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Q61666

- HIRA_MOUSE

UniProt

Q61666 - HIRA_MOUSE

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Protein

Protein HIRA

Gene

Hira

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.By similarity1 Publication

GO - Molecular functioni

  1. chromatin binding Source: InterPro

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. DNA replication-independent nucleosome assembly Source: Ensembl
  3. gastrulation Source: MGI
  4. muscle cell differentiation Source: MGI
  5. osteoblast differentiation Source: MGI
  6. regulation of transcription, DNA-templated Source: UniProtKB-KW
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_209428. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HIRA
Alternative name(s):
TUP1-like enhancer of split protein 1
Gene namesi
Name:Hira
Synonyms:Tuple1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:99430. Hira.

Subcellular locationi

Nucleus By similarity. NucleusPML body By similarity
Note: Primarily, though not exclusively, localized to the nucleus (By similarity). Localizes to PML bodies immediately prior to onset of senescence (By similarity). Localizes specifically to the male nucleus in fertilized eggs. This localization persists from the initiation of sperm nucleus decondensation to pronucleus formation.By similarity2 Publications

GO - Cellular componenti

  1. nuclear chromatin Source: MGI
  2. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic stem cells (ES cells) exhibit accelerated differentiation in the early stages which may be attributable to increased availability of soluble histones.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10151015Protein HIRAPRO_0000051020Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei548 – 5481PhosphoserineBy similarity
Modified residuei554 – 5541Phosphothreonine1 Publication
Modified residuei556 – 5561PhosphoserineBy similarity
Modified residuei575 – 5751PhosphothreonineBy similarity
Modified residuei583 – 5831PhosphoserineBy similarity
Modified residuei608 – 6081PhosphoserineBy similarity
Modified residuei609 – 6091PhosphoserineBy similarity
Modified residuei610 – 6101PhosphoserineBy similarity
Modified residuei612 – 6121PhosphoserineBy similarity
Modified residuei659 – 6591PhosphoserineBy similarity

Post-translational modificationi

Sumoylated.By similarity
Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-554 in vitro (By similarity). Also phosphorylated on Thr-554 in vivo.By similarity1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ61666.
PRIDEiQ61666.

PTM databases

PhosphoSiteiQ61666.

Expressioni

Tissue specificityi

Expressed in cerebrum, cerebellum, heart, kidney, liver, lung and spleen.

Developmental stagei

Throughout development the long isoform is more abundant. In embryos, ubiquitously expressed with high levels detected in cranial neural folds, subregions of pharyngeal arches 1 and 2, circumpharyngeal neural crest and limb buds.2 Publications

Gene expression databases

BgeeiQ61666.
ExpressionAtlasiQ61666. baseline and differential.
GenevestigatoriQ61666.

Interactioni

Subunit structurei

Interacts with CCNA1, HIRIP3 and NFU1/HIRIP5. Part of a complex which includes ASF1A, CABIN1, histone H3.3, histone H4 and UBN1 (By similarity). Interacts with histone H2B, histone H3F3B, PAX3 and PAX7.By similarity1 Publication

Protein-protein interaction databases

BioGridi200309. 8 interactions.
IntActiQ61666. 7 interactions.
STRINGi10090.ENSMUSP00000004222.

Structurei

3D structure databases

ProteinModelPortaliQ61666.
SMRiQ61666. Positions 10-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 5343WD 1Add
BLAST
Repeati68 – 10740WD 2Add
BLAST
Repeati129 – 16840WD 3Add
BLAST
Repeati172 – 21140WD 4Add
BLAST
Repeati220 – 26344WD 5Add
BLAST
Repeati266 – 32257WD 6Add
BLAST
Repeati326 – 36742WD 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni421 – 727307Interaction with CCNA1By similarityAdd
BLAST
Regioni421 – 47959Interaction with ASF1ABy similarityAdd
BLAST
Regioni439 – 47537Required for repression of histone gene transcriptionBy similarityAdd
BLAST
Regioni593 – 737145Interaction with PAX3Add
BLAST
Regioni594 – 824231Interaction with histone H2BBy similarityAdd
BLAST
Regioni736 – 1015280Interaction with histone H4By similarityAdd
BLAST
Regioni738 – 82689Interaction with PAX3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi408 – 4125Poly-Gln
Compositional biasi638 – 6414Poly-Lys
Compositional biasi803 – 8064Poly-Val

Sequence similaritiesi

Belongs to the WD repeat HIR1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00550000074919.
HOGENOMiHOG000007670.
HOVERGENiHBG005969.
InParanoidiQ61666.
KOiK11293.
OMAiAVTNPCM.
OrthoDBiEOG74J975.
PhylomeDBiQ61666.
TreeFamiTF323161.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR011494. Hira.
IPR019015. HIRA_B_motif.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07569. Hira. 1 hit.
PF09453. HIRA_B. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q61666-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLLKPTWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMSPVLQ
60 70 80 90 100
EDDEKDENIP KMLCQMDNHL ACVNCVRWSN SGMYLASGGD DKLIMVWKRA
110 120 130 140 150
TYIGPSTVFG SSGKLANVEQ WRCVSILRSH SGDVMDVAWS PHDAWLASCS
160 170 180 190 200
VDNTVVIWNA VKFPEILATL RGHSGLVKGL TWDPVGKYIA SQADDRSLKV
210 220 230 240 250
WRTLDWQLET SITKPFDECG GTTHVLRLSW SPDGHYLVSA HAMNNSGPTA
260 270 280 290 300
QIIEREGWKT NMDFVGHRKA VTVVKFNPKI FKKKQKNGSS TKPSCPYCCC
310 320 330 340 350
AVGSKDRSLS VWLTCLKRPL VVIHELFDKS IMDISWTLNG LGILVCSMDG
360 370 380 390 400
SVAFLDFSQD ELGDPLSEEE KSRIHQSTYG KSLAIMTEAQ LSTAVIENPE
410 420 430 440 450
MLKYQRRQQQ QQLDQKNATT RETSSASSVT GVVNGESLED IRKNLLKKQV
460 470 480 490 500
ETRTADGRRR ITPLCIAQLD TGDFSTAFFN SIPLSSSLAG TMLSSPSGQQ
510 520 530 540 550
LLPLDSSTPS FGASKPCTEP VAATSARPTG ESVSKDSMNA TSTPAASSPS
560 570 580 590 600
VLTTPSKIEP MKAFDSRFTE RSKATPGAPS LTSVIPTAVE RLKEQNLVKE
610 620 630 640 650
LRSRELESSS DSDEKVHLAK PSSLSKRKLE LEVETVEKKK KGRPRKDSRL
660 670 680 690 700
LPMSLSVQSP AALSTEKEAM CLSAPALALK LPIPGPQRAF TLQVSSDPSM
710 720 730 740 750
YIEVENEVTT VGGIRLSRLK CNREGKEWET VLSSRVLTAA GSCDVVCVAC
760 770 780 790 800
EKRMLSVFST CGRRLLPPIL LPSPISTLHC TGPYVMALTA AATLSVWDVH
810 820 830 840 850
RQVVVVKEES LHSILSGSDM TVSQILLTQH GIPVMNLSDG KAYCFNPSLS
860 870 880 890 900
TWNLVSDKQD SLAQCADFRN SLPSQDAMLC SGPLAIIQGR TSNSGRQAAR
910 920 930 940 950
LFSVPHVVQQ ETTLAYLENQ VAAALTLQSS HEYRHWLLLY ARYLVNEGFE
960 970 980 990 1000
YRLREICKDL LGPVHCSTGS QWESTVVGLR KRELLKELLP VIGQNLRFQR
1010
LFTECQEQLD ILRDK
Length:1,015
Mass (Da):111,767
Last modified:May 1, 2007 - v3
Checksum:i2D84294D45B7A967
GO
Isoform Short (identifier: Q61666-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     556-562: SKIEPMK → PQYIICSP
     563-1015: Missing.

