Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-cell leukemia homeobox protein 2

Gene

Tlx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi157 – 21660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • enteric nervous system development Source: MGI
  • mesoderm formation Source: MGI
  • negative regulation of dendrite morphogenesis Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 2
Alternative name(s):
Enteric neuron homeobox protein
Homeobox TLX-2
Homeobox protein Hox-11L1
Hox11L.1
PMUR10F
Gene namesi
Name:Tlx2
Synonyms:Enx, Hox11l1, Ncx, Tlx1l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1350935. Tlx2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are born at the expected Mendelian ratio and show no visible phenotype at birth. After weaning, about 43% of the mice exhibit distended abdomens and growth retardation, the others remain symptomless. About 36% of the mice die between 3 and 6 weeks after birth. Affected mice display distended proximal colons and cecums. Both affected and asymptotic mice have increased numbers of myenteric neurons in ganglia in the proximal and distal colon with a concomitant increase in myenteric ganglion size. In the urinary system, mice exhibit increased numbers of NADPH diaphorase positive neuronal cells in the vesical ganglia, and concomitant vesicourethral sphincter muscle dysfunction.6 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284T-cell leukemia homeobox protein 2PRO_0000049337Add
BLAST

Proteomic databases

PaxDbiQ61663.
PRIDEiQ61663.

PTM databases

PhosphoSiteiQ61663.

Expressioni

Developmental stagei

Detected in cranial ganglia at 9 dpc, and in dorsal root ganglia by 10.5 dpc. First detected in gut at 11.5 dpc, with a marked increase by 12.5 dpc. After birth, detected in myenteric and submucosal neurons innervating the distal ileum, colon and rectum.1 Publication

Gene expression databases

BgeeiENSMUSG00000068327.
CleanExiMM_TLX2.
ExpressionAtlasiQ61663. baseline and differential.
GenevisibleiQ61663. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087069.

Structurei

3D structure databases

ProteinModelPortaliQ61663.
SMRiQ61663. Positions 164-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 11589Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00840000129678.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiQ61663.
KOiK15606.
OMAiQGHGENG.
OrthoDBiEOG091G0RNV.
PhylomeDBiQ61663.
TreeFamiTF325347.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAVLAAHH LPHHEPISFG IDQILSGPEP PGGGLGPGQS GQSHGESAAF
60 70 80 90 100
SSGFHGASGY APAGSLASLP RGSGVGPGGV IRVPAHRPLP VPPPSGAAPA
110 120 130 140 150
VPGPSGLGGA GGLAGLTFPW MDSGRRFAKD RLTAALSPFS GTRRIGHPYQ
160 170 180 190 200
NRTPPKRKKP RTSFSRSQVL ELERRFLRQK YLASAERAAL AKALRMTDAQ
210 220 230 240 250
VKTWFQNRRT KWRRQTAEER EAERHRAGRL LLHLQQDALP RPLRPPLPPD
260 270 280
PLCLHNSSLF ALQNLQPWAE DNKVASVSGL ASVV
Length:284
Mass (Da):30,361
Last modified:November 1, 1996 - v1
Checksum:iCD1D6D3EB0F8CBDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75953 mRNA. Translation: AAA37805.1.
CH466523 Genomic DNA. Translation: EDK99055.1.
BC138240 mRNA. Translation: AAI38241.1.
BC138241 mRNA. Translation: AAI38242.1.
CCDSiCCDS20269.1.
PIRiB41224.
RefSeqiNP_033418.1. NM_009392.2.
UniGeneiMm.37.

Genome annotation databases

EnsembliENSMUST00000089641; ENSMUSP00000087069; ENSMUSG00000068327.
GeneIDi21909.
KEGGimmu:21909.
UCSCiuc009cme.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75953 mRNA. Translation: AAA37805.1.
CH466523 Genomic DNA. Translation: EDK99055.1.
BC138240 mRNA. Translation: AAI38241.1.
BC138241 mRNA. Translation: AAI38242.1.
CCDSiCCDS20269.1.
PIRiB41224.
RefSeqiNP_033418.1. NM_009392.2.
UniGeneiMm.37.

3D structure databases

ProteinModelPortaliQ61663.
SMRiQ61663. Positions 164-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087069.

PTM databases

PhosphoSiteiQ61663.

Proteomic databases

PaxDbiQ61663.
PRIDEiQ61663.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089641; ENSMUSP00000087069; ENSMUSG00000068327.
GeneIDi21909.
KEGGimmu:21909.
UCSCiuc009cme.1. mouse.

Organism-specific databases

CTDi3196.
MGIiMGI:1350935. Tlx2.

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00840000129678.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiQ61663.
KOiK15606.
OMAiQGHGENG.
OrthoDBiEOG091G0RNV.
PhylomeDBiQ61663.
TreeFamiTF325347.

Miscellaneous databases

PROiQ61663.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068327.
CleanExiMM_TLX2.
ExpressionAtlasiQ61663. baseline and differential.
GenevisibleiQ61663. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLX2_MOUSE
AccessioniPrimary (citable) accession number: Q61663
Secondary accession number(s): B2RR62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be the ortholog of human HOX11.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.