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Q61727 (I10R1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-10 receptor subunit alpha

Short name=IL-10 receptor subunit alpha
Short name=IL-10R subunit alpha
Short name=IL-10RA
Alternative name(s):
CDw210a
Interleukin-10 receptor subunit 1
Short name=IL-10R subunit 1
Short name=IL-10R1
CD_antigen=CD210
Gene names
Name:Il10ra
Synonyms:Il10r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length575 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for IL10; binds IL10 with a high affinity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the type II cytokine receptor family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioninterleukin-10 receptor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 575559Interleukin-10 receptor subunit alpha
PRO_0000011013

Regions

Topological domain17 – 241225Extracellular Potential
Transmembrane242 – 26221Helical; Potential
Topological domain263 – 575313Cytoplasmic Potential

Amino acid modifications

Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation1821N-linked (GlcNAc...) Potential
Glycosylation2381N-linked (GlcNAc...) Potential
Disulfide bond204 ↔ 225 Potential

Sequences

Sequence LengthMass (Da)Tools
Q61727 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 820B9CD576F686B7

FASTA57564,248
        10         20         30         40         50         60 
MLSRLLPFLV TISSLSLEFI AYGTELPSPS YVWFEARFFQ HILHWKPIPN QSESTYYEVA 

        70         80         90        100        110        120 
LKQYGNSTWN DIHICRKAQA LSCDLTTFTL DLYHRSYGYR ARVRAVDNSQ YSNWTTTETR 

       130        140        150        160        170        180 
FTVDEVILTV DSVTLKAMDG IIYGTIHPPR PTITPAGDEY EQVFKDLRVY KISIRKFSEL 

       190        200        210        220        230        240 
KNATKRVKQE TFTLTVPIGV RKFCVKVLPR LESRINKAEW SEEQCLLITT EQYFTVTNLS 

       250        260        270        280        290        300 
ILVISMLLFC GILVCLVLQW YIRHPGKLPT VLVFKKPHDF FPANPLCPET PDAIHIVDLE 

       310        320        330        340        350        360 
VFPKVSLELR DSVLHGSTDS GFGSGKPSLQ TEESQFLLPG SHPQIQGTLG KEESPGLQAT 

       370        380        390        400        410        420 
CGDNTDSGIC LQEPGLHSSM GPAWKQQLGY THQDQDDSDV NLVQNSPGQP KYTQDASALG 

       430        440        450        460        470        480 
HVCLLEPKAP EEKDQVMVTF QGYQKQTRWK AEAAGPAECL DEEIPLTDAF DPELGVHLQD 

       490        500        510        520        530        540 
DLAWPPPALA AGYLKQESQG MASAPPGTPS RQWNQLTEEW SLLGVVSCED LSIESWRFAH 

       550        560        570 
KLDPLDCGAA PGGLLDSLGS NLVTLPLISS LQVEE 

« Hide

References

[1]"A receptor for interleukin 10 is related to interferon receptors."
Ho A.S.-Y., Liu Y., Khan T.A., Hsu D.-H., Bazan J.F., Moore K.W.
Proc. Natl. Acad. Sci. U.S.A. 90:11267-11271(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X AJ F1.
Tissue: Hematopoietic.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L12120 mRNA. Translation: AAA16156.1.
PIRA49667.
RefSeqNP_032374.1. NM_008348.2.
UniGeneMm.379327.

3D structure databases

ProteinModelPortalQ61727.
SMRQ61727. Positions 23-229.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-247N.

PTM databases

PhosphoSiteQ61727.

Proteomic databases

PRIDEQ61727.

Protocols and materials databases

DNASU16154.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034594; ENSMUSP00000034594; ENSMUSG00000032089.
GeneID16154.
KEGGmmu:16154.
UCSCuc009pfn.1. mouse.

Organism-specific databases

CTD3587.
MGIMGI:96538. Il10ra.

Phylogenomic databases

eggNOGNOG43158.
GeneTreeENSGT00510000048847.
HOGENOMHOG000112980.
HOVERGENHBG052056.
InParanoidQ61727.
KOK05134.
OMAWFEAEFF.
OrthoDBEOG7DJSMD.
PhylomeDBQ61727.
TreeFamTF334107.

Gene expression databases

ArrayExpressQ61727.
BgeeQ61727.
CleanExMM_IL10RA.
GenevestigatorQ61727.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamPF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
ProtoNetSearch...

Other

ChiTaRSIL10RA. mouse.
NextBio288955.
PROQ61727.
SOURCESearch...

Entry information

Entry nameI10R1_MOUSE
AccessionPrimary (citable) accession number: Q61727
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot