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Q61626

- GRIK5_MOUSE

UniProt

Q61626 - GRIK5_MOUSE

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Protein
Glutamate receptor ionotropic, kainate 5
Gene
Grik5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate = glutamate >> AMPA.

GO - Molecular functioni

  1. extracellular-glutamate-gated ion channel activity Source: RefGenome
  2. kainate selective glutamate receptor activity Source: MGI
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. cellular response to glucose stimulus Source: Ensembl
  2. establishment of localization in cell Source: Ensembl
  3. ion transmembrane transport Source: GOC
  4. ionotropic glutamate receptor signaling pathway Source: GOC
  5. positive regulation of neuron apoptotic process Source: Ensembl
  6. protein retention in ER lumen Source: Ensembl
  7. receptor clustering Source: Ensembl
  8. regulation of excitatory postsynaptic membrane potential Source: MGI
  9. regulation of membrane potential Source: MGI
  10. regulation of synaptic vesicle fusion to presynaptic membrane Source: MGI
  11. synaptic transmission, glutamatergic Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198694. Activation of Ca-permeable Kainate Receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 5
Short name:
GluK5
Alternative name(s):
Glutamate receptor KA-2
Short name:
KA2
Glutamate receptor gamma-2
Short name:
GluR gamma-2
Gene namesi
Name:Grik5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:95818. Grik5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini15 – 544530Extracellular Reviewed prediction
Add
BLAST
Transmembranei545 – 56521Helical; Reviewed prediction
Add
BLAST
Topological domaini566 – 62257Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei623 – 64321Helical; Reviewed prediction
Add
BLAST
Topological domaini644 – 803160Extracellular Reviewed prediction
Add
BLAST
Transmembranei804 – 82421Helical; Reviewed prediction
Add
BLAST
Topological domaini825 – 979155Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dendrite Source: RefGenome
  3. endoplasmic reticulum Source: MGI
  4. kainate selective glutamate receptor complex Source: MGI
  5. membrane Source: MGI
  6. perikaryon Source: Ensembl
  7. postsynaptic density Source: Ensembl
  8. postsynaptic membrane Source: MGI
  9. presynaptic membrane Source: MGI
  10. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414 Reviewed prediction
Add
BLAST
Chaini15 – 979965Glutamate receptor ionotropic, kainate 5
PRO_0000011553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 292 By similarity
Disulfide bondi83 ↔ 334 By similarity
Disulfide bondi165 ↔ 170 By similarity
Glycosylationi219 – 2191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi271 – 2711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi285 – 2851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi322 – 3221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi372 – 3721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi394 – 3941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi400 – 4001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi407 – 4071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi414 – 4141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi478 – 4781N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61626.
PRIDEiQ61626.

PTM databases

PhosphoSiteiQ61626.

Expressioni

Gene expression databases

ArrayExpressiQ61626.
GenevestigatoriQ61626.

Interactioni

Subunit structurei

Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity By similarity.

Protein-protein interaction databases

IntActiQ61626. 1 interaction.
STRINGi10090.ENSMUSP00000003468.

Structurei

3D structure databases

ProteinModelPortaliQ61626.
SMRiQ61626. Positions 22-828.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi860 – 8667Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG316680.
GeneTreeiENSGT00740000114953.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiQ61626.
KOiK05205.
OMAiGLNCNLT.
OrthoDBiEOG71G9W6.
TreeFamiTF334668.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61626-1 [UniParc]FASTAAdd to Basket

« Hide

MPAELLLLLI VAFANPSCQV LSSLRMAAIL DDQTVCGRGE RLALALAREQ    50
INGIIEVPAK ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP 100
ASASTVSHIC GEKEIPHIKV GPEETPRLQY LRFASVSLYP SNEDVSLAVS 150
RILKSFNYPS ASLICAKAEC LLRLEELVRG FLISKETLSV RMLDDSRDPT 200
PLLKEIRDDK VSTIIIDANA SISHLVLRKA SELGMTSAFY KYILTTMDFP 250
ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMSWRE NCEASTYPGP 300
ALSAALMFDA VHVVVSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL 350
RMVEYDGLTG RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN 400
ATTLDINLSQ TLANKTLVVT TILENPYVMR RPNFQALSGN ERFEGFCVDM 450
LRELAELLRF RYRLRLVEDG LYGAPEPNGS WTGMVGELIN RKADLAVAAF 500
TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD PFSPAVWLFM 550
LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSLWFPV 600
GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV 650
PVESADDLAD QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV 700
FVKSTEEGIA RVLNSRYAFL LESTMNEYHR RLNCNLTQIG GLLDTKGYGI 750
GMPLGSPFRD EITLAILQLQ ENNRLEILKR KWWEGGRCPK EEDHRAKGLG 800
MENIGGIFVV LICGLIIAVF VAVMEFIWST RRSAESEEVS VCQEMLQELR 850
HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG 900
AHGGPQRLLD DPGPPGGPRP QAPTPCTHVR VCQECRRIQA LRASGAGAPP 950
RGLGTPAEAT SPPRPRPGPT GPRELTEHE 979
Length:979
Mass (Da):109,276
Last modified:October 3, 2012 - v2
Checksum:i313E2862746474B1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti610 – 6101I → V in BAA00899. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10011 mRNA. Translation: BAA00899.1.
AC125468 Genomic DNA. No translation available.
CH466593 Genomic DNA. Translation: EDL24295.1.
CCDSiCCDS20970.1.
PIRiJH0589.
RefSeqiNP_032194.2. NM_008168.2.
UniGeneiMm.2879.

Genome annotation databases

EnsembliENSMUST00000003468; ENSMUSP00000003468; ENSMUSG00000003378.
GeneIDi14809.
KEGGimmu:14809.
UCSCiuc009frh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10011 mRNA. Translation: BAA00899.1 .
AC125468 Genomic DNA. No translation available.
CH466593 Genomic DNA. Translation: EDL24295.1 .
CCDSi CCDS20970.1.
PIRi JH0589.
RefSeqi NP_032194.2. NM_008168.2.
UniGenei Mm.2879.

3D structure databases

ProteinModelPortali Q61626.
SMRi Q61626. Positions 22-828.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61626. 1 interaction.
STRINGi 10090.ENSMUSP00000003468.

Chemistry

GuidetoPHARMACOLOGYi 454.

PTM databases

PhosphoSitei Q61626.

Proteomic databases

PaxDbi Q61626.
PRIDEi Q61626.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003468 ; ENSMUSP00000003468 ; ENSMUSG00000003378 .
GeneIDi 14809.
KEGGi mmu:14809.
UCSCi uc009frh.2. mouse.

Organism-specific databases

CTDi 2901.
MGIi MGI:95818. Grik5.

Phylogenomic databases

eggNOGi NOG316680.
GeneTreei ENSGT00740000114953.
HOGENOMi HOG000234371.
HOVERGENi HBG051839.
InParanoidi Q61626.
KOi K05205.
OMAi GLNCNLT.
OrthoDBi EOG71G9W6.
TreeFami TF334668.

Enzyme and pathway databases

Reactomei REACT_198694. Activation of Ca-permeable Kainate Receptor.

Miscellaneous databases

ChiTaRSi GRIK5. mouse.
NextBioi 286991.
PROi Q61626.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61626.
Genevestigatori Q61626.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate."
    Sakimura K., Morita T., Kushiya E., Mishina M.
    Neuron 8:267-274(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Forebrain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGRIK5_MOUSE
AccessioniPrimary (citable) accession number: Q61626
Secondary accession number(s): G5E822
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi