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Q61701

- ELAV4_MOUSE

UniProt

Q61701 - ELAV4_MOUSE

Protein

ELAV-like protein 4

Gene

Elavl4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR. Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA By similarity.By similarity

    GO - Molecular functioni

    1. AU-rich element binding Source: UniProtKB
    2. nucleotide binding Source: InterPro

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ELAV-like protein 4
    Alternative name(s):
    Hu-antigen D
    Short name:
    HuD
    Paraneoplastic encephalomyelitis antigen HuD
    Gene namesi
    Name:Elavl4
    Synonyms:Hud
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:107427. Elavl4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385ELAV-like protein 4PRO_0000081584Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei248 – 2481Omega-N-methylated arginine; by CARM1By similarity

    Post-translational modificationi

    Methylation at Arg-248 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth By similarity.By similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PaxDbiQ61701.
    PRIDEiQ61701.

    PTM databases

    PhosphoSiteiQ61701.

    Expressioni

    Tissue specificityi

    Expressed in brain and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ61701.
    BgeeiQ61701.
    GenevestigatoriQ61701.

    Interactioni

    Subunit structurei

    Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP.1 Publication

    Protein-protein interaction databases

    IntActiQ61701. 1 interaction.
    MINTiMINT-4094262.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61701.
    SMRiQ61701. Positions 49-263, 301-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 12979RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini137 – 21781RRM 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini302 – 38079RRM 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RRM elav family.Curated
    Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0724.
    GeneTreeiENSGT00560000077064.
    HOGENOMiHOG000231162.
    HOVERGENiHBG002295.
    InParanoidiA2A9R7.
    KOiK13208.
    OMAiHGCPSPM.
    PhylomeDBiQ61701.
    TreeFamiTF313377.

    Family and domain databases

    Gene3Di3.30.70.330. 3 hits.
    InterProiIPR006548. ELAD_HUD_SF.
    IPR002343. Hud_Sxl_RNA.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 3 hits.
    [Graphical view]
    PRINTSiPR00961. HUDSXLRNA.
    SMARTiSM00360. RRM. 3 hits.
    [Graphical view]
    TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
    PROSITEiPS50102. RRM. 3 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q61701-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEWNGLKMII STMEPQVSNG PTSNTSNGPS SNNRNCPSPM QTGAATDDSK    50
    TNLIVNYLPQ NMTQEEFRSL FGSIGEIESC KLVRDKITGQ SLGYGFVNYI 100
    DPKDAEKAIN TLNGLRLQTK TIKVSYARPS SASIRDANLY VSGLPKTMTQ 150
    KELEQLFSQY GRIITSRILV DQVTGVSRGV GFIRFDKRIE AEEAIKGLNG 200
    QKPSGATEPI TVKFANNPSQ KSSQALLSQL YQSPNRRYPG PLHHQAQRFR 250
    LDNLLNMAYG VKRLMSGPVP PSACPPRFSP ITIDGMTSLV GMNIPGHTGT 300
    GWCIFVYNLS PDSDESVLWQ LFGPFGAVNN VKVIRDFNTN KCKGFGFVTM 350
    TNYDEAAMAI ASLNGYRLGD RVLQVSFKTN KAHKS 385
    Length:385
    Mass (Da):42,368
    Last modified:November 1, 1996 - v1
    Checksum:i1EA9CDAB7E9BC683
    GO
    Isoform 2 (identifier: Q61701-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         251-277: Missing.

    Show »
    Length:358
    Mass (Da):39,489
    Checksum:iBE2984EA2BBCD038
    GO
    Isoform 3 (identifier: Q61701-3)

    Sequence is not available
    Length:
    Mass (Da):

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei251 – 27727Missing in isoform 2. 1 PublicationVSP_005792Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31953 mRNA. Translation: BAA06723.1.
    AF041341 mRNA. Translation: AAC40080.1.
    AL627425 Genomic DNA. Translation: CAM19662.1.
    CCDSiCCDS18471.1. [Q61701-1]
    PIRiJC2298.
    RefSeqiNP_034618.2. NM_010488.4. [Q61701-1]
    UniGeneiMm.3970.

    Genome annotation databases

    EnsembliENSMUST00000106597; ENSMUSP00000102207; ENSMUSG00000028546. [Q61701-1]
    GeneIDi15572.
    KEGGimmu:15572.
    UCSCiuc008ucw.1. mouse. [Q61701-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31953 mRNA. Translation: BAA06723.1 .
    AF041341 mRNA. Translation: AAC40080.1 .
    AL627425 Genomic DNA. Translation: CAM19662.1 .
    CCDSi CCDS18471.1. [Q61701-1 ]
    PIRi JC2298.
    RefSeqi NP_034618.2. NM_010488.4. [Q61701-1 ]
    UniGenei Mm.3970.

    3D structure databases

    ProteinModelPortali Q61701.
    SMRi Q61701. Positions 49-263, 301-381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61701. 1 interaction.
    MINTi MINT-4094262.

    PTM databases

    PhosphoSitei Q61701.

    Proteomic databases

    PaxDbi Q61701.
    PRIDEi Q61701.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000106597 ; ENSMUSP00000102207 ; ENSMUSG00000028546 . [Q61701-1 ]
    GeneIDi 15572.
    KEGGi mmu:15572.
    UCSCi uc008ucw.1. mouse. [Q61701-1 ]

    Organism-specific databases

    CTDi 1996.
    MGIi MGI:107427. Elavl4.

    Phylogenomic databases

    eggNOGi COG0724.
    GeneTreei ENSGT00560000077064.
    HOGENOMi HOG000231162.
    HOVERGENi HBG002295.
    InParanoidi A2A9R7.
    KOi K13208.
    OMAi HGCPSPM.
    PhylomeDBi Q61701.
    TreeFami TF313377.

    Miscellaneous databases

    NextBioi 288560.
    PROi Q61701.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61701.
    Bgeei Q61701.
    Genevestigatori Q61701.

    Family and domain databases

    Gene3Di 3.30.70.330. 3 hits.
    InterProi IPR006548. ELAD_HUD_SF.
    IPR002343. Hud_Sxl_RNA.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 3 hits.
    [Graphical view ]
    PRINTSi PR00961. HUDSXLRNA.
    SMARTi SM00360. RRM. 3 hits.
    [Graphical view ]
    TIGRFAMsi TIGR01661. ELAV_HUD_SF. 1 hit.
    PROSITEi PS50102. RRM. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tissue-specific expression of the gene encoding a mouse RNA binding protein homologous to human HuD antigen."
      Abe R., Uyeno Y., Yamamoto K., Sakamoto H.
      DNA Res. 1:175-180(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4."
      Inman M.V., Levy S., Mock B.A., Owens G.C.
      Gene 208:139-145(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: ICR.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The insulin-like growth factor mRNA binding-protein IMP-1 and the Ras-regulatory protein G3BP associate with tau mRNA and HuD protein in differentiated P19 neuronal cells."
      Atlas R., Behar L., Elliott E., Ginzburg I.
      J. Neurochem. 89:613-626(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A MRNP COMPLEX WITH IGF2BP1 AND G3BP, INTERACTION WITH IGF2BP1.

    Entry informationi

    Entry nameiELAV4_MOUSE
    AccessioniPrimary (citable) accession number: Q61701
    Secondary accession number(s): A2A9R7, O55010
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3