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Q61646

- HPT_MOUSE

UniProt

Q61646 - HPT_MOUSE

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Protein
Haptoglobin
Gene
Hp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway By similarity.
Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens By similarity.

GO - Molecular functioni

  1. antioxidant activity Source: UniProtKB-KW
  2. catalytic activity Source: InterPro

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
  3. immune system process Source: UniProtKB-KW
  4. liver development Source: Ensembl
  5. organ regeneration Source: Ensembl
  6. response to L-ascorbic acid Source: Ensembl
  7. response to X-ray Source: Ensembl
  8. response to cobalamin Source: Ensembl
  9. response to drug Source: Ensembl
  10. response to glucocorticoid Source: Ensembl
  11. response to heat Source: Ensembl
  12. response to hypoxia Source: Ensembl
  13. response to lead ion Source: Ensembl
  14. response to lipopolysaccharide Source: Ensembl
  15. response to magnesium ion Source: Ensembl
  16. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Antioxidant, Serine protease homolog

Keywords - Biological processi

Acute phase, Immunity

Keywords - Ligandi

Hemoglobin-binding

Enzyme and pathway databases

ReactomeiREACT_196575. Scavenging of heme from plasma.

Protein family/group databases

MEROPSiS01.972.

Names & Taxonomyi

Protein namesi
Recommended name:
Haptoglobin
Alternative name(s):
Zonulin
Cleaved into the following 2 chains:
Gene namesi
Name:Hp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:96211. Hp.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. endoplasmic reticulum Source: Ensembl
  3. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 347329Haptoglobin
PRO_0000028462Add
BLAST
Chaini19 – 10183Haptoglobin alpha chain
PRO_0000028463Add
BLAST
Chaini103 – 347245Haptoglobin beta chain
PRO_0000028464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 – 33Interchain By similarity
Disulfide bondi52 ↔ 86 By similarity
Disulfide bondi90 ↔ 207Interchain (between alpha and beta chains) By similarity
Glycosylationi148 – 1481N-linked (GlcNAc...)1 Publication
Glycosylationi182 – 1821N-linked (GlcNAc...)1 Publication
Disulfide bondi250 ↔ 281 By similarity
Glycosylationi256 – 2561N-linked (GlcNAc...)1 Publication
Glycosylationi264 – 2641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi292 ↔ 322 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61646.
PaxDbiQ61646.
PRIDEiQ61646.

PTM databases

PhosphoSiteiQ61646.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

ArrayExpressiQ61646.
BgeeiQ61646.
CleanExiMM_HP.
GenevestigatoriQ61646.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains; disufide-linked. The Hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers. Interacts with CD163 By similarity.

Protein-protein interaction databases

IntActiQ61646. 2 interactions.
MINTiMINT-1870167.

Structurei

3D structure databases

ProteinModelPortaliQ61646.
SMRiQ61646. Positions 33-345.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 8858Sushi
Add
BLAST
Domaini103 – 345243Peptidase S1
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni259 – 2646Interaction with CD163 By similarity

Domaini

The beta chain mediates most of the interactions with both subunits of hemoglobin, while the alpha chain forms the homodimeric interface By similarity.

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal, Sushi

Phylogenomic databases

eggNOGiNOG246387.
GeneTreeiENSGT00560000076882.
HOGENOMiHOG000112945.
HOVERGENiHBG005989.
InParanoidiQ61646.
KOiK16142.
OMAiDDTWYAA.
OrthoDBiEOG722J8R.
PhylomeDBiQ61646.
TreeFamiTF334326.

Family and domain databases

InterProiIPR008292. Haptoglobin.
IPR001254. Peptidase_S1.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001137. Haptoglobin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00032. CCP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS50923. SUSHI. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61646-1 [UniParc]FASTAAdd to Basket

« Hide

MRALGAVVTL LLWGQLFAVE LGNDAMDFED DSCPKPPEIA NGYVEHLVRY    50
RCRQFYRLRA EGDGVYTLND EKQWVNTVAG EKLPECEAVC GKPKHPVDQV 100
QRIIGGSMDA KGSFPWQAKM ISRHGLTTGA TLISDQWLLT TAKNLFLNHS 150
ETASAKDITP TLTLYVGKNQ LVEIEKVVLH PNHSVVDIGL IKLKQRVLVT 200
ERVMPICLPS KDYIAPGRVG YVSGWGRNAN FRFTDRLKYV MLPVADQDKC 250
VVHYENSTVP EKKNLTSPVG VQPILNEHTF CAGLTKYQED TCYGDAGSAF 300
AIHDMEEDTW YAAGILSFDK SCAVAEYGVY VRATDLKDWV QETMAKN 347
Length:347
Mass (Da):38,752
Last modified:November 1, 1996 - v1
Checksum:i63822D121232F130
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96827 mRNA. Translation: AAA37779.1.
CCDSiCCDS40470.1.
RefSeqiNP_059066.1. NM_017370.2.
UniGeneiMm.26730.

Genome annotation databases

EnsembliENSMUST00000074898; ENSMUSP00000074436; ENSMUSG00000031722.
GeneIDi15439.
KEGGimmu:15439.
UCSCiuc009nin.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96827 mRNA. Translation: AAA37779.1 .
CCDSi CCDS40470.1.
RefSeqi NP_059066.1. NM_017370.2.
UniGenei Mm.26730.

3D structure databases

ProteinModelPortali Q61646.
SMRi Q61646. Positions 33-345.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61646. 2 interactions.
MINTi MINT-1870167.

Protein family/group databases

MEROPSi S01.972.

PTM databases

PhosphoSitei Q61646.

Proteomic databases

MaxQBi Q61646.
PaxDbi Q61646.
PRIDEi Q61646.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000074898 ; ENSMUSP00000074436 ; ENSMUSG00000031722 .
GeneIDi 15439.
KEGGi mmu:15439.
UCSCi uc009nin.2. mouse.

Organism-specific databases

CTDi 3240.
MGIi MGI:96211. Hp.

Phylogenomic databases

eggNOGi NOG246387.
GeneTreei ENSGT00560000076882.
HOGENOMi HOG000112945.
HOVERGENi HBG005989.
InParanoidi Q61646.
KOi K16142.
OMAi DDTWYAA.
OrthoDBi EOG722J8R.
PhylomeDBi Q61646.
TreeFami TF334326.

Enzyme and pathway databases

Reactomei REACT_196575. Scavenging of heme from plasma.

Miscellaneous databases

ChiTaRSi HP. mouse.
NextBioi 288222.
PROi Q61646.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61646.
Bgeei Q61646.
CleanExi MM_HP.
Genevestigatori Q61646.

Family and domain databases

InterProi IPR008292. Haptoglobin.
IPR001254. Peptidase_S1.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PIRSFi PIRSF001137. Haptoglobin. 1 hit.
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00032. CCP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEi PS50923. SUSHI. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of haptoglobin in mouse adipose tissue."
    Ponte P.A., White R.T., Uyeda C.M., Coleman R.T.
    Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-148; ASN-182 AND ASN-256.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiHPT_MOUSE
AccessioniPrimary (citable) accession number: Q61646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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