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Q61672

- S29A2_MOUSE

UniProt

Q61672 - S29A2_MOUSE

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Protein
Equilibrative nucleoside transporter 2
Gene
Slc29a2, Der12, Ent2, Hnp36
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates equilibrative transport of purine and pyrimidine nucleosides, and the purine base hypoxanthine.

Kineticsi

  1. KM=0.75 mM for adenosine

GO - Molecular functioni

  1. nucleoside transmembrane transporter activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. nucleoside transmembrane transport Source: GOC
  2. nucleoside transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.57.1.2. the equilibrative nucleoside transporter (ent) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Equilibrative nucleoside transporter 2
Alternative name(s):
36 kDa hydrophobic nucleolar protein
36 kDa nucleolar protein HNP36
Delayed-early response protein 12
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter
Short name:
Equilibrative NBMPR-insensitive nucleoside transporter
Nucleoside transporter, ei-type
Solute carrier family 29 member 2
Gene namesi
Name:Slc29a2
Synonyms:Der12, Ent2, Hnp36
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1345278. Slc29a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321Helical; Reviewed prediction
Add
BLAST
Transmembranei69 – 8921Helical; Reviewed prediction
Add
BLAST
Transmembranei98 – 11821Helical; Reviewed prediction
Add
BLAST
Transmembranei123 – 14321Helical; Reviewed prediction
Add
BLAST
Transmembranei161 – 18121Helical; Reviewed prediction
Add
BLAST
Transmembranei192 – 21221Helical; Reviewed prediction
Add
BLAST
Transmembranei288 – 30821Helical; Reviewed prediction
Add
BLAST
Transmembranei323 – 34321Helical; Reviewed prediction
Add
BLAST
Transmembranei360 – 38021Helical; Reviewed prediction
Add
BLAST
Transmembranei396 – 41621Helical; Reviewed prediction
Add
BLAST
Transmembranei432 – 45221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. nuclear membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Equilibrative nucleoside transporter 2
PRO_0000209341Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...) Reviewed prediction
Modified residuei252 – 2521Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ61672.

PTM databases

PhosphoSiteiQ61672.

Expressioni

Inductioni

By platelet derived growth factor (PDGF) and fibroblast growth factor (FGF).

Gene expression databases

BgeeiQ61672.
GenevestigatoriQ61672.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025826.

Structurei

3D structure databases

ProteinModelPortaliQ61672.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249415.
GeneTreeiENSGT00390000002232.
HOGENOMiHOG000007684.
HOVERGENiHBG074626.
InParanoidiQ9JIT8.
KOiK15014.
OMAiPEKPSVF.
OrthoDBiEOG7PP56W.
PhylomeDBiQ61672.
TreeFamiTF313950.

Family and domain databases

InterProiIPR002259. Eqnu_transpt.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PANTHERiPTHR10332. PTHR10332. 1 hit.
PfamiPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF016379. ENT. 1 hit.
PRINTSiPR01130. DERENTRNSPRT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00939. 2a57. 1 hit.

Sequencei

Sequence statusi: Complete.

Q61672-1 [UniParc]FASTAAdd to Basket

« Hide

MARGNAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ GRLAGTNSSA    50
ETMGTNHTSP TDTFNFNNWV TLLSQLPLLL FTLLNSFLYQ CIPESVRILG 100
SLLAILLLFA LTAALVKVDL SPGLFFSVTM ASVWFINSFC AVLQGSLFGQ 150
LGTMPSTYST LFLSGQGLAG IFAALAMLMS LASGVDAQTS ALGYFITPCV 200
GILLSIVCYL SLPHLKFARY YLTEKLSQAP TQELETKAEL LQADEKNGVP 250
ISPQQASPTL DLDPEKEPEP EEPQKPGKPS VFVVFRKIWL TALCLVLVFT 300
VTLSVFPAIT AMVTTSSNSP GKWGLFFNPI CCFLLFNVMD WLGRSLTSYF 350
LWPDEDSQQL LPLLVCLRFL FVPLFMLCHV PQHARLPIIF RQDAYFITFM 400
LLFAVSNGYL VSLTMCLAPR QVLPHEREVA GALMTFFLAL GLSCGASLSF 450
LFKALL 456
Length:456
Mass (Da):50,255
Last modified:March 8, 2011 - v2
Checksum:iA9FE7CA037A4468F
GO

Sequence cautioni

The sequence CAA60381.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF183397 mRNA. Translation: AAF78477.1.
CH466612 Genomic DNA. Translation: EDL33088.1.
BC048958 mRNA. Translation: AAH48958.1.
X86682 mRNA. Translation: CAA60381.1. Different initiation.
CCDSiCCDS50354.1.
PIRiJC4195.
RefSeqiNP_031880.2. NM_007854.3.
UniGeneiMm.4930.

Genome annotation databases

EnsembliENSMUST00000025826; ENSMUSP00000025826; ENSMUSG00000024891.
GeneIDi13340.
KEGGimmu:13340.
UCSCiuc008gbv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF183397 mRNA. Translation: AAF78477.1 .
CH466612 Genomic DNA. Translation: EDL33088.1 .
BC048958 mRNA. Translation: AAH48958.1 .
X86682 mRNA. Translation: CAA60381.1 . Different initiation.
CCDSi CCDS50354.1.
PIRi JC4195.
RefSeqi NP_031880.2. NM_007854.3.
UniGenei Mm.4930.

3D structure databases

ProteinModelPortali Q61672.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000025826.

Chemistry

ChEMBLi CHEMBL1287612.

Protein family/group databases

TCDBi 2.A.57.1.2. the equilibrative nucleoside transporter (ent) family.

PTM databases

PhosphoSitei Q61672.

Proteomic databases

PRIDEi Q61672.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025826 ; ENSMUSP00000025826 ; ENSMUSG00000024891 .
GeneIDi 13340.
KEGGi mmu:13340.
UCSCi uc008gbv.2. mouse.

Organism-specific databases

CTDi 3177.
MGIi MGI:1345278. Slc29a2.

Phylogenomic databases

eggNOGi NOG249415.
GeneTreei ENSGT00390000002232.
HOGENOMi HOG000007684.
HOVERGENi HBG074626.
InParanoidi Q9JIT8.
KOi K15014.
OMAi PEKPSVF.
OrthoDBi EOG7PP56W.
PhylomeDBi Q61672.
TreeFami TF313950.

Miscellaneous databases

NextBioi 283654.
PROi Q61672.
SOURCEi Search...

Gene expression databases

Bgeei Q61672.
Genevestigatori Q61672.

Family and domain databases

InterProi IPR002259. Eqnu_transpt.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
PANTHERi PTHR10332. PTHR10332. 1 hit.
Pfami PF01733. Nucleoside_tran. 1 hit.
[Graphical view ]
PIRSFi PIRSF016379. ENT. 1 hit.
PRINTSi PR01130. DERENTRNSPRT.
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00939. 2a57. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional characterization of inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2) equilibrative nucleoside transporters from mouse brain."
    Kiss A., Farah K., Kim J., Garriock R.J., Drysdale T.A., Hammond J.R.
    Biochem. J. 352:363-372(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Brain.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein."
    Williams J.B., Lanahan A.A.
    Biochem. Biophys. Res. Commun. 213:325-333(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 64-456.
    Strain: BALB/c.
    Tissue: Fibroblast.

Entry informationi

Entry nameiS29A2_MOUSE
AccessioniPrimary (citable) accession number: Q61672
Secondary accession number(s): Q9JIT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 8, 2011
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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