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Q61711 (SIAL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone sialoprotein 2
Alternative name(s):
Bone sialoprotein II
Short name=BSP II
Cell-binding sialoprotein
Integrin-binding sialoprotein
Gene names
Name:Ibsp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment By similarity.

Subcellular location

Secreted.

Post-translational modification

N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains By similarity.

Sulfated on either Tyr-320 or Tyr-321 By similarity.

Miscellaneous

It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 By similarity
Chain17 – 324308Bone sialoprotein 2
PRO_0000020331

Regions

Motif293 – 2953Cell attachment site Potential
Compositional bias68 – 179112Asp/Glu-rich (acidic)
Compositional bias77 – 848Poly-Glu
Compositional bias157 – 17216Poly-Glu

Amino acid modifications

Modified residue311Phosphoserine By similarity
Modified residue671Phosphoserine By similarity
Modified residue751Phosphoserine By similarity
Modified residue761Phosphoserine By similarity
Modified residue951Phosphoserine By similarity
Modified residue1551Phosphoserine By similarity
Modified residue3201Sulfotyrosine By similarity
Modified residue3211Sulfotyrosine By similarity
Glycosylation1071N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential
Glycosylation1961N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict731G → C in AAA37326. Ref.2
Sequence conflict1081S → A in AAA21726. Ref.1
Sequence conflict1081S → A in AAA37326. Ref.2
Sequence conflict2591I → V in AAA37326. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q61711 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: D0CD12EA82D27773

FASTA32435,734
        10         20         30         40         50         60 
MKTALILLSI LGMACAFSMK NFHRRIKAED SEENGVFKYR PRYFLYKHAY FYPPLKRFPV 

        70         80         90        100        110        120 
QGGSDSSEEN GDGDSSEEEG EEEETSNEEE NNEDSEGNED QEAEAENSTL STLSGVTASY 

       130        140        150        160        170        180 
GAETTPQAQT FELAALQLPK KAGDAESRAP KVKESDEEEE EEEEEEENEN EEAEVDENEL 

       190        200        210        220        230        240 
AVNGTSTNST EVDGGNGSSG GDNGEEAEAE EASVTEAGAE GTTGGRELTS VGTQTAVLLN 

       250        260        270        280        290        300 
GFQQTTPPPE AYGTTSPPIR KSSTVEYGGE YEQTGNEYNN EYEVYDNENG EPRGDTYRAY 

       310        320 
EDEYSYYKGH GYEGYEGQNY YYHQ 

« Hide

References

« Hide 'large scale' references
[1]"Murine bone sialoprotein (BSP): cDNA cloning, mRNA expression, and genetic mapping."
Young M.F., Ibaraki K., Kerr J.M., Lyu M.S., Kozak C.A.
Mamm. Genome 5:108-111(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Sequence of mouse bone sialoprotein II (BSP) cDNA."
Wuyts W., Tylzanowski P., Merregaert J.
Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Bone.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L20232 mRNA. Translation: AAA21726.1.
L23801 mRNA. Translation: AAA37326.1.
AK132371 mRNA. Translation: BAE21132.1.
BC045143 mRNA. Translation: AAH45143.1.
CH466529 Genomic DNA. Translation: EDL20226.1.
CCDSCCDS19485.1.
PIRI49768.
RefSeqNP_032344.2. NM_008318.3.
UniGeneMm.4987.

3D structure databases

ProteinModelPortalQ61711.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61711. 1 interaction.
MINTMINT-8283231.
STRING10090.ENSMUSP00000031246.

PTM databases

PhosphoSiteQ61711.

Proteomic databases

PRIDEQ61711.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031246; ENSMUSP00000031246; ENSMUSG00000029306.
GeneID15891.
KEGGmmu:15891.
UCSCuc008ykg.2. mouse.

Organism-specific databases

CTD3381.
MGIMGI:96389. Ibsp.

Phylogenomic databases

eggNOGNOG238366.
GeneTreeENSGT00390000002485.
HOGENOMHOG000234824.
HOVERGENHBG007981.
InParanoidQ80VR6.
KOK06253.
OMAAYEDEYS.
OrthoDBEOG7NW6BX.
TreeFamTF338678.

Gene expression databases

BgeeQ61711.
CleanExMM_IBSP.
GenevestigatorQ61711.

Family and domain databases

InterProIPR008412. BSP_II.
[Graphical view]
PANTHERPTHR10345. PTHR10345. 1 hit.
PfamPF05432. BSP_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288596.
PROQ61711.
SOURCESearch...

Entry information

Entry nameSIAL_MOUSE
AccessionPrimary (citable) accession number: Q61711
Secondary accession number(s): Q61363, Q80VR6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot