Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q61626 (GRIK5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate receptor ionotropic, kainate 5

Short name=GluK5
Alternative name(s):
Glutamate receptor KA-2
Short name=KA2
Glutamate receptor gamma-2
Short name=GluR gamma-2
Gene names
Name:Grik5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length979 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate = glutamate >> AMPA.

Subunit structure

Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell junction
Cell membrane
Membrane
Postsynaptic cell membrane
Synapse
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionIon channel
Ligand-gated ion channel
Receptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to glucose stimulus

Inferred from electronic annotation. Source: Ensembl

establishment of localization in cell

Inferred from electronic annotation. Source: Ensembl

ionotropic glutamate receptor signaling pathway

Inferred from genetic interaction Ref.1. Source: GOC

positive regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

protein retention in ER lumen

Inferred from electronic annotation. Source: Ensembl

receptor clustering

Inferred from electronic annotation. Source: Ensembl

regulation of excitatory postsynaptic membrane potential

Inferred from mutant phenotype PubMed 12533602. Source: MGI

regulation of membrane potential

Inferred from genetic interaction Ref.1. Source: MGI

regulation of synaptic vesicle fusion to presynaptic membrane

Inferred from mutant phenotype PubMed 12533602. Source: MGI

synaptic transmission, glutamatergic

Inferred from mutant phenotype PubMed 12533602. Source: MGI

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

dendrite

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum

Inferred from direct assay PubMed 16814779. Source: MGI

kainate selective glutamate receptor complex

Inferred from physical interaction PubMed 12954862PubMed 17174564. Source: MGI

membrane

Inferred from direct assay PubMed 12954862. Source: MGI

perikaryon

Inferred from electronic annotation. Source: Ensembl

postsynaptic density

Inferred from electronic annotation. Source: Ensembl

postsynaptic membrane

Inferred from direct assay PubMed 12954862. Source: MGI

presynaptic membrane

Inferred from direct assay PubMed 12954862. Source: MGI

terminal bouton

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionextracellular-glutamate-gated ion channel activity

Inferred from electronic annotation. Source: InterPro

kainate selective glutamate receptor activity

Inferred from genetic interaction Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1414 Potential
Chain15 – 979965Glutamate receptor ionotropic, kainate 5
PRO_0000011553

Regions

Topological domain15 – 544530Extracellular Potential
Transmembrane545 – 56521Helical; Potential
Topological domain566 – 62257Cytoplasmic Potential
Transmembrane623 – 64321Helical; Potential
Topological domain644 – 803160Extracellular Potential
Transmembrane804 – 82421Helical; Potential
Topological domain825 – 979155Cytoplasmic Potential
Compositional bias860 – 8667Poly-Arg

Amino acid modifications

Glycosylation2191N-linked (GlcNAc...) Potential
Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation2851N-linked (GlcNAc...) Potential
Glycosylation3221N-linked (GlcNAc...) Potential
Glycosylation3721N-linked (GlcNAc...) Potential
Glycosylation3941N-linked (GlcNAc...) Potential
Glycosylation4001N-linked (GlcNAc...) Potential
Glycosylation4071N-linked (GlcNAc...) Potential
Glycosylation4141N-linked (GlcNAc...) Potential
Glycosylation4781N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 292 By similarity
Disulfide bond83 ↔ 334 By similarity
Disulfide bond165 ↔ 170 By similarity

Experimental info

Sequence conflict6101I → V in BAA00899. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61626 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 313E2862746474B1

FASTA979109,276
        10         20         30         40         50         60 
MPAELLLLLI VAFANPSCQV LSSLRMAAIL DDQTVCGRGE RLALALAREQ INGIIEVPAK 

        70         80         90        100        110        120 
ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP ASASTVSHIC GEKEIPHIKV 

       130        140        150        160        170        180 
GPEETPRLQY LRFASVSLYP SNEDVSLAVS RILKSFNYPS ASLICAKAEC LLRLEELVRG 

       190        200        210        220        230        240 
FLISKETLSV RMLDDSRDPT PLLKEIRDDK VSTIIIDANA SISHLVLRKA SELGMTSAFY 

       250        260        270        280        290        300 
KYILTTMDFP ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMSWRE NCEASTYPGP 

       310        320        330        340        350        360 
ALSAALMFDA VHVVVSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL RMVEYDGLTG 

       370        380        390        400        410        420 
RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN ATTLDINLSQ TLANKTLVVT 

       430        440        450        460        470        480 
TILENPYVMR RPNFQALSGN ERFEGFCVDM LRELAELLRF RYRLRLVEDG LYGAPEPNGS 

       490        500        510        520        530        540 
WTGMVGELIN RKADLAVAAF TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD 

       550        560        570        580        590        600 
PFSPAVWLFM LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSLWFPV 

       610        620        630        640        650        660 
GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV PVESADDLAD 

       670        680        690        700        710        720 
QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV FVKSTEEGIA RVLNSRYAFL 

       730        740        750        760        770        780 
LESTMNEYHR RLNCNLTQIG GLLDTKGYGI GMPLGSPFRD EITLAILQLQ ENNRLEILKR 

       790        800        810        820        830        840 
KWWEGGRCPK EEDHRAKGLG MENIGGIFVV LICGLIIAVF VAVMEFIWST RRSAESEEVS 

       850        860        870        880        890        900 
VCQEMLQELR HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG 

       910        920        930        940        950        960 
AHGGPQRLLD DPGPPGGPRP QAPTPCTHVR VCQECRRIQA LRASGAGAPP RGLGTPAEAT 

       970 
SPPRPRPGPT GPRELTEHE 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate."
Sakimura K., Morita T., Kushiya E., Mishina M.
Neuron 8:267-274(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Forebrain.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10011 mRNA. Translation: BAA00899.1.
AC125468 Genomic DNA. No translation available.
CH466593 Genomic DNA. Translation: EDL24295.1.
PIRJH0589.
RefSeqNP_032194.2. NM_008168.2.
UniGeneMm.2879.

3D structure databases

ProteinModelPortalQ61626.
SMRQ61626. Positions 22-828.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61626. 1 interaction.
STRING10090.ENSMUSP00000003468.

PTM databases

PhosphoSiteQ61626.

Proteomic databases

PaxDbQ61626.
PRIDEQ61626.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003468; ENSMUSP00000003468; ENSMUSG00000003378.
GeneID14809.
KEGGmmu:14809.
UCSCuc009frh.2. mouse.

Organism-specific databases

CTD2901.
MGIMGI:95818. Grik5.

Phylogenomic databases

eggNOGNOG316680.
GeneTreeENSGT00740000114953.
HOGENOMHOG000234371.
HOVERGENHBG051839.
InParanoidQ61626.
KOK05205.
OMAGLNCNLT.
OrthoDBEOG71G9W6.
TreeFamTF334668.

Gene expression databases

ArrayExpressQ61626.
GenevestigatorQ61626.

Family and domain databases

InterProIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSPR00177. NMDARECEPTOR.
SMARTSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMSSF53822. SSF53822. 1 hit.
ProtoNetSearch...

Other

ChiTaRSGRIK5. mouse.
NextBio286991.
PROQ61626.
SOURCESearch...

Entry information

Entry nameGRIK5_MOUSE
AccessionPrimary (citable) accession number: Q61626
Secondary accession number(s): G5E822
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot