SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q61660

- FOXJ1_MOUSE

UniProt

Q61660 - FOXJ1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Forkhead box protein J1

Gene
Foxj1, Fkhl13, Hfh4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May play an important role in cell fate determination during lung development and in spermatogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi120 – 21091Fork-headAdd
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. double-stranded DNA binding Source: RefGenome
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  4. transcription factor binding Source: RefGenome
  5. transcription regulatory region sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. actin cytoskeleton organization Source: BHF-UCL
  2. activation of Rho GTPase activity Source: BHF-UCL
  3. brain development Source: BHF-UCL
  4. central tolerance induction Source: BHF-UCL
  5. cilium assembly Source: BHF-UCL
  6. cilium morphogenesis Source: MGI
  7. epithelium development Source: BHF-UCL
  8. establishment of apical/basal cell polarity Source: MGI
  9. glomerular parietal epithelial cell development Source: Ensembl
  10. heart looping Source: RefGenome
  11. humoral immune response Source: BHF-UCL
  12. left/right pattern formation Source: MGI
  13. leukocyte migration Source: BHF-UCL
  14. lung development Source: RefGenome
  15. metanephric part of ureteric bud development Source: Ensembl
  16. negative regulation of B cell activation Source: BHF-UCL
  17. negative regulation of germinal center formation Source: BHF-UCL
  18. negative regulation of humoral immune response mediated by circulating immunoglobulin Source: BHF-UCL
  19. negative regulation of interleukin-6 biosynthetic process Source: BHF-UCL
  20. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  21. negative regulation of T cell differentiation in thymus Source: BHF-UCL
  22. negative regulation of T cell proliferation Source: BHF-UCL
  23. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  24. positive regulation of central B cell tolerance induction Source: BHF-UCL
  25. positive regulation of lung ciliated cell differentiation Source: Ensembl
  26. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  27. regulation of epithelial cell differentiation Source: MGI
  28. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein J1
Alternative name(s):
Forkhead-related protein FKHL13
Hepatocyte nuclear factor 3 forkhead homolog 4
Short name:
HFH-4
Gene namesi
Name:Foxj1
Synonyms:Fkhl13, Hfh4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1347474. Foxj1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Forkhead box protein J1PRO_0000091851Add
BLAST

Expressioni

Gene expression databases

BgeeiQ61660.
CleanExiMM_FOXJ1.
GenevestigatoriQ61660.

Interactioni

Protein-protein interaction databases

BioGridi200289. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ61660.
SMRiQ61660. Positions 121-214.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00750000117242.
HOGENOMiHOG000112631.
HOVERGENiHBG056832.
InParanoidiQ3US42.
KOiK09402.
OMAiWEAIFDA.
OrthoDBiEOG7T4MKM.
TreeFamiTF333250.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61660-1 [UniParc]FASTAAdd to Basket

« Hide

MAESWLRLCG AGPGEEAGPE GGMEEPDALD DSLTSLQWLQ EFSILNAKAP    50
TLPPGGTDPH GYHQVPGLVA PGSPLAADPA CLGQPHTPGK PTSSCTSRSA 100
PPGLQAPPPD DVDYATNPHV KPPYSYATLI CMAMQASKAT KITLSAIYKW 150
ITDNFCYFRH ADPTWQNSIR HNLSLNKCFI KVPREKDEPG KGGFWRIDPQ 200
YAERLLSGAF KKRRLPPVHI HPAFARQASQ EPSAAPWGGP LTVNREAQQL 250
LQEFEEATGE GGWGTGEGRL GHKRKQPLPK RVAKVLRPPS TLLLTQEEQG 300
ELEPLKGNFD WEAIFEAGAL GEELSSLEGL ELSPPLSPSS HGDVDLTVHG 350
RHINCPATWG PPAEQAADSL DFDETFLATS FLQHPWDESG SGCLPPEPIF 400
EAGDATLAAD LQDWASVGAF L 421
Length:421
Mass (Da):45,474
Last modified:July 27, 2011 - v2
Checksum:iB5EB01D747672DFA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti275 – 2762KQ → NE in AAA21689. 1 Publication
Sequence conflicti317 – 3171A → R in AAA21689. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13204 mRNA. Translation: AAA21689.1.
AK140847 mRNA. Translation: BAE24495.1.
AL645861 Genomic DNA. Translation: CAM16804.1.
CH466558 Genomic DNA. Translation: EDL34572.1.
CCDSiCCDS25665.1.
PIRiI49734.
RefSeqiNP_032266.3. NM_008240.3.
XP_006532332.1. XM_006532269.1.
UniGeneiMm.378938.

Genome annotation databases

EnsembliENSMUST00000036215; ENSMUSP00000038351; ENSMUSG00000034227.
GeneIDi15223.
KEGGimmu:15223.
UCSCiuc007mkv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13204 mRNA. Translation: AAA21689.1 .
AK140847 mRNA. Translation: BAE24495.1 .
AL645861 Genomic DNA. Translation: CAM16804.1 .
CH466558 Genomic DNA. Translation: EDL34572.1 .
CCDSi CCDS25665.1.
PIRi I49734.
RefSeqi NP_032266.3. NM_008240.3.
XP_006532332.1. XM_006532269.1.
UniGenei Mm.378938.

3D structure databases

ProteinModelPortali Q61660.
SMRi Q61660. Positions 121-214.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200289. 1 interaction.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036215 ; ENSMUSP00000038351 ; ENSMUSG00000034227 .
GeneIDi 15223.
KEGGi mmu:15223.
UCSCi uc007mkv.2. mouse.

Organism-specific databases

CTDi 2302.
MGIi MGI:1347474. Foxj1.

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00750000117242.
HOGENOMi HOG000112631.
HOVERGENi HBG056832.
InParanoidi Q3US42.
KOi K09402.
OMAi WEAIFDA.
OrthoDBi EOG7T4MKM.
TreeFami TF333250.

Miscellaneous databases

ChiTaRSi FOXJ1. mouse.
NextBioi 287811.
PROi Q61660.
SOURCEi Search...

Gene expression databases

Bgeei Q61660.
CleanExi MM_FOXJ1.
Genevestigatori Q61660.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family."
    Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E., Costa R.H.
    Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Lung.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFOXJ1_MOUSE
AccessioniPrimary (citable) accession number: Q61660
Secondary accession number(s): Q3US42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi