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Q61739

- ITA6_MOUSE

UniProt

Q61739 - ITA6_MOUSE

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Protein
Integrin alpha-6
Gene
Itga6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Mice expressing a null mutation of the alpha-6 subunit gene die soon after birth and develop severe blistering. The blisters are due to separation of the basal epithelial cells from a normally formed basement membrane.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi324 – 3329 Reviewed prediction
Calcium bindingi386 – 3949 Reviewed prediction
Calcium bindingi441 – 4499 Reviewed prediction

GO - Molecular functioni

  1. integrin binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. brown fat cell differentiation Source: MGI
  2. cell adhesion mediated by integrin Source: MGI
  3. cell-matrix adhesion Source: MGI
  4. cellular response to extracellular stimulus Source: MGI
  5. cellular response to organic cyclic compound Source: Ensembl
  6. filopodium assembly Source: MGI
  7. integrin-mediated signaling pathway Source: UniProtKB-KW
  8. leukocyte migration Source: MGI
  9. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  10. odontogenesis of dentin-containing tooth Source: MGI
  11. positive regulation of apoptotic process Source: Ensembl
  12. positive regulation of cell-cell adhesion Source: MGI
  13. positive regulation of cell-substrate adhesion Source: Ensembl
  14. positive regulation of phosphorylation Source: Ensembl
  15. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  16. single organismal cell-cell adhesion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_202342. Laminin interactions.
REACT_211508. Basigin interactions.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-6
Alternative name(s):
CD49 antigen-like family member F
VLA-6
CD_antigen: CD49f
Cleaved into the following 2 chains:
Gene namesi
Name:Itga6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96605. Itga6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 1011988Extracellular Reviewed prediction
Add
BLAST
Transmembranei1012 – 103726Helical; Reviewed prediction
Add
BLAST
Topological domaini1038 – 109154Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basal part of cell Source: MGI
  2. basal plasma membrane Source: MGI
  3. basement membrane Source: MGI
  4. basolateral plasma membrane Source: MGI
  5. cell surface Source: MGI
  6. cell-cell adherens junction Source: Ensembl
  7. external side of plasma membrane Source: MGI
  8. filopodium Source: Ensembl
  9. hemidesmosome Source: MGI
  10. integrin alpha6-beta4 complex Source: Ensembl
  11. integrin complex Source: MGI
  12. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarity
Add
BLAST
Chaini24 – 10911068Integrin alpha-6
PRO_0000016261Add
BLAST
Chaini24 – 899876Integrin alpha-6 heavy chain Reviewed prediction
PRO_0000016262Add
BLAST
Chaini903 – 1091189Integrin alpha-6 light chain Reviewed prediction
PRO_0000016263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi86 ↔ 94 By similarity
Disulfide bondi131 ↔ 154 By similarity
Disulfide bondi175 ↔ 188 By similarity
Glycosylationi223 – 2231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi284 – 2841N-linked (GlcNAc...)1 Publication
Glycosylationi370 – 3701N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi489 ↔ 496 By similarity
Disulfide bondi502 ↔ 562 By similarity
Disulfide bondi626 ↔ 632 By similarity
Disulfide bondi726 ↔ 737 By similarity
Glycosylationi731 – 7311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi746 – 7461N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi881 ↔ 928Interchain (between heavy and light chains) By similarity
Glycosylationi927 – 9271N-linked (GlcNAc...)1 Publication
Disulfide bondi934 ↔ 939 By similarity
Glycosylationi958 – 9581N-linked (GlcNAc...)1 Publication
Lipidationi1039 – 10391S-palmitoyl cysteine; by DHHC3 By similarity

Post-translational modificationi

Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1064' of isoform alpha-6X1A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand By similarity.
Palmitoylation by DHHC3 enhances stability and cell surface expression By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ61739.
PaxDbiQ61739.
PRIDEiQ61739.

PTM databases

PhosphoSiteiQ61739.

Expressioni

Gene expression databases

ArrayExpressiQ61739.
BgeeiQ61739.
CleanExiMM_ITGA6.
GenevestigatoriQ61739.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with RAB21 By similarity.

