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Protein

Transcription factor HES-3

Gene

Hes3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription.

GO - Molecular functioni

  • protein dimerization activity Source: InterPro
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • hindbrain morphogenesis Source: MGI
  • in utero embryonic development Source: MGI
  • midbrain development Source: MGI
  • midbrain-hindbrain boundary morphogenesis Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • neural tube development Source: MGI
  • oculomotor nerve development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of neurogenesis Source: MGI
  • regulation of timing of neuron differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • trochlear nerve development Source: MGI

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-3
Alternative name(s):
Hairy and enhancer of split 3
Gene namesi
Name:Hes3
Synonyms:Hes-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:104877 Hes3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272091 – 175Transcription factor HES-3Add BLAST175

Proteomic databases

PaxDbiQ61657
PRIDEiQ61657

Expressioni

Gene expression databases

BgeeiENSMUSG00000028946
CleanExiMM_HES3
ExpressionAtlasiQ61657 baseline and differential
GenevisibleiQ61657 MM

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

  • protein dimerization activity Source: InterPro
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

ELMiQ61657
STRINGi10090.ENSMUSP00000092006

Structurei

3D structure databases

ProteinModelPortaliQ61657
SMRiQ61657
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 49bHLHPROSITE-ProRule annotationAdd BLAST49
Domaini65 – 98OrangePROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi172 – 175WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 167Pro-richAdd BLAST60

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Phylogenomic databases

eggNOGiENOG410JC70 Eukaryota
ENOG4112CPE LUCA
GeneTreeiENSGT00730000111482
HOGENOMiHOG000236346
HOVERGENiHBG005959
InParanoidiQ61657
KOiK09088
OMAiCTPAVWA
OrthoDBiEOG091G0D3I
PhylomeDBiQ61657
TreeFamiTF351373

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q61657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKRRARIN VSLEQLRSLL ERHYSHQIRK RKLEKADILE LSVKYMRSLQ
60 70 80 90 100
NSLQGLWPVP SGVDYPSGFQ GGLRGVSQRL RPGEGDSGLR CPLLLQRREG
110 120 130 140 150
STTDSANPQA TSVLNPCLPA IWAPSRAAGG SHSPQSPLPL PGGLLESSTD
160 170
VVAPHPASNC QAESTRPGFR VWRPW
Length:175
Mass (Da):19,294
Last modified:December 12, 2006 - v2
Checksum:iCB5FEAD4A64A7F62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70Q → H (PubMed:8074710).Curated1
Sequence conflicti70Q → H (Ref. 2) Curated1
Sequence conflicti155H → Q (PubMed:8074710).Curated1
Sequence conflicti155H → Q (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32200 Genomic DNA Translation: BAA06899.1
D85169 Genomic DNA Translation: BAA19799.1
AK090218 mRNA Translation: BAC41140.1
BC116444 mRNA Translation: AAI16445.1
CCDSiCCDS18997.1
RefSeqiNP_032263.2, NM_008237.4
XP_011248495.1, XM_011250193.2
UniGeneiMm.3516

Genome annotation databases

EnsembliENSMUST00000094438; ENSMUSP00000092006; ENSMUSG00000028946
GeneIDi15207
KEGGimmu:15207
UCSCiuc008wac.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHES3_MOUSE
AccessioniPrimary (citable) accession number: Q61657
Secondary accession number(s): O09083, O09150, Q8BTI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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