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Protein

Glutamate receptor ionotropic, delta-1

Gene

Grid1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei73Essential for dimerization1 Publication1

GO - Molecular functioni

GO - Biological processi

  • social behavior Source: UniProtKB

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, delta-1
Short name:
GluD1
Short name:
GluR delta-1 subunit
Gene namesi
Name:Grid1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:95812. Grid1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 562ExtracellularSequence analysisAdd BLAST542
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Topological domaini584 – 637CytoplasmicSequence analysisAdd BLAST54
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Topological domaini659 – 830ExtracellularSequence analysisAdd BLAST172
Transmembranei831 – 851HelicalSequence analysisAdd BLAST21
Topological domaini852 – 1009CytoplasmicSequence analysisAdd BLAST158

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi73F → D: Abolishes dimerization. Weakly interacts with C1q domain of CBLN1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001156221 – 1009Glutamate receptor ionotropic, delta-1Add BLAST989

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 351Combined sources1 Publication
Disulfide bondi96 ↔ 128Combined sources1 Publication
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi294 ↔ 306Combined sources1 Publication
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei882PhosphoserineBy similarity1
Modified residuei1008PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61627.
PaxDbiQ61627.
PeptideAtlasiQ61627.
PRIDEiQ61627.

PTM databases

iPTMnetiQ61627.
PhosphoSitePlusiQ61627.

Expressioni

Tissue specificityi

Equally in forebrain and cerebellum.1 Publication

Gene expression databases

BgeeiENSMUSG00000041078.
CleanExiMM_GRID1.
GenevisibleiQ61627. MM.

Interactioni

Subunit structurei

Dimer (PubMed:27418511). Interacts (via extracellular N-terminal domain) with CBLN1 (via C1q domain), and more weakly with CBLN2 (PubMed:22220752, PubMed:27418511).2 Publications

Protein-protein interaction databases

IntActiQ61627. 1 interactor.
MINTiMINT-1791814.
STRINGi10090.ENSMUSP00000044009.

Structurei

Secondary structure

11009
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 33Combined sources11
Helixi35 – 51Combined sources17
Beta strandi53 – 55Combined sources3
Beta strandi59 – 67Combined sources9
Helixi72 – 84Combined sources13
Beta strandi90 – 93Combined sources4
Helixi96 – 109Combined sources14
Beta strandi113 – 115Combined sources3
Beta strandi140 – 142Combined sources3
Helixi149 – 159Combined sources11
Beta strandi163 – 169Combined sources7
Helixi175 – 178Combined sources4
Helixi179 – 187Combined sources9
Beta strandi191 – 196Combined sources6
Helixi201 – 211Combined sources11
Helixi214 – 223Combined sources10
Beta strandi226 – 231Combined sources6
Helixi233 – 245Combined sources13
Beta strandi254 – 258Combined sources5
Helixi264 – 273Combined sources10
Beta strandi275 – 283Combined sources9
Turni291 – 294Combined sources4
Turni304 – 306Combined sources3
Turni310 – 312Combined sources3
Helixi313 – 315Combined sources3
Helixi318 – 339Combined sources22
Beta strandi351 – 353Combined sources3
Helixi362 – 370Combined sources9
Beta strandi373 – 376Combined sources4
Beta strandi379 – 382Combined sources4
Beta strandi393 – 402Combined sources10
Turni403 – 405Combined sources3
Beta strandi406 – 416Combined sources11
Turni417 – 419Combined sources3
Beta strandi420 – 423Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KC9X-ray2.30A/B/C21-436[»]
ProteinModelPortaliQ61627.
SMRiQ61627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 436Interaction with CBLN11 PublicationAdd BLAST416

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1052. Eukaryota.
ENOG410XQQV. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000264260.
HOVERGENiHBG051840.
InParanoidiQ61627.
KOiK05206.
OMAiKDSHWVY.
OrthoDBiEOG091G010L.
TreeFamiTF352434.

