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Protein

Interleukin-10 receptor subunit alpha

Gene

Il10ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for IL10; binds IL10 with a high affinity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10 receptor subunit alpha
Short name:
IL-10 receptor subunit alpha
Short name:
IL-10R subunit alpha
Short name:
IL-10RA
Alternative name(s):
CDw210a
Interleukin-10 receptor subunit 1
Short name:
IL-10R subunit 1
Short name:
IL-10R1
CD_antigen: CD210
Gene namesi
Name:Il10ra
Synonyms:Il10r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:96538. Il10ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 241225ExtracellularSequence AnalysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence AnalysisAdd
BLAST
Topological domaini263 – 575313CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 575559Interleukin-10 receptor subunit alphaPRO_0000011013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi204 ↔ 225Sequence Analysis
Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ61727.

PTM databases

PhosphoSiteiQ61727.

Expressioni

Gene expression databases

BgeeiQ61727.
CleanExiMM_IL10RA.
ExpressionAtlasiQ61727. baseline and differential.
GenevisibleiQ61727. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-247N.
STRINGi10090.ENSMUSP00000034594.

Structurei

3D structure databases

ProteinModelPortaliQ61727.
SMRiQ61727. Positions 23-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43158.
GeneTreeiENSGT00510000048847.
HOGENOMiHOG000112980.
HOVERGENiHBG052056.
InParanoidiQ61727.
KOiK05134.
OMAiHFREYEI.
OrthoDBiEOG7DJSMD.
PhylomeDBiQ61727.
TreeFamiTF334107.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRLLPFLV TISSLSLEFI AYGTELPSPS YVWFEARFFQ HILHWKPIPN
60 70 80 90 100
QSESTYYEVA LKQYGNSTWN DIHICRKAQA LSCDLTTFTL DLYHRSYGYR
110 120 130 140 150
ARVRAVDNSQ YSNWTTTETR FTVDEVILTV DSVTLKAMDG IIYGTIHPPR
160 170 180 190 200
PTITPAGDEY EQVFKDLRVY KISIRKFSEL KNATKRVKQE TFTLTVPIGV
210 220 230 240 250
RKFCVKVLPR LESRINKAEW SEEQCLLITT EQYFTVTNLS ILVISMLLFC
260 270 280 290 300
GILVCLVLQW YIRHPGKLPT VLVFKKPHDF FPANPLCPET PDAIHIVDLE
310 320 330 340 350
VFPKVSLELR DSVLHGSTDS GFGSGKPSLQ TEESQFLLPG SHPQIQGTLG
360 370 380 390 400
KEESPGLQAT CGDNTDSGIC LQEPGLHSSM GPAWKQQLGY THQDQDDSDV
410 420 430 440 450
NLVQNSPGQP KYTQDASALG HVCLLEPKAP EEKDQVMVTF QGYQKQTRWK
460 470 480 490 500
AEAAGPAECL DEEIPLTDAF DPELGVHLQD DLAWPPPALA AGYLKQESQG
510 520 530 540 550
MASAPPGTPS RQWNQLTEEW SLLGVVSCED LSIESWRFAH KLDPLDCGAA
560 570
PGGLLDSLGS NLVTLPLISS LQVEE
Length:575
Mass (Da):64,248
Last modified:November 1, 1996 - v1
Checksum:i820B9CD576F686B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12120 mRNA. Translation: AAA16156.1.
CCDSiCCDS23131.1.
PIRiA49667.
RefSeqiNP_032374.1. NM_008348.2.
UniGeneiMm.379327.

Genome annotation databases

EnsembliENSMUST00000034594; ENSMUSP00000034594; ENSMUSG00000032089.
GeneIDi16154.
KEGGimmu:16154.
UCSCiuc009pfn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12120 mRNA. Translation: AAA16156.1.
CCDSiCCDS23131.1.
PIRiA49667.
RefSeqiNP_032374.1. NM_008348.2.
UniGeneiMm.379327.

3D structure databases

ProteinModelPortaliQ61727.
SMRiQ61727. Positions 23-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-247N.
STRINGi10090.ENSMUSP00000034594.

PTM databases

PhosphoSiteiQ61727.

Proteomic databases

PRIDEiQ61727.

Protocols and materials databases

DNASUi16154.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034594; ENSMUSP00000034594; ENSMUSG00000032089.
GeneIDi16154.
KEGGimmu:16154.
UCSCiuc009pfn.1. mouse.

Organism-specific databases

CTDi3587.
MGIiMGI:96538. Il10ra.

Phylogenomic databases

eggNOGiNOG43158.
GeneTreeiENSGT00510000048847.
HOGENOMiHOG000112980.
HOVERGENiHBG052056.
InParanoidiQ61727.
KOiK05134.
OMAiHFREYEI.
OrthoDBiEOG7DJSMD.
PhylomeDBiQ61727.
TreeFamiTF334107.

Miscellaneous databases

NextBioi288955.
PROiQ61727.
SOURCEiSearch...

Gene expression databases

BgeeiQ61727.
CleanExiMM_IL10RA.
ExpressionAtlasiQ61727. baseline and differential.
GenevisibleiQ61727. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "A receptor for interleukin 10 is related to interferon receptors."
    Ho A.S.-Y., Liu Y., Khan T.A., Hsu D.-H., Bazan J.F., Moore K.W.
    Proc. Natl. Acad. Sci. U.S.A. 90:11267-11271(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X AJ F1.
    Tissue: Hematopoietic.

Entry informationi

Entry nameiI10R1_MOUSE
AccessioniPrimary (citable) accession number: Q61727
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.