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Q61658

- HESX1_MOUSE

UniProt

Q61658 - HESX1_MOUSE

Protein

Homeobox expressed in ES cells 1

Gene

Hesx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi108 – 16760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. protein binding Source: MGI
    3. protein C-terminus binding Source: MGI
    4. protein N-terminus binding Source: MGI
    5. sequence-specific DNA binding Source: InterPro
    6. sequence-specific DNA binding transcription factor activity Source: InterPro
    7. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. brain development Source: MGI
    2. forebrain morphogenesis Source: MGI
    3. negative regulation of transcription, DNA-templated Source: MGI
    4. nose development Source: MGI
    5. otic vesicle formation Source: MGI
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox expressed in ES cells 1
    Alternative name(s):
    Anterior-restricted homeobox protein
    Homeobox protein ANF
    Rathke pouch homeo box
    Gene namesi
    Name:Hesx1
    Synonyms:Hes-1, Rpx
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:96071. Hesx1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Homeobox expressed in ES cells 1PRO_0000048923Add
    BLAST

    Proteomic databases

    PRIDEiQ61658.

    Expressioni

    Tissue specificityi

    High levels found in the embryonic liver, lower level expression seen in the viscera, amnion and yolk sac.

    Developmental stagei

    Early expression seen in the anterior midline endoderm and prechordal plate precursor, subsequently activated in the overlying ectoderm of the cephalic neural plate. Later disappears in the mesendoderm while remaining in the prospective prosencephalic region of the neural plate ectoderm, ultimately expression is restricted to Rathke pouch, the primordium of the pituitary. Expressed in embryonic stem cells.1 Publication

    Inductioni

    Down-regulated during embryonic stem (ES) cell differentiation.

    Gene expression databases

    CleanExiMM_HESX1.
    GenevestigatoriQ61658.

    Interactioni

    Subunit structurei

    Can form heterodimers with PROP1 in binding to DNA Interacts with TLE1.By similarity

    Protein-protein interaction databases

    BioGridi200279. 5 interactions.
    STRINGi10090.ENSMUSP00000041999.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61658.
    SMRiQ61658. Positions 108-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ANF homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG326168.
    GeneTreeiENSGT00750000117223.
    HOGENOMiHOG000112889.
    HOVERGENiHBG004226.
    InParanoidiQ61658.
    KOiK09354.
    OMAiHPMPEER.
    OrthoDBiEOG7WMCMW.
    TreeFamiTF335506.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61658-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPSLREGAQ LRESKPAPCS FSIESILGLD QKKDCTTSVR PHRPWTDTCG    50
    DSEKGGNPPL HAPDLPSETS FPCPVDHPRP EERAPKYENY FSASETRSLK 100
    RELSWYRGRR PRTAFTQNQV EVLENVFRVN CYPGIDIRED LAQKLNLEED 150
    RIQIWFQNRR AKMKRSRRES QFLMAKKPFN PDLLK 185
    Length:185
    Mass (Da):21,504
    Last modified:October 3, 2012 - v2
    Checksum:i5C18A524BF281246
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti51 – 511D → N in CAA56344. (PubMed:7876132)Curated
    Sequence conflicti51 – 511D → N in AAA97869. (PubMed:8565852)Curated
    Sequence conflicti55 – 551G → D in CAA56344. (PubMed:7876132)Curated
    Sequence conflicti55 – 551G → D in AAA97869. (PubMed:8565852)Curated
    Sequence conflicti176 – 1761K → R in CAA56344. (PubMed:7876132)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80040 mRNA. Translation: CAA56344.1.
    U40720 mRNA. Translation: AAA97869.1.
    AK082831 mRNA. Translation: BAC38643.1.
    AC124603 Genomic DNA. No translation available.
    BC132051 mRNA. Translation: AAI32052.1.
    BC132053 mRNA. Translation: AAI32054.1.
    BC145262 mRNA. Translation: AAI45263.1.
    CCDSiCCDS26884.1.
    PIRiA55882.
    RefSeqiNP_034550.2. NM_010420.2.
    XP_006518633.1. XM_006518570.1.
    UniGeneiMm.4802.

    Genome annotation databases

    EnsembliENSMUST00000035433; ENSMUSP00000041999; ENSMUSG00000040726.
    GeneIDi15209.
    KEGGimmu:15209.
    UCSCiuc007stj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80040 mRNA. Translation: CAA56344.1 .
    U40720 mRNA. Translation: AAA97869.1 .
    AK082831 mRNA. Translation: BAC38643.1 .
    AC124603 Genomic DNA. No translation available.
    BC132051 mRNA. Translation: AAI32052.1 .
    BC132053 mRNA. Translation: AAI32054.1 .
    BC145262 mRNA. Translation: AAI45263.1 .
    CCDSi CCDS26884.1.
    PIRi A55882.
    RefSeqi NP_034550.2. NM_010420.2.
    XP_006518633.1. XM_006518570.1.
    UniGenei Mm.4802.

    3D structure databases

    ProteinModelPortali Q61658.
    SMRi Q61658. Positions 108-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200279. 5 interactions.
    STRINGi 10090.ENSMUSP00000041999.

    Proteomic databases

    PRIDEi Q61658.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035433 ; ENSMUSP00000041999 ; ENSMUSG00000040726 .
    GeneIDi 15209.
    KEGGi mmu:15209.
    UCSCi uc007stj.1. mouse.

    Organism-specific databases

    CTDi 8820.
    MGIi MGI:96071. Hesx1.

    Phylogenomic databases

    eggNOGi NOG326168.
    GeneTreei ENSGT00750000117223.
    HOGENOMi HOG000112889.
    HOVERGENi HBG004226.
    InParanoidi Q61658.
    KOi K09354.
    OMAi HPMPEER.
    OrthoDBi EOG7WMCMW.
    TreeFami TF335506.

    Miscellaneous databases

    NextBioi 287773.
    PROi Q61658.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_HESX1.
    Genevestigatori Q61658.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, genomic organization, and expression of the novel homeobox gene Hesx1."
      Thomas P.Q., Johnson B.V., Rathjen J., Rathjen P.D.
      J. Biol. Chem. 270:3869-3875(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
      Tissue: Embryonic stem cell.
    2. "Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo."
      Hermesz E., Mackem S., Mahon K.A.
      Development 122:41-52(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "HES-1, a novel homeobox gene expressed by murine embryonic stem cells, identifies a new class of homeobox genes."
      Thomas P.Q., Rathjen P.D.
      Nucleic Acids Res. 20:5840-5840(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    7. Cited for: FUNCTION.

    Entry informationi

    Entry nameiHESX1_MOUSE
    AccessioniPrimary (citable) accession number: Q61658
    Secondary accession number(s): Q61047, Q8C477
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3