Q61751 (Z354A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 354A

Alternative name(s):
Kidney, ischemia, and developmentally-regulated protein 1
Renal transcription factor Kid-1
Transcription factor 17
Short name=TCF-17

Gene names

Name:	Znf354a
Synonyms:	Kid1, Tcf17, Zfp354a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
Subcellular location	Nucleus.
Tissue specificity	Highly expressed in eye and kidney. Detected at high levels in adult brain and kidney, and at lower levels in adult liver, lung, skeletal muscle, heart, salivary gland, testis and tongue. Detected in embryonic brain, heart, lung,kidney and gut. Ref.2
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 13 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 572	572	Zinc finger protein 354A		PRO_0000047239
Regions
	Domain	14 – 85	72	KRAB
	Zinc finger	184 – 206	23	C2H2-type 1
	Zinc finger	212 – 234	23	C2H2-type 2
	Zinc finger	240 – 262	23	C2H2-type 3
	Zinc finger	268 – 290	23	C2H2-type 4
	Zinc finger	321 – 343	23	C2H2-type 5
	Zinc finger	349 – 371	23	C2H2-type 6
	Zinc finger	377 – 399	23	C2H2-type 7
	Zinc finger	405 – 427	23	C2H2-type 8
	Zinc finger	431 – 455	25	C2H2-type 9
	Zinc finger	461 – 483	23	C2H2-type 10
	Zinc finger	489 – 511	23	C2H2-type 11
	Zinc finger	517 – 539	23	C2H2-type 12
	Zinc finger	545 – 567	23	C2H2-type 13
Experimental info
	Sequence conflict	82	1	G → D in AAA96309. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q61751 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 1BB5DDFAA51AA9B3	FASTA	572	65,662
	10 20 30 40 50 60 MAPEQWEATS QVSLTFEDVA VLFTRDEWKK LVPSQRSLYR EVMLENYSNL ASLGFPFTKP 70 80 90 100 110 120 KVISLLQQGE DPWKVEEEGP GGFSLGLKCS QRTTKSTQTQ DSSFRELIMR KSKRKEPWNM 130 140 150 160 170 180 KSENLSIHEG KLEEKWDVNA STIERSYKSN ELSPKSHREK RSSECEKQIS YLSNPLGITP 190 200 210 220 230 240 DKRYKCSMCE KTFINTSSLR KHEKNHSGEK LFKCKECSKA FSQSSALIQH QITHTGEKPY 250 260 270 280 290 300 VCKECGKAFT LSTSLYKHLR THTVEKSYRC KECGKSFGRR SGLFIHQKVH AGENPYKYNP 310 320 330 340 350 360 GRKASTSLSG CQRIHSRKKT YLCNECGNTF KSSSSLRYHQ RIHTGEKPFK CSECGRAFSQ 370 380 390 400 410 420 SASLIQHERI HTGEKPYRCS ECGKGFTSIS RLNRHRIIHT GEKFYNCNEC GKALSSHSTL 430 440 450 460 470 480 IIHERIHTGE KPCKCKVCGK AFRQSSALIQ HQRMHTGERP YKCNECGKTF RCNSSLSNHQ 490 500 510 520 530 540 RTHTGEKPYR CQECGMSFGQ SSALIQHRRI HTGEKPFKCN TCGKTFRQSS SRIAHQRIHT 550 560 570 GEKPYECNTC GKLFNHRSSL TNHYKIHVDE DP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcription factor, Kid-1, is highly expressed in both eye and kidney of the mouse." Brady J.P., Duncan M.K., Wawrousek E.F., Piatigorsky J. Exp. Eye Res. 64:287-290(1997) [PubMed: 9176064] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lens.
[2]	"Characterization of the mouse Kid1 gene and identification of a highly related gene, Kid2." Tekki-Kessaris N., Bonventre J.V., Boulter C.A. Gene 240:13-22(1999) [PubMed: 10564808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: 129/Sv.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6.
[4]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Limb.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77247 mRNA. Translation: AAA96309.1. AF184111 mRNA. Translation: AAF01033.1. AL645962 Genomic DNA. Translation: CAI24599.1. CH466575 Genomic DNA. Translation: EDL33680.1. BC050843 mRNA. Translation: AAH50843.1.
IPI	IPI00648650.
RefSeq	NP_033355.2. NM_009329.3.
UniGene	Mm.4792.
3D structure databases
ProteinModelPortal	Q61751.
SMR	Q61751. Positions 7-62, 159-567.
ModBase	Search...
Protein-protein interaction databases
STRING	Q61751.
PTM databases
PhosphoSite	Q61751.
Proteomic databases
PRIDE	Q61751.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000020628; ENSMUSP00000020628; ENSMUSG00000020364. ENSMUST00000102766; ENSMUSP00000099827; ENSMUSG00000020364.
GeneID	21408.
KEGG	mmu:21408.
Organism-specific databases
CTD	21408.
MGI	MGI:103172. Zfp354a.
Phylogenomic databases
HOVERGEN	HBG018163.
OrthoDB	EOG43XV2Z.
Gene expression databases
ArrayExpress	Q61751.
Bgee	Q61751.
CleanEx	MM_ZFP354A.
Genevestigator	Q61751.
GermOnline	ENSMUSG00000020364. Mus musculus.
Family and domain databases
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 13 hits.
KO	K09228.
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 13 hits. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 13 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 13 hits. PS50157. ZINC_FINGER_C2H2_2. 13 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Z354A_MOUSE

Accession

Primary (citable) accession number: Q61751
Secondary accession number(s): Q9QXU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 27, 2011
Last modified:	December 14, 2011
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program