Q61727 (I10R1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-10 receptor subunit alpha
Short name=IL-10 receptor subunit alpha
Short name=IL-10R subunit alpha
Short name=IL-10RA

Alternative name(s):
CDw210a
Interleukin-10 receptor subunit 1
Short name=IL-10R subunit 1
Short name=IL-10R1
CD_antigen=CD210

Gene names

Name:	Il10ra
Synonyms:	Il10r

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	575 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for IL10; binds IL10 with a high affinity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the type II cytokine receptor family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 575	559	Interleukin-10 receptor subunit alpha		PRO_0000011013
Regions
	Topological domain	17 – 241	225	Extracellular Potential
	Transmembrane	242 – 262	21	Helical; Potential
	Topological domain	263 – 575	313	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	50	1	N-linked (GlcNAc...) Potential
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Glycosylation	113	1	N-linked (GlcNAc...) Potential
	Glycosylation	182	1	N-linked (GlcNAc...) Potential
	Glycosylation	238	1	N-linked (GlcNAc...) Potential
	Disulfide bond	204 ↔ 225		Potential

Sequences

	Sequence		Length	Mass (Da)
	Q61727 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 820B9CD576F686B7	FASTA	575	64,248
	10 20 30 40 50 60 MLSRLLPFLV TISSLSLEFI AYGTELPSPS YVWFEARFFQ HILHWKPIPN QSESTYYEVA 70 80 90 100 110 120 LKQYGNSTWN DIHICRKAQA LSCDLTTFTL DLYHRSYGYR ARVRAVDNSQ YSNWTTTETR 130 140 150 160 170 180 FTVDEVILTV DSVTLKAMDG IIYGTIHPPR PTITPAGDEY EQVFKDLRVY KISIRKFSEL 190 200 210 220 230 240 KNATKRVKQE TFTLTVPIGV RKFCVKVLPR LESRINKAEW SEEQCLLITT EQYFTVTNLS 250 260 270 280 290 300 ILVISMLLFC GILVCLVLQW YIRHPGKLPT VLVFKKPHDF FPANPLCPET PDAIHIVDLE 310 320 330 340 350 360 VFPKVSLELR DSVLHGSTDS GFGSGKPSLQ TEESQFLLPG SHPQIQGTLG KEESPGLQAT 370 380 390 400 410 420 CGDNTDSGIC LQEPGLHSSM GPAWKQQLGY THQDQDDSDV NLVQNSPGQP KYTQDASALG 430 440 450 460 470 480 HVCLLEPKAP EEKDQVMVTF QGYQKQTRWK AEAAGPAECL DEEIPLTDAF DPELGVHLQD 490 500 510 520 530 540 DLAWPPPALA AGYLKQESQG MASAPPGTPS RQWNQLTEEW SLLGVVSCED LSIESWRFAH 550 560 570 KLDPLDCGAA PGGLLDSLGS NLVTLPLISS LQVEE

References

[1]	"A receptor for interleukin 10 is related to interferon receptors." Ho A.S.-Y., Liu Y., Khan T.A., Hsu D.-H., Bazan J.F., Moore K.W. Proc. Natl. Acad. Sci. U.S.A. 90:11267-11271(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X AJ F1. Tissue: Hematopoietic.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L12120 mRNA. Translation: AAA16156.1.
IPI	IPI00124801.
PIR	A49667.
RefSeq	NP_032374.1. NM_008348.2.
UniGene	Mm.379327.
3D structure databases
ProteinModelPortal	Q61727.
SMR	Q61727. Positions 23-229.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-247N.
PTM databases
PhosphoSite	Q61727.
Proteomic databases
PRIDE	Q61727.
Protocols and materials databases
DNASU	16154.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000034594; ENSMUSP00000034594; ENSMUSG00000032089.
GeneID	16154.
KEGG	mmu:16154.
Organism-specific databases
CTD	3587.
MGI	MGI:96538. Il10ra.
Phylogenomic databases
eggNOG	NOG43158.
GeneTree	ENSGT00510000048847.
HOGENOM	HOG000112980.
HOVERGEN	HBG052056.
InParanoid	Q61727.
KO	K05134.
OMA	WFEAEFF.
OrthoDB	EOG4SF96V.
Gene expression databases
ArrayExpress	Q61727.
Bgee	Q61727.
CleanEx	MM_IL10RA.
Genevestigator	Q61727.
GermOnline	ENSMUSG00000032089. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits.
ProtoNet	Search...
Other
ChiTaRS	IL10RA. mouse.
NextBio	288955.
SOURCE	Search...

Entry information

Entry name

I10R1_MOUSE

Accession

Primary (citable) accession number: Q61727

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program