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Q61743

- KCJ11_MOUSE

UniProt

Q61743 - KCJ11_MOUSE

Protein

ATP-sensitive inward rectifier potassium channel 11

Gene

Kcnj11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei160 – 1601Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

    GO - Molecular functioni

    1. ankyrin binding Source: BHF-UCL
    2. ATP-activated inward rectifier potassium channel activity Source: BHF-UCL
    3. ATP binding Source: BHF-UCL
    4. potassium ion binding Source: BHF-UCL
    5. protein binding Source: IntAct

    GO - Biological processi

    1. cellular response to glucose stimulus Source: Ensembl
    2. cellular response to nicotine Source: Ensembl
    3. cellular response to tumor necrosis factor Source: Ensembl
    4. glucose metabolic process Source: Ensembl
    5. negative regulation of insulin secretion Source: Ensembl
    6. neurological system process Source: Ensembl
    7. positive regulation of cation channel activity Source: Ensembl
    8. potassium ion import Source: BHF-UCL
    9. regulation of membrane potential Source: Ensembl
    10. response to ATP Source: Ensembl
    11. response to drug Source: Ensembl
    12. response to estradiol Source: Ensembl
    13. response to ischemia Source: Ensembl
    14. response to testosterone Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199102. ATP sensitive Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 11
    Alternative name(s):
    Inward rectifier K(+) channel Kir6.2
    Potassium channel, inwardly rectifying subfamily J member 11
    Gene namesi
    Name:Kcnj11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:107501. Kcnj11.

    Subcellular locationi

    GO - Cellular componenti

    1. ATP-sensitive potassium channel complex Source: BHF-UCL
    2. axolemma Source: Ensembl
    3. cell body fiber Source: Ensembl
    4. cytosol Source: Ensembl
    5. endoplasmic reticulum Source: Ensembl
    6. endosome Source: Ensembl
    7. intercalated disc Source: Ensembl
    8. mitochondrion Source: Ensembl
    9. myelin sheath Source: Ensembl
    10. neuronal cell body Source: Ensembl
    11. nuclear envelope Source: Ensembl
    12. plasma membrane Source: MGI
    13. T-tubule Source: BHF-UCL
    14. voltage-gated potassium channel complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390ATP-sensitive inward rectifier potassium channel 11PRO_0000154958Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei341 – 3411Phosphothreonine; by MAPK1By similarity
    Modified residuei385 – 3851Phosphoserine; by MAPK1By similarity

    Post-translational modificationi

    Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ61743.

    PTM databases

    PhosphoSiteiQ61743.

    Expressioni

    Gene expression databases

    BgeeiQ61743.
    GenevestigatoriQ61743.

    Interactioni

    Subunit structurei

    Interacts with ABCC9/SUR2 By similarity. Interacts with ABCC8/SUR.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AP2A2O949732EBI-8603527,EBI-1642835From a different organism.

    Protein-protein interaction databases

    BioGridi200896. 1 interaction.
    DIPiDIP-42790N.
    IntActiQ61743. 1 interaction.
    MINTiMINT-2982880.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61743.
    SMRiQ61743. Positions 32-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6868CytoplasmicBy similarityAdd
    BLAST
    Topological domaini94 – 11623ExtracellularBy similarityAdd
    BLAST
    Topological domaini136 – 1449ExtracellularBy similarity
    Topological domaini167 – 390224CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei117 – 12812Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei129 – 1357Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei69 – 9325Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei145 – 16622Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi130 – 1356Selectivity filterBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72812.
    GeneTreeiENSGT00690000102074.
    HOGENOMiHOG000237325.
    HOVERGENiHBG006178.
    InParanoidiQ61743.
    KOiK05004.
    OMAiHHQDLEI.
    OrthoDBiEOG7XPZ5K.
    PhylomeDBiQ61743.
    TreeFamiTF313676.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003279. K_chnl_inward-rec_Kir6.2.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01332. KIR62CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q61743-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSRKGIIPE EYVLTRLAED PAEPRYRTRE RRARFVSKKG NCNVAHKNIR    50
    EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMVW WLIAFAHGDL 100
    APGEGTNVPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI 150
    VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIT LRHGRLCFML 200
    RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNGIF 250
    LVAPLIIYHV IDSNSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA 300
    RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTIKVP TPLCTARQLD 350
    EDRSLLDALT LASSRGPLRK RSVAVAKAKP KFSISPDSLS 390
    Length:390
    Mass (Da):43,562
    Last modified:November 1, 1996 - v1
    Checksum:i6AFBFFD284C92C3A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti248 – 2481G → S in AAD02096. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50581 mRNA. Translation: BAA09130.1.
    U73626 mRNA. Translation: AAB17355.1.
    AF037313 Genomic DNA. Translation: AAD02096.1.
    BC052731 mRNA. Translation: AAH52731.1.
    BC057006 mRNA. Translation: AAH57006.1.
    CCDSiCCDS21274.1.
    PIRiS68403.
    RefSeqiNP_034732.1. NM_010602.3.
    UniGeneiMm.333863.
    Mm.428799.

