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Q61743

- KCJ11_MOUSE

UniProt

Q61743 - KCJ11_MOUSE

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Protein

ATP-sensitive inward rectifier potassium channel 11

Gene

Kcnj11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei160 – 1601Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

GO - Molecular functioni

  1. ankyrin binding Source: BHF-UCL
  2. ATP-activated inward rectifier potassium channel activity Source: BHF-UCL
  3. ATP binding Source: BHF-UCL
  4. potassium ion binding Source: BHF-UCL

GO - Biological processi

  1. cellular response to glucose stimulus Source: Ensembl
  2. cellular response to nicotine Source: Ensembl
  3. cellular response to tumor necrosis factor Source: Ensembl
  4. glucose metabolic process Source: Ensembl
  5. negative regulation of insulin secretion Source: Ensembl
  6. neurological system process Source: Ensembl
  7. positive regulation of cation channel activity Source: Ensembl
  8. potassium ion import Source: BHF-UCL
  9. regulation of membrane potential Source: Ensembl
  10. response to ATP Source: Ensembl
  11. response to drug Source: Ensembl
  12. response to estradiol Source: Ensembl
  13. response to ischemia Source: Ensembl
  14. response to testosterone Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199102. ATP sensitive Potassium channels.
REACT_263148. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 11
Alternative name(s):
Inward rectifier K(+) channel Kir6.2
Potassium channel, inwardly rectifying subfamily J member 11
Gene namesi
Name:Kcnj11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:107501. Kcnj11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6868CytoplasmicBy similarityAdd
BLAST
Transmembranei69 – 9325Helical; Name=M1By similarityAdd
BLAST
Topological domaini94 – 11623ExtracellularBy similarityAdd
BLAST
Intramembranei117 – 12812Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei129 – 1357Pore-formingBy similarity
Topological domaini136 – 1449ExtracellularBy similarity
Transmembranei145 – 16622Helical; Name=M2By similarityAdd
BLAST
Topological domaini167 – 390224CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. ATP-sensitive potassium channel complex Source: BHF-UCL
  2. axolemma Source: Ensembl
  3. cell body fiber Source: Ensembl
  4. cytosol Source: Ensembl
  5. endoplasmic reticulum Source: Ensembl
  6. endosome Source: Ensembl
  7. intercalated disc Source: Ensembl
  8. mitochondrion Source: Ensembl
  9. myelin sheath Source: Ensembl
  10. neuronal cell body Source: Ensembl
  11. nuclear envelope Source: Ensembl
  12. plasma membrane Source: MGI
  13. T-tubule Source: BHF-UCL
  14. voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390ATP-sensitive inward rectifier potassium channel 11PRO_0000154958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei341 – 3411Phosphothreonine; by MAPK1By similarity
Modified residuei385 – 3851Phosphoserine; by MAPK1By similarity

Post-translational modificationi

Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ61743.

PTM databases

PhosphoSiteiQ61743.

Expressioni

Gene expression databases

BgeeiQ61743.
ExpressionAtlasiQ61743. baseline and differential.
GenevestigatoriQ61743.

Interactioni

Subunit structurei

Interacts with ABCC9/SUR2 (By similarity). Interacts with ABCC8/SUR.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AP2A2O949732EBI-8603527,EBI-1642835From a different organism.

Protein-protein interaction databases

BioGridi200896. 1 interaction.
DIPiDIP-42790N.
IntActiQ61743. 1 interaction.
MINTiMINT-2982880.

