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Q61738

- ITA7_MOUSE

UniProt

Q61738 - ITA7_MOUSE

Protein

Integrin alpha-7

Gene

Itga7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Mice carrying a ITGA7 null allele are viable and fertile, but show progressive muscular dystrophy starting soon after birth, but with a distinct variability in different muscle types. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi372 – 3809Sequence Analysis
    Calcium bindingi434 – 4429Sequence Analysis
    Calcium bindingi492 – 5009Sequence Analysis

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. blood vessel morphogenesis Source: MGI
    2. cell adhesion Source: MGI
    3. cell migration Source: MGI
    4. integrin-mediated signaling pathway Source: UniProtKB-KW
    5. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion, Cell shape

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin alpha-7
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Itga7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:102700. Itga7.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. integrin alpha7-beta1 complex Source: MGI
    3. muscle tendon junction Source: MGI
    4. neuromuscular junction Source: MGI
    5. sarcolemma Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 33331 PublicationAdd
    BLAST
    Chaini34 – 11791146Integrin alpha-7PRO_0000016270Add
    BLAST
    Chaini34 – 955922Integrin alpha-7 heavy chainSequence AnalysisPRO_0000016271Add
    BLAST
    Chaini959 – 1179221Integrin alpha-7 light chainSequence AnalysisPRO_0000016272Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi94 ↔ 103By similarity
    Disulfide bondi140 ↔ 163By similarity
    Disulfide bondi184 ↔ 197By similarity
    Disulfide bondi539 ↔ 546By similarity
    Disulfide bondi552 ↔ 615By similarity
    Disulfide bondi681 ↔ 687By similarity
    Disulfide bondi781 ↔ 792By similarity
    Glycosylationi784 – 7841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi939 ↔ 993Interchain (between heavy and light chains)By similarity
    Glycosylationi988 – 9881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi999 ↔ 1004By similarity
    Glycosylationi1023 – 10231N-linked (GlcNAc...)1 Publication
    Glycosylationi1043 – 10431N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes (in vitro).
    No proteolytic cleavage to produce the 70 kDa form is seen due to the presence of a Gly instead of an arginine residue at position 647.

    Keywords - PTMi

    ADP-ribosylation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ61738.
    PaxDbiQ61738.
    PRIDEiQ61738.

    PTM databases

    PhosphoSiteiQ61738.

    Expressioni

    Tissue specificityi

    Isoforms containing segment X2 are found in adult heart, lung and skeletal muscle. Isoforms containing segment X1 are expressed in adult heart, lung and in proliferating skeletal myoblasts but not in adult skeletal muscle. Isoforms containing segment a are exclusively found in skeletal muscle. Isoforms containing segment B are widely expressed. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites.1 Publication

    Developmental stagei

    Isoforms are developmentally regulated during the formation of skeletal muscle. Undifferentiated (replicating) myoblasts express isoforms containing segment B only, whereas differentiated myoblasts express isoforms containing segments A or B.

    Gene expression databases

    CleanExiMM_ITGA7.
    GenevestigatoriQ61738.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-7 associates with beta-1. Interacts with COMP. Interacts (via C-terminus intracellular tail region) with CIB1; the interaction is stabilized/increased in a calcium- and magnesium-dependent manner By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Def6Q8C2K13EBI-1786329,EBI-2121188
    Swap70Q6A0282EBI-1786329,EBI-2121215

    Protein-protein interaction databases

    IntActiQ61738. 5 interactions.
    MINTiMINT-4098899.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 10761043ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1103 – 117977CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1077 – 110226HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati38 – 10366FG-GAP 1Add
    BLAST
    Repeati110 – 17566FG-GAP 2Add
    BLAST
    Repeati185 – 23854FG-GAP 3Add
    BLAST
    Repeati292 – 35059FG-GAP 4Add
    BLAST
    Repeati351 – 41161FG-GAP 5Add
    BLAST
    Repeati412 – 46756FG-GAP 6Add
    BLAST
    Repeati471 – 53060FG-GAP 7Add
    BLAST
    Repeati1155 – 115841
    Repeati1163 – 116642
    Repeati1171 – 117443

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1155 – 1174203 X 4 AA repeats of D-X-H-PAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1105 – 11095GFFKR motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi953 – 9586Poly-Arg

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.Curated
    Contains 7 FG-GAP repeats.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26407.
    HOGENOMiHOG000015786.
    HOVERGENiHBG108011.
    InParanoidiQ61738.
    PhylomeDBiQ61738.

    Family and domain databases

    InterProiIPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view]
    PfamiPF08441. Integrin_alpha2. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 5 hits.
    [Graphical view]
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains, two extracellular (X1 and X2) and two cytoplasmic (A and B). A third potential alternatively spliced cytoplasmic domain (C) doesn't appear to be expressed. So far detected are isoform alpha-7X1A, isoform alpha-7X1B and isoform alpha-7X2B. Experimental confirmation may be lacking for some isoforms.

    Isoform Alpha-7X1X2B (identifier: Q61738-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARIPRCDFL RPPGIYYLIT SLLAGLFLPP AIAFNLDVMG AIRKEGEPGS     50
    LFGFSVALHR QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE 100
    TDCYRVDIDR GANVQKESKE NQWLGVSVRS QGAGGKIVTC AHRYESRQRV 150
    DQALETRDVI GRCFVLSQDL AIRDELDGGE WKFCEGRPQG HEQFGFCQQG 200
    TAATFSPDSH YLVFGAPGTY NWKGTARVEL CAQGSPDLAH LDDGPYEAGG 250
    EKEQDPRLIP VPANSYLGLL FVTNIDSSDP DQLVYKTLDP ADRLTGPAGD 300
    LTLNSYLGFS IDSGKGLMRS EELSFVAGAP RANHKGAVVI LRKDSATRLI 350
    PEVVLSGERL TSGFGYSLAV TDLNNDGWAD LIVGAPYFFE RQEELGGAVY 400
    VYMNQGGHWA DISPLRICGS PDSMFGISLA VLGDLNQDGF PDIAVGAPFD 450
    GDGKVFIYHG SSLGVVVKPS QVLEGEAVGI KSFGYSLSGG LDVDGNHYPD 500
    LLVGSLADTA ALFRARPVLH VSQEIFIDPR AIDLEQPNCA DGRLVCVDIK 550
    ICFSYVAVPS SYSPSVALDY MLDGDTDRRL RGQVPRVTFL SRGLDDLRHQ 600
    SSGTVWLKHQ HDRVCGDTVF QLQENVKDKL RAIVVTLSYG LRTPPLGRQA 650
    PGQELPTVAP ILNAHQPSTQ RTEIHFLKQG CGQDKICQSN LQLERYQFCS 700
    RISDTEFQAL PMDLDGRTAL FALSGQPFIG LELTVTNLPS DPSRPQADGD 750
    DAHEAQLLVT LPASLRYSGV RALDSVEKPL CLSNDSASHV ECELGNPMKR 800
    GAQVTFYLIL STSGITIETT ELEVKLLLAT ISEQELDPVS VRAHVFIELP 850
    LSISGVATPQ QLFFSGEVKG ESAMRSEREL GRKVKYEVTV SNQGQSLNTL 900
    GSANLNIMWP HEIANGKWLL YPMRVELEGG QGPGKRGICS PRPNILQLDV 950
    DSRDRRRREL GQPEPQEPPE KVEPSTSWWP VSSAEKRNMT LDCPRTAKCV 1000
    VFSCPLYSFD RAAVLHVWGR LWNSTFLEEY MAVKSLEVIV RANITVKSSI 1050
    KNLLLRDAST VIPVMVYLDP MAVVVEGVPW WVILLGVLAG LLVLALLVLL 1100
    LWKLGFFKRA KHPEATVPQY HAVKIPREDR QQFKEEKTGT IQRSNWGNSQ 1150
    WEGSDAHPIL AADWHPELGP DGHPVPATA 1179
    Length:1,179
    Mass (Da):129,329
    Last modified:October 5, 2010 - v3
    Checksum:i3C26D5BABF2E463D
    GO
    Isoform Alpha-7X1A (identifier: Q61738-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         268-307: Missing.
         1104-1179: LGFFKRAKHP...PDGHPVPATA → CGFFRRNSPS...PRPPCPSTTQ

    Show »
    Length:1,120
    Mass (Da):122,492
    Checksum:iC47BD71A00A96C14
    GO
    Isoform Alpha-7X1B (identifier: Q61738-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         268-307: Missing.

    Show »
    Length:1,139
    Mass (Da):125,037
    Checksum:i318EE0ED64709E7B
    GO
    Isoform Alpha-7X2A (identifier: Q61738-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         224-267: Missing.
         1104-1179: LGFFKRAKHP...PDGHPVPATA → CGFFRRNSPS...PRPPCPSTTQ

    Show »
    Length:1,116
    Mass (Da):122,151
    Checksum:iF9ED8397C6373324
    GO
    Isoform Alpha-7X2B (identifier: Q61738-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         224-267: Missing.

    Show »
    Length:1,135
    Mass (Da):124,696
    Checksum:iB4C1D6D65C7E3676
    GO
    Isoform Alpha-7X1X2A (identifier: Q61738-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1104-1179: LGFFKRAKHP...PDGHPVPATA → CGFFRRNSPS...PRPPCPSTTQ

    Show »
    Length:1,160
    Mass (Da):126,784
    Checksum:iCAF7035497AAA400
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti133 – 1331A → P in CAA73023. 1 PublicationCurated
    Sequence conflicti133 – 1331A → P in CAA73024. 1 PublicationCurated
    Sequence conflicti347 – 3471T → Q in AAA16599. (PubMed:8253814)Curated
    Sequence conflicti347 – 3471T → S in CAA73023. 1 PublicationCurated
    Sequence conflicti347 – 3471T → S in CAA73024. 1 PublicationCurated
    Sequence conflicti647 – 6471G → R in AAA16600. (PubMed:8253814)Curated
    Sequence conflicti879 – 8802EL → DV in CAA73023. 1 PublicationCurated
    Sequence conflicti879 – 8802EL → DV in CAA73024. 1 PublicationCurated
    Sequence conflicti882 – 8821R → S in CAA73023. 1 PublicationCurated
    Sequence conflicti882 – 8821R → S in CAA73024. 1 PublicationCurated
    Sequence conflicti904 – 9041N → F in CAA73023. 1 PublicationCurated
    Sequence conflicti904 – 9041N → F in CAA73024. 1 PublicationCurated
    Sequence conflicti989 – 9891M → V in CAA73023. 1 PublicationCurated
    Sequence conflicti989 – 9891M → V in CAA73024. 1 PublicationCurated
    Sequence conflicti994 – 9952PR → AQG in CAA73023. 1 PublicationCurated
    Sequence conflicti994 – 9952PR → AQG in CAA73024. 1 PublicationCurated
    Sequence conflicti1031 – 10344MAVK → LLIN in AAA16598. (PubMed:8253814)Curated
    Sequence conflicti1086 – 10861G → A in CAA73023. 1 PublicationCurated
    Sequence conflicti1086 – 10861G → A in CAA73024. 1 PublicationCurated
    Isoform Alpha-7X2A (identifier: Q61738-4)
    Sequence conflicti1042 – 10421G → A in L16544. (PubMed:8360188)Curated
    Sequence conflicti1115 – 11162TQ → T in AAA16598. (PubMed:8253814)Curated
    Isoform Alpha-7X1A (identifier: Q61738-2)
    Sequence conflicti1046 – 10461G → A in L16544. (PubMed:8360188)Curated
    Sequence conflicti1119 – 11202TQ → T in AAA16598. (PubMed:8253814)Curated
    Isoform Alpha-7X1X2A (identifier: Q61738-6)
    Sequence conflicti1086 – 10861G → A in L16544. (PubMed:8360188)Curated
    Sequence conflicti1159 – 11602TQ → T in AAA16598. (PubMed:8253814)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei224 – 26744Missing in isoform Alpha-7X2A and isoform Alpha-7X2B. 1 PublicationVSP_002731Add
    BLAST
    Alternative sequencei268 – 30740Missing in isoform Alpha-7X1A and isoform Alpha-7X1B. CuratedVSP_002732Add
    BLAST
    Alternative sequencei1104 – 117976LGFFK…VPATA → CGFFRRNSPSSSFPTNYHRA HLAVQPSAMEAGGPGTVGWD SSSGRSTPRPPCPSTTQ in isoform Alpha-7X1A, isoform Alpha-7X2A and isoform Alpha-7X1X2A. CuratedVSP_002733Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23423 mRNA. Translation: AAA16600.1.
    Y12380
    , Y12383, Y12384, Y12385, Y12386, Y12387, Y12388, Y12389, Y12390, Y12382 Genomic DNA. Translation: CAA73023.1.
    L23422 Genomic DNA. Translation: AAA16599.1.
    Y12380
    , Y12383, Y12384, Y12385, Y12386, Y12387, Y12388, Y12389, Y12390, Y12381, Y12382 Genomic DNA. Translation: CAA73024.1.
    U60419 Genomic DNA. Translation: AAC52772.1.
    L23421 mRNA. Translation: AAA16598.1.
    L16544 mRNA. No translation available.
    PIRiI61186.
    I61187.
    UniGeneiMm.179747.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23423 mRNA. Translation: AAA16600.1 .
    Y12380
    , Y12383 , Y12384 , Y12385 , Y12386 , Y12387 , Y12388 , Y12389 , Y12390 , Y12382 Genomic DNA. Translation: CAA73023.1 .
    L23422 Genomic DNA. Translation: AAA16599.1 .
    Y12380
    , Y12383 , Y12384 , Y12385 , Y12386 , Y12387 , Y12388 , Y12389 , Y12390 , Y12381 , Y12382 Genomic DNA. Translation: CAA73024.1 .
    U60419 Genomic DNA. Translation: AAC52772.1 .
    L23421 mRNA. Translation: AAA16598.1 .
    L16544 mRNA. No translation available.
    PIRi I61186.
    I61187.
    UniGenei Mm.179747.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61738. 5 interactions.
    MINTi MINT-4098899.

    PTM databases

    PhosphoSitei Q61738.

    Proteomic databases

    MaxQBi Q61738.
    PaxDbi Q61738.
    PRIDEi Q61738.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:102700. Itga7.

    Phylogenomic databases

    eggNOGi NOG26407.
    HOGENOMi HOG000015786.
    HOVERGENi HBG108011.
    InParanoidi Q61738.
    PhylomeDBi Q61738.

    Miscellaneous databases

    PROi Q61738.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_ITGA7.
    Genevestigatori Q61738.

    Family and domain databases

    InterProi IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view ]
    Pfami PF08441. Integrin_alpha2. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 5 hits.
    [Graphical view ]
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development."
      Ziober B.L., Vu M.P., Waleh N., Crawford J., Lin C.-S., Kramer R.H.
      J. Biol. Chem. 268:26773-26783(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-7X2B), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-70 (ISOFORM ALPHA-7X1X2B), NUCLEOTIDE SEQUENCE [MRNA] OF 1031-1179 (ISOFORMS ALPHA-7X1A/ALPHA-7X2A/ALPHA-7X1X2A), ALTERNATIVE SPLICING.
      Strain: BALB/c.
      Tissue: Heart.
    2. "Genomic organization and chromosomal localization of the mouse integrin alpha7 gene."
      Saher G., Echtermeyer F., Beier D.R., Poeschl E., Mayer U.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS ALPHA-7X1X2A AND ALPHA-7X1X2B).
      Strain: 129/Sv.
    3. "Identification and characterization of the cell type-specific and developmentally regulated alpha7 integrin gene promoter."
      Ziober B.L., Kramer R.H.
      J. Biol. Chem. 271:22915-22922(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-70.
      Strain: C57BL/6 X CBA.
    4. "Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes."
      Kramer R.H., Vu M.P., Cheng Y.F., Ramos D.M., Timpl R., Waleh N.
      Cell Regul. 2:805-817(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 34-58.
      Tissue: Melanoma.
    5. "A new isoform of the laminin receptor integrin alpha 7 beta 1 is developmentally regulated in skeletal muscle."
      Collo G., Starr L., Quaranta V.
      J. Biol. Chem. 268:19019-19024(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1013-1179 (ISOFORMS ALPHA-7X1A/ALPHA-7X2A/ALPHA-7X1X2A).
      Strain: C57BL/6 X BALB/c.
    6. "Synaptic integrins in developing, adult, and mutant muscle: selective association of alpha1, alpha7A, and alpha7B integrins with the neuromuscular junction."
      Martin P.T., Kaufman S.J., Kramer R.H., Sanes J.R.
      Dev. Biol. 174:125-139(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. Cited for: FUNCTION.
    8. "Processing of ADP-ribosylated integrin alpha 7 in skeletal muscle myotubes."
      Zolkiewska A., Moss J.
      J. Biol. Chem. 270:9227-9233(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: ADP-RIBOSYLATION.
    9. "Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function."
      Liu J., Gurpur P.B., Kaufman S.J.
      J. Biol. Chem. 283:35668-35678(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: ABSENCE OF CLEAVAGE BY UROKINASE.
    10. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1023.
      Tissue: Myoblast.

    Entry informationi

    Entry nameiITA7_MOUSE
    AccessioniPrimary (citable) accession number: Q61738
    Secondary accession number(s): O88731
    , O88732, P70350, Q61737, Q61741
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3