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Q61670

- HLX_MOUSE

UniProt

Q61670 - HLX_MOUSE

Protein

H2.0-like homeobox protein

Gene

Hlx

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi273 – 33260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. embryonic digestive tract morphogenesis Source: MGI
    3. enteric nervous system development Source: MGI
    4. liver development Source: MGI
    5. negative regulation of T-helper 2 cell differentiation Source: MGI
    6. organ development Source: MGI
    7. positive regulation of cell proliferation Source: MGI
    8. positive regulation of organ growth Source: MGI
    9. positive regulation of T-helper 1 cell differentiation Source: MGI
    10. skeletal muscle tissue development Source: MGI
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    H2.0-like homeobox protein
    Alternative name(s):
    Homeobox protein HLX1
    Gene namesi
    Name:Hlx
    Synonyms:Hlx1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:96109. Hlx.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Th1 cells lacking Hlx or Tbx21 fail to express normal levels of the Th1-specific cytokine Ifng.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476H2.0-like homeobox proteinPRO_0000048979Add
    BLAST

    Proteomic databases

    PRIDEiQ61670.

    Expressioni

    Tissue specificityi

    Expressed in Th1 cells, CD8-positive T-cells, B-cells and NK cells.1 Publication

    Inductioni

    By TBX21 in developing as well as mature Th1 cells.1 Publication

    Gene expression databases

    ArrayExpressiQ61670.
    BgeeiQ61670.
    CleanExiMM_HLX.
    GenevestigatoriQ61670.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61670.
    SMRiQ61670. Positions 280-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi91 – 16676Pro-richAdd
    BLAST
    Compositional biasi129 – 1368Poly-Gln
    Compositional biasi362 – 465104Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the H2.0 homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG331357.
    GeneTreeiENSGT00730000110534.
    HOGENOMiHOG000112911.
    HOVERGENiHBG000457.
    InParanoidiQ61670.
    KOiK09339.
    OMAiAHPHASF.
    OrthoDBiEOG7FR7H1.
    PhylomeDBiQ61670.
    TreeFamiTF350735.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61670-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFALDPAAVK KPSFCIADIL    50
    HAGVGEPGPA AEGLVGASAA LTAHLGSVHP HASFQAAARS PLRPTPVVAP 100
    SEVPAGFPQR LSPLSAAFHQ HLPQQSPTQQ QQPQQQPPPP PRAVSLQPPT 150
    SGTRVVPHHS GSAPAPSSKD LKFGIDRILS AEFDPKVKEG NTLRDLTSLL 200
    TGGRPAGVHL AGLQPSAGQF FASLDPISEA SAILSPLSSN PRNSVQHQFQ 250
    DTFPGPYAVL TKDTMPQTYK RKRSWSRAVF SNLQRKGLEK RFEIQKYVTK 300
    PDRKQLAAML GLTDAQVKVW FQNRRMKWRH SKEAQAQKDK DKEAGEKPSG 350
    GVPAEGEREE RSPSRSEGEA ESESSDSESL DMAPSDTERT EGTERSLHQT 400
    TVIKASAAGA LITASSSTSG SSFSFSSTSS LGSGNTHVGS ASSLGGNCSE 450
    LPSAHQPSVT SSPQSPEIAQ APLAGL 476
    Length:476
    Mass (Da):50,079
    Last modified:November 1, 1996 - v1
    Checksum:iF1C1B5F29218AC45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58250 mRNA. Translation: CAA41204.1.
    CCDSiCCDS15593.1.
    PIRiA39621.
    RefSeqiNP_032276.1. NM_008250.2.
    UniGeneiMm.1347.

    Genome annotation databases

    EnsembliENSMUST00000048572; ENSMUSP00000040505; ENSMUSG00000039377.
    GeneIDi15284.
    KEGGimmu:15284.
    UCSCiuc007dyn.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58250 mRNA. Translation: CAA41204.1 .
    CCDSi CCDS15593.1.
    PIRi A39621.
    RefSeqi NP_032276.1. NM_008250.2.
    UniGenei Mm.1347.

    3D structure databases

    ProteinModelPortali Q61670.
    SMRi Q61670. Positions 280-331.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q61670.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048572 ; ENSMUSP00000040505 ; ENSMUSG00000039377 .
    GeneIDi 15284.
    KEGGi mmu:15284.
    UCSCi uc007dyn.2. mouse.

    Organism-specific databases

    CTDi 3142.
    MGIi MGI:96109. Hlx.

    Phylogenomic databases

    eggNOGi NOG331357.
    GeneTreei ENSGT00730000110534.
    HOGENOMi HOG000112911.
    HOVERGENi HBG000457.
    InParanoidi Q61670.
    KOi K09339.
    OMAi AHPHASF.
    OrthoDBi EOG7FR7H1.
    PhylomeDBi Q61670.
    TreeFami TF350735.

    Miscellaneous databases

    NextBioi 287919.
    PROi Q61670.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61670.
    Bgeei Q61670.
    CleanExi MM_HLX.
    Genevestigatori Q61670.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis."
      Allen J.D., Lints T., Jenkins N.A., Copeland N.G., Strasser A., Harvey R.P., Adams J.M.
      Genes Dev. 5:509-520(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X DBA/2J.
    2. "Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction."
      Mullen A.C., Hutchins A.S., High F.A., Lee H.W., Sykes K.J., Chodosh L.A., Reiner S.L.
      Nat. Immunol. 3:652-658(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiHLX_MOUSE
    AccessioniPrimary (citable) accession number: Q61670
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3