Structurei

3D structure databases

ProteinModelPortaliQ61743.
SMRiQ61743. Positions 32-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi130 – 1356Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72812.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiQ61743.
KOiK05004.
OMAiHHQDLEI.
OrthoDBiEOG7XPZ5K.
PhylomeDBiQ61743.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003279. K_chnl_inward-rec_Kir6.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01332. KIR62CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q61743-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSRKGIIPE EYVLTRLAED PAEPRYRTRE RRARFVSKKG NCNVAHKNIR
60 70 80 90 100
EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMVW WLIAFAHGDL
110 120 130 140 150
APGEGTNVPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI
160 170 180 190 200
VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIT LRHGRLCFML
210 220 230 240 250
RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNGIF
260 270 280 290 300
LVAPLIIYHV IDSNSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA
310 320 330 340 350
RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTIKVP TPLCTARQLD
360 370 380 390
EDRSLLDALT LASSRGPLRK RSVAVAKAKP KFSISPDSLS
Length:390
Mass (Da):43,562
Last modified:November 1, 1996 - v1
Checksum:i6AFBFFD284C92C3A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2481G → S in AAD02096. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50581 mRNA. Translation: BAA09130.1.
U73626 mRNA. Translation: AAB17355.1.
AF037313 Genomic DNA. Translation: AAD02096.1.
BC052731 mRNA. Translation: AAH52731.1.
BC057006 mRNA. Translation: AAH57006.1.
CCDSiCCDS21274.1.
PIRiS68403.
RefSeqiNP_034732.1. NM_010602.3.
UniGeneiMm.333863.
Mm.428799.

Genome annotation databases

EnsembliENSMUST00000180081; ENSMUSP00000136002; ENSMUSG00000096146.
GeneIDi16514.
KEGGimmu:16514.
UCSCiuc009gyc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50581 mRNA. Translation: BAA09130.1 .
U73626 mRNA. Translation: AAB17355.1 .
AF037313 Genomic DNA. Translation: AAD02096.1 .
BC052731 mRNA. Translation: AAH52731.1 .
BC057006 mRNA. Translation: AAH57006.1 .
CCDSi CCDS21274.1.
PIRi S68403.
RefSeqi NP_034732.1. NM_010602.3.
UniGenei Mm.333863.
Mm.428799.

3D structure databases

ProteinModelPortali Q61743.
SMRi Q61743. Positions 32-356.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200896. 1 interaction.
DIPi DIP-42790N.
IntActi Q61743. 1 interaction.
MINTi MINT-2982880.

Chemistry

GuidetoPHARMACOLOGYi 442.

PTM databases

PhosphoSitei Q61743.

Proteomic databases

PRIDEi Q61743.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000180081 ; ENSMUSP00000136002 ; ENSMUSG00000096146 .
GeneIDi 16514.
KEGGi mmu:16514.
UCSCi uc009gyc.2. mouse.

Organism-specific databases

CTDi 3767.
MGIi MGI:107501. Kcnj11.

Phylogenomic databases

eggNOGi NOG72812.
GeneTreei ENSGT00760000118842.
HOGENOMi HOG000237325.
HOVERGENi HBG006178.
InParanoidi Q61743.
KOi K05004.
OMAi HHQDLEI.
OrthoDBi EOG7XPZ5K.
PhylomeDBi Q61743.
TreeFami TF313676.

Enzyme and pathway databases

Reactomei REACT_199102. ATP sensitive Potassium channels.
REACT_263148. Regulation of insulin secretion.

Miscellaneous databases

NextBioi 289865.
PROi Q61743.
SOURCEi Search...

Gene expression databases

Bgeei Q61743.
ExpressionAtlasi Q61743. baseline and differential.
Genevestigatori Q61743.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003279. K_chnl_inward-rec_Kir6.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01332. KIR62CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor."
    Inagaki N., Gonoi T., Clement J.P. IV, Namba N., Inazawa J., Gonzalez G., Aguilar-Bryan L., Seino S., Bryan J.
    Science 270:1166-1170(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Pancreatic islet.
  2. "Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle."
    Sakura H., Aemmaelae C., Smith P.A., Gribble F.M., Ashcroft F.M.
    FEBS Lett. 377:338-344(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Pancreatic islet.
  3. "Structural characterization of the mouse sulfonylurea receptor-1 and potassium inward rectifier 6.2 genes."
    Kooptiwut S., Shelton K.D., Magnuson M.A.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Ola.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiKCJ11_MOUSE
AccessioniPrimary (citable) accession number: Q61743
Secondary accession number(s): Q9QX21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3