Family and domain databases

InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
PRINTSiPR00177. NMDARECEPTOR.
SMARTiView protein in SMART
SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALTLWLLP WICQCVTVRA DSIIHIGAIF EENAAKDDRV FQLAVSDLSL
60 70 80 90 100
NDDILQSEKI TYSIKVIEAN NPFQAVQEAC DLMTQGILAL VTSTGCASAN
110 120 130 140 150
ALQSLTDAMH IPHLFVQRNP GGSPRTACHL NPSPDGEAYT LASRPPVRLN
160 170 180 190 200
DVMLRLVTEL RWQKFVMFYD SEYDIRGLQS FLDQASRLGL DVSLQKVDKN
210 220 230 240 250
ISHVFTSLFT TMKTEELNRY RDTLRRAILL LSPQGAHSFI NEAVETNLAS
260 270 280 290 300
KDSHWVFVNE EISDPEILDL VHSALGRMTV VRQIFPSAKD NQKCMRNNHR
310 320 330 340 350
ISSLLCDPQE GYLQMLQISN LYLYDSVLML ANAFHRKLED RKWHSMASLN
360 370 380 390 400
CIRKSTKPWN GGRSMLDTIK KGHITGLTGV MEFREDSSNP YVQFEILGTT
410 420 430 440 450
YSETFGKDMR KLATWDSEKG LNGSLQERPM GSRLQGLTLK VVTVLEEPFV
460 470 480 490 500
MVAENILGQP KRYKGFSIDV LDALAKALGF KYEIYQAPDG RYGHQLHNTS
510 520 530 540 550
WNGMIGELIS KRADLAISAI TITPERESVV DFSKRYMDYS VGILIKKPEE
560 570 580 590 600
KISIFSLFAP FDFAVWACIA AAIPVVGVLI FVLNRIQAVR SQSATQPRPS
610 620 630 640 650
ASATLHSAIW IVYGAFVQQG GESSVNSVAM RIVMGSWWLF TLIVCSSYTA
660 670 680 690 700
NLAAFLTVSR MDNPIRTFQD LSKQLEMSYG TVRDSAVYEY FRAKGTNPLE
710 720 730 740 750
QDSTFAELWR TISKNGGADN CVSNPSEGIR KAKKGNYAFL WDVAVVEYAA
760 770 780 790 800
LTDDDCSVTV IGNSISSKGY GIALQHGSPY RDLFSQRILE LQDTGDLDVL
810 820 830 840 850
KQKWWPHTGR CDLTSHSSTQ TEGKSLKLHS FAGVFCILAI GLLLACLVAA
860 870 880 890 900
LELWWNSNRC HQETPKEDKE VNLEQVHRRI NSLMDEDIAH KQISPASIEL
910 920 930 940 950
SALEMGGLAP SQALEPTREY QNTQLSVSTF LPEQSSHGTS RTLSSGPSSN
960 970 980 990 1000
LPLPLSSSAT MPSIQCKHRS PNGGLFRQSP VKTPIPMSFQ PVPGGVLPEA

LDTSHGTSI
Length:1,009
Mass (Da):112,210
Last modified:July 27, 2011 - v2
Checksum:i143243A1E3EBD660
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178L → F in BAA01041 (PubMed:1372507).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10171 mRNA. Translation: BAA01041.1.
AK138279 mRNA. Translation: BAE23610.1.
CT009532
, AC114572, AC154388, AC154730, AC163280, AC169510, CT030647 Genomic DNA. Translation: CAX15538.1.
CT030647
, AC114572, AC154388, AC154730, AC163280, AC169510, CT009532 Genomic DNA. Translation: CAX15982.1.
CH466573 Genomic DNA. Translation: EDL24889.1.
CCDSiCCDS26944.1.
PIRiJH0266.
RefSeqiNP_032192.2. NM_008166.2.
UniGeneiMm.121569.
Mm.413604.
Mm.483550.

Genome annotation databases

EnsembliENSMUST00000043349; ENSMUSP00000044009; ENSMUSG00000041078.
GeneIDi14803.
KEGGimmu:14803.
UCSCiuc007tbj.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiGRID1_MOUSE
AccessioniPrimary (citable) accession number: Q61627
Secondary accession number(s): Q3UUL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families