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Q61645

- HAIR_MOUSE

UniProt

Q61645 - HAIR_MOUSE

Protein

Lysine-specific demethylase hairless

Gene

Hr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (15 Aug 2003)
      Previous versions | rss
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    Functioni

    Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle By similarity.By similarity

    Cofactori

    Binds 1 Fe2+ ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi1000 – 10001Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi1002 – 10021Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi1118 – 11181Iron; catalyticPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri595 – 62026C6-typeAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. oxidoreductase activity Source: UniProtKB-KW
    4. protein binding Source: MGI
    5. transcription corepressor activity Source: MGI

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: MGI
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Iron, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysine-specific demethylase hairless (EC:1.14.11.-)
    Gene namesi
    Name:Hr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:96223. Hr.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear body Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Hr are the cause of a number of pleiotropic effects including structural abnormalities of epithelial cells in the hair follicles, hair loss towards the end of the first hair growth cycle, and the failure of subsequent hair growth cycles. Older mice carrying a hr mutation have been reported to possess altered ratios of T-cell-dependent B-cell responses. Mice homozygous for hr mutation are uniquely sensitive to UV and chemically induced skin tumors.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11821182Lysine-specific demethylase hairlessPRO_0000083891Add
    BLAST

    Proteomic databases

    PaxDbiQ61645.
    PRIDEiQ61645.

    PTM databases

    PhosphoSiteiQ61645.

    Expressioni

    Tissue specificityi

    Expressed predominantly in brain, hair follicles and interfollicular epidermis. No expression in dermis.

    Gene expression databases

    BgeeiQ61645.
    CleanExiMM_HR.
    GenevestigatoriQ61645.

    Interactioni

    Protein-protein interaction databases

    BioGridi200415. 3 interactions.
    STRINGi10090.ENSMUSP00000022691.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61645.
    SMRiQ61645. Positions 840-1137.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini939 – 1150212JmjCPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi561 – 5655LXXLL motif 1
    Motifi753 – 7575LXXLL motif 2

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi535 – 5406Poly-Gly

    Domaini

    Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors (By similarity).By similarity
    The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.By similarity

    Sequence similaritiesi

    Contains 1 JmjC domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri595 – 62026C6-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG243648.
    GeneTreeiENSGT00530000063039.
    HOGENOMiHOG000293150.
    HOVERGENiHBG000171.
    InParanoidiQ61645.
    OrthoDBiEOG7PZRWJ.
    PhylomeDBiQ61645.
    TreeFamiTF324723.

    Family and domain databases

    InterProiIPR003347. JmjC_dom.
    [Graphical view]
    PfamiPF02373. JmjC. 1 hit.
    [Graphical view]
    SMARTiSM00558. JmjC. 1 hit.
    [Graphical view]
    PROSITEiPS51184. JMJC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61645-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESMPSFLKD TPAWEKTAPV NGIVGQEPGT SPQDGLRHGA LCLGEPAPFW     50
    RGVLSTPDSW LPPGFLQGPK DTLSLVEGEG PRNGERKGSW LGGKEGLRWK 100
    EAMLAHPLAF CGPACPPRYG PLIPEHSGGH PKSDPVAFRP LHCPFLLETK 150
    ILERAPFWVP TCLPPYLMSS LPPERPYDWP LAPNPWVYSG SQPKVPSAFG 200
    LGSKGFYHKD PNILRPAKEP LAESGMLGLA PGGHLQQACE SEGPSLHQRD 250
    GETGAGRQQN LCPVFLGYPD TVPRAPWPSC PPGLVHSLGN IWAGPGSNSL 300
    GYQLGPPATP RCPSPGPPTP PGGCCSSHLP AREGDLGPCR KCQDSPEGGS 350
    SGPGESSEER NKADSRACPP SHHTKLKKTW LTRHSEQFEC PGGCSGKEES 400
    PATGLRALKR AGSPEVQGAS RGPAPKRPSH PFPGTGRQGA RAWQETPETI 450
    IGSKAEAEQQ EEQRGPRDGR IRLQESRLVD TSCQHHLAGV TQCQSCVQAA 500
    GEVGVLTGHS QKSRRSPLEE KQLEEEDSSA TSEEGGGGPG PEASLNKGLA 550
    KHLLSGLGDR LCRLLRKERE ALAWAQREGQ GPAMTEDSPG IPHCCSRCHH 600
    GLFNTHWRCS HCSHRLCVAC GRIAGAGKNR EKTGSQEQHT DDCAQEAGHA 650
    ACSLILTQFV SSQALAELST VMHQVWAKFD IRGHCFCQVD ARVWAPGDGG 700
    QQKEPTEKTP PTPQPSCNGD SNRTKDIKEE TPDSTESPAE DGAGRSPLPC 750
    PSLCELLAST AVKLCLGHDR IHMAFAPVTP ALPSDDRITN ILDSIIAQVV 800
    ERKIQEKALG PGLRAGSGLR KGLSLPLSPV RTRLSPPGAL LWLQEPRPKH 850
    GFHLFQEHWR QGQPVLVSGI QKTLRLSLWG MEALGTLGGQ VQTLTALGPP 900
    QPTNLDSTAF WEGFSHPETR PKLDEGSVLL LHRTLGDKDA SRVQNLASSL 950
    PLPEYCAHQG KLNLASYLPL GLTLHPLEPQ LWAAYGVNSH RGHLGTKNLC 1000
    VEVSDLISIL VHAEAQLPPW YRAQKDFLSG LDGEGLWSPG SQTSTVWHVF 1050
    RAQDAQRIRR FLQMVCPAGA GTLEPGAPGS CYLDAGLRRR LREEWGVSCW 1100
    TLLQAPGEAV LVPAGAPHQV QGLVSTISVT QHFLSPETSA LSAQLYHQGA 1150
    SLPPDHRMLY AQMDRAVFQA VKAAVGALQE AK 1182
    Length:1,182
    Mass (Da):127,193
    Last modified:August 15, 2003 - v2
    Checksum:i3AFABE96C6EB3241
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti401 – 4011P → S in CAA83587. (PubMed:8052649)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z32675 mRNA. Translation: CAA83587.1.
    BC049182 mRNA. Translation: AAH49182.1.
    CCDSiCCDS27257.1.
    PIRiI48378.
    RefSeqiNP_068677.2. NM_021877.3.
    UniGeneiMm.7598.

    Genome annotation databases

    EnsembliENSMUST00000022691; ENSMUSP00000022691; ENSMUSG00000022096.
    ENSMUST00000161069; ENSMUSP00000124816; ENSMUSG00000022096.
    GeneIDi15460.
    KEGGimmu:15460.
    UCSCiuc007uoj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z32675 mRNA. Translation: CAA83587.1 .
    BC049182 mRNA. Translation: AAH49182.1 .
    CCDSi CCDS27257.1.
    PIRi I48378.
    RefSeqi NP_068677.2. NM_021877.3.
    UniGenei Mm.7598.

    3D structure databases

    ProteinModelPortali Q61645.
    SMRi Q61645. Positions 840-1137.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200415. 3 interactions.
    STRINGi 10090.ENSMUSP00000022691.

    PTM databases

    PhosphoSitei Q61645.

    Proteomic databases

    PaxDbi Q61645.
    PRIDEi Q61645.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022691 ; ENSMUSP00000022691 ; ENSMUSG00000022096 .
    ENSMUST00000161069 ; ENSMUSP00000124816 ; ENSMUSG00000022096 .
    GeneIDi 15460.
    KEGGi mmu:15460.
    UCSCi uc007uoj.1. mouse.

    Organism-specific databases

    CTDi 55806.
    MGIi MGI:96223. Hr.

    Phylogenomic databases

    eggNOGi NOG243648.
    GeneTreei ENSGT00530000063039.
    HOGENOMi HOG000293150.
    HOVERGENi HBG000171.
    InParanoidi Q61645.
    OrthoDBi EOG7PZRWJ.
    PhylomeDBi Q61645.
    TreeFami TF324723.

    Miscellaneous databases

    ChiTaRSi HR. mouse.
    NextBioi 288274.
    PROi Q61645.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61645.
    CleanExi MM_HR.
    Genevestigatori Q61645.

    Family and domain databases

    InterProi IPR003347. JmjC_dom.
    [Graphical view ]
    Pfami PF02373. JmjC. 1 hit.
    [Graphical view ]
    SMARTi SM00558. JmjC. 1 hit.
    [Graphical view ]
    PROSITEi PS51184. JMJC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Skin.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Retina.

    Entry informationi

    Entry nameiHAIR_MOUSE
    AccessioniPrimary (citable) accession number: Q61645
    Secondary accession number(s): Q80Y47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: August 15, 2003
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3