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Q61754

- K1B24_MOUSE

UniProt

Q61754 - K1B24_MOUSE

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Protein

Kallikrein 1-related peptidase b24

Gene

Klk1b24

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.Curated

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay systemBy similarity
Active sitei122 – 1221Charge relay systemBy similarity
Active sitei215 – 2151Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB

GO - Biological processi

  1. proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

Protein family/group databases

MEROPSiS01.069.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b24 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein K24
Short name:
mGK-24
Tissue kallikrein 24
Gene namesi
Name:Klk1b24
Synonyms:Klk-24, Klk24
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:892021. Klk1b24.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 247Activation peptideBy similarityPRO_0000027991
Chaini25 – 263239Kallikrein 1-related peptidase b24PRO_0000027992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 175By similarityPROSITE-ProRule annotation
Disulfide bondi50 ↔ 66By similarityPROSITE-ProRule annotation
Glycosylationi69 – 691N-linked (GlcNAc...)Curated
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi154 ↔ 221By similarityPROSITE-ProRule annotation
Glycosylationi185 – 1851N-linked (GlcNAc...)Curated
Disulfide bondi186 ↔ 200By similarityPROSITE-ProRule annotation
Disulfide bondi211 ↔ 236By similarityPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ61754.
PaxDbiQ61754.
PRIDEiQ61754.

PTM databases

PhosphoSiteiQ61754.

Expressioni

Gene expression databases

BgeeiQ61754.
CleanExiMM_KLK1B24.
ExpressionAtlasiQ61754. baseline and differential.
GenevestigatoriQ61754.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073392.

Structurei

3D structure databases

ProteinModelPortaliQ61754.
SMRiQ61754. Positions 25-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 260236Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ61754.
KOiK01325.
OMAiLTWINDT.
OrthoDBiEOG7VDXPV.
PhylomeDBiQ61754.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61754-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWFLILFLAL SLGGIDAAPP VQSRVVGGFK CEKNSQPWHV AVFRYNKYIC
60 70 80 90 100
GGVLLNPNWV LTAAHCYGNA TSQYNVWLGK NKLFQREPSA QHRWVSKSFP
110 120 130 140 150
HPDYNMSLLN DDIPQPKDKS NDLMLLRLSE PADITDAVKP IDLPTEEPKL
160 170 180 190 200
GSTCLASGWG SITPTKWQKP NDLQCVFIKL LPNENCTKPY LHKVTDVMLC
210 220 230 240 250
AGEMGGGKDT CAGDSGGPLI CDGILHGITS WGPVPCGKPN APAIYTKLIK
260
FASWIKDTMA KNP
Length:263
Mass (Da):28,926
Last modified:June 7, 2004 - v3
Checksum:i4EE052242B7A415F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039277 mRNA. Translation: BAA92320.1.
BC146015 mRNA. Translation: AAI46016.1.
BC146019 mRNA. Translation: AAI46020.1.
M18619, M18599 Genomic DNA. Translation: AAG11390.1.
CCDSiCCDS21198.1.
PIRiI70016.
I70017.
RefSeqiNP_034773.1. NM_010643.1.
UniGeneiMm.483098.

Genome annotation databases

EnsembliENSMUST00000073713; ENSMUSP00000073392; ENSMUSG00000063713.
GeneIDi16617.
KEGGimmu:16617.
UCSCiuc009gok.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039277 mRNA. Translation: BAA92320.1 .
BC146015 mRNA. Translation: AAI46016.1 .
BC146019 mRNA. Translation: AAI46020.1 .
M18619 , M18599 Genomic DNA. Translation: AAG11390.1 .
CCDSi CCDS21198.1.
PIRi I70016.
I70017.
RefSeqi NP_034773.1. NM_010643.1.
UniGenei Mm.483098.

3D structure databases

ProteinModelPortali Q61754.
SMRi Q61754. Positions 25-262.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000073392.

Protein family/group databases

MEROPSi S01.069.

PTM databases

PhosphoSitei Q61754.

Proteomic databases

MaxQBi Q61754.
PaxDbi Q61754.
PRIDEi Q61754.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073713 ; ENSMUSP00000073392 ; ENSMUSG00000063713 .
GeneIDi 16617.
KEGGi mmu:16617.
UCSCi uc009gok.1. mouse.

Organism-specific databases

CTDi 16617.
MGIi MGI:892021. Klk1b24.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118862.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi Q61754.
KOi K01325.
OMAi LTWINDT.
OrthoDBi EOG7VDXPV.
PhylomeDBi Q61754.
TreeFami TF331065.

Enzyme and pathway databases

Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

Miscellaneous databases

NextBioi 290215.
PROi Q61754.
SOURCEi Search...

Gene expression databases

Bgeei Q61754.
CleanExi MM_KLK1B24.
ExpressionAtlasi Q61754. baseline and differential.
Genevestigatori Q61754.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of mouse Klk27, a novel tissue kallikrein expressed in testicular Leydig cells and exhibiting chymotrypsin-like specificity."
    Matsui H., Moriyama A., Takahashi T.
    Eur. J. Biochem. 267:6858-6865(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis1 Publication.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus."
    Evans B.A., Drinkwater C.C., Richards R.I.
    J. Biol. Chem. 262:8027-8034(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-54 AND 73-124.
    Strain: BALB/c1 Publication.
    Tissue: Liver1 Publication.

Entry informationi

Entry nameiK1B24_MOUSE
AccessioniPrimary (citable) accession number: Q61754
Secondary accession number(s): A6H6V7, Q61755, Q9JM69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 29, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3