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Q61672

- S29A2_MOUSE

UniProt

Q61672 - S29A2_MOUSE

Protein

Equilibrative nucleoside transporter 2

Gene

Slc29a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Mediates equilibrative transport of purine and pyrimidine nucleosides, and the purine base hypoxanthine.

    Kineticsi

    1. KM=0.75 mM for adenosine

    GO - Molecular functioni

    1. nucleoside transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. nucleoside transmembrane transport Source: GOC
    2. nucleoside transport Source: MGI

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.57.1.2. the equilibrative nucleoside transporter (ent) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Equilibrative nucleoside transporter 2
    Alternative name(s):
    36 kDa hydrophobic nucleolar protein
    36 kDa nucleolar protein HNP36
    Delayed-early response protein 12
    Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter
    Short name:
    Equilibrative NBMPR-insensitive nucleoside transporter
    Nucleoside transporter, ei-type
    Solute carrier family 29 member 2
    Gene namesi
    Name:Slc29a2
    Synonyms:Der12, Ent2, Hnp36
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1345278. Slc29a2.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. nuclear membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Equilibrative nucleoside transporter 2PRO_0000209341Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Modified residuei252 – 2521PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ61672.

    PTM databases

    PhosphoSiteiQ61672.

    Expressioni

    Inductioni

    By platelet derived growth factor (PDGF) and fibroblast growth factor (FGF).

    Gene expression databases

    BgeeiQ61672.
    GenevestigatoriQ61672.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000025826.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61672.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei360 – 38021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei396 – 41621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249415.
    GeneTreeiENSGT00390000002232.
    HOGENOMiHOG000007684.
    HOVERGENiHBG074626.
    InParanoidiQ9JIT8.
    KOiK15014.
    OMAiPEKPSVF.
    OrthoDBiEOG7PP56W.
    PhylomeDBiQ61672.
    TreeFamiTF313950.

    Family and domain databases

    InterProiIPR002259. Eqnu_transpt.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PANTHERiPTHR10332. PTHR10332. 1 hit.
    PfamiPF01733. Nucleoside_tran. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016379. ENT. 1 hit.
    PRINTSiPR01130. DERENTRNSPRT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00939. 2a57. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q61672-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGNAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ GRLAGTNSSA    50
    ETMGTNHTSP TDTFNFNNWV TLLSQLPLLL FTLLNSFLYQ CIPESVRILG 100
    SLLAILLLFA LTAALVKVDL SPGLFFSVTM ASVWFINSFC AVLQGSLFGQ 150
    LGTMPSTYST LFLSGQGLAG IFAALAMLMS LASGVDAQTS ALGYFITPCV 200
    GILLSIVCYL SLPHLKFARY YLTEKLSQAP TQELETKAEL LQADEKNGVP 250
    ISPQQASPTL DLDPEKEPEP EEPQKPGKPS VFVVFRKIWL TALCLVLVFT 300
    VTLSVFPAIT AMVTTSSNSP GKWGLFFNPI CCFLLFNVMD WLGRSLTSYF 350
    LWPDEDSQQL LPLLVCLRFL FVPLFMLCHV PQHARLPIIF RQDAYFITFM 400
    LLFAVSNGYL VSLTMCLAPR QVLPHEREVA GALMTFFLAL GLSCGASLSF 450
    LFKALL 456
    Length:456
    Mass (Da):50,255
    Last modified:March 8, 2011 - v2
    Checksum:iA9FE7CA037A4468F
    GO

    Sequence cautioni

    The sequence CAA60381.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF183397 mRNA. Translation: AAF78477.1.
    CH466612 Genomic DNA. Translation: EDL33088.1.
    BC048958 mRNA. Translation: AAH48958.1.
    X86682 mRNA. Translation: CAA60381.1. Different initiation.
    CCDSiCCDS50354.1.
    PIRiJC4195.
    RefSeqiNP_031880.2. NM_007854.3.
    UniGeneiMm.4930.

    Genome annotation databases

    EnsembliENSMUST00000025826; ENSMUSP00000025826; ENSMUSG00000024891.
    GeneIDi13340.
    KEGGimmu:13340.
    UCSCiuc008gbv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF183397 mRNA. Translation: AAF78477.1 .
    CH466612 Genomic DNA. Translation: EDL33088.1 .
    BC048958 mRNA. Translation: AAH48958.1 .
    X86682 mRNA. Translation: CAA60381.1 . Different initiation.
    CCDSi CCDS50354.1.
    PIRi JC4195.
    RefSeqi NP_031880.2. NM_007854.3.
    UniGenei Mm.4930.

    3D structure databases

    ProteinModelPortali Q61672.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000025826.

    Chemistry

    ChEMBLi CHEMBL1287612.

    Protein family/group databases

    TCDBi 2.A.57.1.2. the equilibrative nucleoside transporter (ent) family.

    PTM databases

    PhosphoSitei Q61672.

    Proteomic databases

    PRIDEi Q61672.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025826 ; ENSMUSP00000025826 ; ENSMUSG00000024891 .
    GeneIDi 13340.
    KEGGi mmu:13340.
    UCSCi uc008gbv.2. mouse.

    Organism-specific databases

    CTDi 3177.
    MGIi MGI:1345278. Slc29a2.

    Phylogenomic databases

    eggNOGi NOG249415.
    GeneTreei ENSGT00390000002232.
    HOGENOMi HOG000007684.
    HOVERGENi HBG074626.
    InParanoidi Q9JIT8.
    KOi K15014.
    OMAi PEKPSVF.
    OrthoDBi EOG7PP56W.
    PhylomeDBi Q61672.
    TreeFami TF313950.

    Miscellaneous databases

    NextBioi 283654.
    PROi Q61672.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61672.
    Genevestigatori Q61672.

    Family and domain databases

    InterProi IPR002259. Eqnu_transpt.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    PANTHERi PTHR10332. PTHR10332. 1 hit.
    Pfami PF01733. Nucleoside_tran. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016379. ENT. 1 hit.
    PRINTSi PR01130. DERENTRNSPRT.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00939. 2a57. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional characterization of inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2) equilibrative nucleoside transporters from mouse brain."
      Kiss A., Farah K., Kim J., Garriock R.J., Drysdale T.A., Hammond J.R.
      Biochem. J. 352:363-372(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Brain.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    4. "A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein."
      Williams J.B., Lanahan A.A.
      Biochem. Biophys. Res. Commun. 213:325-333(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 64-456.
      Strain: BALB/c.
      Tissue: Fibroblast.

    Entry informationi

    Entry nameiS29A2_MOUSE
    AccessioniPrimary (citable) accession number: Q61672
    Secondary accession number(s): Q9JIT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3