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Protein

Glutamate receptor ionotropic, kainate 5

Gene

Grik5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate = glutamate >> AMPA.

GO - Molecular functioni

  • extracellular-glutamate-gated ion channel activity Source: InterPro
  • kainate selective glutamate receptor activity Source: MGI

GO - Biological processi

  • cellular response to glucose stimulus Source: Ensembl
  • establishment of localization in cell Source: Ensembl
  • excitatory postsynaptic potential Source: MGI
  • positive regulation of neuron apoptotic process Source: Ensembl
  • protein retention in ER lumen Source: Ensembl
  • receptor clustering Source: Ensembl
  • regulation of membrane potential Source: MGI
  • regulation of synaptic vesicle fusion to presynaptic membrane Source: MGI
  • synaptic transmission, glutamatergic Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-451308. Activation of Ca-permeable Kainate Receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 5
Short name:
GluK5
Alternative name(s):
Glutamate receptor KA-2
Short name:
KA2
Glutamate receptor gamma-2
Short name:
GluR gamma-2
Gene namesi
Name:Grik5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95818. Grik5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini15 – 544ExtracellularSequence analysisAdd BLAST530
Transmembranei545 – 565HelicalSequence analysisAdd BLAST21
Topological domaini566 – 622CytoplasmicSequence analysisAdd BLAST57
Transmembranei623 – 643HelicalSequence analysisAdd BLAST21
Topological domaini644 – 803ExtracellularSequence analysisAdd BLAST160
Transmembranei804 – 824HelicalSequence analysisAdd BLAST21
Topological domaini825 – 979CytoplasmicSequence analysisAdd BLAST155

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • dendrite Source: Ensembl
  • endoplasmic reticulum Source: MGI
  • kainate selective glutamate receptor complex Source: MGI
  • membrane Source: MGI
  • perikaryon Source: Ensembl
  • postsynaptic density Source: Ensembl
  • postsynaptic membrane Source: MGI
  • presynaptic membrane Source: MGI
  • terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000001155315 – 979Glutamate receptor ionotropic, kainate 5Add BLAST965

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 292By similarity
Disulfide bondi83 ↔ 334By similarity
Disulfide bondi165 ↔ 170By similarity
Glycosylationi219N-linked (GlcNAc...)Sequence analysis1
Glycosylationi271N-linked (GlcNAc...)Sequence analysis1
Glycosylationi285N-linked (GlcNAc...)Sequence analysis1
Glycosylationi322N-linked (GlcNAc...)Sequence analysis1
Glycosylationi372N-linked (GlcNAc...)Sequence analysis1
Glycosylationi394N-linked (GlcNAc...)Sequence analysis1
Glycosylationi400N-linked (GlcNAc...)Sequence analysis1
Glycosylationi407N-linked (GlcNAc...)Sequence analysis1
Glycosylationi414N-linked (GlcNAc...)Sequence analysis1
Glycosylationi478N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61626.
PRIDEiQ61626.

PTM databases

iPTMnetiQ61626.
PhosphoSitePlusiQ61626.

Expressioni

Gene expression databases

BgeeiENSMUSG00000003378.
ExpressionAtlasiQ61626. baseline and differential.
GenevisibleiQ61626. MM.

Interactioni

Subunit structurei

Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity (By similarity).By similarity

Protein-protein interaction databases

IntActiQ61626. 1 interactor.
STRINGi10090.ENSMUSP00000003468.

Structurei

3D structure databases

ProteinModelPortaliQ61626.
SMRiQ61626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi860 – 866Poly-Arg7

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISR4. Eukaryota.
ENOG410XRUE. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiQ61626.
KOiK05205.
OMAiCTSSNIW.
OrthoDBiEOG091G02LN.
TreeFamiTF334668.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAELLLLLI VAFANPSCQV LSSLRMAAIL DDQTVCGRGE RLALALAREQ
60 70 80 90 100
INGIIEVPAK ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP
110 120 130 140 150
ASASTVSHIC GEKEIPHIKV GPEETPRLQY LRFASVSLYP SNEDVSLAVS
160 170 180 190 200
RILKSFNYPS ASLICAKAEC LLRLEELVRG FLISKETLSV RMLDDSRDPT
210 220 230 240 250
PLLKEIRDDK VSTIIIDANA SISHLVLRKA SELGMTSAFY KYILTTMDFP
260 270 280 290 300
ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMSWRE NCEASTYPGP
310 320 330 340 350
ALSAALMFDA VHVVVSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL
360 370 380 390 400
RMVEYDGLTG RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN
410 420 430 440 450
ATTLDINLSQ TLANKTLVVT TILENPYVMR RPNFQALSGN ERFEGFCVDM
460 470 480 490 500
LRELAELLRF RYRLRLVEDG LYGAPEPNGS WTGMVGELIN RKADLAVAAF
510 520 530 540 550
TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD PFSPAVWLFM
560 570 580 590 600
LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSLWFPV
610 620 630 640 650
GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV
660 670 680 690 700
PVESADDLAD QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV
710 720 730 740 750
FVKSTEEGIA RVLNSRYAFL LESTMNEYHR RLNCNLTQIG GLLDTKGYGI
760 770 780 790 800
GMPLGSPFRD EITLAILQLQ ENNRLEILKR KWWEGGRCPK EEDHRAKGLG
810 820 830 840 850
MENIGGIFVV LICGLIIAVF VAVMEFIWST RRSAESEEVS VCQEMLQELR
860 870 880 890 900
HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG
910 920 930 940 950
AHGGPQRLLD DPGPPGGPRP QAPTPCTHVR VCQECRRIQA LRASGAGAPP
960 970
RGLGTPAEAT SPPRPRPGPT GPRELTEHE
Length:979
Mass (Da):109,276
Last modified:October 3, 2012 - v2
Checksum:i313E2862746474B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti610I → V in BAA00899 (PubMed:1310861).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10011 mRNA. Translation: BAA00899.1.
AC125468 Genomic DNA. No translation available.
CH466593 Genomic DNA. Translation: EDL24295.1.
CCDSiCCDS20970.1.
PIRiJH0589.
RefSeqiNP_032194.2. NM_008168.2.
UniGeneiMm.2879.

Genome annotation databases

EnsembliENSMUST00000003468; ENSMUSP00000003468; ENSMUSG00000003378.
GeneIDi14809.
KEGGimmu:14809.
UCSCiuc009frh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10011 mRNA. Translation: BAA00899.1.
AC125468 Genomic DNA. No translation available.
CH466593 Genomic DNA. Translation: EDL24295.1.
CCDSiCCDS20970.1.
PIRiJH0589.
RefSeqiNP_032194.2. NM_008168.2.
UniGeneiMm.2879.

3D structure databases

ProteinModelPortaliQ61626.
SMRiQ61626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61626. 1 interactor.
STRINGi10090.ENSMUSP00000003468.

PTM databases

iPTMnetiQ61626.
PhosphoSitePlusiQ61626.

Proteomic databases

PaxDbiQ61626.
PRIDEiQ61626.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003468; ENSMUSP00000003468; ENSMUSG00000003378.
GeneIDi14809.
KEGGimmu:14809.
UCSCiuc009frh.2. mouse.

Organism-specific databases

CTDi2901.
MGIiMGI:95818. Grik5.

Phylogenomic databases

eggNOGiENOG410ISR4. Eukaryota.
ENOG410XRUE. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiQ61626.
KOiK05205.
OMAiCTSSNIW.
OrthoDBiEOG091G02LN.
TreeFamiTF334668.

Enzyme and pathway databases

ReactomeiR-MMU-451308. Activation of Ca-permeable Kainate Receptor.

Miscellaneous databases

ChiTaRSiGrik5. mouse.
PROiQ61626.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003378.
ExpressionAtlasiQ61626. baseline and differential.
GenevisibleiQ61626. MM.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGRIK5_MOUSE
AccessioniPrimary (citable) accession number: Q61626
Secondary accession number(s): G5E822
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.