRule annotation
    Glycosylationi185 – 1851N-linked (GlcNAc...)Curated
    Disulfide bondi186 ↔ 200By similarityPROSITE-ProRule annotation
    Disulfide bondi211 ↔ 236By similarityPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiQ61754.
    PaxDbiQ61754.
    PRIDEiQ61754.

    PTM databases

    PhosphoSiteiQ61754.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61754.
    BgeeiQ61754.
    CleanExiMM_KLK1B24.
    GenevestigatoriQ61754.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000073392.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61754.
    SMRiQ61754. Positions 25-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 260236Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00750000117405.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiA6H6V7.
    KOiK01325.
    OMAiLTWINDT.
    OrthoDBiEOG7VDXPV.
    PhylomeDBiQ61754.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61754-1 [UniParc]FASTAAdd to Basket

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    MWFLILFLAL SLGGIDAAPP VQSRVVGGFK CEKNSQPWHV AVFRYNKYIC    50
    GGVLLNPNWV LTAAHCYGNA TSQYNVWLGK NKLFQREPSA QHRWVSKSFP 100
    HPDYNMSLLN DDIPQPKDKS NDLMLLRLSE PADITDAVKP IDLPTEEPKL 150
    GSTCLASGWG SITPTKWQKP NDLQCVFIKL LPNENCTKPY LHKVTDVMLC 200
    AGEMGGGKDT CAGDSGGPLI CDGILHGITS WGPVPCGKPN APAIYTKLIK 250
    FASWIKDTMA KNP 263
    Length:263
    Mass (Da):28,926
    Last modified:June 7, 2004 - v3
    Checksum:i4EE052242B7A415F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039277 mRNA. Translation: BAA92320.1.
    BC146015 mRNA. Translation: AAI46016.1.
    BC146019 mRNA. Translation: AAI46020.1.
    M18619, M18599 Genomic DNA. Translation: AAG11390.1.
    CCDSiCCDS21198.1.
    PIRiI70016.
    I70017.
    RefSeqiNP_034773.1. NM_010643.1.
    UniGeneiMm.483098.

    Genome annotation databases

    EnsembliENSMUST00000073713; ENSMUSP00000073392; ENSMUSG00000063713.
    GeneIDi16617.
    KEGGimmu:16617.
    UCSCiuc009gok.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039277 mRNA. Translation: BAA92320.1 .
    BC146015 mRNA. Translation: AAI46016.1 .
    BC146019 mRNA. Translation: AAI46020.1 .
    M18619 , M18599 Genomic DNA. Translation: AAG11390.1 .
    CCDSi CCDS21198.1.
    PIRi I70016.
    I70017.
    RefSeqi NP_034773.1. NM_010643.1.
    UniGenei Mm.483098.

    3D structure databases

    ProteinModelPortali Q61754.
    SMRi Q61754. Positions 25-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000073392.

    Protein family/group databases

    MEROPSi S01.069.

    PTM databases

    PhosphoSitei Q61754.

    Proteomic databases

    MaxQBi Q61754.
    PaxDbi Q61754.
    PRIDEi Q61754.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073713 ; ENSMUSP00000073392 ; ENSMUSG00000063713 .
    GeneIDi 16617.
    KEGGi mmu:16617.
    UCSCi uc009gok.1. mouse.

    Organism-specific databases

    CTDi 16617.
    MGIi MGI:892021. Klk1b24.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00750000117405.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi A6H6V7.
    KOi K01325.
    OMAi LTWINDT.
    OrthoDBi EOG7VDXPV.
    PhylomeDBi Q61754.
    TreeFami TF331065.

    Enzyme and pathway databases

    Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

    Miscellaneous databases

    NextBioi 290215.
    PROi Q61754.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61754.
    Bgeei Q61754.
    CleanExi MM_KLK1B24.
    Genevestigatori Q61754.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of mouse Klk27, a novel tissue kallikrein expressed in testicular Leydig cells and exhibiting chymotrypsin-like specificity."
      Matsui H., Moriyama A., Takahashi T.
      Eur. J. Biochem. 267:6858-6865(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis1 Publication.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus."
      Evans B.A., Drinkwater C.C., Richards R.I.
      J. Biol. Chem. 262:8027-8034(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-54 AND 73-124.
      Strain: BALB/c1 Publication.
      Tissue: Liver1 Publication.

    Entry informationi

    Entry nameiK1B24_MOUSE
    AccessioniPrimary (citable) accession number: Q61754
    Secondary accession number(s): A6H6V7, Q61755, Q9JM69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3