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Protein

Inter-alpha-trypsin inhibitor heavy chain H1

Gene

Itih1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H1
Short name:
ITI heavy chain H1
Short name:
ITI-HC1
Short name:
Inter-alpha-inhibitor heavy chain 1
Gene namesi
Name:Itih1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:96618. Itih1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Propeptidei27 – 315By similarityPRO_0000016509
Chaini32 – 668637Inter-alpha-trypsin inhibitor heavy chain H1PRO_0000016510Add
BLAST
Propeptidei669 – 907239By similarityPRO_0000016511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571S-linked (Hex...)By similarity
Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence analysis
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence analysis
Modified residuei399 – 3991PhosphothreonineBy similarity
Modified residuei404 – 4041PhosphothreonineBy similarity
Glycosylationi585 – 5851N-linked (GlcNAc...)2 Publications
Glycosylationi650 – 6501O-linked (GalNAc...)By similarity
Modified residuei668 – 6681Aspartate 1-(chondroitin 4-sulfate)-esterBy similarity

Post-translational modificationi

Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.By similarity
The S-linked glycan is composed of two 6-carbon sugars, possibly Glc or Gal.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiQ61702.
PaxDbiQ61702.
PRIDEiQ61702.

PTM databases

PhosphoSiteiQ61702.

Expressioni

Tissue specificityi

Liver specific.

Gene expression databases

BgeeiENSMUSG00000006529.
CleanExiMM_ITIH1.
ExpressionAtlasiQ61702. baseline and differential.
GenevisibleiQ61702. MM.

Interactioni

Subunit structurei

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126449.

Structurei

3D structure databases

ProteinModelPortaliQ61702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 163130VITPROSITE-ProRule annotationAdd
BLAST
Domaini287 – 447161VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ITIH family.Curated
Contains 1 VIT domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
GeneTreeiENSGT00550000074468.
HOVERGENiHBG057734.
InParanoidiQ61702.
KOiK19014.
PhylomeDBiQ61702.
TreeFamiTF328982.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGATGLRVL LCLLPLLTLQ ARPALGLATG RPRGSEKRHA VDTSVNGVSI
60 70 80 90 100
KSLKVNCKVT SRFAHYVITS QVVNNADKAR EVAFDVEIPK TAFISDFAIT
110 120 130 140 150
SDGKAFIGDI KDKVTAWKQY RKAAVLGESA GLVRASGRNM EQFTIHITVG
160 170 180 190 200
AQSKATFRLT YEEVLKRRLM QYDITIKVRP KQLVQHFEID VDIFEPQGIS
210 220 230 240 250
KLDAQASFLS EELAAQTIKK SFSGKKGHVL FRPTVSQQQS CPTCSTSLLN
260 270 280 290 300
GEFKVTYDVN RDKLCDLLVA NNYFTHFFAP KNLTNMSKNL VFVIDISGSM
310 320 330 340 350
EGQKVRQTKE ALLKILEDMR PVDNFDLVLF GSKVQSWKGS LVPASNANLQ
360 370 380 390 400
AAQDFVRRFS LAGATNLNGG LLRGIEILNK AQGSHPELSS PASILIMLTD
410 420 430 440 450
GEPTEGETDR SQILKNVRNA IRGRFPLYNL GFGHDLDFSF LEVMSTENNG
460 470 480 490 500
WAQRIYEDHD ATQQLQGFYN QVANPLLTDV ELQYPQDAVL ALTQHRHKQY
510 520 530 540 550
YDGSEIVVAG RIANHKLNTF KADVRARGEK QEFRATCLVD EEEMKKLLRE
560 570 580 590 600
RGHVLENHVE RLWAYLTIQE LLAKRMKTEG EERANLSSQV LKMSLDYHFV
610 620 630 640 650
TPLTSLTIRG LTDEDGLEPT IDKPLEDSQP LEMVGPRRTF VLSAIQPSPT
660 670 680 690 700
AHPIDSKLPL RVTGVDTDPH FIIYVPSKED SLCFNINEEP GVILNLVQDP
710 720 730 740 750
DTGFTVNGQL IGNKASSPGQ HESTYFGRLG ISSPTSDFQL EVTPQNITLN
760 770 780 790 800
PSSSGSMFSW RDQAVLQKDG VVVTINKKRN LVVSVDDGAT FEIVLHRTWK
810 820 830 840 850
GSAVHQDFLG FYVLDSFRMS ARTKGLLGQF FSPLDFEVFD LHPGSDPTKT
860 870 880 890 900
DATMVVKNRQ LTVTRGLQKD YSKDPRHGAE VPCWFVHDNG AGLIDGVHTD

YVVSDIF
Length:907
Mass (Da):101,067
Last modified:July 27, 2011 - v2
Checksum:iAF430E611C1755CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti344 – 3441A → V in CAA49841 (PubMed:7534067).Curated
Sequence conflicti654 – 6541I → T in CAA49841 (PubMed:7534067).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70391 mRNA. Translation: CAA49841.1.
AK149500 mRNA. Translation: BAE28922.1.
CH466573 Genomic DNA. Translation: EDL24774.1.
CCDSiCCDS49435.1.
PIRiS54353.
RefSeqiNP_001293007.1. NM_001306078.1.
NP_032432.2. NM_008406.3.
UniGeneiMm.3227.

Genome annotation databases

EnsembliENSMUST00000163118; ENSMUSP00000126449; ENSMUSG00000006529.
GeneIDi16424.
KEGGimmu:16424.
UCSCiuc007svz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70391 mRNA. Translation: CAA49841.1.
AK149500 mRNA. Translation: BAE28922.1.
CH466573 Genomic DNA. Translation: EDL24774.1.
CCDSiCCDS49435.1.
PIRiS54353.
RefSeqiNP_001293007.1. NM_001306078.1.
NP_032432.2. NM_008406.3.
UniGeneiMm.3227.

3D structure databases

ProteinModelPortaliQ61702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126449.

PTM databases

PhosphoSiteiQ61702.

Proteomic databases

MaxQBiQ61702.
PaxDbiQ61702.
PRIDEiQ61702.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163118; ENSMUSP00000126449; ENSMUSG00000006529.
GeneIDi16424.
KEGGimmu:16424.
UCSCiuc007svz.1. mouse.

Organism-specific databases

CTDi3697.
MGIiMGI:96618. Itih1.

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
GeneTreeiENSGT00550000074468.
HOVERGENiHBG057734.
InParanoidiQ61702.
KOiK19014.
PhylomeDBiQ61702.
TreeFamiTF328982.

Miscellaneous databases

PROiQ61702.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006529.
CleanExiMM_ITIH1.
ExpressionAtlasiQ61702. baseline and differential.
GenevisibleiQ61702. MM.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITIH1_MOUSE
AccessioniPrimary (citable) accession number: Q61702
Secondary accession number(s): Q3UEI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.