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Protein

Interleukin-10 receptor subunit alpha

Gene

Il10ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for IL10; binds IL10 with a high affinity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10 receptor subunit alpha
Short name:
IL-10 receptor subunit alpha
Short name:
IL-10R subunit alpha
Short name:
IL-10RA
Alternative name(s):
CDw210a
Interleukin-10 receptor subunit 1
Short name:
IL-10R subunit 1
Short name:
IL-10R1
CD_antigen: CD210
Gene namesi
Name:Il10ra
Synonyms:Il10r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:96538. Il10ra.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 241ExtracellularSequence analysisAdd BLAST225
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 575CytoplasmicSequence analysisAdd BLAST313

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001101317 – 575Interleukin-10 receptor subunit alphaAdd BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Glycosylationi66N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi204 ↔ 225Sequence analysis
Glycosylationi238N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61727.
PRIDEiQ61727.

PTM databases

PhosphoSitePlusiQ61727.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032089.
CleanExiMM_IL10RA.
ExpressionAtlasiQ61727. baseline and differential.
GenevisibleiQ61727. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-247N.
STRINGi10090.ENSMUSP00000034594.

Structurei

3D structure databases

ProteinModelPortaliQ61727.
SMRiQ61727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGAG. Eukaryota.
ENOG410YMSK. LUCA.
GeneTreeiENSGT00510000048847.
HOGENOMiHOG000112980.
HOVERGENiHBG052056.
InParanoidiQ61727.
KOiK05134.
OMAiHFREYEI.
OrthoDBiEOG091G04DG.
PhylomeDBiQ61727.
TreeFamiTF334107.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRLLPFLV TISSLSLEFI AYGTELPSPS YVWFEARFFQ HILHWKPIPN
60 70 80 90 100
QSESTYYEVA LKQYGNSTWN DIHICRKAQA LSCDLTTFTL DLYHRSYGYR
110 120 130 140 150
ARVRAVDNSQ YSNWTTTETR FTVDEVILTV DSVTLKAMDG IIYGTIHPPR
160 170 180 190 200
PTITPAGDEY EQVFKDLRVY KISIRKFSEL KNATKRVKQE TFTLTVPIGV
210 220 230 240 250
RKFCVKVLPR LESRINKAEW SEEQCLLITT EQYFTVTNLS ILVISMLLFC
260 270 280 290 300
GILVCLVLQW YIRHPGKLPT VLVFKKPHDF FPANPLCPET PDAIHIVDLE
310 320 330 340 350
VFPKVSLELR DSVLHGSTDS GFGSGKPSLQ TEESQFLLPG SHPQIQGTLG
360 370 380 390 400
KEESPGLQAT CGDNTDSGIC LQEPGLHSSM GPAWKQQLGY THQDQDDSDV
410 420 430 440 450
NLVQNSPGQP KYTQDASALG HVCLLEPKAP EEKDQVMVTF QGYQKQTRWK
460 470 480 490 500
AEAAGPAECL DEEIPLTDAF DPELGVHLQD DLAWPPPALA AGYLKQESQG
510 520 530 540 550
MASAPPGTPS RQWNQLTEEW SLLGVVSCED LSIESWRFAH KLDPLDCGAA
560 570
PGGLLDSLGS NLVTLPLISS LQVEE
Length:575
Mass (Da):64,248
Last modified:November 1, 1996 - v1
Checksum:i820B9CD576F686B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12120 mRNA. Translation: AAA16156.1.
CCDSiCCDS23131.1.
PIRiA49667.
RefSeqiNP_032374.1. NM_008348.3.
UniGeneiMm.379327.

Genome annotation databases

EnsembliENSMUST00000034594; ENSMUSP00000034594; ENSMUSG00000032089.
GeneIDi16154.
KEGGimmu:16154.
UCSCiuc009pfn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12120 mRNA. Translation: AAA16156.1.
CCDSiCCDS23131.1.
PIRiA49667.
RefSeqiNP_032374.1. NM_008348.3.
UniGeneiMm.379327.

3D structure databases

ProteinModelPortaliQ61727.
SMRiQ61727.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-247N.
STRINGi10090.ENSMUSP00000034594.

PTM databases

PhosphoSitePlusiQ61727.

Proteomic databases

PaxDbiQ61727.
PRIDEiQ61727.

Protocols and materials databases

DNASUi16154.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034594; ENSMUSP00000034594; ENSMUSG00000032089.
GeneIDi16154.
KEGGimmu:16154.
UCSCiuc009pfn.1. mouse.

Organism-specific databases

CTDi3587.
MGIiMGI:96538. Il10ra.

Phylogenomic databases

eggNOGiENOG410IGAG. Eukaryota.
ENOG410YMSK. LUCA.
GeneTreeiENSGT00510000048847.
HOGENOMiHOG000112980.
HOVERGENiHBG052056.
InParanoidiQ61727.
KOiK05134.
OMAiHFREYEI.
OrthoDBiEOG091G04DG.
PhylomeDBiQ61727.
TreeFamiTF334107.

Miscellaneous databases

PROiQ61727.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032089.
CleanExiMM_IL10RA.
ExpressionAtlasiQ61727. baseline and differential.
GenevisibleiQ61727. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiI10R1_MOUSE
AccessioniPrimary (citable) accession number: Q61727
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.