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Protein

Forkhead box protein J1

Gene

Foxj1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required for motile ciliogenesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi120 – 21091Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  3. transcription regulatory region sequence-specific DNA binding Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: BHF-UCL
  2. activation of GTPase activity Source: BHF-UCL
  3. brain development Source: BHF-UCL
  4. central tolerance induction Source: BHF-UCL
  5. cilium assembly Source: UniProtKB
  6. cilium morphogenesis Source: UniProtKB
  7. epithelium development Source: BHF-UCL
  8. establishment of apical/basal cell polarity Source: MGI
  9. glomerular parietal epithelial cell development Source: Ensembl
  10. humoral immune response Source: BHF-UCL
  11. left/right pattern formation Source: MGI
  12. leukocyte migration Source: BHF-UCL
  13. metanephric part of ureteric bud development Source: Ensembl
  14. negative regulation of B cell activation Source: BHF-UCL
  15. negative regulation of germinal center formation Source: BHF-UCL
  16. negative regulation of humoral immune response mediated by circulating immunoglobulin Source: BHF-UCL
  17. negative regulation of interleukin-6 biosynthetic process Source: BHF-UCL
  18. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  19. negative regulation of T cell differentiation in thymus Source: BHF-UCL
  20. negative regulation of T cell proliferation Source: BHF-UCL
  21. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  22. positive regulation of central B cell tolerance induction Source: BHF-UCL
  23. positive regulation of lung ciliated cell differentiation Source: MGI
  24. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  25. regulation of epithelial cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cilium biogenesis/degradation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein J1
Alternative name(s):
Forkhead-related protein FKHL13
Hepatocyte nuclear factor 3 forkhead homolog 4
Short name:
HFH-4
Gene namesi
Name:Foxj1
Synonyms:Fkhl13, Hfh4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1347474. Foxj1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice lack motile respiratory tract cilia and exhibit randomization of the left-right body axis due to loss of motile cilia in the embryonic node.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Forkhead box protein J1PRO_0000091851Add
BLAST

Expressioni

Gene expression databases

BgeeiQ61660.
CleanExiMM_FOXJ1.
GenevestigatoriQ61660.

Interactioni

Protein-protein interaction databases

BioGridi200289. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ61660.
SMRiQ61660. Positions 121-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121840.
HOGENOMiHOG000112631.
HOVERGENiHBG056832.
InParanoidiQ61660.
KOiK09402.
OMAiHGHHIDC.
OrthoDBiEOG7T4MKM.
TreeFamiTF333250.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESWLRLCG AGPGEEAGPE GGMEEPDALD DSLTSLQWLQ EFSILNAKAP
60 70 80 90 100
TLPPGGTDPH GYHQVPGLVA PGSPLAADPA CLGQPHTPGK PTSSCTSRSA
110 120 130 140 150
PPGLQAPPPD DVDYATNPHV KPPYSYATLI CMAMQASKAT KITLSAIYKW
160 170 180 190 200
ITDNFCYFRH ADPTWQNSIR HNLSLNKCFI KVPREKDEPG KGGFWRIDPQ
210 220 230 240 250
YAERLLSGAF KKRRLPPVHI HPAFARQASQ EPSAAPWGGP LTVNREAQQL
260 270 280 290 300
LQEFEEATGE GGWGTGEGRL GHKRKQPLPK RVAKVLRPPS TLLLTQEEQG
310 320 330 340 350
ELEPLKGNFD WEAIFEAGAL GEELSSLEGL ELSPPLSPSS HGDVDLTVHG
360 370 380 390 400
RHINCPATWG PPAEQAADSL DFDETFLATS FLQHPWDESG SGCLPPEPIF
410 420
EAGDATLAAD LQDWASVGAF L
Length:421
Mass (Da):45,474
Last modified:July 27, 2011 - v2
Checksum:iB5EB01D747672DFA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti275 – 2762KQ → NE in AAA21689 (PubMed:7683413).Curated
Sequence conflicti317 – 3171A → R in AAA21689 (PubMed:7683413).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13204 mRNA. Translation: AAA21689.1.
AK140847 mRNA. Translation: BAE24495.1.
AL645861 Genomic DNA. Translation: CAM16804.1.
CH466558 Genomic DNA. Translation: EDL34572.1.
CCDSiCCDS25665.1.
PIRiI49734.
RefSeqiNP_032266.3. NM_008240.3.
XP_006532332.1. XM_006532269.2.
UniGeneiMm.378938.

Genome annotation databases

EnsembliENSMUST00000036215; ENSMUSP00000038351; ENSMUSG00000034227.
GeneIDi15223.
KEGGimmu:15223.
UCSCiuc007mkv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13204 mRNA. Translation: AAA21689.1.
AK140847 mRNA. Translation: BAE24495.1.
AL645861 Genomic DNA. Translation: CAM16804.1.
CH466558 Genomic DNA. Translation: EDL34572.1.
CCDSiCCDS25665.1.
PIRiI49734.
RefSeqiNP_032266.3. NM_008240.3.
XP_006532332.1. XM_006532269.2.
UniGeneiMm.378938.

3D structure databases

ProteinModelPortaliQ61660.
SMRiQ61660. Positions 121-214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200289. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036215; ENSMUSP00000038351; ENSMUSG00000034227.
GeneIDi15223.
KEGGimmu:15223.
UCSCiuc007mkv.2. mouse.

Organism-specific databases

CTDi2302.
MGIiMGI:1347474. Foxj1.

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121840.
HOGENOMiHOG000112631.
HOVERGENiHBG056832.
InParanoidiQ61660.
KOiK09402.
OMAiHGHHIDC.
OrthoDBiEOG7T4MKM.
TreeFamiTF333250.

Miscellaneous databases

ChiTaRSiFoxj1. mouse.
NextBioi287811.
PROiQ61660.
SOURCEiSearch...

Gene expression databases

BgeeiQ61660.
CleanExiMM_FOXJ1.
GenevestigatoriQ61660.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family."
    Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E., Costa R.H.
    Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Lung.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry."
    Chen J., Knowles H.J., Hebert J.L., Hackett B.P.
    J. Clin. Invest. 102:1077-1082(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiFOXJ1_MOUSE
AccessioniPrimary (citable) accession number: Q61660
Secondary accession number(s): Q3US42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: April 29, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.