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Q61660

- FOXJ1_MOUSE

UniProt

Q61660 - FOXJ1_MOUSE

Protein

Forkhead box protein J1

Gene

Foxj1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May play an important role in cell fate determination during lung development and in spermatogenesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi120 – 21091Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: Ensembl

    GO - Biological processi

    1. actin cytoskeleton organization Source: BHF-UCL
    2. activation of Rho GTPase activity Source: BHF-UCL
    3. brain development Source: BHF-UCL
    4. central tolerance induction Source: BHF-UCL
    5. cilium assembly Source: BHF-UCL
    6. cilium morphogenesis Source: MGI
    7. epithelium development Source: BHF-UCL
    8. establishment of apical/basal cell polarity Source: MGI
    9. glomerular parietal epithelial cell development Source: Ensembl
    10. humoral immune response Source: BHF-UCL
    11. left/right pattern formation Source: MGI
    12. leukocyte migration Source: BHF-UCL
    13. metanephric part of ureteric bud development Source: Ensembl
    14. negative regulation of B cell activation Source: BHF-UCL
    15. negative regulation of germinal center formation Source: BHF-UCL
    16. negative regulation of humoral immune response mediated by circulating immunoglobulin Source: BHF-UCL
    17. negative regulation of interleukin-6 biosynthetic process Source: BHF-UCL
    18. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
    19. negative regulation of T cell differentiation in thymus Source: BHF-UCL
    20. negative regulation of T cell proliferation Source: BHF-UCL
    21. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    22. positive regulation of central B cell tolerance induction Source: BHF-UCL
    23. positive regulation of lung ciliated cell differentiation Source: Ensembl
    24. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    25. regulation of epithelial cell differentiation Source: MGI
    26. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein J1
    Alternative name(s):
    Forkhead-related protein FKHL13
    Hepatocyte nuclear factor 3 forkhead homolog 4
    Short name:
    HFH-4
    Gene namesi
    Name:Foxj1
    Synonyms:Fkhl13, Hfh4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1347474. Foxj1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 421421Forkhead box protein J1PRO_0000091851Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ61660.
    CleanExiMM_FOXJ1.
    GenevestigatoriQ61660.

    Interactioni

    Protein-protein interaction databases

    BioGridi200289. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61660.
    SMRiQ61660. Positions 121-214.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00750000117242.
    HOGENOMiHOG000112631.
    HOVERGENiHBG056832.
    InParanoidiQ3US42.
    KOiK09402.
    OMAiWEAIFDA.
    OrthoDBiEOG7T4MKM.
    TreeFamiTF333250.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61660-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAESWLRLCG AGPGEEAGPE GGMEEPDALD DSLTSLQWLQ EFSILNAKAP    50
    TLPPGGTDPH GYHQVPGLVA PGSPLAADPA CLGQPHTPGK PTSSCTSRSA 100
    PPGLQAPPPD DVDYATNPHV KPPYSYATLI CMAMQASKAT KITLSAIYKW 150
    ITDNFCYFRH ADPTWQNSIR HNLSLNKCFI KVPREKDEPG KGGFWRIDPQ 200
    YAERLLSGAF KKRRLPPVHI HPAFARQASQ EPSAAPWGGP LTVNREAQQL 250
    LQEFEEATGE GGWGTGEGRL GHKRKQPLPK RVAKVLRPPS TLLLTQEEQG 300
    ELEPLKGNFD WEAIFEAGAL GEELSSLEGL ELSPPLSPSS HGDVDLTVHG 350
    RHINCPATWG PPAEQAADSL DFDETFLATS FLQHPWDESG SGCLPPEPIF 400
    EAGDATLAAD LQDWASVGAF L 421
    Length:421
    Mass (Da):45,474
    Last modified:July 27, 2011 - v2
    Checksum:iB5EB01D747672DFA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti275 – 2762KQ → NE in AAA21689. (PubMed:7683413)Curated
    Sequence conflicti317 – 3171A → R in AAA21689. (PubMed:7683413)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13204 mRNA. Translation: AAA21689.1.
    AK140847 mRNA. Translation: BAE24495.1.
    AL645861 Genomic DNA. Translation: CAM16804.1.
    CH466558 Genomic DNA. Translation: EDL34572.1.
    CCDSiCCDS25665.1.
    PIRiI49734.
    RefSeqiNP_032266.3. NM_008240.3.
    XP_006532332.1. XM_006532269.1.
    UniGeneiMm.378938.

    Genome annotation databases

    EnsembliENSMUST00000036215; ENSMUSP00000038351; ENSMUSG00000034227.
    GeneIDi15223.
    KEGGimmu:15223.
    UCSCiuc007mkv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13204 mRNA. Translation: AAA21689.1 .
    AK140847 mRNA. Translation: BAE24495.1 .
    AL645861 Genomic DNA. Translation: CAM16804.1 .
    CH466558 Genomic DNA. Translation: EDL34572.1 .
    CCDSi CCDS25665.1.
    PIRi I49734.
    RefSeqi NP_032266.3. NM_008240.3.
    XP_006532332.1. XM_006532269.1.
    UniGenei Mm.378938.

    3D structure databases

    ProteinModelPortali Q61660.
    SMRi Q61660. Positions 121-214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200289. 1 interaction.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036215 ; ENSMUSP00000038351 ; ENSMUSG00000034227 .
    GeneIDi 15223.
    KEGGi mmu:15223.
    UCSCi uc007mkv.2. mouse.

    Organism-specific databases

    CTDi 2302.
    MGIi MGI:1347474. Foxj1.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00750000117242.
    HOGENOMi HOG000112631.
    HOVERGENi HBG056832.
    InParanoidi Q3US42.
    KOi K09402.
    OMAi WEAIFDA.
    OrthoDBi EOG7T4MKM.
    TreeFami TF333250.

    Miscellaneous databases

    ChiTaRSi FOXJ1. mouse.
    NextBioi 287811.
    PROi Q61660.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61660.
    CleanExi MM_FOXJ1.
    Genevestigatori Q61660.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family."
      Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E., Costa R.H.
      Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Lung.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiFOXJ1_MOUSE
    AccessioniPrimary (citable) accession number: Q61660
    Secondary accession number(s): Q3US42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3