SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q61645

- HAIR_MOUSE

UniProt

Q61645 - HAIR_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Lysine-specific demethylase hairless

Gene
Hr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle By similarity.

Cofactori

Binds 1 Fe2+ ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1000 – 10001Iron; catalytic By similarity
Metal bindingi1002 – 10021Iron; catalytic By similarity
Metal bindingi1118 – 11181Iron; catalytic By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri595 – 62026C6-typeAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: UniProtKB-KW
  4. protein binding Source: MGI
  5. transcription corepressor activity Source: MGI

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: MGI
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine-specific demethylase hairless (EC:1.14.11.-)
Gene namesi
Name:Hr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:96223. Hr.

Subcellular locationi

GO - Cellular componenti

  1. nuclear body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Hr are the cause of a number of pleiotropic effects including structural abnormalities of epithelial cells in the hair follicles, hair loss towards the end of the first hair growth cycle, and the failure of subsequent hair growth cycles. Older mice carrying a hr mutation have been reported to possess altered ratios of T-cell-dependent B-cell responses. Mice homozygous for hr mutation are uniquely sensitive to UV and chemically induced skin tumors.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11821182Lysine-specific demethylase hairlessPRO_0000083891Add
BLAST

Proteomic databases

PaxDbiQ61645.
PRIDEiQ61645.

PTM databases

PhosphoSiteiQ61645.

Expressioni

Tissue specificityi

Expressed predominantly in brain, hair follicles and interfollicular epidermis. No expression in dermis.

Gene expression databases

BgeeiQ61645.
CleanExiMM_HR.
GenevestigatoriQ61645.

Interactioni

Protein-protein interaction databases

BioGridi200415. 3 interactions.
STRINGi10090.ENSMUSP00000022691.

Structurei

3D structure databases

ProteinModelPortaliQ61645.
SMRiQ61645. Positions 840-1137.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini939 – 1150212JmjCAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi561 – 5655LXXLL motif 1
Motifi753 – 7575LXXLL motif 2

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi535 – 5406Poly-Gly

Domaini

Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors (By similarity).
The JmjC domain and the C6-type zinc-finger are required for the demethylation activity By similarity.

Sequence similaritiesi

Contains 1 JmjC domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri595 – 62026C6-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG243648.
GeneTreeiENSGT00530000063039.
HOGENOMiHOG000293150.
HOVERGENiHBG000171.
InParanoidiQ61645.
OrthoDBiEOG7PZRWJ.
PhylomeDBiQ61645.
TreeFamiTF324723.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PfamiPF02373. JmjC. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61645-1 [UniParc]FASTAAdd to Basket

« Hide

MESMPSFLKD TPAWEKTAPV NGIVGQEPGT SPQDGLRHGA LCLGEPAPFW     50
RGVLSTPDSW LPPGFLQGPK DTLSLVEGEG PRNGERKGSW LGGKEGLRWK 100
EAMLAHPLAF CGPACPPRYG PLIPEHSGGH PKSDPVAFRP LHCPFLLETK 150
ILERAPFWVP TCLPPYLMSS LPPERPYDWP LAPNPWVYSG SQPKVPSAFG 200
LGSKGFYHKD PNILRPAKEP LAESGMLGLA PGGHLQQACE SEGPSLHQRD 250
GETGAGRQQN LCPVFLGYPD TVPRAPWPSC PPGLVHSLGN IWAGPGSNSL 300
GYQLGPPATP RCPSPGPPTP PGGCCSSHLP AREGDLGPCR KCQDSPEGGS 350
SGPGESSEER NKADSRACPP SHHTKLKKTW LTRHSEQFEC PGGCSGKEES 400
PATGLRALKR AGSPEVQGAS RGPAPKRPSH PFPGTGRQGA RAWQETPETI 450
IGSKAEAEQQ EEQRGPRDGR IRLQESRLVD TSCQHHLAGV TQCQSCVQAA 500
GEVGVLTGHS QKSRRSPLEE KQLEEEDSSA TSEEGGGGPG PEASLNKGLA 550
KHLLSGLGDR LCRLLRKERE ALAWAQREGQ GPAMTEDSPG IPHCCSRCHH 600
GLFNTHWRCS HCSHRLCVAC GRIAGAGKNR EKTGSQEQHT DDCAQEAGHA 650
ACSLILTQFV SSQALAELST VMHQVWAKFD IRGHCFCQVD ARVWAPGDGG 700
QQKEPTEKTP PTPQPSCNGD SNRTKDIKEE TPDSTESPAE DGAGRSPLPC 750
PSLCELLAST AVKLCLGHDR IHMAFAPVTP ALPSDDRITN ILDSIIAQVV 800
ERKIQEKALG PGLRAGSGLR KGLSLPLSPV RTRLSPPGAL LWLQEPRPKH 850
GFHLFQEHWR QGQPVLVSGI QKTLRLSLWG MEALGTLGGQ VQTLTALGPP 900
QPTNLDSTAF WEGFSHPETR PKLDEGSVLL LHRTLGDKDA SRVQNLASSL 950
PLPEYCAHQG KLNLASYLPL GLTLHPLEPQ LWAAYGVNSH RGHLGTKNLC 1000
VEVSDLISIL VHAEAQLPPW YRAQKDFLSG LDGEGLWSPG SQTSTVWHVF 1050
RAQDAQRIRR FLQMVCPAGA GTLEPGAPGS CYLDAGLRRR LREEWGVSCW 1100
TLLQAPGEAV LVPAGAPHQV QGLVSTISVT QHFLSPETSA LSAQLYHQGA 1150
SLPPDHRMLY AQMDRAVFQA VKAAVGALQE AK 1182
Length:1,182
Mass (Da):127,193
Last modified:August 15, 2003 - v2
Checksum:i3AFABE96C6EB3241
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti401 – 4011P → S in CAA83587. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z32675 mRNA. Translation: CAA83587.1.
BC049182 mRNA. Translation: AAH49182.1.
CCDSiCCDS27257.1.
PIRiI48378.
RefSeqiNP_068677.2. NM_021877.3.
UniGeneiMm.7598.

Genome annotation databases

EnsembliENSMUST00000022691; ENSMUSP00000022691; ENSMUSG00000022096.
ENSMUST00000161069; ENSMUSP00000124816; ENSMUSG00000022096.
GeneIDi15460.
KEGGimmu:15460.
UCSCiuc007uoj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z32675 mRNA. Translation: CAA83587.1 .
BC049182 mRNA. Translation: AAH49182.1 .
CCDSi CCDS27257.1.
PIRi I48378.
RefSeqi NP_068677.2. NM_021877.3.
UniGenei Mm.7598.

3D structure databases

ProteinModelPortali Q61645.
SMRi Q61645. Positions 840-1137.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200415. 3 interactions.
STRINGi 10090.ENSMUSP00000022691.

PTM databases

PhosphoSitei Q61645.

Proteomic databases

PaxDbi Q61645.
PRIDEi Q61645.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022691 ; ENSMUSP00000022691 ; ENSMUSG00000022096 .
ENSMUST00000161069 ; ENSMUSP00000124816 ; ENSMUSG00000022096 .
GeneIDi 15460.
KEGGi mmu:15460.
UCSCi uc007uoj.1. mouse.

Organism-specific databases

CTDi 55806.
MGIi MGI:96223. Hr.

Phylogenomic databases

eggNOGi NOG243648.
GeneTreei ENSGT00530000063039.
HOGENOMi HOG000293150.
HOVERGENi HBG000171.
InParanoidi Q61645.
OrthoDBi EOG7PZRWJ.
PhylomeDBi Q61645.
TreeFami TF324723.

Miscellaneous databases

ChiTaRSi HR. mouse.
NextBioi 288274.
PROi Q61645.
SOURCEi Search...

Gene expression databases

Bgeei Q61645.
CleanExi MM_HR.
Genevestigatori Q61645.

Family and domain databases

InterProi IPR003347. JmjC_dom.
[Graphical view ]
Pfami PF02373. JmjC. 1 hit.
[Graphical view ]
SMARTi SM00558. JmjC. 1 hit.
[Graphical view ]
PROSITEi PS51184. JMJC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Retina.

Entry informationi

Entry nameiHAIR_MOUSE
AccessioniPrimary (citable) accession number: Q61645
Secondary accession number(s): Q80Y47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 15, 2003
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi