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Protein

Translation initiation factor eIF-2B subunit delta

Gene

Eif2b4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-72731 Recycling of eIF2:GDP

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit delta
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit delta
Gene namesi
Name:Eif2b4
Synonyms:Eif2b, Eif2bd, Jgr1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95300 Eif2b4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001560682 – 524Translation initiation factor eIF-2B subunit deltaAdd BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei86PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ61749
PaxDbiQ61749
PRIDEiQ61749

PTM databases

iPTMnetiQ61749
PhosphoSitePlusiQ61749

Expressioni

Gene expression databases

BgeeiENSMUSG00000029145
ExpressionAtlasiQ61749 baseline and differential
GenevisibleiQ61749 MM

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110250

Structurei

3D structure databases

ProteinModelPortaliQ61749
SMRiQ61749
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1467 Eukaryota
COG1184 LUCA
GeneTreeiENSGT00550000075009
HOGENOMiHOG000176924
HOVERGENiHBG051459
InParanoidiQ61749
KOiK03680
OrthoDBiEOG091G09DP
TreeFamiTF101508

Family and domain databases

InterProiView protein in InterPro
IPR000649 IF-2B-related
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01008 IF-2B, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q61749-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVAVAVRE ESRSEMKTEL SPRPGAAGRE LTQEEKLQLR KEKKQQKKKR
60 70 80 90 100
KEEKGADQEI GSAVSAAQRQ DPIRELPGPG SQLGGTAGEK LPAGRSKAEL
110 120 130 140 150
RAERRAKQEA ERALKQARKG EQGGVPPQAC PSTAGETTSG VKRVPEHTPA
160 170 180 190 200
DDPTLLRRLL RKPDRQQVPT RKDYGSKVSL FSHLPQYSRQ SSLTQYMSIP
210 220 230 240 250
SSVIHPAMVR LGLQYSQGLI SGSNARCIAL LHALQQVIQD YTTPPSEELS
260 270 280 290 300
RDLVNKLKPY ISFLTQCRPM SASMCNAIKF LTKEVTGMSS SKREEEAKSE
310 320 330 340 350
LREALDRYVQ EKIVLAAQAI SRFASTKISD GDVILVYGCS SLVSRILQEA
360 370 380 390 400
RVEGRRFRVV VVDSRPRLEG RHMLHSLVRA GVPTSYLLIP AASYVLPEVS
410 420 430 440 450
KVLLGAHALL ANGSVMSRVG TAQLALVARA HNVPVLVCCE TYKFCERVQT
460 470 480 490 500
DAFVSNELDD PDDLQCKRGD QVALANWQSH PSLRLLNLVY DVTPPELVDL
510 520
VITELGMIPC SSVPVVLRVK SSDQ
Length:524
Mass (Da):57,624
Last modified:July 27, 2011 - v2
Checksum:i86CDB70C63285A02
GO
Isoform 2 (identifier: Q61749-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MAAVAVAVRE → MPTQQPAAPTSLPKSSRSLSGSLCALFSDA

Show »
Length:544
Mass (Da):59,657
Checksum:iD46CB29EB50B6C42
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti302R → K in AAA68046 (PubMed:7982969).Curated1
Sequence conflicti302R → K in AAA68047 (PubMed:7982969).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0014341 – 10MAAVAVAVRE → MPTQQPAAPTSLPKSSRSLS GSLCALFSDA in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98036 mRNA Translation: AAA68047.1
M98035 mRNA Translation: AAA68046.1
AK158282 mRNA Translation: BAE34444.1
CH466524 Genomic DNA Translation: EDL37345.1
BC021884 mRNA Translation: AAH21884.1
CCDSiCCDS19176.1 [Q61749-1]
CCDS51457.1 [Q61749-2]
PIRiA55146
RefSeqiNP_001120827.1, NM_001127355.1 [Q61749-2]
NP_001120828.1, NM_001127356.1 [Q61749-2]
NP_034252.2, NM_010122.2 [Q61749-1]
UniGeneiMm.29394

Genome annotation databases

EnsembliENSMUST00000077693; ENSMUSP00000076875; ENSMUSG00000029145 [Q61749-1]
ENSMUST00000114603; ENSMUSP00000110250; ENSMUSG00000029145 [Q61749-2]
ENSMUST00000166769; ENSMUSP00000130880; ENSMUSG00000029145 [Q61749-2]
GeneIDi13667
KEGGimmu:13667
UCSCiuc008wxk.2 mouse [Q61749-2]
uc008wxl.2 mouse [Q61749-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEI2BD_MOUSE
AccessioniPrimary (citable) accession number: Q61749
Secondary accession number(s): Q3TYW7, Q61748, Q8VC35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome