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Q61646

- HPT_MOUSE

UniProt

Q61646 - HPT_MOUSE

Protein

Haptoglobin

Gene

Hp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway By similarity.By similarity
    Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.By similarity

    GO - Molecular functioni

    1. antioxidant activity Source: UniProtKB-KW
    2. catalytic activity Source: InterPro

    GO - Biological processi

    1. acute-phase response Source: UniProtKB-KW
    2. defense response to bacterium Source: UniProtKB-KW
    3. immune system process Source: UniProtKB-KW
    4. liver development Source: Ensembl
    5. organ regeneration Source: Ensembl
    6. response to cobalamin Source: Ensembl
    7. response to drug Source: Ensembl
    8. response to glucocorticoid Source: Ensembl
    9. response to heat Source: Ensembl
    10. response to hypoxia Source: Ensembl
    11. response to L-ascorbic acid Source: Ensembl
    12. response to lead ion Source: Ensembl
    13. response to lipopolysaccharide Source: Ensembl
    14. response to magnesium ion Source: Ensembl
    15. response to X-ray Source: Ensembl
    16. spermatogenesis Source: Ensembl

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Antioxidant, Serine protease homolog

    Keywords - Biological processi

    Acute phase, Immunity

    Keywords - Ligandi

    Hemoglobin-binding

    Enzyme and pathway databases

    ReactomeiREACT_196575. Scavenging of heme from plasma.

    Protein family/group databases

    MEROPSiS01.972.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Haptoglobin
    Alternative name(s):
    Zonulin
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Hp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:96211. Hp.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. extracellular space Source: Ensembl
    3. Golgi apparatus Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 347329HaptoglobinPRO_0000028462Add
    BLAST
    Chaini19 – 10183Haptoglobin alpha chainPRO_0000028463Add
    BLAST
    Chaini103 – 347245Haptoglobin beta chainPRO_0000028464Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 – 33InterchainBy similarity
    Disulfide bondi52 ↔ 86By similarity
    Disulfide bondi90 ↔ 207Interchain (between alpha and beta chains)PROSITE-ProRule annotation
    Glycosylationi148 – 1481N-linked (GlcNAc...)1 Publication
    Glycosylationi182 – 1821N-linked (GlcNAc...)1 Publication
    Disulfide bondi250 ↔ 281By similarity
    Glycosylationi256 – 2561N-linked (GlcNAc...)1 Publication
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi292 ↔ 322By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ61646.
    PaxDbiQ61646.
    PRIDEiQ61646.

    PTM databases

    PhosphoSiteiQ61646.

    Expressioni

    Tissue specificityi

    Expressed by the liver and secreted in plasma.

    Gene expression databases

    ArrayExpressiQ61646.
    BgeeiQ61646.
    CleanExiMM_HP.
    GenevestigatoriQ61646.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains; disufide-linked. The Hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers. Interacts with CD163 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ61646. 2 interactions.
    MINTiMINT-1870167.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61646.
    SMRiQ61646. Positions 33-345.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 8858SushiPROSITE-ProRule annotationAdd
    BLAST
    Domaini103 – 345243Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni259 – 2646Interaction with CD163By similarity

    Domaini

    The beta chain mediates most of the interactions with both subunits of hemoglobin, while the alpha chain forms the homodimeric interface.By similarity

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
    Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Sushi

    Phylogenomic databases

    eggNOGiNOG246387.
    GeneTreeiENSGT00560000076882.
    HOGENOMiHOG000112945.
    HOVERGENiHBG005989.
    InParanoidiQ61646.
    KOiK16142.
    OMAiDDTWYAA.
    OrthoDBiEOG722J8R.
    PhylomeDBiQ61646.
    TreeFamiTF334326.

    Family and domain databases

    InterProiIPR008292. Haptoglobin.
    IPR001254. Peptidase_S1.
    IPR001314. Peptidase_S1A.
    IPR000436. Sushi_SCR_CCP.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001137. Haptoglobin. 1 hit.
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00032. CCP. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF57535. SSF57535. 1 hit.
    PROSITEiPS50923. SUSHI. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61646-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRALGAVVTL LLWGQLFAVE LGNDAMDFED DSCPKPPEIA NGYVEHLVRY    50
    RCRQFYRLRA EGDGVYTLND EKQWVNTVAG EKLPECEAVC GKPKHPVDQV 100
    QRIIGGSMDA KGSFPWQAKM ISRHGLTTGA TLISDQWLLT TAKNLFLNHS 150
    ETASAKDITP TLTLYVGKNQ LVEIEKVVLH PNHSVVDIGL IKLKQRVLVT 200
    ERVMPICLPS KDYIAPGRVG YVSGWGRNAN FRFTDRLKYV MLPVADQDKC 250
    VVHYENSTVP EKKNLTSPVG VQPILNEHTF CAGLTKYQED TCYGDAGSAF 300
    AIHDMEEDTW YAAGILSFDK SCAVAEYGVY VRATDLKDWV QETMAKN 347
    Length:347
    Mass (Da):38,752
    Last modified:November 1, 1996 - v1
    Checksum:i63822D121232F130
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96827 mRNA. Translation: AAA37779.1.
    CCDSiCCDS40470.1.
    RefSeqiNP_059066.1. NM_017370.2.
    UniGeneiMm.26730.

    Genome annotation databases

    EnsembliENSMUST00000074898; ENSMUSP00000074436; ENSMUSG00000031722.
    GeneIDi15439.
    KEGGimmu:15439.
    UCSCiuc009nin.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96827 mRNA. Translation: AAA37779.1 .
    CCDSi CCDS40470.1.
    RefSeqi NP_059066.1. NM_017370.2.
    UniGenei Mm.26730.

    3D structure databases

    ProteinModelPortali Q61646.
    SMRi Q61646. Positions 33-345.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61646. 2 interactions.
    MINTi MINT-1870167.

    Protein family/group databases

    MEROPSi S01.972.

    PTM databases

    PhosphoSitei Q61646.

    Proteomic databases

    MaxQBi Q61646.
    PaxDbi Q61646.
    PRIDEi Q61646.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074898 ; ENSMUSP00000074436 ; ENSMUSG00000031722 .
    GeneIDi 15439.
    KEGGi mmu:15439.
    UCSCi uc009nin.2. mouse.

    Organism-specific databases

    CTDi 3240.
    MGIi MGI:96211. Hp.

    Phylogenomic databases

    eggNOGi NOG246387.
    GeneTreei ENSGT00560000076882.
    HOGENOMi HOG000112945.
    HOVERGENi HBG005989.
    InParanoidi Q61646.
    KOi K16142.
    OMAi DDTWYAA.
    OrthoDBi EOG722J8R.
    PhylomeDBi Q61646.
    TreeFami TF334326.

    Enzyme and pathway databases

    Reactomei REACT_196575. Scavenging of heme from plasma.

    Miscellaneous databases

    ChiTaRSi HP. mouse.
    NextBioi 288222.
    PROi Q61646.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61646.
    Bgeei Q61646.
    CleanExi MM_HP.
    Genevestigatori Q61646.

    Family and domain databases

    InterProi IPR008292. Haptoglobin.
    IPR001254. Peptidase_S1.
    IPR001314. Peptidase_S1A.
    IPR000436. Sushi_SCR_CCP.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001137. Haptoglobin. 1 hit.
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00032. CCP. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF57535. SSF57535. 1 hit.
    PROSITEi PS50923. SUSHI. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of haptoglobin in mouse adipose tissue."
      Ponte P.A., White R.T., Uyeda C.M., Coleman R.T.
      Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
      Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
      J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-148; ASN-182 AND ASN-256.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiHPT_MOUSE
    AccessioniPrimary (citable) accession number: Q61646
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3