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Protein

Inter-alpha-trypsin inhibitor heavy chain H2

Gene

Itih2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H2
Short name:
ITI heavy chain H2
Short name:
ITI-HC2
Short name:
Inter-alpha-inhibitor heavy chain 2
Gene namesi
Name:Itih2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96619. Itih2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 5436By similarityPRO_0000016520Add
BLAST
Chaini55 – 702648Inter-alpha-trypsin inhibitor heavy chain H2PRO_0000016521Add
BLAST
Propeptidei703 – 946244By similarityPRO_0000016522Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601PhosphoserineCombined sources
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence analysis
Glycosylationi118 – 1181N-linked (GlcNAc...)2 Publications
Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence analysis
Modified residuei282 – 28214-carboxyglutamateBy similarity
Modified residuei283 – 28314-carboxyglutamateBy similarity
Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence analysis
Modified residuei466 – 4661PhosphoserineBy similarity
Modified residuei702 – 7021Aspartate 1-(chondroitin 4-sulfate)-esterBy similarity
Modified residuei886 – 8861PhosphoserineBy similarity

Post-translational modificationi

Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.By similarity
Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiQ61703.
PaxDbiQ61703.
PRIDEiQ61703.

PTM databases

iPTMnetiQ61703.
PhosphoSiteiQ61703.

Expressioni

Tissue specificityi

Expressed in both liver and brain.

Gene expression databases

BgeeiENSMUSG00000037254.
CleanExiMM_ITIH2.

Interactioni

Subunit structurei

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.

Protein-protein interaction databases

IntActiQ61703. 4 interactions.
MINTiMINT-4099077.
STRINGi10090.ENSMUSP00000046530.

Structurei

3D structure databases

ProteinModelPortaliQ61703.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 185130VITPROSITE-ProRule annotationAdd
BLAST
Domaini308 – 468161VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ITIH family.Curated
Contains 1 VIT domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
HOGENOMiHOG000000680.
HOVERGENiHBG057734.
InParanoidiQ61703.
KOiK19015.
PhylomeDBiQ61703.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRPVCLLIW LFLLEAQAFE IPINGNSEFA EYSDLVELAP DKLPFVQENG
60 70 80 90 100
RHQRSLPEES GEETDTVDPV TLYSYKVQST ITSRVATTTI QSKLVNNSPL
110 120 130 140 150
PQSVVFDVQI PKGAFISNFT MTVNGMTFTS SIKEKTVGRA LYSQARAKGK
160 170 180 190 200
TAGWVRSRTL DMENFNTEVN IPPGAKVQFE LHYQEVKWRK LGSYEHKIHL
210 220 230 240 250
QPGKLAKHLE VNVWIIEPQG MRFLHVPDTF EGHFQGVPVI SKGQQKAHVS
260 270 280 290 300
FKPTVAQQRK CPNCTETAVN GELVVMYDVN REEKAGELEV FNGYFVHFFA
310 320 330 340 350
PENLDPIPKN ILFVIDVSGS MWGIKMKQTV EAMKTILDDL RTDDQFSVVD
360 370 380 390 400
FNHNVRTWRN DLVSATKTQI ADAKRYIEKI QPSGGTNINE ALLRAIFILN
410 420 430 440 450
EASNMGLLNP DSVSLIILVS DGDPTVGELK LSKIQKNVKQ SIQDNISLFS
460 470 480 490 500
LGIGFDVDYD FLKRLSNENR GIAQRIYGNQ DTSSQLKKFY NQVSTPLLRN
510 520 530 540 550
VQFNYPQASV TDVTQNNFHN YFGGSEIVVA GKFDPSKLTE VQSIITATSA
560 570 580 590 600
NTELVLETLS QMDDLEEFLS KDKHADPDFT KKLWAYLTIN QLLAERSLAP
610 620 630 640 650
TAAIKRKITK TILQMSLDHH IVTPLTAMVI ENDAGDERML ADSPPQDHSC
660 670 680 690 700
CSGALYYGTK VASGPIPSWA NPSPTPMSAM LAVGAKPLES TPPTHLNQVE
710 720 730 740 750
NDPHFIIYLP KSKRNICFNI DSEPGKILSL VSDPESGIVV NGQLIGAKRA
760 770 780 790 800
ENGKLSTYFG KLGFYFQKEG MKIEISTETI TLSSGSSTSR LSWSDTAHLG
810 820 830 840 850
NSRVLISVKK EKSVTLTLNK ELFFSVLLHR VWRKHPVNVD FLGIYAPPID
860 870 880 890 900
KFSPRVHGLL GQFMQEPAIH IFNERPGKEP GKPEASMEVK GHKLTVTRGL
910 920 930 940
QKDYRTDIVF GTDVPCWFVH NSGKGFIDGH YKDYFVPQLY SFLKRP
Length:946
Mass (Da):105,928
Last modified:November 1, 1996 - v1
Checksum:i40DB6716433ED9DC
GO

Sequence cautioni

The sequence BAE21837 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti833 – 8331R → G in BAE21837 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70392 mRNA. Translation: CAA49842.1.
AK133782 mRNA. Translation: BAE21837.1. Different initiation.
AL772367 Genomic DNA. Translation: CAM13914.1.
PIRiS54354.
RefSeqiNP_034712.2. NM_010582.3.
UniGeneiMm.182043.

Genome annotation databases

GeneIDi16425.
KEGGimmu:16425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70392 mRNA. Translation: CAA49842.1.
AK133782 mRNA. Translation: BAE21837.1. Different initiation.
AL772367 Genomic DNA. Translation: CAM13914.1.
PIRiS54354.
RefSeqiNP_034712.2. NM_010582.3.
UniGeneiMm.182043.

3D structure databases

ProteinModelPortaliQ61703.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61703. 4 interactions.
MINTiMINT-4099077.
STRINGi10090.ENSMUSP00000046530.

PTM databases

iPTMnetiQ61703.
PhosphoSiteiQ61703.

Proteomic databases

MaxQBiQ61703.
PaxDbiQ61703.
PRIDEiQ61703.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16425.
KEGGimmu:16425.

Organism-specific databases

CTDi3698.
MGIiMGI:96619. Itih2.

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
HOGENOMiHOG000000680.
HOVERGENiHBG057734.
InParanoidiQ61703.
KOiK19015.
PhylomeDBiQ61703.

Miscellaneous databases

ChiTaRSiItih2. mouse.
PROiQ61703.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037254.
CleanExiMM_ITIH2.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITIH2_MOUSE
AccessioniPrimary (citable) accession number: Q61703
Secondary accession number(s): A2AKU6, Q3UZM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.