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Q61672 (S29A2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Equilibrative nucleoside transporter 2
Alternative name(s):
36 kDa hydrophobic nucleolar protein
36 kDa nucleolar protein HNP36
Delayed-early response protein 12
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter
Short name=Equilibrative NBMPR-insensitive nucleoside transporter
Nucleoside transporter, ei-type
Solute carrier family 29 member 2
Gene names
Name:Slc29a2
Synonyms:Der12, Ent2, Hnp36
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates equilibrative transport of purine and pyrimidine nucleosides, and the purine base hypoxanthine.

Subcellular location

Nucleus membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein By similarity.

Induction

By platelet derived growth factor (PDGF) and fibroblast growth factor (FGF).

Sequence similarities

Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. [View classification]

Biophysicochemical properties

Kinetic parameters:

KM=0.75 mM for adenosine

Sequence caution

The sequence CAA60381.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456Equilibrative nucleoside transporter 2
PRO_0000209341

Regions

Transmembrane13 – 3321Helical; Potential
Transmembrane69 – 8921Helical; Potential
Transmembrane98 – 11821Helical; Potential
Transmembrane123 – 14321Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane192 – 21221Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane323 – 34321Helical; Potential
Transmembrane360 – 38021Helical; Potential
Transmembrane396 – 41621Helical; Potential
Transmembrane432 – 45221Helical; Potential

Amino acid modifications

Modified residue2521Phosphoserine By similarity
Glycosylation561N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q61672 [UniParc].

Last modified March 8, 2011. Version 2.
Checksum: A9FE7CA037A4468F

FASTA45650,255
        10         20         30         40         50         60 
MARGNAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ GRLAGTNSSA ETMGTNHTSP 

        70         80         90        100        110        120 
TDTFNFNNWV TLLSQLPLLL FTLLNSFLYQ CIPESVRILG SLLAILLLFA LTAALVKVDL 

       130        140        150        160        170        180 
SPGLFFSVTM ASVWFINSFC AVLQGSLFGQ LGTMPSTYST LFLSGQGLAG IFAALAMLMS 

       190        200        210        220        230        240 
LASGVDAQTS ALGYFITPCV GILLSIVCYL SLPHLKFARY YLTEKLSQAP TQELETKAEL 

       250        260        270        280        290        300 
LQADEKNGVP ISPQQASPTL DLDPEKEPEP EEPQKPGKPS VFVVFRKIWL TALCLVLVFT 

       310        320        330        340        350        360 
VTLSVFPAIT AMVTTSSNSP GKWGLFFNPI CCFLLFNVMD WLGRSLTSYF LWPDEDSQQL 

       370        380        390        400        410        420 
LPLLVCLRFL FVPLFMLCHV PQHARLPIIF RQDAYFITFM LLFAVSNGYL VSLTMCLAPR 

       430        440        450 
QVLPHEREVA GALMTFFLAL GLSCGASLSF LFKALL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and functional characterization of inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2) equilibrative nucleoside transporters from mouse brain."
Kiss A., Farah K., Kim J., Garriock R.J., Drysdale T.A., Hammond J.R.
Biochem. J. 352:363-372(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
Tissue: Brain.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[4]"A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein."
Williams J.B., Lanahan A.A.
Biochem. Biophys. Res. Commun. 213:325-333(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 64-456.
Strain: BALB/c.
Tissue: Fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF183397 mRNA. Translation: AAF78477.1.
CH466612 Genomic DNA. Translation: EDL33088.1.
BC048958 mRNA. Translation: AAH48958.1.
X86682 mRNA. Translation: CAA60381.1. Different initiation.
PIRJC4195.
RefSeqNP_031880.2. NM_007854.3.
UniGeneMm.4930.

3D structure databases

ProteinModelPortalQ61672.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000025826.

Chemistry

ChEMBLCHEMBL1287612.

Protein family/group databases

TCDB2.A.57.1.2. the equilibrative nucleoside transporter (ent) family.

PTM databases

PhosphoSiteQ61672.

Proteomic databases

PRIDEQ61672.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025826; ENSMUSP00000025826; ENSMUSG00000024891.
GeneID13340.
KEGGmmu:13340.
UCSCuc008gbv.2. mouse.

Organism-specific databases

CTD3177.
MGIMGI:1345278. Slc29a2.

Phylogenomic databases

eggNOGNOG249415.
GeneTreeENSGT00390000002232.
HOGENOMHOG000007684.
HOVERGENHBG074626.
InParanoidQ9JIT8.
KOK15014.
OMAPEKPSVF.
OrthoDBEOG7PP56W.
PhylomeDBQ61672.
TreeFamTF313950.

Gene expression databases

BgeeQ61672.
GenevestigatorQ61672.

Family and domain databases

InterProIPR002259. Eqnu_transpt.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PANTHERPTHR10332. PTHR10332. 1 hit.
PfamPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFPIRSF016379. ENT. 1 hit.
PRINTSPR01130. DERENTRNSPRT.
SUPFAMSSF103473. SSF103473. 2 hits.
TIGRFAMsTIGR00939. 2a57. 1 hit.
ProtoNetSearch...

Other

NextBio283654.
PROQ61672.
SOURCESearch...

Entry information

Entry nameS29A2_MOUSE
AccessionPrimary (citable) accession number: Q61672
Secondary accession number(s): Q9JIT8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 8, 2011
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot