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Q61666

- HIRA_MOUSE

UniProt

Q61666 - HIRA_MOUSE

Protein

Protein HIRA

Gene

Hira

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 3 (01 May 2007)
      Previous versions | rss
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    Functioni

    Required for the periodic repression of histone gene transcription during the cell cycle By similarity. Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.By similarity1 Publication

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. protein binding Source: MGI

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. gastrulation Source: MGI
    3. muscle cell differentiation Source: MGI
    4. osteoblast differentiation Source: MGI
    5. regulation of transcription, DNA-templated Source: UniProtKB-KW
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_209428. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein HIRA
    Alternative name(s):
    TUP1-like enhancer of split protein 1
    Gene namesi
    Name:Hira
    Synonyms:Tuple1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:99430. Hira.

    Subcellular locationi

    Nucleus By similarity. NucleusPML body By similarity
    Note: Primarily, though not exclusively, localized to the nucleus By similarity. Localizes to PML bodies immediately prior to onset of senescence By similarity. Localizes specifically to the male nucleus in fertilized eggs. This localization persists from the initiation of sperm nucleus decondensation to pronucleus formation.By similarity2 Publications

    GO - Cellular componenti

    1. nuclear chromatin Source: MGI
    2. PML body Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Embryonic stem cells (ES cells) exhibit accelerated differentiation in the early stages which may be attributable to increased availability of soluble histones.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10151015Protein HIRAPRO_0000051020Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei548 – 5481PhosphoserineBy similarity
    Modified residuei554 – 5541Phosphothreonine1 Publication
    Modified residuei556 – 5561PhosphoserineBy similarity
    Modified residuei575 – 5751PhosphothreonineBy similarity
    Modified residuei583 – 5831PhosphoserineBy similarity
    Modified residuei608 – 6081PhosphoserineBy similarity
    Modified residuei609 – 6091PhosphoserineBy similarity
    Modified residuei610 – 6101PhosphoserineBy similarity
    Modified residuei612 – 6121PhosphoserineBy similarity
    Modified residuei659 – 6591PhosphoserineBy similarity

    Post-translational modificationi

    Sumoylated.By similarity
    Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-554 in vitro By similarity. Also phosphorylated on Thr-554 in vivo.By similarity1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ61666.
    PRIDEiQ61666.

    PTM databases

    PhosphoSiteiQ61666.

    Expressioni

    Tissue specificityi

    Expressed in cerebrum, cerebellum, heart, kidney, liver, lung and spleen.

    Developmental stagei

    Throughout development the long isoform is more abundant. In embryos, ubiquitously expressed with high levels detected in cranial neural folds, subregions of pharyngeal arches 1 and 2, circumpharyngeal neural crest and limb buds.2 Publications

    Gene expression databases

    ArrayExpressiQ61666.
    BgeeiQ61666.
    GenevestigatoriQ61666.

    Interactioni

    Subunit structurei

    Interacts with CCNA1, HIRIP3 and NFU1/HIRIP5. Part of a complex which includes ASF1A, CABIN1, histone H3.3, histone H4 and UBN1 By similarity. Interacts with histone H2B, histone H3F3B, PAX3 and PAX7.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi200309. 8 interactions.
    IntActiQ61666. 7 interactions.
    STRINGi10090.ENSMUSP00000004222.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61666.
    SMRiQ61666. Positions 10-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 5343WD 1Add
    BLAST
    Repeati68 – 10740WD 2Add
    BLAST
    Repeati129 – 16840WD 3Add
    BLAST
    Repeati172 – 21140WD 4Add
    BLAST
    Repeati220 – 26344WD 5Add
    BLAST
    Repeati266 – 32257WD 6Add
    BLAST
    Repeati326 – 36742WD 7Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni421 – 727307Interaction with CCNA1By similarityAdd
    BLAST
    Regioni421 – 47959Interaction with ASF1ABy similarityAdd
    BLAST
    Regioni439 – 47537Required for repression of histone gene transcriptionBy similarityAdd
    BLAST
    Regioni593 – 737145Interaction with PAX3Add
    BLAST
    Regioni594 – 824231Interaction with histone H2BBy similarityAdd
    BLAST
    Regioni736 – 1015280Interaction with histone H4By similarityAdd
    BLAST
    Regioni738 – 82689Interaction with PAX3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi408 – 4125Poly-Gln
    Compositional biasi638 – 6414Poly-Lys
    Compositional biasi803 – 8064Poly-Val

    Sequence similaritiesi

    Belongs to the WD repeat HIR1 family.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00550000074919.
    HOGENOMiHOG000007670.
    HOVERGENiHBG005969.
    InParanoidiQ61666.
    KOiK11293.
    OMAiAVTNPCM.
    OrthoDBiEOG74J975.
    PhylomeDBiQ61666.
    TreeFamiTF323161.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR011494. Hira.
    IPR019015. HIRA_B_motif.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF07569. Hira. 1 hit.
    PF09453. HIRA_B. 1 hit.
    PF00400. WD40. 5 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q61666-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKLLKPTWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMSPVLQ     50
    EDDEKDENIP KMLCQMDNHL ACVNCVRWSN SGMYLASGGD DKLIMVWKRA 100
    TYIGPSTVFG SSGKLANVEQ WRCVSILRSH SGDVMDVAWS PHDAWLASCS 150
    VDNTVVIWNA VKFPEILATL RGHSGLVKGL TWDPVGKYIA SQADDRSLKV 200
    WRTLDWQLET SITKPFDECG GTTHVLRLSW SPDGHYLVSA HAMNNSGPTA 250
    QIIEREGWKT NMDFVGHRKA VTVVKFNPKI FKKKQKNGSS TKPSCPYCCC 300
    AVGSKDRSLS VWLTCLKRPL VVIHELFDKS IMDISWTLNG LGILVCSMDG 350
    SVAFLDFSQD ELGDPLSEEE KSRIHQSTYG KSLAIMTEAQ LSTAVIENPE 400
    MLKYQRRQQQ QQLDQKNATT RETSSASSVT GVVNGESLED IRKNLLKKQV 450
    ETRTADGRRR ITPLCIAQLD TGDFSTAFFN SIPLSSSLAG TMLSSPSGQQ 500
    LLPLDSSTPS FGASKPCTEP VAATSARPTG ESVSKDSMNA TSTPAASSPS 550
    VLTTPSKIEP MKAFDSRFTE RSKATPGAPS LTSVIPTAVE RLKEQNLVKE 600
    LRSRELESSS DSDEKVHLAK PSSLSKRKLE LEVETVEKKK KGRPRKDSRL 650
    LPMSLSVQSP AALSTEKEAM CLSAPALALK LPIPGPQRAF TLQVSSDPSM 700
    YIEVENEVTT VGGIRLSRLK CNREGKEWET VLSSRVLTAA GSCDVVCVAC 750
    EKRMLSVFST CGRRLLPPIL LPSPISTLHC TGPYVMALTA AATLSVWDVH 800
    RQVVVVKEES LHSILSGSDM TVSQILLTQH GIPVMNLSDG KAYCFNPSLS 850
    TWNLVSDKQD SLAQCADFRN SLPSQDAMLC SGPLAIIQGR TSNSGRQAAR 900
    LFSVPHVVQQ ETTLAYLENQ VAAALTLQSS HEYRHWLLLY ARYLVNEGFE 950
    YRLREICKDL LGPVHCSTGS QWESTVVGLR KRELLKELLP VIGQNLRFQR 1000
    LFTECQEQLD ILRDK 1015
    Length:1,015
    Mass (Da):111,767
    Last modified:May 1, 2007 - v3
    Checksum:i2D84294D45B7A967
    GO
    Isoform Short (identifier: Q61666-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         556-562: SKIEPMK → PQYIICSP
         563-1015: Missing.

    Show »
    Length:563
    Mass (Da):61,642
    Checksum:i7F687DA1201815BD
    GO
    Isoform 3 (identifier: Q61666-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-44: Missing.
         473-497: DFSTAFFNSIPLSSSLAGTMLSSPS → YSLLHQAFCGLVWGGLLFFCCQLAS
         498-1015: Missing.

    Show »
    Length:453
    Mass (Da):50,449
    Checksum:iFF189AF5E97CF083
    GO
    Isoform 4 (identifier: Q61666-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-652: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:363
    Mass (Da):40,090
    Checksum:iFD785BD8473346A1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti216 – 2161F → C in CAA63334. (PubMed:8611624)Curated
    Sequence conflicti400 – 4001E → G in AAH52856. (PubMed:15489334)Curated
    Sequence conflicti459 – 4591R → S in CAA63334. (PubMed:8611624)Curated
    Sequence conflicti650 – 6501L → F in CAA63334. (PubMed:8611624)Curated
    Sequence conflicti712 – 7121G → R in CAA68049. (PubMed:9063745)Curated
    Sequence conflicti1007 – 10071E → G in CAA63334. (PubMed:8611624)Curated
    Sequence conflicti1013 – 10142RD → WG in CAA63334. (PubMed:8611624)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 652652Missing in isoform 4. 1 PublicationVSP_025049Add
    BLAST
    Alternative sequencei1 – 4444Missing in isoform 3. 1 PublicationVSP_025050Add
    BLAST
    Alternative sequencei473 – 49725DFSTA…LSSPS → YSLLHQAFCGLVWGGLLFFC CQLAS in isoform 3. 1 PublicationVSP_025051Add
    BLAST
    Alternative sequencei498 – 1015518Missing in isoform 3. 1 PublicationVSP_025052Add
    BLAST
    Alternative sequencei556 – 5627SKIEPMK → PQYIICSP in isoform Short. 1 PublicationVSP_006773
    Alternative sequencei563 – 1015453Missing in isoform Short. 1 PublicationVSP_006774Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92590 mRNA. Translation: CAA63334.1.
    X99712 mRNA. Translation: CAA68049.1.
    X75295 mRNA. Translation: CAA53043.1.
    AK135928 mRNA. Translation: BAE22728.1.
    AK168963 mRNA. Translation: BAE40768.1.
    BC052856 mRNA. Translation: AAH52856.1.
    CCDSiCCDS28031.1. [Q61666-1]
    PIRiS45345.
    S68141.
    RefSeqiNP_034565.2. NM_010435.2. [Q61666-1]
    UniGeneiMm.15694.
    Mm.453041.

    Genome annotation databases

    EnsembliENSMUST00000004222; ENSMUSP00000004222; ENSMUSG00000022702. [Q61666-1]
    ENSMUST00000120532; ENSMUSP00000112614; ENSMUSG00000022702. [Q61666-3]
    GeneIDi15260.
    KEGGimmu:15260.
    UCSCiuc007yoq.1. mouse. [Q61666-1]
    uc007yor.1. mouse. [Q61666-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92590 mRNA. Translation: CAA63334.1 .
    X99712 mRNA. Translation: CAA68049.1 .
    X75295 mRNA. Translation: CAA53043.1 .
    AK135928 mRNA. Translation: BAE22728.1 .
    AK168963 mRNA. Translation: BAE40768.1 .
    BC052856 mRNA. Translation: AAH52856.1 .
    CCDSi CCDS28031.1. [Q61666-1 ]
    PIRi S45345.
    S68141.
    RefSeqi NP_034565.2. NM_010435.2. [Q61666-1 ]
    UniGenei Mm.15694.
    Mm.453041.

    3D structure databases

    ProteinModelPortali Q61666.
    SMRi Q61666. Positions 10-365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200309. 8 interactions.
    IntActi Q61666. 7 interactions.
    STRINGi 10090.ENSMUSP00000004222.

    PTM databases

    PhosphoSitei Q61666.

    Proteomic databases

    MaxQBi Q61666.
    PRIDEi Q61666.

    Protocols and materials databases

    DNASUi 15260.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004222 ; ENSMUSP00000004222 ; ENSMUSG00000022702 . [Q61666-1 ]
    ENSMUST00000120532 ; ENSMUSP00000112614 ; ENSMUSG00000022702 . [Q61666-3 ]
    GeneIDi 15260.
    KEGGi mmu:15260.
    UCSCi uc007yoq.1. mouse. [Q61666-1 ]
    uc007yor.1. mouse. [Q61666-3 ]

    Organism-specific databases

    CTDi 7290.
    MGIi MGI:99430. Hira.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00550000074919.
    HOGENOMi HOG000007670.
    HOVERGENi HBG005969.
    InParanoidi Q61666.
    KOi K11293.
    OMAi AVTNPCM.
    OrthoDBi EOG74J975.
    PhylomeDBi Q61666.
    TreeFami TF323161.

    Enzyme and pathway databases

    Reactomei REACT_209428. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

    Miscellaneous databases

    NextBioi 287885.
    PROi Q61666.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61666.
    Bgeei Q61666.
    Genevestigatori Q61666.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR011494. Hira.
    IPR019015. HIRA_B_motif.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF07569. Hira. 1 hit.
    PF09453. HIRA_B. 1 hit.
    PF00400. WD40. 5 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The HIR protein family: isolation and characterization of a complete murine cDNA."
      Scamps C., Lorain S., Lamour V., Lipinski M.
      Biochim. Biophys. Acta 1306:5-8(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
      Strain: DBA/2.
    2. "The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients."
      Wilming L.G., Snoeren C.A.S., van Rijswijk A., Grosveld F., Meijers C.
      Hum. Mol. Genet. 6:247-258(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), DEVELOPMENTAL STAGE.
      Strain: ICR X Swiss Webster.
      Tissue: Embryo.
    3. "Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease."
      Halford S., Wadey R., Roberts C., Daw S.C.M., Whiting J.A., O'Donnell H., Dunham I., Bentley D., Lindsay E., Baldini A., Francis F., Lehrach H., Williamson R., Wilson D.I., Goodship J., Cross I., Burn J., Scambler P.J.
      Hum. Mol. Genet. 2:2099-2107(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-562 (ISOFORM SHORT).
      Strain: BALB/c and C57BL/6J.
      Tissue: Embryo and Kidney.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 748-1015 (ISOFORMS LONG/4).
      Strain: C57BL/6J.
      Tissue: Egg.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C3H/He.
      Tissue: Mesenchymal stem cell.
    6. "HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3."
      Magnaghi P., Roberts C., Lorain S., Lipinski M., Scambler P.J.
      Nat. Genet. 20:74-77(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HISTONE H2B; HISTONE H3F3B; PAX3 AND PAX7, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    7. "HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression."
      Hall C., Nelson D.M., Ye X., Baker K., DeCaprio J.A., Seeholzer S., Lipinski M., Adams P.D.
      Mol. Cell. Biol. 21:1854-1865(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-554.
    8. "Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote."
      van der Heijden G.W., Dieker J.W., Derijck A.A.H.A., Muller S., Berden J.H.M., Braat D.D.M., van der Vlag J., de Boer P.
      Mech. Dev. 122:1008-1022(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    9. "Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells."
      Meshorer E., Yellajoshula D., George E., Scambler P.J., Brown D.T., Misteli T.
      Dev. Cell 10:105-116(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiHIRA_MOUSE
    AccessioniPrimary (citable) accession number: Q61666
    Secondary accession number(s): O08845
    , Q3TFY0, Q3UX35, Q62365, Q7TMW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3