Protein-protein interaction databases

IntActiQ61739. 1 interaction.
MINTiMINT-225133.
STRINGi10090.ENSMUSP00000040155.

Structurei

3D structure databases

ProteinModelPortaliQ61739.
SMRiQ61739. Positions 24-591, 1013-1048.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati30 – 9566FG-GAP 1
Add
BLAST
Repeati101 – 16666FG-GAP 2
Add
BLAST
Repeati176 – 22954FG-GAP 3
Add
BLAST
Repeati244 – 30158FG-GAP 4
Add
BLAST
Repeati302 – 36362FG-GAP 5
Add
BLAST
Repeati364 – 41956FG-GAP 6
Add
BLAST
Repeati420 – 47960FG-GAP 7
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1040 – 10445GFFKR motif

Sequence similaritiesi

Contains 7 FG-GAP repeats.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26407.
GeneTreeiENSGT00730000110529.
HOGENOMiHOG000015786.
HOVERGENiHBG108011.
InParanoidiA2AU04.
KOiK06485.
OMAiVYINQQG.
OrthoDBiEOG7K3TK7.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Alpha-6X1B (identifier: Q61739-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAVAGQLCLL YLSAGLLARL GTAFNLDTRE DNVIRKSGDP GSLFGFSLAM     50
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITS RGPCTRIEFD 100
NDADPMSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 150
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 200
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETDHDESLV 250
PVPANSYLGF SLDSGKGIVS KDDITFVSGA PRANHSGAVV LLKRDMKSAH 300
LLPEYIFDGE GLASSFGYDV AVVDLNADGW QDIVIGAPQY FDRDGEVGGA 350
VYVYINQQGK WSNVKPIRLN GTKDSMFGIS VKNIGDINQD GYPDIAVGAP 400
YDDLGKVFIY HGSPTGIITK PTQVLEGTSP YFGYSIAGNM DLDRNSYPDL 450
AVGSLSDSVT IFRSRPVINI LKTITVTPNR IDLRQKSMCG SPSGICLKVK 500
ACFEYTAKPS GYNPPISILG ILEAEKERRK SGLSSRVQFR NQGSEPKYTQ 550
ELTLNRQKQR ACMEETLWLQ ENIRDKLRPI PITASVEIQE PSSRRRVNSL 600
PEVLPILNSN EAKTVQTDVH FLKEGCGDDN VCNSNLKLEY KFGTREGNQD 650
KFSYLPIQKG IPELVLKDQK DIALEITVTN SPSDPRNPRK DGDDAHEAKL 700
IATFPDTLTY SAYRELRAFP EKQLSCVANQ NGSQADCELG NPFKRNSSVT 750
FYLILSTTEV TFDTTDLDIN LKLETTSNQD NLAPITAKAK VVIELLLSVS 800
GVAKPSQVYF GGTVVGEQAM KSEDEVGSLI EYEFRVINLG KPLKNLGTAT 850
LNIQWPKEIS NGKWLLYLMK VESKGLEQIV CEPHNEINYL KLKESHNSRK 900
KRELPEKQID DSRKFSLFPE RKYQTLNCSV NVRCVNIRCP LRGLDSKASL 950
VLRSRLWNST FLEEYSKLNY LDILLRASID VTAAAQNIKL PHAGTQVRVT 1000
VFPSKTVAQY SGVAWWIILL AVLAGILMLA LLVFLLWKCG FFKRSRYDDS 1050
IPRYHAVRIR KEEREIKDEK HMDNLEKKQW ITKWNENESY S 1091
Length:1,091
Mass (Da):122,159
Last modified:July 27, 2011 - v3
Checksum:iF33B055C2E8BAFAD
GO
Isoform Alpha-6X1A (identifier: Q61739-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1045-1091: SRYDDSIPRY...TKWNENESYS → NKKDHYDATYHKAEIHTQPSDKERLTSDA

Show »
Length:1,073
Mass (Da):119,606
Checksum:iC128E9EE14170218
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1045 – 109147SRYDD…NESYS → NKKDHYDATYHKAEIHTQPS DKERLTSDA in isoform Alpha-6X1A.
VSP_002726Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti592 – 5921S → T in CAA49527. 1 Publication
Sequence conflicti781 – 7811N → K in CAA49527. 1 Publication
Sequence conflicti799 – 7991V → L in CAA49527. 1 Publication
Sequence conflicti946 – 9461S → T in CAA49527. 1 Publication
Sequence conflicti953 – 9531R → C in CAA49527. 1 Publication
Sequence conflicti975 – 9751L → V in CAA49527. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69902 mRNA. Translation: CAA49527.1.
AL928963 Genomic DNA. Translation: CAM26370.1.
CCDSiCCDS16118.1. [Q61739-2]
CCDS71074.1. [Q61739-1]
PIRiA40463.
RefSeqiNP_001264899.1. NM_001277970.1. [Q61739-1]
XP_006498868.1. XM_006498805.1. [Q61739-1]
UniGeneiMm.225096.

Genome annotation databases

EnsembliENSMUST00000028522; ENSMUSP00000028522; ENSMUSG00000027111. [Q61739-2]
ENSMUST00000112101; ENSMUSP00000107729; ENSMUSG00000027111. [Q61739-1]
GeneIDi16403.
KEGGimmu:16403.
UCSCiuc008kbd.1. mouse. [Q61739-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69902 mRNA. Translation: CAA49527.1 .
AL928963 Genomic DNA. Translation: CAM26370.1 .
CCDSi CCDS16118.1. [Q61739-2 ]
CCDS71074.1. [Q61739-1 ]
PIRi A40463.
RefSeqi NP_001264899.1. NM_001277970.1. [Q61739-1 ]
XP_006498868.1. XM_006498805.1. [Q61739-1 ]
UniGenei Mm.225096.

3D structure databases

ProteinModelPortali Q61739.
SMRi Q61739. Positions 24-591, 1013-1048.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61739. 1 interaction.
MINTi MINT-225133.
STRINGi 10090.ENSMUSP00000040155.

PTM databases

PhosphoSitei Q61739.

Proteomic databases

MaxQBi Q61739.
PaxDbi Q61739.
PRIDEi Q61739.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028522 ; ENSMUSP00000028522 ; ENSMUSG00000027111 . [Q61739-2 ]
ENSMUST00000112101 ; ENSMUSP00000107729 ; ENSMUSG00000027111 . [Q61739-1 ]
GeneIDi 16403.
KEGGi mmu:16403.
UCSCi uc008kbd.1. mouse. [Q61739-1 ]

Organism-specific databases

CTDi 3655.
MGIi MGI:96605. Itga6.

Phylogenomic databases

eggNOGi NOG26407.
GeneTreei ENSGT00730000110529.
HOGENOMi HOG000015786.
HOVERGENi HBG108011.
InParanoidi A2AU04.
KOi K06485.
OMAi VYINQQG.
OrthoDBi EOG7K3TK7.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_202342. Laminin interactions.
REACT_211508. Basigin interactions.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

PROi Q61739.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61739.
Bgeei Q61739.
CleanExi MM_ITGA6.
Genevestigatori Q61739.

Family and domain databases

InterProi IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view ]
Pfami PF08441. Integrin_alpha2. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Variants of the alpha 6 beta 1 laminin receptor in early murine development: distribution, molecular cloning and chromosomal localization of the mouse integrin alpha 6 subunit."
    Hierck B.P., Thorsteinsdottir S., Niessen C.M., Freund E., van Iperen L., Feyen A., Hogervorst F., Poelmann R.E., Mummery C.L., Sonnenberg A.
    Cell Adhes. Commun. 1:33-53(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-6X1A AND ALPHA-6X1B).
    Strain: BALB/c.
    Tissue: Mammary gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-284; ASN-927 AND ASN-958.

Entry informationi

Entry nameiITA6_MOUSE
AccessioniPrimary (citable) accession number: Q61739
Secondary accession number(s): A2AU04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi