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Protein

Haptoglobin

Gene

Hp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).By similarity
Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.By similarity

Caution

Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Antioxidant, Serine protease homolog
Biological processAcute phase, Immunity
LigandHemoglobin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2168880 Scavenging of heme from plasma
R-MMU-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiS01.972

Names & Taxonomyi

Protein namesi
Recommended name:
Haptoglobin
Alternative name(s):
Zonulin
Cleaved into the following 2 chains:
Gene namesi
Name:Hp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96211 Hp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002846219 – 347HaptoglobinAdd BLAST329
ChainiPRO_000002846319 – 101Haptoglobin alpha chainAdd BLAST83
ChainiPRO_0000028464103 – 347Haptoglobin beta chainAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33InterchainBy similarity
Disulfide bondi52 ↔ 86By similarity
Disulfide bondi90 ↔ 207Interchain (between alpha and beta chains)PROSITE-ProRule annotation
Glycosylationi148N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi182N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi250 ↔ 281By similarity
Glycosylationi256N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi292 ↔ 322By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61646
PaxDbiQ61646
PeptideAtlasiQ61646
PRIDEiQ61646

PTM databases

CarbonylDBiQ61646
GlyConnecti717
iPTMnetiQ61646
PhosphoSitePlusiQ61646
SwissPalmiQ61646

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSMUSG00000031722
CleanExiMM_HP
ExpressionAtlasiQ61646 baseline and differential
GenevisibleiQ61646 MM

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains; disulfide-linked. The Hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers. Interacts with CD163 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200400, 1 interactor
IntActiQ61646, 2 interactors
MINTiQ61646
STRINGi10090.ENSMUSP00000074436

Structurei

3D structure databases

ProteinModelPortaliQ61646
SMRiQ61646
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 88SushiPROSITE-ProRule annotationAdd BLAST58
Domaini103 – 345Peptidase S1PROSITE-ProRule annotationAdd BLAST243

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni259 – 264Interaction with CD163By similarity6

Domaini

The beta chain mediates most of the interactions with both subunits of hemoglobin, while the alpha chain forms the homodimeric interface.By similarity

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Sushi

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118890
HOGENOMiHOG000112945
HOVERGENiHBG005989
InParanoidiQ61646
KOiK16142
OMAiNPVDQVQ
OrthoDBiEOG091G099M
PhylomeDBiQ61646
TreeFamiTF334326

Family and domain databases

CDDicd00033 CCP, 1 hit
cd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR008292 Haptoglobin
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001137 Haptoglobin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS50923 SUSHI, 1 hit
PS50240 TRYPSIN_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALGAVVTL LLWGQLFAVE LGNDAMDFED DSCPKPPEIA NGYVEHLVRY
60 70 80 90 100
RCRQFYRLRA EGDGVYTLND EKQWVNTVAG EKLPECEAVC GKPKHPVDQV
110 120 130 140 150
QRIIGGSMDA KGSFPWQAKM ISRHGLTTGA TLISDQWLLT TAKNLFLNHS
160 170 180 190 200
ETASAKDITP TLTLYVGKNQ LVEIEKVVLH PNHSVVDIGL IKLKQRVLVT
210 220 230 240 250
ERVMPICLPS KDYIAPGRVG YVSGWGRNAN FRFTDRLKYV MLPVADQDKC
260 270 280 290 300
VVHYENSTVP EKKNLTSPVG VQPILNEHTF CAGLTKYQED TCYGDAGSAF
310 320 330 340
AIHDMEEDTW YAAGILSFDK SCAVAEYGVY VRATDLKDWV QETMAKN
Length:347
Mass (Da):38,752
Last modified:November 1, 1996 - v1
Checksum:i63822D121232F130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96827 mRNA Translation: AAA37779.1
CCDSiCCDS40470.1
RefSeqiNP_059066.1, NM_017370.2
UniGeneiMm.26730

Genome annotation databases

EnsembliENSMUST00000074898; ENSMUSP00000074436; ENSMUSG00000031722
GeneIDi15439
KEGGimmu:15439
UCSCiuc009nin.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHPT_MOUSE
AccessioniPrimary (citable) accession number: Q61646
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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