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Protein

H2.0-like homeobox protein

Gene

Hlx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi273 – 33260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • embryonic digestive tract morphogenesis Source: MGI
  • enteric nervous system development Source: MGI
  • liver development Source: MGI
  • negative regulation of T-helper 2 cell differentiation Source: MGI
  • organ development Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of organ growth Source: MGI
  • positive regulation of T-helper 1 cell differentiation Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • skeletal muscle tissue development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
H2.0-like homeobox protein
Alternative name(s):
Homeobox protein HLX1
Gene namesi
Name:Hlx
Synonyms:Hlx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96109. Hlx.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Th1 cells lacking Hlx or Tbx21 fail to express normal levels of the Th1-specific cytokine Ifng.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476H2.0-like homeobox proteinPRO_0000048979Add
BLAST

Proteomic databases

PRIDEiQ61670.

Expressioni

Tissue specificityi

Expressed in Th1 cells, CD8-positive T-cells, B-cells and NK cells.1 Publication

Inductioni

By TBX21 in developing as well as mature Th1 cells.1 Publication

Gene expression databases

BgeeiQ61670.
CleanExiMM_HLX.
ExpressionAtlasiQ61670. baseline and differential.
GenevisibleiQ61670. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040505.

Structurei

3D structure databases

ProteinModelPortaliQ61670.
SMRiQ61670. Positions 280-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi91 – 16676Pro-richAdd
BLAST
Compositional biasi129 – 1368Poly-Gln
Compositional biasi362 – 465104Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the H2.0 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG331357.
GeneTreeiENSGT00790000122955.
HOGENOMiHOG000112911.
HOVERGENiHBG000457.
InParanoidiQ61670.
KOiK09339.
OMAiPMNEASA.
OrthoDBiEOG7FR7H1.
PhylomeDBiQ61670.
TreeFamiTF350735.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFALDPAAVK KPSFCIADIL
60 70 80 90 100
HAGVGEPGPA AEGLVGASAA LTAHLGSVHP HASFQAAARS PLRPTPVVAP
110 120 130 140 150
SEVPAGFPQR LSPLSAAFHQ HLPQQSPTQQ QQPQQQPPPP PRAVSLQPPT
160 170 180 190 200
SGTRVVPHHS GSAPAPSSKD LKFGIDRILS AEFDPKVKEG NTLRDLTSLL
210 220 230 240 250
TGGRPAGVHL AGLQPSAGQF FASLDPISEA SAILSPLSSN PRNSVQHQFQ
260 270 280 290 300
DTFPGPYAVL TKDTMPQTYK RKRSWSRAVF SNLQRKGLEK RFEIQKYVTK
310 320 330 340 350
PDRKQLAAML GLTDAQVKVW FQNRRMKWRH SKEAQAQKDK DKEAGEKPSG
360 370 380 390 400
GVPAEGEREE RSPSRSEGEA ESESSDSESL DMAPSDTERT EGTERSLHQT
410 420 430 440 450
TVIKASAAGA LITASSSTSG SSFSFSSTSS LGSGNTHVGS ASSLGGNCSE
460 470
LPSAHQPSVT SSPQSPEIAQ APLAGL
Length:476
Mass (Da):50,079
Last modified:November 1, 1996 - v1
Checksum:iF1C1B5F29218AC45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58250 mRNA. Translation: CAA41204.1.
CCDSiCCDS15593.1.
PIRiA39621.
RefSeqiNP_032276.1. NM_008250.2.
UniGeneiMm.1347.

Genome annotation databases

EnsembliENSMUST00000048572; ENSMUSP00000040505; ENSMUSG00000039377.
GeneIDi15284.
KEGGimmu:15284.
UCSCiuc007dyn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58250 mRNA. Translation: CAA41204.1.
CCDSiCCDS15593.1.
PIRiA39621.
RefSeqiNP_032276.1. NM_008250.2.
UniGeneiMm.1347.

3D structure databases

ProteinModelPortaliQ61670.
SMRiQ61670. Positions 280-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040505.

Proteomic databases

PRIDEiQ61670.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048572; ENSMUSP00000040505; ENSMUSG00000039377.
GeneIDi15284.
KEGGimmu:15284.
UCSCiuc007dyn.2. mouse.

Organism-specific databases

CTDi3142.
MGIiMGI:96109. Hlx.

Phylogenomic databases

eggNOGiNOG331357.
GeneTreeiENSGT00790000122955.
HOGENOMiHOG000112911.
HOVERGENiHBG000457.
InParanoidiQ61670.
KOiK09339.
OMAiPMNEASA.
OrthoDBiEOG7FR7H1.
PhylomeDBiQ61670.
TreeFamiTF350735.

Miscellaneous databases

NextBioi287919.
PROiQ61670.
SOURCEiSearch...

Gene expression databases

BgeeiQ61670.
CleanExiMM_HLX.
ExpressionAtlasiQ61670. baseline and differential.
GenevisibleiQ61670. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis."
    Allen J.D., Lints T., Jenkins N.A., Copeland N.G., Strasser A., Harvey R.P., Adams J.M.
    Genes Dev. 5:509-520(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X DBA/2J.
  2. "Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction."
    Mullen A.C., Hutchins A.S., High F.A., Lee H.W., Sykes K.J., Chodosh L.A., Reiner S.L.
    Nat. Immunol. 3:652-658(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiHLX_MOUSE
AccessioniPrimary (citable) accession number: Q61670
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.