Show »
Length:563
Mass (Da):61,642
Checksum:i7F687DA1201815BD
GO
Isoform 3 (identifier: Q61666-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     473-497: DFSTAFFNSIPLSSSLAGTMLSSPS → YSLLHQAFCGLVWGGLLFFCCQLAS
     498-1015: Missing.

Show »
Length:453
Mass (Da):50,449
Checksum:iFF189AF5E97CF083
GO
Isoform 4 (identifier: Q61666-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-652: Missing.

Note: No experimental confirmation available.

Show »
Length:363
Mass (Da):40,090
Checksum:iFD785BD8473346A1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161F → C in CAA63334. (PubMed:8611624)Curated
Sequence conflicti400 – 4001E → G in AAH52856. (PubMed:15489334)Curated
Sequence conflicti459 – 4591R → S in CAA63334. (PubMed:8611624)Curated
Sequence conflicti650 – 6501L → F in CAA63334. (PubMed:8611624)Curated
Sequence conflicti712 – 7121G → R in CAA68049. (PubMed:9063745)Curated
Sequence conflicti1007 – 10071E → G in CAA63334. (PubMed:8611624)Curated
Sequence conflicti1013 – 10142RD → WG in CAA63334. (PubMed:8611624)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 652652Missing in isoform 4. 1 PublicationVSP_025049Add
BLAST
Alternative sequencei1 – 4444Missing in isoform 3. 1 PublicationVSP_025050Add
BLAST
Alternative sequencei473 – 49725DFSTA…LSSPS → YSLLHQAFCGLVWGGLLFFC CQLAS in isoform 3. 1 PublicationVSP_025051Add
BLAST
Alternative sequencei498 – 1015518Missing in isoform 3. 1 PublicationVSP_025052Add
BLAST
Alternative sequencei556 – 5627SKIEPMK → PQYIICSP in isoform Short. 1 PublicationVSP_006773
Alternative sequencei563 – 1015453Missing in isoform Short. 1 PublicationVSP_006774Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92590 mRNA. Translation: CAA63334.1.
X99712 mRNA. Translation: CAA68049.1.
X75295 mRNA. Translation: CAA53043.1.
AK135928 mRNA. Translation: BAE22728.1.
AK168963 mRNA. Translation: BAE40768.1.
BC052856 mRNA. Translation: AAH52856.1.
CCDSiCCDS28031.1. [Q61666-1]
PIRiS45345.
S68141.
RefSeqiNP_034565.2. NM_010435.2. [Q61666-1]
UniGeneiMm.15694.
Mm.453041.

Genome annotation databases

EnsembliENSMUST00000004222; ENSMUSP00000004222; ENSMUSG00000022702. [Q61666-1]
ENSMUST00000120532; ENSMUSP00000112614; ENSMUSG00000022702. [Q61666-3]
GeneIDi15260.
KEGGimmu:15260.
UCSCiuc007yoq.1. mouse. [Q61666-1]
uc007yor.1. mouse. [Q61666-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92590 mRNA. Translation: CAA63334.1 .
X99712 mRNA. Translation: CAA68049.1 .
X75295 mRNA. Translation: CAA53043.1 .
AK135928 mRNA. Translation: BAE22728.1 .
AK168963 mRNA. Translation: BAE40768.1 .
BC052856 mRNA. Translation: AAH52856.1 .
CCDSi CCDS28031.1. [Q61666-1 ]
PIRi S45345.
S68141.
RefSeqi NP_034565.2. NM_010435.2. [Q61666-1 ]
UniGenei Mm.15694.
Mm.453041.

3D structure databases

ProteinModelPortali Q61666.
SMRi Q61666. Positions 10-365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200309. 8 interactions.
IntActi Q61666. 7 interactions.
STRINGi 10090.ENSMUSP00000004222.

PTM databases

PhosphoSitei Q61666.

Proteomic databases

MaxQBi Q61666.
PRIDEi Q61666.

Protocols and materials databases

DNASUi 15260.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004222 ; ENSMUSP00000004222 ; ENSMUSG00000022702 . [Q61666-1 ]
ENSMUST00000120532 ; ENSMUSP00000112614 ; ENSMUSG00000022702 . [Q61666-3 ]
GeneIDi 15260.
KEGGi mmu:15260.
UCSCi uc007yoq.1. mouse. [Q61666-1 ]
uc007yor.1. mouse. [Q61666-3 ]

Organism-specific databases

CTDi 7290.
MGIi MGI:99430. Hira.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00550000074919.
HOGENOMi HOG000007670.
HOVERGENi HBG005969.
InParanoidi Q61666.
KOi K11293.
OMAi AVTNPCM.
OrthoDBi EOG74J975.
PhylomeDBi Q61666.
TreeFami TF323161.

Enzyme and pathway databases

Reactomei REACT_209428. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Miscellaneous databases

NextBioi 287885.
PROi Q61666.
SOURCEi Search...

Gene expression databases

Bgeei Q61666.
ExpressionAtlasi Q61666. baseline and differential.
Genevestigatori Q61666.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR011494. Hira.
IPR019015. HIRA_B_motif.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF07569. Hira. 1 hit.
PF09453. HIRA_B. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view ]
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The HIR protein family: isolation and characterization of a complete murine cDNA."
    Scamps C., Lorain S., Lamour V., Lipinski M.
    Biochim. Biophys. Acta 1306:5-8(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    Strain: DBA/2.
  2. "The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients."
    Wilming L.G., Snoeren C.A.S., van Rijswijk A., Grosveld F., Meijers C.
    Hum. Mol. Genet. 6:247-258(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), DEVELOPMENTAL STAGE.
    Strain: ICR X Swiss Webster.
    Tissue: Embryo.
  3. "Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease."
    Halford S., Wadey R., Roberts C., Daw S.C.M., Whiting J.A., O'Donnell H., Dunham I., Bentley D., Lindsay E., Baldini A., Francis F., Lehrach H., Williamson R., Wilson D.I., Goodship J., Cross I., Burn J., Scambler P.J.
    Hum. Mol. Genet. 2:2099-2107(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-562 (ISOFORM SHORT).
    Strain: BALB/c and C57BL/6J.
    Tissue: Embryo and Kidney.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 748-1015 (ISOFORMS LONG/4).
    Strain: C57BL/6J.
    Tissue: Egg.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C3H/He.
    Tissue: Mesenchymal stem cell.
  6. "HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3."
    Magnaghi P., Roberts C., Lorain S., Lipinski M., Scambler P.J.
    Nat. Genet. 20:74-77(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HISTONE H2B; HISTONE H3F3B; PAX3 AND PAX7, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  7. "HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression."
    Hall C., Nelson D.M., Ye X., Baker K., DeCaprio J.A., Seeholzer S., Lipinski M., Adams P.D.
    Mol. Cell. Biol. 21:1854-1865(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-554.
  8. "Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote."
    van der Heijden G.W., Dieker J.W., Derijck A.A.H.A., Muller S., Berden J.H.M., Braat D.D.M., van der Vlag J., de Boer P.
    Mech. Dev. 122:1008-1022(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells."
    Meshorer E., Yellajoshula D., George E., Scambler P.J., Brown D.T., Misteli T.
    Dev. Cell 10:105-116(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiHIRA_MOUSE
AccessioniPrimary (citable) accession number: Q61666
Secondary accession number(s): O08845
, Q3TFY0, Q3UX35, Q62365, Q7TMW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3