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Q61727

- I10R1_MOUSE

UniProt

Q61727 - I10R1_MOUSE

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Protein

Interleukin-10 receptor subunit alpha

Gene

Il10ra

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for IL10; binds IL10 with a high affinity.

GO - Molecular functioni

  1. interleukin-10 receptor activity Source: Ensembl

GO - Biological processi

  1. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10 receptor subunit alpha
Short name:
IL-10 receptor subunit alpha
Short name:
IL-10R subunit alpha
Short name:
IL-10RA
Alternative name(s):
CDw210a
Interleukin-10 receptor subunit 1
Short name:
IL-10R subunit 1
Short name:
IL-10R1
CD_antigen: CD210
Gene namesi
Name:Il10ra
Synonyms:Il10r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:96538. Il10ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 241225ExtracellularSequence AnalysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence AnalysisAdd
BLAST
Topological domaini263 – 575313CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 575559Interleukin-10 receptor subunit alphaPRO_0000011013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi204 ↔ 225Sequence Analysis
Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ61727.

PTM databases

PhosphoSiteiQ61727.

Expressioni

Gene expression databases

BgeeiQ61727.
CleanExiMM_IL10RA.
ExpressionAtlasiQ61727. baseline and differential.
GenevestigatoriQ61727.

Interactioni

Protein-protein interaction databases

DIPiDIP-247N.

Structurei

3D structure databases

ProteinModelPortaliQ61727.
SMRiQ61727. Positions 23-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43158.
GeneTreeiENSGT00510000048847.
HOGENOMiHOG000112980.
HOVERGENiHBG052056.
InParanoidiQ61727.
KOiK05134.
OMAiWFEAEFF.
OrthoDBiEOG7DJSMD.
PhylomeDBiQ61727.
TreeFamiTF334107.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61727-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSRLLPFLV TISSLSLEFI AYGTELPSPS YVWFEARFFQ HILHWKPIPN
60 70 80 90 100
QSESTYYEVA LKQYGNSTWN DIHICRKAQA LSCDLTTFTL DLYHRSYGYR
110 120 130 140 150
ARVRAVDNSQ YSNWTTTETR FTVDEVILTV DSVTLKAMDG IIYGTIHPPR
160 170 180 190 200
PTITPAGDEY EQVFKDLRVY KISIRKFSEL KNATKRVKQE TFTLTVPIGV
210 220 230 240 250
RKFCVKVLPR LESRINKAEW SEEQCLLITT EQYFTVTNLS ILVISMLLFC
260 270 280 290 300
GILVCLVLQW YIRHPGKLPT VLVFKKPHDF FPANPLCPET PDAIHIVDLE
310 320 330 340 350
VFPKVSLELR DSVLHGSTDS GFGSGKPSLQ TEESQFLLPG SHPQIQGTLG
360 370 380 390 400
KEESPGLQAT CGDNTDSGIC LQEPGLHSSM GPAWKQQLGY THQDQDDSDV
410 420 430 440 450
NLVQNSPGQP KYTQDASALG HVCLLEPKAP EEKDQVMVTF QGYQKQTRWK
460 470 480 490 500
AEAAGPAECL DEEIPLTDAF DPELGVHLQD DLAWPPPALA AGYLKQESQG
510 520 530 540 550
MASAPPGTPS RQWNQLTEEW SLLGVVSCED LSIESWRFAH KLDPLDCGAA
560 570
PGGLLDSLGS NLVTLPLISS LQVEE
Length:575
Mass (Da):64,248
Last modified:November 1, 1996 - v1
Checksum:i820B9CD576F686B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12120 mRNA. Translation: AAA16156.1.
CCDSiCCDS23131.1.
PIRiA49667.
RefSeqiNP_032374.1. NM_008348.2.
UniGeneiMm.379327.

Genome annotation databases

EnsembliENSMUST00000034594; ENSMUSP00000034594; ENSMUSG00000032089.
GeneIDi16154.
KEGGimmu:16154.
UCSCiuc009pfn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12120 mRNA. Translation: AAA16156.1 .
CCDSi CCDS23131.1.
PIRi A49667.
RefSeqi NP_032374.1. NM_008348.2.
UniGenei Mm.379327.

3D structure databases

ProteinModelPortali Q61727.
SMRi Q61727. Positions 23-229.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-247N.

PTM databases

PhosphoSitei Q61727.

Proteomic databases

PRIDEi Q61727.

Protocols and materials databases

DNASUi 16154.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034594 ; ENSMUSP00000034594 ; ENSMUSG00000032089 .
GeneIDi 16154.
KEGGi mmu:16154.
UCSCi uc009pfn.1. mouse.

Organism-specific databases

CTDi 3587.
MGIi MGI:96538. Il10ra.

Phylogenomic databases

eggNOGi NOG43158.
GeneTreei ENSGT00510000048847.
HOGENOMi HOG000112980.
HOVERGENi HBG052056.
InParanoidi Q61727.
KOi K05134.
OMAi WFEAEFF.
OrthoDBi EOG7DJSMD.
PhylomeDBi Q61727.
TreeFami TF334107.

Miscellaneous databases

NextBioi 288955.
PROi Q61727.
SOURCEi Search...

Gene expression databases

Bgeei Q61727.
CleanExi MM_IL10RA.
ExpressionAtlasi Q61727. baseline and differential.
Genevestigatori Q61727.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF01108. Tissue_fac. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "A receptor for interleukin 10 is related to interferon receptors."
    Ho A.S.-Y., Liu Y., Khan T.A., Hsu D.-H., Bazan J.F., Moore K.W.
    Proc. Natl. Acad. Sci. U.S.A. 90:11267-11271(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X AJ F1.
    Tissue: Hematopoietic.

Entry informationi

Entry nameiI10R1_MOUSE
AccessioniPrimary (citable) accession number: Q61727
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3