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Protein

DnaJ homolog subfamily C member 1

Gene

Dnajc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May modulate protein synthesis.By similarity

GO - Molecular functioni

  • chaperone binding Source: MGI
  • DNA binding Source: UniProtKB-KW
  • ribosome binding Source: UniProtKB

GO - Biological processi

  • protein folding Source: MGI
  • regulation of protein secretion Source: UniProtKB
  • regulation of translation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 1
Alternative name(s):
DnaJ protein homolog MTJ1
Gene namesi
Name:Dnajc1
Synonyms:Dnajl1, Mtj1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:103268. Dnajc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini44 – 149106LumenalBy similarityAdd
BLAST
Transmembranei150 – 17021HelicalSequence analysisAdd
BLAST
Topological domaini171 – 552382CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • cytosol Source: GO_Central
  • endoplasmic reticulum Source: MGI
  • endoplasmic reticulum lumen Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
  • membrane Source: MGI
  • nuclear membrane Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4343Sequence analysisAdd
BLAST
Chaini44 – 552509DnaJ homolog subfamily C member 1PRO_0000071043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei379 – 3791PhosphoserineBy similarity
Modified residuei477 – 4771PhosphoserineCombined sources
Modified residuei478 – 4781PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ61712.
MaxQBiQ61712.
PaxDbiQ61712.
PeptideAtlasiQ61712.
PRIDEiQ61712.

PTM databases

iPTMnetiQ61712.
PhosphoSiteiQ61712.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000026740.
CleanExiMM_DNAJC1.
ExpressionAtlasiQ61712. baseline and differential.
GenevisibleiQ61712. MM.

Interactioni

Subunit structurei

Interacts (via J domain) with HSPA5. Interacts (via cytosolic domain) with ribosomes. Interacts (via SANT 2 domain) with SERPINA3; the interaction delays the formation of the covalent inhibitory complex SERPINA3-chymotrypsin, but does not alter the catalytic activity of SERPINA3. Interacts (via SANT 2 domain) with ITIH4 (via C-terminus); the interaction protects ITIH4 against in vitro cleavage by kallikrein (By similarity).By similarity

GO - Molecular functioni

  • chaperone binding Source: MGI

Protein-protein interaction databases

BioGridi199250. 3 interactions.
DIPiDIP-60498N.
STRINGi10090.ENSMUSP00000088980.

Structurei

3D structure databases

ProteinModelPortaliQ61712.
SMRiQ61712. Positions 61-133, 325-382, 484-541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 12974JPROSITE-ProRule annotationAdd
BLAST
Domaini323 – 37755SANT 1PROSITE-ProRule annotationAdd
BLAST
Domaini490 – 54556SANT 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation
Contains 2 SANT domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INV7. Eukaryota.
COG2214. LUCA.
GeneTreeiENSGT00530000063419.
HOGENOMiHOG000231867.
HOVERGENiHBG051374.
InParanoidiQ61712.
KOiK09521.
OMAiILICAIN.
OrthoDBiEOG091G0I6J.
PhylomeDBiQ61712.
TreeFamiTF105161.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
SM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF46689. SSF46689. 2 hits.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWVPGFGSAR LPQRRRSGLE SSSVRPLWLL LLFLLAAVRP VRAWESGDLE
60 70 80 90 100
LFDLVEEVQL NFYEFLGVQQ DASSADIRKA YRKLSLTLHP DKNKDENAET
110 120 130 140 150
QFRQLVAIYE VLKDDERRQR YDDVLINGLP DWRQPVFYYR RVRKMSNAEL
160 170 180 190 200
ALLLFIILTV GHYAVVWSIY LEKQLDELLG RKKRERKKKT GSKSVDAAKL
210 220 230 240 250
GASEKNERLL IKPQWHDLLP CKLGIWFCLT LKALPHLIQD AGQFYAKYKE
260 270 280 290 300
TKLKEKEDAL ARIEIETLQK QKKVKVKKPK PEFPVYMPLE NTYIQSYDHG
310 320 330 340 350
TSIEEIEEQM DDWLENRKRT QKRQAPEWTE EDLSQLTRSM VKFPGGTPGR
360 370 380 390 400
WDKIAHELGR SVTDVTTKAK ELKDSVTSSP GMTRLSELKS NGQNSRPIKI
410 420 430 440 450
ATALPDDIIT QREDSAGAME DEEHEAAEGE QESATTEARP RRRKSARAAE
460 470 480 490 500
AVTRVEPEEK LRGKRQKDFD ISEQNDSSDE EKQRKERTRA AEEAWTQSQQ
510 520 530 540 550
KLLELALQQY PKGASDRWDK IAKCVPSKSK EDCIARYKLL VELVQKKKQA

KS
Length:552
Mass (Da):63,870
Last modified:November 1, 1996 - v1
Checksum:i8DFABB217717ECDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16953 mRNA. Translation: AAA66349.1.
BC080300 mRNA. No translation available.
CCDSiCCDS15709.1.
PIRiJC4030.
RefSeqiNP_001177746.1. NM_001190817.1.
NP_031895.1. NM_007869.3.
UniGeneiMm.246674.

Genome annotation databases

EnsembliENSMUST00000091418; ENSMUSP00000088980; ENSMUSG00000026740.
ENSMUST00000166495; ENSMUSP00000126321; ENSMUSG00000026740.
GeneIDi13418.
KEGGimmu:13418.
UCSCiuc008ilt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16953 mRNA. Translation: AAA66349.1.
BC080300 mRNA. No translation available.
CCDSiCCDS15709.1.
PIRiJC4030.
RefSeqiNP_001177746.1. NM_001190817.1.
NP_031895.1. NM_007869.3.
UniGeneiMm.246674.

3D structure databases

ProteinModelPortaliQ61712.
SMRiQ61712. Positions 61-133, 325-382, 484-541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199250. 3 interactions.
DIPiDIP-60498N.
STRINGi10090.ENSMUSP00000088980.

PTM databases

iPTMnetiQ61712.
PhosphoSiteiQ61712.

Proteomic databases

EPDiQ61712.
MaxQBiQ61712.
PaxDbiQ61712.
PeptideAtlasiQ61712.
PRIDEiQ61712.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091418; ENSMUSP00000088980; ENSMUSG00000026740.
ENSMUST00000166495; ENSMUSP00000126321; ENSMUSG00000026740.
GeneIDi13418.
KEGGimmu:13418.
UCSCiuc008ilt.2. mouse.

Organism-specific databases

CTDi64215.
MGIiMGI:103268. Dnajc1.

Phylogenomic databases

eggNOGiENOG410INV7. Eukaryota.
COG2214. LUCA.
GeneTreeiENSGT00530000063419.
HOGENOMiHOG000231867.
HOVERGENiHBG051374.
InParanoidiQ61712.
KOiK09521.
OMAiILICAIN.
OrthoDBiEOG091G0I6J.
PhylomeDBiQ61712.
TreeFamiTF105161.

Miscellaneous databases

PROiQ61712.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026740.
CleanExiMM_DNAJC1.
ExpressionAtlasiQ61712. baseline and differential.
GenevisibleiQ61712. MM.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
SM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF46689. SSF46689. 2 hits.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNJC1_MOUSE
AccessioniPrimary (citable) accession number: Q61712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.