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Q61670 (HLX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
H2.0-like homeobox protein
Alternative name(s):
Homeobox protein HLX1
Gene names
Name:Hlx
Synonyms:Hlx1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis. Ref.2

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed in Th1 cells, CD8-positive T-cells, B-cells and NK cells. Ref.2

Induction

By TBX21 in developing as well as mature Th1 cells. Ref.2

Disruption phenotype

Th1 cells lacking Hlx or Tbx21 fail to express normal levels of the Th1-specific cytokine Ifng. Ref.2

Sequence similarities

Belongs to the H2.0 homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processDifferentiation
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

embryonic digestive tract morphogenesis

Inferred from mutant phenotype PubMed 8557196. Source: MGI

enteric nervous system development

Inferred from mutant phenotype PubMed 16854219. Source: MGI

liver development

Inferred from mutant phenotype PubMed 8557196. Source: MGI

negative regulation of T-helper 2 cell differentiation

Inferred from mutant phenotype PubMed 16424184. Source: MGI

organ development

Inferred from mutant phenotype PubMed 8557196. Source: MGI

positive regulation of T-helper 1 cell differentiation

Inferred from mutant phenotype PubMed 16424184. Source: MGI

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 8557196. Source: MGI

positive regulation of organ growth

Inferred from mutant phenotype PubMed 8557196. Source: MGI

skeletal muscle tissue development

Inferred from mutant phenotype PubMed 8557196. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

transcription regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 476476H2.0-like homeobox protein
PRO_0000048979

Regions

DNA binding273 – 33260Homeobox
Compositional bias91 – 16676Pro-rich
Compositional bias129 – 1368Poly-Gln
Compositional bias362 – 465104Ser-rich

Sequences

Sequence LengthMass (Da)Tools
Q61670 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F1C1B5F29218AC45

FASTA47650,079
        10         20         30         40         50         60 
MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFALDPAAVK KPSFCIADIL HAGVGEPGPA 

        70         80         90        100        110        120 
AEGLVGASAA LTAHLGSVHP HASFQAAARS PLRPTPVVAP SEVPAGFPQR LSPLSAAFHQ 

       130        140        150        160        170        180 
HLPQQSPTQQ QQPQQQPPPP PRAVSLQPPT SGTRVVPHHS GSAPAPSSKD LKFGIDRILS 

       190        200        210        220        230        240 
AEFDPKVKEG NTLRDLTSLL TGGRPAGVHL AGLQPSAGQF FASLDPISEA SAILSPLSSN 

       250        260        270        280        290        300 
PRNSVQHQFQ DTFPGPYAVL TKDTMPQTYK RKRSWSRAVF SNLQRKGLEK RFEIQKYVTK 

       310        320        330        340        350        360 
PDRKQLAAML GLTDAQVKVW FQNRRMKWRH SKEAQAQKDK DKEAGEKPSG GVPAEGEREE 

       370        380        390        400        410        420 
RSPSRSEGEA ESESSDSESL DMAPSDTERT EGTERSLHQT TVIKASAAGA LITASSSTSG 

       430        440        450        460        470 
SSFSFSSTSS LGSGNTHVGS ASSLGGNCSE LPSAHQPSVT SSPQSPEIAQ APLAGL 

« Hide

References

[1]"Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis."
Allen J.D., Lints T., Jenkins N.A., Copeland N.G., Strasser A., Harvey R.P., Adams J.M.
Genes Dev. 5:509-520(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X DBA/2J.
[2]"Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction."
Mullen A.C., Hutchins A.S., High F.A., Lee H.W., Sykes K.J., Chodosh L.A., Reiner S.L.
Nat. Immunol. 3:652-658(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X58250 mRNA. Translation: CAA41204.1.
CCDSCCDS15593.1.
PIRA39621.
RefSeqNP_032276.1. NM_008250.2.
UniGeneMm.1347.

3D structure databases

ProteinModelPortalQ61670.
SMRQ61670. Positions 280-331.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ61670.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048572; ENSMUSP00000040505; ENSMUSG00000039377.
GeneID15284.
KEGGmmu:15284.
UCSCuc007dyn.2. mouse.

Organism-specific databases

CTD3142.
MGIMGI:96109. Hlx.

Phylogenomic databases

eggNOGNOG331357.
GeneTreeENSGT00730000110534.
HOGENOMHOG000112911.
HOVERGENHBG000457.
InParanoidQ61670.
KOK09339.
OMAAHPHASF.
OrthoDBEOG7FR7H1.
PhylomeDBQ61670.
TreeFamTF350735.

Gene expression databases

ArrayExpressQ61670.
BgeeQ61670.
CleanExMM_HLX.
GenevestigatorQ61670.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio287919.
PROQ61670.
SOURCESearch...

Entry information

Entry nameHLX_MOUSE
AccessionPrimary (citable) accession number: Q61670
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot