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Protein

ELAV-like protein 4

Gene

Elavl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR. Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA (By similarity).By similarity

GO - Molecular functioni

  • AU-rich element binding Source: UniProtKB
  • mRNA binding Source: MGI
  • nucleotide binding Source: InterPro

GO - Biological processi

  • dendrite morphogenesis Source: MGI
  • learning Source: MGI
  • locomotory behavior Source: MGI
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 4
Alternative name(s):
Hu-antigen D
Short name:
HuD
Paraneoplastic encephalomyelitis antigen HuD
Gene namesi
Name:Elavl4
Synonyms:Hud
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:107427. Elavl4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385ELAV-like protein 4PRO_0000081584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481Omega-N-methylated arginine; by CARM1By similarity

Post-translational modificationi

Methylation at Arg-248 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).By similarity

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ61701.
PaxDbiQ61701.
PRIDEiQ61701.

PTM databases

PhosphoSiteiQ61701.

Expressioni

Tissue specificityi

Expressed in brain and testis.1 Publication

Gene expression databases

BgeeiQ61701.
ExpressionAtlasiQ61701. baseline and differential.
GenevestigatoriQ61701.

Interactioni

Subunit structurei

Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP.1 Publication

Protein-protein interaction databases

IntActiQ61701. 1 interaction.
MINTiMINT-4094262.

Structurei

3D structure databases

ProteinModelPortaliQ61701.
SMRiQ61701. Positions 49-263, 301-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 12979RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini137 – 21781RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini302 – 38079RRM 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RRM elav family.Curated
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000231162.
HOVERGENiHBG002295.
InParanoidiQ61701.
KOiK13208.
OMAiGYKWEIL.
PhylomeDBiQ61701.
TreeFamiTF313377.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q61701-1) [UniParc]FASTAAdd to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEWNGLKMII STMEPQVSNG PTSNTSNGPS SNNRNCPSPM QTGAATDDSK
60 70 80 90 100
TNLIVNYLPQ NMTQEEFRSL FGSIGEIESC KLVRDKITGQ SLGYGFVNYI
110 120 130 140 150
DPKDAEKAIN TLNGLRLQTK TIKVSYARPS SASIRDANLY VSGLPKTMTQ
160 170 180 190 200
KELEQLFSQY GRIITSRILV DQVTGVSRGV GFIRFDKRIE AEEAIKGLNG
210 220 230 240 250
QKPSGATEPI TVKFANNPSQ KSSQALLSQL YQSPNRRYPG PLHHQAQRFR
260 270 280 290 300
LDNLLNMAYG VKRLMSGPVP PSACPPRFSP ITIDGMTSLV GMNIPGHTGT
310 320 330 340 350
GWCIFVYNLS PDSDESVLWQ LFGPFGAVNN VKVIRDFNTN KCKGFGFVTM
360 370 380
TNYDEAAMAI ASLNGYRLGD RVLQVSFKTN KAHKS
Length:385
Mass (Da):42,368
Last modified:November 1, 1996 - v1
Checksum:i1EA9CDAB7E9BC683
GO
Isoform 2 (identifier: Q61701-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     251-277: Missing.

Show »
Length:358
Mass (Da):39,489
Checksum:iBE2984EA2BBCD038
GO
Isoform 3 (identifier: Q61701-3)

Sequence is not available
Length:
Mass (Da):

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei251 – 27727Missing in isoform 2. 1 PublicationVSP_005792Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31953 mRNA. Translation: BAA06723.1.
AF041341 mRNA. Translation: AAC40080.1.
AL627425 Genomic DNA. Translation: CAM19662.1.
CCDSiCCDS18471.1. [Q61701-1]
PIRiJC2298.
RefSeqiNP_034618.2. NM_010488.4. [Q61701-1]
UniGeneiMm.3970.

Genome annotation databases

EnsembliENSMUST00000106597; ENSMUSP00000102207; ENSMUSG00000028546. [Q61701-1]
GeneIDi15572.
KEGGimmu:15572.
UCSCiuc008ucw.1. mouse. [Q61701-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31953 mRNA. Translation: BAA06723.1.
AF041341 mRNA. Translation: AAC40080.1.
AL627425 Genomic DNA. Translation: CAM19662.1.
CCDSiCCDS18471.1. [Q61701-1]
PIRiJC2298.
RefSeqiNP_034618.2. NM_010488.4. [Q61701-1]
UniGeneiMm.3970.

3D structure databases

ProteinModelPortaliQ61701.
SMRiQ61701. Positions 49-263, 301-381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61701. 1 interaction.
MINTiMINT-4094262.

PTM databases

PhosphoSiteiQ61701.

Proteomic databases

MaxQBiQ61701.
PaxDbiQ61701.
PRIDEiQ61701.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106597; ENSMUSP00000102207; ENSMUSG00000028546. [Q61701-1]
GeneIDi15572.
KEGGimmu:15572.
UCSCiuc008ucw.1. mouse. [Q61701-1]

Organism-specific databases

CTDi1996.
MGIiMGI:107427. Elavl4.

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000231162.
HOVERGENiHBG002295.
InParanoidiQ61701.
KOiK13208.
OMAiGYKWEIL.
PhylomeDBiQ61701.
TreeFamiTF313377.

Miscellaneous databases

NextBioi288560.
PROiQ61701.
SOURCEiSearch...

Gene expression databases

BgeeiQ61701.
ExpressionAtlasiQ61701. baseline and differential.
GenevestigatoriQ61701.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue-specific expression of the gene encoding a mouse RNA binding protein homologous to human HuD antigen."
    Abe R., Uyeno Y., Yamamoto K., Sakamoto H.
    DNA Res. 1:175-180(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4."
    Inman M.V., Levy S., Mock B.A., Owens G.C.
    Gene 208:139-145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: ICR.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The insulin-like growth factor mRNA binding-protein IMP-1 and the Ras-regulatory protein G3BP associate with tau mRNA and HuD protein in differentiated P19 neuronal cells."
    Atlas R., Behar L., Elliott E., Ginzburg I.
    J. Neurochem. 89:613-626(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A MRNP COMPLEX WITH IGF2BP1 AND G3BP, INTERACTION WITH IGF2BP1.

Entry informationi

Entry nameiELAV4_MOUSE
AccessioniPrimary (citable) accession number: Q61701
Secondary accession number(s): A2A9R7, O55010
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.