    Genome annotation databases

    EnsembliENSMUST00000180081; ENSMUSP00000136002; ENSMUSG00000096146.
    GeneIDi16514.
    KEGGimmu:16514.
    UCSCiuc009gyc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50581 mRNA. Translation: BAA09130.1 .
    U73626 mRNA. Translation: AAB17355.1 .
    AF037313 Genomic DNA. Translation: AAD02096.1 .
    BC052731 mRNA. Translation: AAH52731.1 .
    BC057006 mRNA. Translation: AAH57006.1 .
    CCDSi CCDS21274.1.
    PIRi S68403.
    RefSeqi NP_034732.1. NM_010602.3.
    UniGenei Mm.333863.
    Mm.428799.

    3D structure databases

    ProteinModelPortali Q61743.
    SMRi Q61743. Positions 32-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200896. 1 interaction.
    DIPi DIP-42790N.
    IntActi Q61743. 1 interaction.
    MINTi MINT-2982880.

    Chemistry

    GuidetoPHARMACOLOGYi 442.

    PTM databases

    PhosphoSitei Q61743.

    Proteomic databases

    PRIDEi Q61743.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000180081 ; ENSMUSP00000136002 ; ENSMUSG00000096146 .
    GeneIDi 16514.
    KEGGi mmu:16514.
    UCSCi uc009gyc.2. mouse.

    Organism-specific databases

    CTDi 3767.
    MGIi MGI:107501. Kcnj11.

    Phylogenomic databases

    eggNOGi NOG72812.
    GeneTreei ENSGT00690000102074.
    HOGENOMi HOG000237325.
    HOVERGENi HBG006178.
    InParanoidi Q61743.
    KOi K05004.
    OMAi HHQDLEI.
    OrthoDBi EOG7XPZ5K.
    PhylomeDBi Q61743.
    TreeFami TF313676.

    Enzyme and pathway databases

    Reactomei REACT_199102. ATP sensitive Potassium channels.

    Miscellaneous databases

    NextBioi 289865.
    PROi Q61743.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61743.
    Genevestigatori Q61743.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003279. K_chnl_inward-rec_Kir6.2.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01332. KIR62CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor."
      Inagaki N., Gonoi T., Clement J.P. IV, Namba N., Inazawa J., Gonzalez G., Aguilar-Bryan L., Seino S., Bryan J.
      Science 270:1166-1170(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Pancreatic islet.
    2. "Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle."
      Sakura H., Aemmaelae C., Smith P.A., Gribble F.M., Ashcroft F.M.
      FEBS Lett. 377:338-344(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Pancreatic islet.
    3. "Structural characterization of the mouse sulfonylurea receptor-1 and potassium inward rectifier 6.2 genes."
      Kooptiwut S., Shelton K.D., Magnuson M.A.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Ola.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiKCJ11_MOUSE
    AccessioniPrimary (citable) accession number: Q61743
    Secondary accession number(s): Q9QX21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3