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Q61626

- GRIK5_MOUSE

UniProt

Q61626 - GRIK5_MOUSE

Protein

Glutamate receptor ionotropic, kainate 5

Gene

Grik5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate = glutamate >> AMPA.

    GO - Molecular functioni

    1. extracellular-glutamate-gated ion channel activity Source: RefGenome
    2. kainate selective glutamate receptor activity Source: MGI
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to glucose stimulus Source: Ensembl
    2. establishment of localization in cell Source: Ensembl
    3. ionotropic glutamate receptor signaling pathway Source: GOC
    4. ion transmembrane transport Source: GOC
    5. positive regulation of neuron apoptotic process Source: Ensembl
    6. protein retention in ER lumen Source: Ensembl
    7. receptor clustering Source: Ensembl
    8. regulation of excitatory postsynaptic membrane potential Source: MGI
    9. regulation of membrane potential Source: MGI
    10. regulation of synaptic vesicle fusion to presynaptic membrane Source: MGI
    11. synaptic transmission, glutamatergic Source: MGI

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198694. Activation of Ca-permeable Kainate Receptor.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate receptor ionotropic, kainate 5
    Short name:
    GluK5
    Alternative name(s):
    Glutamate receptor KA-2
    Short name:
    KA2
    Glutamate receptor gamma-2
    Short name:
    GluR gamma-2
    Gene namesi
    Name:Grik5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:95818. Grik5.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. dendrite Source: RefGenome
    3. endoplasmic reticulum Source: MGI
    4. kainate selective glutamate receptor complex Source: MGI
    5. membrane Source: MGI
    6. perikaryon Source: Ensembl
    7. postsynaptic density Source: Ensembl
    8. postsynaptic membrane Source: MGI
    9. presynaptic membrane Source: MGI
    10. terminal bouton Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1414Sequence AnalysisAdd
    BLAST
    Chaini15 – 979965Glutamate receptor ionotropic, kainate 5PRO_0000011553Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 292By similarity
    Disulfide bondi83 ↔ 334By similarity
    Disulfide bondi165 ↔ 170By similarity
    Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ61626.
    PRIDEiQ61626.

    PTM databases

    PhosphoSiteiQ61626.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61626.
    GenevestigatoriQ61626.

    Interactioni

    Subunit structurei

    Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ61626. 1 interaction.
    STRINGi10090.ENSMUSP00000003468.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61626.
    SMRiQ61626. Positions 22-828.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini15 – 544530ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini566 – 62257CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini644 – 803160ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini825 – 979155CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei545 – 56521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei623 – 64321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei804 – 82421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi860 – 8667Poly-Arg

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG316680.
    GeneTreeiENSGT00740000114953.
    HOGENOMiHOG000234371.
    HOVERGENiHBG051839.
    InParanoidiQ61626.
    KOiK05205.
    OMAiGLNCNLT.
    OrthoDBiEOG71G9W6.
    TreeFamiTF334668.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF10613. Lig_chan-Glu_bd. 1 hit.
    [Graphical view]
    PRINTSiPR00177. NMDARECEPTOR.
    SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view]
    SUPFAMiSSF53822. SSF53822. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61626-1 [UniParc]FASTAAdd to Basket

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    MPAELLLLLI VAFANPSCQV LSSLRMAAIL DDQTVCGRGE RLALALAREQ    50
    INGIIEVPAK ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP 100
    ASASTVSHIC GEKEIPHIKV GPEETPRLQY LRFASVSLYP SNEDVSLAVS 150
    RILKSFNYPS ASLICAKAEC LLRLEELVRG FLISKETLSV RMLDDSRDPT 200
    PLLKEIRDDK VSTIIIDANA SISHLVLRKA SELGMTSAFY KYILTTMDFP 250
    ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMSWRE NCEASTYPGP 300
    ALSAALMFDA VHVVVSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL 350
    RMVEYDGLTG RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN 400
    ATTLDINLSQ TLANKTLVVT TILENPYVMR RPNFQALSGN ERFEGFCVDM 450
    LRELAELLRF RYRLRLVEDG LYGAPEPNGS WTGMVGELIN RKADLAVAAF 500
    TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD PFSPAVWLFM 550
    LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSLWFPV 600
    GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV 650
    PVESADDLAD QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV 700
    FVKSTEEGIA RVLNSRYAFL LESTMNEYHR RLNCNLTQIG GLLDTKGYGI 750
    GMPLGSPFRD EITLAILQLQ ENNRLEILKR KWWEGGRCPK EEDHRAKGLG 800
    MENIGGIFVV LICGLIIAVF VAVMEFIWST RRSAESEEVS VCQEMLQELR 850
    HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG 900
    AHGGPQRLLD DPGPPGGPRP QAPTPCTHVR VCQECRRIQA LRASGAGAPP 950
    RGLGTPAEAT SPPRPRPGPT GPRELTEHE 979
    Length:979
    Mass (Da):109,276
    Last modified:October 3, 2012 - v2
    Checksum:i313E2862746474B1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti610 – 6101I → V in BAA00899. (PubMed:1310861)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10011 mRNA. Translation: BAA00899.1.
    AC125468 Genomic DNA. No translation available.
    CH466593 Genomic DNA. Translation: EDL24295.1.
    CCDSiCCDS20970.1.
    PIRiJH0589.
    RefSeqiNP_032194.2. NM_008168.2.
    UniGeneiMm.2879.

    Genome annotation databases

    EnsembliENSMUST00000003468; ENSMUSP00000003468; ENSMUSG00000003378.
    GeneIDi14809.
    KEGGimmu:14809.
    UCSCiuc009frh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10011 mRNA. Translation: BAA00899.1 .
    AC125468 Genomic DNA. No translation available.
    CH466593 Genomic DNA. Translation: EDL24295.1 .
    CCDSi CCDS20970.1.
    PIRi JH0589.
    RefSeqi NP_032194.2. NM_008168.2.
    UniGenei Mm.2879.

    3D structure databases

    ProteinModelPortali Q61626.
    SMRi Q61626. Positions 22-828.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61626. 1 interaction.
    STRINGi 10090.ENSMUSP00000003468.

    Chemistry

    GuidetoPHARMACOLOGYi 454.

    PTM databases

    PhosphoSitei Q61626.

    Proteomic databases

    PaxDbi Q61626.
    PRIDEi Q61626.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003468 ; ENSMUSP00000003468 ; ENSMUSG00000003378 .
    GeneIDi 14809.
    KEGGi mmu:14809.
    UCSCi uc009frh.2. mouse.

    Organism-specific databases

    CTDi 2901.
    MGIi MGI:95818. Grik5.

    Phylogenomic databases

    eggNOGi NOG316680.
    GeneTreei ENSGT00740000114953.
    HOGENOMi HOG000234371.
    HOVERGENi HBG051839.
    InParanoidi Q61626.
    KOi K05205.
    OMAi GLNCNLT.
    OrthoDBi EOG71G9W6.
    TreeFami TF334668.

    Enzyme and pathway databases

    Reactomei REACT_198694. Activation of Ca-permeable Kainate Receptor.

    Miscellaneous databases

    ChiTaRSi GRIK5. mouse.
    NextBioi 286991.
    PROi Q61626.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61626.
    Genevestigatori Q61626.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF10613. Lig_chan-Glu_bd. 1 hit.
    [Graphical view ]
    PRINTSi PR00177. NMDARECEPTOR.
    SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53822. SSF53822. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate."
      Sakimura K., Morita T., Kushiya E., Mishina M.
      Neuron 8:267-274(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Forebrain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGRIK5_MOUSE
    AccessioniPrimary (citable) accession number: Q61626
    Secondary accession number(s): G5E822
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3