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Q61701 (ELAV4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ELAV-like protein 4
Alternative name(s):
Hu-antigen D
Short name=HuD
Paraneoplastic encephalomyelitis antigen HuD
Gene names
Name:Elavl4
Synonyms:Hud
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR. Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA By similarity.

Subunit structure

Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP. Ref.4

Tissue specificity

Expressed in brain and testis. Ref.1

Post-translational modification

Methylation at Arg-248 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth By similarity.

Sequence similarities

Belongs to the RRM elav family.

Contains 3 RRM (RNA recognition motif) domains.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainRepeat
   LigandRNA-binding
   PTMMethylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionAU-rich element binding

Inferred from sequence or structural similarity. Source: UniProtKB

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q61701-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q61701-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     251-277: Missing.
Isoform 3 (identifier: Q61701-3)

The sequence of this isoform is not available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 385385ELAV-like protein 4
PRO_0000081584

Regions

Domain51 – 12979RRM 1
Domain137 – 21781RRM 2
Domain302 – 38079RRM 3

Amino acid modifications

Modified residue2481Omega-N-methylated arginine; by CARM1 By similarity

Natural variations

Alternative sequence251 – 27727Missing in isoform 2.
VSP_005792

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Long) [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 1EA9CDAB7E9BC683

FASTA38542,368
        10         20         30         40         50         60 
MEWNGLKMII STMEPQVSNG PTSNTSNGPS SNNRNCPSPM QTGAATDDSK TNLIVNYLPQ 

        70         80         90        100        110        120 
NMTQEEFRSL FGSIGEIESC KLVRDKITGQ SLGYGFVNYI DPKDAEKAIN TLNGLRLQTK 

       130        140        150        160        170        180 
TIKVSYARPS SASIRDANLY VSGLPKTMTQ KELEQLFSQY GRIITSRILV DQVTGVSRGV 

       190        200        210        220        230        240 
GFIRFDKRIE AEEAIKGLNG QKPSGATEPI TVKFANNPSQ KSSQALLSQL YQSPNRRYPG 

       250        260        270        280        290        300 
PLHHQAQRFR LDNLLNMAYG VKRLMSGPVP PSACPPRFSP ITIDGMTSLV GMNIPGHTGT 

       310        320        330        340        350        360 
GWCIFVYNLS PDSDESVLWQ LFGPFGAVNN VKVIRDFNTN KCKGFGFVTM TNYDEAAMAI 

       370        380 
ASLNGYRLGD RVLQVSFKTN KAHKS 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: BE2984EA2BBCD038
Show »

FASTA35839,489
Isoform 3 (Sequence not available).

References

« Hide 'large scale' references
[1]"Tissue-specific expression of the gene encoding a mouse RNA binding protein homologous to human HuD antigen."
Abe R., Uyeno Y., Yamamoto K., Sakamoto H.
DNA Res. 1:175-180(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Brain.
[2]"Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4."
Inman M.V., Levy S., Mock B.A., Owens G.C.
Gene 208:139-145(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Strain: ICR.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The insulin-like growth factor mRNA binding-protein IMP-1 and the Ras-regulatory protein G3BP associate with tau mRNA and HuD protein in differentiated P19 neuronal cells."
Atlas R., Behar L., Elliott E., Ginzburg I.
J. Neurochem. 89:613-626(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A MRNP COMPLEX WITH IGF2BP1 AND G3BP, INTERACTION WITH IGF2BP1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D31953 mRNA. Translation: BAA06723.1.
AF041341 mRNA. Translation: AAC40080.1.
AL627425 Genomic DNA. Translation: CAM19662.1.
CCDSCCDS18471.1. [Q61701-1]
PIRJC2298.
RefSeqNP_034618.2. NM_010488.4. [Q61701-1]
UniGeneMm.3970.

3D structure databases

ProteinModelPortalQ61701.
SMRQ61701. Positions 49-263, 301-381.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61701. 1 interaction.
MINTMINT-4094262.

PTM databases

PhosphoSiteQ61701.

Proteomic databases

PaxDbQ61701.
PRIDEQ61701.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000106597; ENSMUSP00000102207; ENSMUSG00000028546. [Q61701-1]
GeneID15572.
KEGGmmu:15572.
UCSCuc008ucw.1. mouse. [Q61701-1]

Organism-specific databases

CTD1996.
MGIMGI:107427. Elavl4.

Phylogenomic databases

eggNOGCOG0724.
GeneTreeENSGT00560000077064.
HOGENOMHOG000231162.
HOVERGENHBG002295.
InParanoidA2A9R7.
KOK13208.
OMAHGCPSPM.
PhylomeDBQ61701.
TreeFamTF313377.

Gene expression databases

ArrayExpressQ61701.
BgeeQ61701.
GenevestigatorQ61701.

Family and domain databases

Gene3D3.30.70.330. 3 hits.
InterProIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSPR00961. HUDSXLRNA.
SMARTSM00360. RRM. 3 hits.
[Graphical view]
TIGRFAMsTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio288560.
PROQ61701.
SOURCESearch...

Entry information

Entry nameELAV4_MOUSE
AccessionPrimary (citable) accession number: Q61701
Secondary accession number(s): A2A9R7, O55010
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot