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Q61701

- ELAV4_MOUSE

UniProt

Q61701 - ELAV4_MOUSE

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Protein
ELAV-like protein 4
Gene
Elavl4, Hud
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR. Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA By similarity.

GO - Molecular functioni

  1. AU-rich element binding Source: UniProtKB
  2. nucleotide binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 4
Alternative name(s):
Hu-antigen D
Short name:
HuD
Paraneoplastic encephalomyelitis antigen HuD
Gene namesi
Name:Elavl4
Synonyms:Hud
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:107427. Elavl4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385ELAV-like protein 4
PRO_0000081584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481Omega-N-methylated arginine; by CARM1 By similarity

Post-translational modificationi

Methylation at Arg-248 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth By similarity.

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ61701.
PRIDEiQ61701.

PTM databases

PhosphoSiteiQ61701.

Expressioni

Tissue specificityi

Expressed in brain and testis.1 Publication

Gene expression databases

ArrayExpressiQ61701.
BgeeiQ61701.
GenevestigatoriQ61701.

Interactioni

Subunit structurei

Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP.1 Publication

Protein-protein interaction databases

IntActiQ61701. 1 interaction.
MINTiMINT-4094262.

Structurei

3D structure databases

ProteinModelPortaliQ61701.
SMRiQ61701. Positions 49-263, 301-381.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 12979RRM 1
Add
BLAST
Domaini137 – 21781RRM 2
Add
BLAST
Domaini302 – 38079RRM 3
Add
BLAST

Sequence similaritiesi

Belongs to the RRM elav family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00560000077064.
HOGENOMiHOG000231162.
HOVERGENiHBG002295.
InParanoidiA2A9R7.
KOiK13208.
OMAiHGCPSPM.
PhylomeDBiQ61701.
TreeFamiTF313377.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q61701-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEWNGLKMII STMEPQVSNG PTSNTSNGPS SNNRNCPSPM QTGAATDDSK    50
TNLIVNYLPQ NMTQEEFRSL FGSIGEIESC KLVRDKITGQ SLGYGFVNYI 100
DPKDAEKAIN TLNGLRLQTK TIKVSYARPS SASIRDANLY VSGLPKTMTQ 150
KELEQLFSQY GRIITSRILV DQVTGVSRGV GFIRFDKRIE AEEAIKGLNG 200
QKPSGATEPI TVKFANNPSQ KSSQALLSQL YQSPNRRYPG PLHHQAQRFR 250
LDNLLNMAYG VKRLMSGPVP PSACPPRFSP ITIDGMTSLV GMNIPGHTGT 300
GWCIFVYNLS PDSDESVLWQ LFGPFGAVNN VKVIRDFNTN KCKGFGFVTM 350
TNYDEAAMAI ASLNGYRLGD RVLQVSFKTN KAHKS 385
Length:385
Mass (Da):42,368
Last modified:November 1, 1996 - v1
Checksum:i1EA9CDAB7E9BC683
GO
Isoform 2 (identifier: Q61701-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     251-277: Missing.

Show »
Length:358
Mass (Da):39,489
Checksum:iBE2984EA2BBCD038
GO
Isoform 3 (identifier: Q61701-3)

Sequence is not available
Length:
Mass (Da):

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei251 – 27727Missing in isoform 2.
VSP_005792Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31953 mRNA. Translation: BAA06723.1.
AF041341 mRNA. Translation: AAC40080.1.
AL627425 Genomic DNA. Translation: CAM19662.1.
CCDSiCCDS18471.1. [Q61701-1]
PIRiJC2298.
RefSeqiNP_034618.2. NM_010488.4. [Q61701-1]
UniGeneiMm.3970.

Genome annotation databases

EnsembliENSMUST00000106597; ENSMUSP00000102207; ENSMUSG00000028546. [Q61701-1]
GeneIDi15572.
KEGGimmu:15572.
UCSCiuc008ucw.1. mouse. [Q61701-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31953 mRNA. Translation: BAA06723.1 .
AF041341 mRNA. Translation: AAC40080.1 .
AL627425 Genomic DNA. Translation: CAM19662.1 .
CCDSi CCDS18471.1. [Q61701-1 ]
PIRi JC2298.
RefSeqi NP_034618.2. NM_010488.4. [Q61701-1 ]
UniGenei Mm.3970.

3D structure databases

ProteinModelPortali Q61701.
SMRi Q61701. Positions 49-263, 301-381.
ModBasei Search...

Protein-protein interaction databases

IntActi Q61701. 1 interaction.
MINTi MINT-4094262.

PTM databases

PhosphoSitei Q61701.

Proteomic databases

PaxDbi Q61701.
PRIDEi Q61701.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000106597 ; ENSMUSP00000102207 ; ENSMUSG00000028546 . [Q61701-1 ]
GeneIDi 15572.
KEGGi mmu:15572.
UCSCi uc008ucw.1. mouse. [Q61701-1 ]

Organism-specific databases

CTDi 1996.
MGIi MGI:107427. Elavl4.

Phylogenomic databases

eggNOGi COG0724.
GeneTreei ENSGT00560000077064.
HOGENOMi HOG000231162.
HOVERGENi HBG002295.
InParanoidi A2A9R7.
KOi K13208.
OMAi HGCPSPM.
PhylomeDBi Q61701.
TreeFami TF313377.

Miscellaneous databases

NextBioi 288560.
PROi Q61701.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61701.
Bgeei Q61701.
Genevestigatori Q61701.

Family and domain databases

Gene3Di 3.30.70.330. 3 hits.
InterProi IPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 3 hits.
[Graphical view ]
PRINTSi PR00961. HUDSXLRNA.
SMARTi SM00360. RRM. 3 hits.
[Graphical view ]
TIGRFAMsi TIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEi PS50102. RRM. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue-specific expression of the gene encoding a mouse RNA binding protein homologous to human HuD antigen."
    Abe R., Uyeno Y., Yamamoto K., Sakamoto H.
    DNA Res. 1:175-180(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4."
    Inman M.V., Levy S., Mock B.A., Owens G.C.
    Gene 208:139-145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: ICR.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The insulin-like growth factor mRNA binding-protein IMP-1 and the Ras-regulatory protein G3BP associate with tau mRNA and HuD protein in differentiated P19 neuronal cells."
    Atlas R., Behar L., Elliott E., Ginzburg I.
    J. Neurochem. 89:613-626(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A MRNP COMPLEX WITH IGF2BP1 AND G3BP, INTERACTION WITH IGF2BP1.

Entry informationi

Entry nameiELAV4_MOUSE
AccessioniPrimary (citable) accession number: Q61701
Secondary accession number(s): A2A9R7, O55010
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi