Reviewed, UniProtKB/Swiss-Prot Q61751 (Z354A_MOUSE)

Names and origin

Protein names

Recommended name:
    Zinc finger protein 354A
Alternative name(s):
    Transcription factor 17
    Kidney, ischemia, and developmentally-regulated protein 1
    Renal transcription factor Kid-1

Gene names

Name:	Znf354a
Synonyms:	Kid1, Tcf17, Zfp354a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
Subcellular location	Nucleus.
Tissue specificity	Highly expressed in eye and kidney.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 13 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 572	572	Zinc finger protein 354A		PRO_0000047239
Regions
	Domain	14 – 85	72	KRAB
	Zinc finger	184 – 206	23	C2H2-type 1
	Zinc finger	212 – 234	23	C2H2-type 2
	Zinc finger	240 – 262	23	C2H2-type 3
	Zinc finger	268 – 290	23	C2H2-type 4
	Zinc finger	321 – 343	23	C2H2-type 5
	Zinc finger	349 – 371	23	C2H2-type 6
	Zinc finger	377 – 399	23	C2H2-type 7
	Zinc finger	405 – 427	23	C2H2-type 8
	Zinc finger	431 – 455	25	C2H2-type 9
	Zinc finger	461 – 483	23	C2H2-type 10
	Zinc finger	489 – 511	23	C2H2-type 11
	Zinc finger	517 – 539	23	C2H2-type 12
	Zinc finger	545 – 567	23	C2H2-type 13

Sequences

	Sequence		Length	Mass (Da)
	Q61751-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: E9FCF9CEF7AF82E1	FASTA	572	65,720
	10 20 30 40 50 60 MAPEQWEATS QVSLTFEDVA VLFTRDEWKK LVPSQRSLYR EVMLENYSNL ASLGFPFTKP 70 80 90 100 110 120 KVISLLQQGE DPWKVEEEGP GDFSLGLKCS QRTTKSTQTQ DSSFRELIMR KSKRKEPWNM 130 140 150 160 170 180 KSENLSIHEG KLEEKWDVNA STIERSYKSN ELSPKSHREK RSSECEKQIS YLSNPLGITP 190 200 210 220 230 240 DKRYKCSMCE KTFINTSSLR KHEKNHSGEK LFKCKECSKA FSQSSALIQH QITHTGEKPY 250 260 270 280 290 300 VCKECGKAFT LSTSLYKHLR THTVEKSYRC KECGKSFGRR SGLFIHQKVH AGENPYKYNP 310 320 330 340 350 360 GRKASTSLSG CQRIHSRKKT YLCNECGNTF KSSSSLRYHQ RIHTGEKPFK CSECGRAFSQ 370 380 390 400 410 420 SASLIQHERI HTGEKPYRCS ECGKGFTSIS RLNRHRIIHT GEKFYNCNEC GKALSSHSTL 430 440 450 460 470 480 IIHERIHTGE KPCKCKVCGK AFRQSSALIQ HQRMHTGERP YKCNECGKTF RCNSSLSNHQ 490 500 510 520 530 540 RTHTGEKPYR CQECGMSFGQ SSALIQHRRI HTGEKPFKCN TCGKTFRQSS SRIAHQRIHT 550 560 570 GEKPYECNTC GKLFNHRSSL TNHYKIHVDE DP

References

[1]	"The transcription factor, Kid-1, is highly expressed in both eye and kidney of the mouse." Brady J.P., Duncan M.K., Wawrousek E.F., Piatigorsky J. Exp. Eye Res. 64:287-290(1997) [PubMed: 9176064] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lens.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L77247 mRNA. Translation: AAA96309.1.
IPI	IPI00331372.
UniGene	Mm.4792
3D structure databases
HSSP	HSSP built from PDB template 1SP2 based on UniProtKB P08047.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000020364. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:103172. Zfp354a.
Phylogenomic databases
HOVERGEN	Q61751.
Gene expression databases
ArrayExpress	Q61751.
Bgee	Q61751.
CleanEx	MM_ZFP354A.
GermOnline	ENSMUSG00000020364. Mus musculus.
Family and domain databases
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 13 hits.
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 13 hits. [Graphical view]
ProDom	PD000003. Znf_C2H2. 13 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 13 hits. [Graphical view]
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 13 hits. PS50157. ZINC_FINGER_C2H2_2. 13 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

Z354A_MOUSE

Accession

Primary (citable) accession number: Q61751

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)