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Q61727

- I10R1_MOUSE

UniProt

Q61727 - I10R1_MOUSE

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Protein

Interleukin-10 receptor subunit alpha

Gene
Il10ra, Il10r
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for IL10; binds IL10 with a high affinity.

GO - Molecular functioni

  1. interleukin-10 receptor activity Source: Ensembl

GO - Biological processi

  1. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10 receptor subunit alpha
Short name:
IL-10 receptor subunit alpha
Short name:
IL-10R subunit alpha
Short name:
IL-10RA
Alternative name(s):
CDw210a
Interleukin-10 receptor subunit 1
Short name:
IL-10R subunit 1
Short name:
IL-10R1
CD_antigen: CD210
Gene namesi
Name:Il10ra
Synonyms:Il10r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:96538. Il10ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 241225Extracellular Reviewed predictionAdd
BLAST
Transmembranei242 – 26221Helical; Reviewed predictionAdd
BLAST
Topological domaini263 – 575313Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed predictionAdd
BLAST
Chaini17 – 575559Interleukin-10 receptor subunit alphaPRO_0000011013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi66 – 661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi182 – 1821N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi204 ↔ 225 Reviewed prediction
Glycosylationi238 – 2381N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ61727.

PTM databases

PhosphoSiteiQ61727.

Expressioni

Gene expression databases

ArrayExpressiQ61727.
BgeeiQ61727.
CleanExiMM_IL10RA.
GenevestigatoriQ61727.

Interactioni

Protein-protein interaction databases

DIPiDIP-247N.

Structurei

3D structure databases

ProteinModelPortaliQ61727.
SMRiQ61727. Positions 23-229.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43158.
GeneTreeiENSGT00510000048847.
HOGENOMiHOG000112980.
HOVERGENiHBG052056.
InParanoidiQ61727.
KOiK05134.
OMAiWFEAEFF.
OrthoDBiEOG7DJSMD.
PhylomeDBiQ61727.
TreeFamiTF334107.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61727-1 [UniParc]FASTAAdd to Basket

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MLSRLLPFLV TISSLSLEFI AYGTELPSPS YVWFEARFFQ HILHWKPIPN    50
QSESTYYEVA LKQYGNSTWN DIHICRKAQA LSCDLTTFTL DLYHRSYGYR 100
ARVRAVDNSQ YSNWTTTETR FTVDEVILTV DSVTLKAMDG IIYGTIHPPR 150
PTITPAGDEY EQVFKDLRVY KISIRKFSEL KNATKRVKQE TFTLTVPIGV 200
RKFCVKVLPR LESRINKAEW SEEQCLLITT EQYFTVTNLS ILVISMLLFC 250
GILVCLVLQW YIRHPGKLPT VLVFKKPHDF FPANPLCPET PDAIHIVDLE 300
VFPKVSLELR DSVLHGSTDS GFGSGKPSLQ TEESQFLLPG SHPQIQGTLG 350
KEESPGLQAT CGDNTDSGIC LQEPGLHSSM GPAWKQQLGY THQDQDDSDV 400
NLVQNSPGQP KYTQDASALG HVCLLEPKAP EEKDQVMVTF QGYQKQTRWK 450
AEAAGPAECL DEEIPLTDAF DPELGVHLQD DLAWPPPALA AGYLKQESQG 500
MASAPPGTPS RQWNQLTEEW SLLGVVSCED LSIESWRFAH KLDPLDCGAA 550
PGGLLDSLGS NLVTLPLISS LQVEE 575
Length:575
Mass (Da):64,248
Last modified:November 1, 1996 - v1
Checksum:i820B9CD576F686B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12120 mRNA. Translation: AAA16156.1.
CCDSiCCDS23131.1.
PIRiA49667.
RefSeqiNP_032374.1. NM_008348.2.
UniGeneiMm.379327.

Genome annotation databases

EnsembliENSMUST00000034594; ENSMUSP00000034594; ENSMUSG00000032089.
GeneIDi16154.
KEGGimmu:16154.
UCSCiuc009pfn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12120 mRNA. Translation: AAA16156.1 .
CCDSi CCDS23131.1.
PIRi A49667.
RefSeqi NP_032374.1. NM_008348.2.
UniGenei Mm.379327.

3D structure databases

ProteinModelPortali Q61727.
SMRi Q61727. Positions 23-229.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-247N.

PTM databases

PhosphoSitei Q61727.

Proteomic databases

PRIDEi Q61727.

Protocols and materials databases

DNASUi 16154.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034594 ; ENSMUSP00000034594 ; ENSMUSG00000032089 .
GeneIDi 16154.
KEGGi mmu:16154.
UCSCi uc009pfn.1. mouse.

Organism-specific databases

CTDi 3587.
MGIi MGI:96538. Il10ra.

Phylogenomic databases

eggNOGi NOG43158.
GeneTreei ENSGT00510000048847.
HOGENOMi HOG000112980.
HOVERGENi HBG052056.
InParanoidi Q61727.
KOi K05134.
OMAi WFEAEFF.
OrthoDBi EOG7DJSMD.
PhylomeDBi Q61727.
TreeFami TF334107.

Miscellaneous databases

ChiTaRSi IL10RA. mouse.
NextBioi 288955.
PROi Q61727.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61727.
Bgeei Q61727.
CleanExi MM_IL10RA.
Genevestigatori Q61727.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF01108. Tissue_fac. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "A receptor for interleukin 10 is related to interferon receptors."
    Ho A.S.-Y., Liu Y., Khan T.A., Hsu D.-H., Bazan J.F., Moore K.W.
    Proc. Natl. Acad. Sci. U.S.A. 90:11267-11271(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X AJ F1.
    Tissue: Hematopoietic.

Entry informationi

Entry nameiI10R1_MOUSE
AccessioniPrimary (citable) accession number: Q61727
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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