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Protein

Forkhead box protein J1

Gene

Foxj1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor specifically required for the formation of motile cilia (PubMed:9096351, PubMed:9739041, PubMed:10873152, PubMed:14996907, PubMed:22357932, PubMed:27965440). Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157 (PubMed:27965440). Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T) (PubMed:9096351).6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi120 – 210Fork-headPROSITE-ProRule annotationAdd BLAST91

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: BHF-UCL
  • activation of GTPase activity Source: BHF-UCL
  • brain development Source: BHF-UCL
  • central tolerance induction Source: BHF-UCL
  • cilium assembly Source: UniProtKB
  • determination of left/right symmetry Source: MGI
  • epithelium development Source: BHF-UCL
  • establishment of apical/basal cell polarity Source: MGI
  • glomerular parietal epithelial cell development Source: Ensembl
  • heart development Source: MGI
  • humoral immune response Source: BHF-UCL
  • left/right pattern formation Source: MGI
  • leukocyte migration Source: BHF-UCL
  • lung epithelium development Source: Ensembl
  • metanephric part of ureteric bud development Source: Ensembl
  • motile cilium assembly Source: UniProtKB
  • negative regulation of B cell activation Source: BHF-UCL
  • negative regulation of germinal center formation Source: BHF-UCL
  • negative regulation of humoral immune response mediated by circulating immunoglobulin Source: BHF-UCL
  • negative regulation of interleukin-6 biosynthetic process Source: BHF-UCL
  • negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  • negative regulation of T cell differentiation in thymus Source: BHF-UCL
  • negative regulation of T cell proliferation Source: BHF-UCL
  • negative regulation of transcription by RNA polymerase II Source: BHF-UCL
  • positive regulation of central B cell tolerance induction Source: BHF-UCL
  • positive regulation of lung ciliated cell differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • regulation of epithelial cell differentiation Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCilium biogenesis/degradation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein J1Curated
Alternative name(s):
Hepatocyte nuclear factor 3 forkhead homolog 41 Publication
Short name:
HFH-41 Publication
Gene namesi
Name:Foxj1Imported
Synonyms:Hfh41 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1347474 Foxj1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice lack motile respiratory tract cilia and exhibit randomization of the left-right body axis due to loss of motile cilia in the embryonic node (PubMed:9739041, PubMed:10873152). Motile type cilia with a '9 + 2' microtubule ultrastructure are absent in epithelial cells, including those in the airways (PubMed:10873152).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918511 – 421Forkhead box protein J1Add BLAST421

Proteomic databases

MaxQBiQ61660
PaxDbiQ61660
PRIDEiQ61660

PTM databases

iPTMnetiQ61660
PhosphoSitePlusiQ61660

Expressioni

Gene expression databases

BgeeiENSMUSG00000034227
CleanExiMM_FOXJ1
GenevisibleiQ61660 MM

Interactioni

Protein-protein interaction databases

BioGridi200289, 1 interactor
STRINGi10090.ENSMUSP00000038351

Structurei

3D structure databases

ProteinModelPortaliQ61660
SMRiQ61660
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FOXJ1 family.Curated

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00900000140781
HOGENOMiHOG000112631
HOVERGENiHBG056832
InParanoidiQ61660
KOiK09402
OMAiTSFLQHP
OrthoDBiEOG091G06N9
TreeFamiTF333250

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q61660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESWLRLCG AGPGEEAGPE GGMEEPDALD DSLTSLQWLQ EFSILNAKAP
60 70 80 90 100
TLPPGGTDPH GYHQVPGLVA PGSPLAADPA CLGQPHTPGK PTSSCTSRSA
110 120 130 140 150
PPGLQAPPPD DVDYATNPHV KPPYSYATLI CMAMQASKAT KITLSAIYKW
160 170 180 190 200
ITDNFCYFRH ADPTWQNSIR HNLSLNKCFI KVPREKDEPG KGGFWRIDPQ
210 220 230 240 250
YAERLLSGAF KKRRLPPVHI HPAFARQASQ EPSAAPWGGP LTVNREAQQL
260 270 280 290 300
LQEFEEATGE GGWGTGEGRL GHKRKQPLPK RVAKVLRPPS TLLLTQEEQG
310 320 330 340 350
ELEPLKGNFD WEAIFEAGAL GEELSSLEGL ELSPPLSPSS HGDVDLTVHG
360 370 380 390 400
RHINCPATWG PPAEQAADSL DFDETFLATS FLQHPWDESG SGCLPPEPIF
410 420
EAGDATLAAD LQDWASVGAF L
Length:421
Mass (Da):45,474
Last modified:July 27, 2011 - v2
Checksum:iB5EB01D747672DFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti275 – 276KQ → NE in AAA21689 (PubMed:7683413).Curated2
Sequence conflicti317A → R in AAA21689 (PubMed:7683413).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13204 mRNA Translation: AAA21689.1
AK140847 mRNA Translation: BAE24495.1
AL645861 Genomic DNA Translation: CAM16804.1
CH466558 Genomic DNA Translation: EDL34572.1
CCDSiCCDS25665.1
PIRiI49734
RefSeqiNP_032266.3, NM_008240.3
XP_006532332.1, XM_006532269.2
UniGeneiMm.378938

Genome annotation databases

EnsembliENSMUST00000036215; ENSMUSP00000038351; ENSMUSG00000034227
GeneIDi15223
KEGGimmu:15223
UCSCiuc007mkv.2 mouse

Entry informationi

Entry nameiFOXJ1_MOUSE
AccessioniPrimary (citable) accession number: Q61660
Secondary accession number(s): Q3US42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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