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Protein

Interleukin-10 receptor subunit alpha

Gene

Il10ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for IL10; binds IL10 with a high affinity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-6783783 Interleukin-10 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10 receptor subunit alpha
Short name:
IL-10 receptor subunit alpha
Short name:
IL-10R subunit alpha
Short name:
IL-10RA
Alternative name(s):
CDw210a
Interleukin-10 receptor subunit 1
Short name:
IL-10R subunit 1
Short name:
IL-10R1
CD_antigen: CD210
Gene namesi
Name:Il10ra
Synonyms:Il10r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:96538 Il10ra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 241ExtracellularSequence analysisAdd BLAST225
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 575CytoplasmicSequence analysisAdd BLAST313

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001101317 – 575Interleukin-10 receptor subunit alphaAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi204 ↔ 225Sequence analysis
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61727
PRIDEiQ61727

PTM databases

PhosphoSitePlusiQ61727

Expressioni

Gene expression databases

BgeeiENSMUSG00000032089
CleanExiMM_IL10RA
ExpressionAtlasiQ61727 baseline and differential
GenevisibleiQ61727 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-247N
STRINGi10090.ENSMUSP00000034594

Structurei

3D structure databases

ProteinModelPortaliQ61727
SMRiQ61727
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGAG Eukaryota
ENOG410YMSK LUCA
GeneTreeiENSGT00510000048847
HOGENOMiHOG000112980
HOVERGENiHBG052056
InParanoidiQ61727
KOiK05134
OMAiTEEPQFL
OrthoDBiEOG091G04DG
PhylomeDBiQ61727
TreeFamiTF334107

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF01108 Tissue_fac, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRLLPFLV TISSLSLEFI AYGTELPSPS YVWFEARFFQ HILHWKPIPN
60 70 80 90 100
QSESTYYEVA LKQYGNSTWN DIHICRKAQA LSCDLTTFTL DLYHRSYGYR
110 120 130 140 150
ARVRAVDNSQ YSNWTTTETR FTVDEVILTV DSVTLKAMDG IIYGTIHPPR
160 170 180 190 200
PTITPAGDEY EQVFKDLRVY KISIRKFSEL KNATKRVKQE TFTLTVPIGV
210 220 230 240 250
RKFCVKVLPR LESRINKAEW SEEQCLLITT EQYFTVTNLS ILVISMLLFC
260 270 280 290 300
GILVCLVLQW YIRHPGKLPT VLVFKKPHDF FPANPLCPET PDAIHIVDLE
310 320 330 340 350
VFPKVSLELR DSVLHGSTDS GFGSGKPSLQ TEESQFLLPG SHPQIQGTLG
360 370 380 390 400
KEESPGLQAT CGDNTDSGIC LQEPGLHSSM GPAWKQQLGY THQDQDDSDV
410 420 430 440 450
NLVQNSPGQP KYTQDASALG HVCLLEPKAP EEKDQVMVTF QGYQKQTRWK
460 470 480 490 500
AEAAGPAECL DEEIPLTDAF DPELGVHLQD DLAWPPPALA AGYLKQESQG
510 520 530 540 550
MASAPPGTPS RQWNQLTEEW SLLGVVSCED LSIESWRFAH KLDPLDCGAA
560 570
PGGLLDSLGS NLVTLPLISS LQVEE
Length:575
Mass (Da):64,248
Last modified:November 1, 1996 - v1
Checksum:i820B9CD576F686B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12120 mRNA Translation: AAA16156.1
CCDSiCCDS23131.1
PIRiA49667
RefSeqiNP_032374.1, NM_008348.3
UniGeneiMm.379327

Genome annotation databases

EnsembliENSMUST00000034594; ENSMUSP00000034594; ENSMUSG00000032089
GeneIDi16154
KEGGimmu:16154
UCSCiuc009pfn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiI10R1_MOUSE
AccessioniPrimary (citable) accession number: Q61727
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health