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Q61660 (FOXJ1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein J1
Alternative name(s):
Forkhead-related protein FKHL13
Hepatocyte nuclear factor 3 forkhead homolog 4
Short name=HFH-4
Gene names
Name:Foxj1
Synonyms:Fkhl13, Hfh4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play an important role in cell fate determination during lung development and in spermatogenesis.

Subcellular location

Nucleus.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin cytoskeleton organization

Inferred from mutant phenotype PubMed 17488776. Source: BHF-UCL

activation of Rho GTPase activity

Inferred from direct assay PubMed 17488776. Source: BHF-UCL

brain development

Inferred from expression pattern PubMed 9096351. Source: BHF-UCL

central tolerance induction

Inferred from mutant phenotype PubMed 16339515. Source: BHF-UCL

cilium assembly

Inferred from mutant phenotype PubMed 17488776. Source: BHF-UCL

cilium morphogenesis

Inferred from genetic interaction PubMed 22357932. Source: MGI

epithelium development

Inferred from expression pattern PubMed 9096351. Source: BHF-UCL

establishment of apical/basal cell polarity

Inferred from mutant phenotype PubMed 14996907. Source: MGI

glomerular parietal epithelial cell development

Inferred from electronic annotation. Source: Ensembl

heart looping

Inferred from Biological aspect of Ancestor. Source: RefGenome

humoral immune response

Inferred from mutant phenotype PubMed 16339515. Source: BHF-UCL

left/right pattern formation

Inferred from mutant phenotype PubMed 10873152. Source: MGI

leukocyte migration

Inferred from mutant phenotype PubMed 16339515. Source: BHF-UCL

lung development

Inferred from Biological aspect of Ancestor. Source: RefGenome

metanephric part of ureteric bud development

Inferred from electronic annotation. Source: Ensembl

negative regulation of B cell activation

Inferred from mutant phenotype PubMed 16002694. Source: BHF-UCL

negative regulation of NF-kappaB transcription factor activity

Inferred from mutant phenotype PubMed 16002694. Source: BHF-UCL

negative regulation of T cell differentiation in thymus

Inferred from mutant phenotype PubMed 16339515. Source: BHF-UCL

negative regulation of T cell proliferation

Inferred from mutant phenotype PubMed 14963332. Source: BHF-UCL

negative regulation of germinal center formation

Inferred from mutant phenotype PubMed 16002694. Source: BHF-UCL

negative regulation of humoral immune response mediated by circulating immunoglobulin

Inferred from mutant phenotype PubMed 16002694. Source: BHF-UCL

negative regulation of interleukin-6 biosynthetic process

Inferred from mutant phenotype PubMed 16002694. Source: BHF-UCL

negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 16002694. Source: BHF-UCL

positive regulation of central B cell tolerance induction

Inferred from mutant phenotype PubMed 16002694. Source: BHF-UCL

positive regulation of lung ciliated cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16574095. Source: MGI

regulation of epithelial cell differentiation

Inferred from direct assay PubMed 16574095. Source: MGI

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

   Cellular_componentnucleus

Inferred from direct assay PubMed 11724907PubMed 14625387PubMed 16574095PubMed 17383628. Source: MGI

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Forkhead box protein J1
PRO_0000091851

Regions

DNA binding120 – 21091Fork-head

Experimental info

Sequence conflict275 – 2762KQ → NE in AAA21689. Ref.1
Sequence conflict3171A → R in AAA21689. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61660 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: B5EB01D747672DFA

FASTA42145,474
        10         20         30         40         50         60 
MAESWLRLCG AGPGEEAGPE GGMEEPDALD DSLTSLQWLQ EFSILNAKAP TLPPGGTDPH 

        70         80         90        100        110        120 
GYHQVPGLVA PGSPLAADPA CLGQPHTPGK PTSSCTSRSA PPGLQAPPPD DVDYATNPHV 

       130        140        150        160        170        180 
KPPYSYATLI CMAMQASKAT KITLSAIYKW ITDNFCYFRH ADPTWQNSIR HNLSLNKCFI 

       190        200        210        220        230        240 
KVPREKDEPG KGGFWRIDPQ YAERLLSGAF KKRRLPPVHI HPAFARQASQ EPSAAPWGGP 

       250        260        270        280        290        300 
LTVNREAQQL LQEFEEATGE GGWGTGEGRL GHKRKQPLPK RVAKVLRPPS TLLLTQEEQG 

       310        320        330        340        350        360 
ELEPLKGNFD WEAIFEAGAL GEELSSLEGL ELSPPLSPSS HGDVDLTVHG RHINCPATWG 

       370        380        390        400        410        420 
PPAEQAADSL DFDETFLATS FLQHPWDESG SGCLPPEPIF EAGDATLAAD LQDWASVGAF 


L 

« Hide

References

« Hide 'large scale' references
[1]"Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family."
Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E., Costa R.H.
Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X CBA.
Tissue: Lung.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L13204 mRNA. Translation: AAA21689.1.
AK140847 mRNA. Translation: BAE24495.1.
AL645861 Genomic DNA. Translation: CAM16804.1.
CH466558 Genomic DNA. Translation: EDL34572.1.
CCDSCCDS25665.1.
PIRI49734.
RefSeqNP_032266.3. NM_008240.3.
XP_006532332.1. XM_006532269.1.
UniGeneMm.378938.

3D structure databases

ProteinModelPortalQ61660.
SMRQ61660. Positions 121-214.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200289. 1 interaction.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036215; ENSMUSP00000038351; ENSMUSG00000034227.
GeneID15223.
KEGGmmu:15223.
UCSCuc007mkv.2. mouse.

Organism-specific databases

CTD2302.
MGIMGI:1347474. Foxj1.

Phylogenomic databases

eggNOGCOG5025.
GeneTreeENSGT00750000117242.
HOGENOMHOG000112631.
HOVERGENHBG056832.
InParanoidQ3US42.
KOK09402.
OMAWEAIFDA.
OrthoDBEOG7T4MKM.
TreeFamTF333250.

Gene expression databases

BgeeQ61660.
CleanExMM_FOXJ1.
GenevestigatorQ61660.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFOXJ1. mouse.
NextBio287811.
PROQ61660.
SOURCESearch...

Entry information

Entry nameFOXJ1_MOUSE
AccessionPrimary (citable) accession number: Q61660
Secondary accession number(s): Q3US42
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot