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Q61645

- HAIR_MOUSE

UniProt

Q61645 - HAIR_MOUSE

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Protein

Lysine-specific demethylase hairless

Gene

Hr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle (By similarity).By similarity

Cofactori

Fe2+By similarityNote: Binds 1 Fe(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1000 – 10001Iron; catalyticPROSITE-ProRule annotation
Metal bindingi1002 – 10021Iron; catalyticPROSITE-ProRule annotation
Metal bindingi1118 – 11181Iron; catalyticPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri595 – 62026C6-typeAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: UniProtKB-KW
  4. transcription corepressor activity Source: MGI

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: MGI
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine-specific demethylase hairless (EC:1.14.11.-)
Gene namesi
Name:Hr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:96223. Hr.

Subcellular locationi

GO - Cellular componenti

  1. nuclear body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Hr are the cause of a number of pleiotropic effects including structural abnormalities of epithelial cells in the hair follicles, hair loss towards the end of the first hair growth cycle, and the failure of subsequent hair growth cycles. Older mice carrying a hr mutation have been reported to possess altered ratios of T-cell-dependent B-cell responses. Mice homozygous for hr mutation are uniquely sensitive to UV and chemically induced skin tumors.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11821182Lysine-specific demethylase hairlessPRO_0000083891Add
BLAST

Proteomic databases

PaxDbiQ61645.
PRIDEiQ61645.

PTM databases

PhosphoSiteiQ61645.

Expressioni

Tissue specificityi

Expressed predominantly in brain, hair follicles and interfollicular epidermis. No expression in dermis.

Gene expression databases

BgeeiQ61645.
CleanExiMM_HR.
ExpressionAtlasiQ61645. baseline and differential.
GenevestigatoriQ61645.

Interactioni

Protein-protein interaction databases

BioGridi200415. 3 interactions.
STRINGi10090.ENSMUSP00000022691.

Structurei

3D structure databases

ProteinModelPortaliQ61645.
SMRiQ61645. Positions 840-1137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini939 – 1150212JmjCPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi561 – 5655LXXLL motif 1
Motifi753 – 7575LXXLL motif 2

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi535 – 5406Poly-Gly

Domaini

Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors (By similarity).By similarity
The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.By similarity

Sequence similaritiesi

Contains 1 JmjC domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri595 – 62026C6-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG243648.
GeneTreeiENSGT00530000063039.
HOGENOMiHOG000293150.
HOVERGENiHBG000171.
InParanoidiQ61645.
OrthoDBiEOG7PZRWJ.
PhylomeDBiQ61645.
TreeFamiTF324723.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PfamiPF02373. JmjC. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61645-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESMPSFLKD TPAWEKTAPV NGIVGQEPGT SPQDGLRHGA LCLGEPAPFW
60 70 80 90 100
RGVLSTPDSW LPPGFLQGPK DTLSLVEGEG PRNGERKGSW LGGKEGLRWK
110 120 130 140 150
EAMLAHPLAF CGPACPPRYG PLIPEHSGGH PKSDPVAFRP LHCPFLLETK
160 170 180 190 200
ILERAPFWVP TCLPPYLMSS LPPERPYDWP LAPNPWVYSG SQPKVPSAFG
210 220 230 240 250
LGSKGFYHKD PNILRPAKEP LAESGMLGLA PGGHLQQACE SEGPSLHQRD
260 270 280 290 300
GETGAGRQQN LCPVFLGYPD TVPRAPWPSC PPGLVHSLGN IWAGPGSNSL
310 320 330 340 350
GYQLGPPATP RCPSPGPPTP PGGCCSSHLP AREGDLGPCR KCQDSPEGGS
360 370 380 390 400
SGPGESSEER NKADSRACPP SHHTKLKKTW LTRHSEQFEC PGGCSGKEES
410 420 430 440 450
PATGLRALKR AGSPEVQGAS RGPAPKRPSH PFPGTGRQGA RAWQETPETI
460 470 480 490 500
IGSKAEAEQQ EEQRGPRDGR IRLQESRLVD TSCQHHLAGV TQCQSCVQAA
510 520 530 540 550
GEVGVLTGHS QKSRRSPLEE KQLEEEDSSA TSEEGGGGPG PEASLNKGLA
560 570 580 590 600
KHLLSGLGDR LCRLLRKERE ALAWAQREGQ GPAMTEDSPG IPHCCSRCHH
610 620 630 640 650
GLFNTHWRCS HCSHRLCVAC GRIAGAGKNR EKTGSQEQHT DDCAQEAGHA
660 670 680 690 700
ACSLILTQFV SSQALAELST VMHQVWAKFD IRGHCFCQVD ARVWAPGDGG
710 720 730 740 750
QQKEPTEKTP PTPQPSCNGD SNRTKDIKEE TPDSTESPAE DGAGRSPLPC
760 770 780 790 800
PSLCELLAST AVKLCLGHDR IHMAFAPVTP ALPSDDRITN ILDSIIAQVV
810 820 830 840 850
ERKIQEKALG PGLRAGSGLR KGLSLPLSPV RTRLSPPGAL LWLQEPRPKH
860 870 880 890 900
GFHLFQEHWR QGQPVLVSGI QKTLRLSLWG MEALGTLGGQ VQTLTALGPP
910 920 930 940 950
QPTNLDSTAF WEGFSHPETR PKLDEGSVLL LHRTLGDKDA SRVQNLASSL
960 970 980 990 1000
PLPEYCAHQG KLNLASYLPL GLTLHPLEPQ LWAAYGVNSH RGHLGTKNLC
1010 1020 1030 1040 1050
VEVSDLISIL VHAEAQLPPW YRAQKDFLSG LDGEGLWSPG SQTSTVWHVF
1060 1070 1080 1090 1100
RAQDAQRIRR FLQMVCPAGA GTLEPGAPGS CYLDAGLRRR LREEWGVSCW
1110 1120 1130 1140 1150
TLLQAPGEAV LVPAGAPHQV QGLVSTISVT QHFLSPETSA LSAQLYHQGA
1160 1170 1180
SLPPDHRMLY AQMDRAVFQA VKAAVGALQE AK
Length:1,182
Mass (Da):127,193
Last modified:August 15, 2003 - v2
Checksum:i3AFABE96C6EB3241
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti401 – 4011P → S in CAA83587. (PubMed:8052649)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32675 mRNA. Translation: CAA83587.1.
BC049182 mRNA. Translation: AAH49182.1.
CCDSiCCDS27257.1.
PIRiI48378.
RefSeqiNP_068677.2. NM_021877.3.
UniGeneiMm.7598.

Genome annotation databases

EnsembliENSMUST00000022691; ENSMUSP00000022691; ENSMUSG00000022096.
ENSMUST00000161069; ENSMUSP00000124816; ENSMUSG00000022096.
GeneIDi15460.
KEGGimmu:15460.
UCSCiuc007uoj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32675 mRNA. Translation: CAA83587.1 .
BC049182 mRNA. Translation: AAH49182.1 .
CCDSi CCDS27257.1.
PIRi I48378.
RefSeqi NP_068677.2. NM_021877.3.
UniGenei Mm.7598.

3D structure databases

ProteinModelPortali Q61645.
SMRi Q61645. Positions 840-1137.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200415. 3 interactions.
STRINGi 10090.ENSMUSP00000022691.

PTM databases

PhosphoSitei Q61645.

Proteomic databases

PaxDbi Q61645.
PRIDEi Q61645.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022691 ; ENSMUSP00000022691 ; ENSMUSG00000022096 .
ENSMUST00000161069 ; ENSMUSP00000124816 ; ENSMUSG00000022096 .
GeneIDi 15460.
KEGGi mmu:15460.
UCSCi uc007uoj.1. mouse.

Organism-specific databases

CTDi 55806.
MGIi MGI:96223. Hr.

Phylogenomic databases

eggNOGi NOG243648.
GeneTreei ENSGT00530000063039.
HOGENOMi HOG000293150.
HOVERGENi HBG000171.
InParanoidi Q61645.
OrthoDBi EOG7PZRWJ.
PhylomeDBi Q61645.
TreeFami TF324723.

Miscellaneous databases

ChiTaRSi Hr. mouse.
NextBioi 288274.
PROi Q61645.
SOURCEi Search...

Gene expression databases

Bgeei Q61645.
CleanExi MM_HR.
ExpressionAtlasi Q61645. baseline and differential.
Genevestigatori Q61645.

Family and domain databases

InterProi IPR003347. JmjC_dom.
[Graphical view ]
Pfami PF02373. JmjC. 1 hit.
[Graphical view ]
SMARTi SM00558. JmjC. 1 hit.
[Graphical view ]
PROSITEi PS51184. JMJC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Retina.

Entry informationi

Entry nameiHAIR_MOUSE
AccessioniPrimary (citable) accession number: Q61645
Secondary accession number(s): Q80Y47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 15, 2003
Last modified: November 26, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3