Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q61645 (HAIR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysine-specific demethylase hairless

EC=1.14.11.-
Gene names
Name:Hr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1182 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle By similarity.

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed predominantly in brain, hair follicles and interfollicular epidermis. No expression in dermis.

Domain

Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors By similarity.

The JmjC domain and the C6-type zinc-finger are required for the demethylation activity By similarity.

Involvement in disease

Defects in Hr are the cause of a number of pleiotropic effects including structural abnormalities of epithelial cells in the hair follicles, hair loss towards the end of the first hair growth cycle, and the failure of subsequent hair growth cycles. Older mice carrying a hr mutation have been reported to possess altered ratios of T-cell-dependent B-cell responses. Mice homozygous for hr mutation are uniquely sensitive to UV and chemically induced skin tumors.

Sequence similarities

Contains 1 JmjC domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11821182Lysine-specific demethylase hairless
PRO_0000083891

Regions

Domain939 – 1150212JmjC
Zinc finger595 – 62026C6-type
Motif561 – 5655LXXLL motif 1
Motif753 – 7575LXXLL motif 2
Compositional bias535 – 5406Poly-Gly

Sites

Metal binding10001Iron; catalytic By similarity
Metal binding10021Iron; catalytic By similarity
Metal binding11181Iron; catalytic By similarity

Experimental info

Sequence conflict4011P → S in CAA83587. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61645 [UniParc].

Last modified August 15, 2003. Version 2.
Checksum: 3AFABE96C6EB3241

FASTA1,182127,193
        10         20         30         40         50         60 
MESMPSFLKD TPAWEKTAPV NGIVGQEPGT SPQDGLRHGA LCLGEPAPFW RGVLSTPDSW 

        70         80         90        100        110        120 
LPPGFLQGPK DTLSLVEGEG PRNGERKGSW LGGKEGLRWK EAMLAHPLAF CGPACPPRYG 

       130        140        150        160        170        180 
PLIPEHSGGH PKSDPVAFRP LHCPFLLETK ILERAPFWVP TCLPPYLMSS LPPERPYDWP 

       190        200        210        220        230        240 
LAPNPWVYSG SQPKVPSAFG LGSKGFYHKD PNILRPAKEP LAESGMLGLA PGGHLQQACE 

       250        260        270        280        290        300 
SEGPSLHQRD GETGAGRQQN LCPVFLGYPD TVPRAPWPSC PPGLVHSLGN IWAGPGSNSL 

       310        320        330        340        350        360 
GYQLGPPATP RCPSPGPPTP PGGCCSSHLP AREGDLGPCR KCQDSPEGGS SGPGESSEER 

       370        380        390        400        410        420 
NKADSRACPP SHHTKLKKTW LTRHSEQFEC PGGCSGKEES PATGLRALKR AGSPEVQGAS 

       430        440        450        460        470        480 
RGPAPKRPSH PFPGTGRQGA RAWQETPETI IGSKAEAEQQ EEQRGPRDGR IRLQESRLVD 

       490        500        510        520        530        540 
TSCQHHLAGV TQCQSCVQAA GEVGVLTGHS QKSRRSPLEE KQLEEEDSSA TSEEGGGGPG 

       550        560        570        580        590        600 
PEASLNKGLA KHLLSGLGDR LCRLLRKERE ALAWAQREGQ GPAMTEDSPG IPHCCSRCHH 

       610        620        630        640        650        660 
GLFNTHWRCS HCSHRLCVAC GRIAGAGKNR EKTGSQEQHT DDCAQEAGHA ACSLILTQFV 

       670        680        690        700        710        720 
SSQALAELST VMHQVWAKFD IRGHCFCQVD ARVWAPGDGG QQKEPTEKTP PTPQPSCNGD 

       730        740        750        760        770        780 
SNRTKDIKEE TPDSTESPAE DGAGRSPLPC PSLCELLAST AVKLCLGHDR IHMAFAPVTP 

       790        800        810        820        830        840 
ALPSDDRITN ILDSIIAQVV ERKIQEKALG PGLRAGSGLR KGLSLPLSPV RTRLSPPGAL 

       850        860        870        880        890        900 
LWLQEPRPKH GFHLFQEHWR QGQPVLVSGI QKTLRLSLWG MEALGTLGGQ VQTLTALGPP 

       910        920        930        940        950        960 
QPTNLDSTAF WEGFSHPETR PKLDEGSVLL LHRTLGDKDA SRVQNLASSL PLPEYCAHQG 

       970        980        990       1000       1010       1020 
KLNLASYLPL GLTLHPLEPQ LWAAYGVNSH RGHLGTKNLC VEVSDLISIL VHAEAQLPPW 

      1030       1040       1050       1060       1070       1080 
YRAQKDFLSG LDGEGLWSPG SQTSTVWHVF RAQDAQRIRR FLQMVCPAGA GTLEPGAPGS 

      1090       1100       1110       1120       1130       1140 
CYLDAGLRRR LREEWGVSCW TLLQAPGEAV LVPAGAPHQV QGLVSTISVT QHFLSPETSA 

      1150       1160       1170       1180 
LSAQLYHQGA SLPPDHRMLY AQMDRAVFQA VKAAVGALQE AK 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of the hairless gene of mice."
Cachon-Gonzalez M.B., Fenner S., Coffin J.M., Moran C., Best S., Stoye J.P.
Proc. Natl. Acad. Sci. U.S.A. 91:7717-7721(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Skin.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z32675 mRNA. Translation: CAA83587.1.
BC049182 mRNA. Translation: AAH49182.1.
CCDSCCDS27257.1.
PIRI48378.
RefSeqNP_068677.2. NM_021877.3.
UniGeneMm.7598.

3D structure databases

ProteinModelPortalQ61645.
SMRQ61645. Positions 840-1137.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200415. 3 interactions.
STRING10090.ENSMUSP00000022691.

PTM databases

PhosphoSiteQ61645.

Proteomic databases

PaxDbQ61645.
PRIDEQ61645.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022691; ENSMUSP00000022691; ENSMUSG00000022096.
ENSMUST00000161069; ENSMUSP00000124816; ENSMUSG00000022096.
GeneID15460.
KEGGmmu:15460.
UCSCuc007uoj.1. mouse.

Organism-specific databases

CTD55806.
MGIMGI:96223. Hr.

Phylogenomic databases

eggNOGNOG243648.
GeneTreeENSGT00530000063039.
HOGENOMHOG000293150.
HOVERGENHBG000171.
InParanoidQ61645.
OrthoDBEOG7PZRWJ.
PhylomeDBQ61645.
TreeFamTF324723.

Gene expression databases

BgeeQ61645.
CleanExMM_HR.
GenevestigatorQ61645.

Family and domain databases

InterProIPR003347. JmjC_dom.
[Graphical view]
PfamPF02373. JmjC. 1 hit.
[Graphical view]
SMARTSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHR. mouse.
NextBio288274.
PROQ61645.
SOURCESearch...

Entry information

Entry nameHAIR_MOUSE
AccessionPrimary (citable) accession number: Q61645
Secondary accession number(s): Q80Y47
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 15, 2003
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot