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Q61727

- I10R1_MOUSE

UniProt

Q61727 - I10R1_MOUSE

Protein

Interleukin-10 receptor subunit alpha

Gene

Il10ra

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Receptor for IL10; binds IL10 with a high affinity.

    GO - Molecular functioni

    1. interleukin-10 receptor activity Source: Ensembl

    GO - Biological processi

    1. response to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-10 receptor subunit alpha
    Short name:
    IL-10 receptor subunit alpha
    Short name:
    IL-10R subunit alpha
    Short name:
    IL-10RA
    Alternative name(s):
    CDw210a
    Interleukin-10 receptor subunit 1
    Short name:
    IL-10R subunit 1
    Short name:
    IL-10R1
    CD_antigen: CD210
    Gene namesi
    Name:Il10ra
    Synonyms:Il10r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:96538. Il10ra.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 575559Interleukin-10 receptor subunit alphaPRO_0000011013Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi204 ↔ 225Sequence Analysis
    Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ61727.

    PTM databases

    PhosphoSiteiQ61727.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61727.
    BgeeiQ61727.
    CleanExiMM_IL10RA.
    GenevestigatoriQ61727.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-247N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61727.
    SMRiQ61727. Positions 23-229.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 241225ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini263 – 575313CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei242 – 26221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type II cytokine receptor family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43158.
    GeneTreeiENSGT00510000048847.
    HOGENOMiHOG000112980.
    HOVERGENiHBG052056.
    InParanoidiQ61727.
    KOiK05134.
    OMAiWFEAEFF.
    OrthoDBiEOG7DJSMD.
    PhylomeDBiQ61727.
    TreeFamiTF334107.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF01108. Tissue_fac. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61727-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSRLLPFLV TISSLSLEFI AYGTELPSPS YVWFEARFFQ HILHWKPIPN    50
    QSESTYYEVA LKQYGNSTWN DIHICRKAQA LSCDLTTFTL DLYHRSYGYR 100
    ARVRAVDNSQ YSNWTTTETR FTVDEVILTV DSVTLKAMDG IIYGTIHPPR 150
    PTITPAGDEY EQVFKDLRVY KISIRKFSEL KNATKRVKQE TFTLTVPIGV 200
    RKFCVKVLPR LESRINKAEW SEEQCLLITT EQYFTVTNLS ILVISMLLFC 250
    GILVCLVLQW YIRHPGKLPT VLVFKKPHDF FPANPLCPET PDAIHIVDLE 300
    VFPKVSLELR DSVLHGSTDS GFGSGKPSLQ TEESQFLLPG SHPQIQGTLG 350
    KEESPGLQAT CGDNTDSGIC LQEPGLHSSM GPAWKQQLGY THQDQDDSDV 400
    NLVQNSPGQP KYTQDASALG HVCLLEPKAP EEKDQVMVTF QGYQKQTRWK 450
    AEAAGPAECL DEEIPLTDAF DPELGVHLQD DLAWPPPALA AGYLKQESQG 500
    MASAPPGTPS RQWNQLTEEW SLLGVVSCED LSIESWRFAH KLDPLDCGAA 550
    PGGLLDSLGS NLVTLPLISS LQVEE 575
    Length:575
    Mass (Da):64,248
    Last modified:November 1, 1996 - v1
    Checksum:i820B9CD576F686B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12120 mRNA. Translation: AAA16156.1.
    CCDSiCCDS23131.1.
    PIRiA49667.
    RefSeqiNP_032374.1. NM_008348.2.
    UniGeneiMm.379327.

    Genome annotation databases

    EnsembliENSMUST00000034594; ENSMUSP00000034594; ENSMUSG00000032089.
    GeneIDi16154.
    KEGGimmu:16154.
    UCSCiuc009pfn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12120 mRNA. Translation: AAA16156.1 .
    CCDSi CCDS23131.1.
    PIRi A49667.
    RefSeqi NP_032374.1. NM_008348.2.
    UniGenei Mm.379327.

    3D structure databases

    ProteinModelPortali Q61727.
    SMRi Q61727. Positions 23-229.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-247N.

    PTM databases

    PhosphoSitei Q61727.

    Proteomic databases

    PRIDEi Q61727.

    Protocols and materials databases

    DNASUi 16154.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034594 ; ENSMUSP00000034594 ; ENSMUSG00000032089 .
    GeneIDi 16154.
    KEGGi mmu:16154.
    UCSCi uc009pfn.1. mouse.

    Organism-specific databases

    CTDi 3587.
    MGIi MGI:96538. Il10ra.

    Phylogenomic databases

    eggNOGi NOG43158.
    GeneTreei ENSGT00510000048847.
    HOGENOMi HOG000112980.
    HOVERGENi HBG052056.
    InParanoidi Q61727.
    KOi K05134.
    OMAi WFEAEFF.
    OrthoDBi EOG7DJSMD.
    PhylomeDBi Q61727.
    TreeFami TF334107.

    Miscellaneous databases

    ChiTaRSi IL10RA. mouse.
    NextBioi 288955.
    PROi Q61727.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61727.
    Bgeei Q61727.
    CleanExi MM_IL10RA.
    Genevestigatori Q61727.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF01108. Tissue_fac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "A receptor for interleukin 10 is related to interferon receptors."
      Ho A.S.-Y., Liu Y., Khan T.A., Hsu D.-H., Bazan J.F., Moore K.W.
      Proc. Natl. Acad. Sci. U.S.A. 90:11267-11271(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X AJ F1.
      Tissue: Hematopoietic.

    Entry informationi

    Entry nameiI10R1_MOUSE
    AccessioniPrimary (citable) accession number: Q61727
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3