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Protein

ELAV-like protein 4

Gene

Elavl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR. Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA (By similarity).By similarity

GO - Molecular functioni

  • AU-rich element binding Source: UniProtKB
  • mRNA binding Source: MGI

GO - Biological processi

  • dendrite morphogenesis Source: MGI
  • learning Source: MGI
  • locomotory behavior Source: MGI

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 4
Alternative name(s):
Hu-antigen D
Short name:
HuD
Paraneoplastic encephalomyelitis antigen HuD
Gene namesi
Name:Elavl4
Synonyms:Hud
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:107427 Elavl4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815841 – 385ELAV-like protein 4Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei248Omega-N-methylated arginine; by CARM1By similarity1

Post-translational modificationi

Methylation at Arg-248 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ61701
PeptideAtlasiQ61701
PRIDEiQ61701

PTM databases

iPTMnetiQ61701
PhosphoSitePlusiQ61701

Expressioni

Tissue specificityi

Expressed in brain and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000028546
ExpressionAtlasiQ61701 baseline and differential
GenevisibleiQ61701 MM

Interactioni

Subunit structurei

Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP.1 Publication

Protein-protein interaction databases

BioGridi200486, 5 interactors
IntActiQ61701, 4 interactors
MINTiQ61701
STRINGi10090.ENSMUSP00000102207

Structurei

3D structure databases

ProteinModelPortaliQ61701
SMRiQ61701
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 129RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini137 – 217RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini302 – 380RRM 3PROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the RRM elav family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0145 Eukaryota
ENOG410XP7S LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000231162
HOVERGENiHBG002295
InParanoidiQ61701
KOiK13208
OMAiGEIDSCK
OrthoDBiEOG091G0G9L
PhylomeDBiQ61701
TreeFamiTF313377

Family and domain databases

CDDicd12650 RRM1_Hu, 1 hit
cd12656 RRM3_HuD, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006548 ELAD_HU_SF
IPR034775 ELAV/Hu_RRM1
IPR034918 HuD_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01661 ELAV_HUD_SF, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q61701-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEWNGLKMII STMEPQVSNG PTSNTSNGPS SNNRNCPSPM QTGAATDDSK
60 70 80 90 100
TNLIVNYLPQ NMTQEEFRSL FGSIGEIESC KLVRDKITGQ SLGYGFVNYI
110 120 130 140 150
DPKDAEKAIN TLNGLRLQTK TIKVSYARPS SASIRDANLY VSGLPKTMTQ
160 170 180 190 200
KELEQLFSQY GRIITSRILV DQVTGVSRGV GFIRFDKRIE AEEAIKGLNG
210 220 230 240 250
QKPSGATEPI TVKFANNPSQ KSSQALLSQL YQSPNRRYPG PLHHQAQRFR
260 270 280 290 300
LDNLLNMAYG VKRLMSGPVP PSACPPRFSP ITIDGMTSLV GMNIPGHTGT
310 320 330 340 350
GWCIFVYNLS PDSDESVLWQ LFGPFGAVNN VKVIRDFNTN KCKGFGFVTM
360 370 380
TNYDEAAMAI ASLNGYRLGD RVLQVSFKTN KAHKS
Length:385
Mass (Da):42,368
Last modified:November 1, 1996 - v1
Checksum:i1EA9CDAB7E9BC683
GO
Isoform 2 (identifier: Q61701-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     251-277: Missing.

Show »
Length:358
Mass (Da):39,489
Checksum:iBE2984EA2BBCD038
GO
Isoform 3 (identifier: Q61701-3)
Sequence is not available
Length:
Mass (Da):

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005792251 – 277Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31953 mRNA Translation: BAA06723.1
AF041341 mRNA Translation: AAC40080.1
AL627425 Genomic DNA No translation available.
CCDSiCCDS18471.1 [Q61701-1]
PIRiJC2298
RefSeqiNP_034618.2, NM_010488.4 [Q61701-1]
UniGeneiMm.3970

Genome annotation databases

EnsembliENSMUST00000106597; ENSMUSP00000102207; ENSMUSG00000028546 [Q61701-1]
GeneIDi15572
KEGGimmu:15572
UCSCiuc008ucw.1 mouse [Q61701-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiELAV4_MOUSE
AccessioniPrimary (citable) accession number: Q61701
Secondary accession number(s): A2A9R7, O55010
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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