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Q61626 (GRIK5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamate receptor, ionotropic kainate 5
Alternative name(s):
Glutamate receptor KA-2
Short name=KA2
Glutamate receptor gamma-2
Short name=GluR gamma-2
Gene names
Name:Grik5
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length979 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate = glutamate >> AMPA.

Subunit structure

Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1414 Potential
Chain15 – 979965Glutamate receptor, ionotropic kainate 5
PRO_0000011553

Regions

Topological domain15 – 544530Extracellular Potential
Transmembrane545 – 56521Helical; Potential
Topological domain566 – 62257Cytoplasmic Potential
Transmembrane623 – 64321Helical; Potential
Topological domain644 – 803160Extracellular Potential
Transmembrane804 – 82421Helical; Potential
Topological domain825 – 979155Cytoplasmic Potential
Compositional bias860 – 8667Poly-Arg

Amino acid modifications

Glycosylation2191N-linked (GlcNAc...) Potential
Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation2851N-linked (GlcNAc...) Potential
Glycosylation3221N-linked (GlcNAc...) Potential
Glycosylation3721N-linked (GlcNAc...) Potential
Glycosylation3941N-linked (GlcNAc...) Potential
Glycosylation4001N-linked (GlcNAc...) Potential
Glycosylation4071N-linked (GlcNAc...) Potential
Glycosylation4141N-linked (GlcNAc...) Potential
Glycosylation4781N-linked (GlcNAc...) Potential

Natural variations

Natural variant6101V → I.

Sequences

Sequence LengthMass (Da)Tools
Q61626 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 123C071BAF0C4E16

FASTA979109,262
        10         20         30         40         50         60 
MPAELLLLLI VAFANPSCQV LSSLRMAAIL DDQTVCGRGE RLALALAREQ INGIIEVPAK 

        70         80         90        100        110        120 
ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP ASASTVSHIC GEKEIPHIKV 

       130        140        150        160        170        180 
GPEETPRLQY LRFASVSLYP SNEDVSLAVS RILKSFNYPS ASLICAKAEC LLRLEELVRG 

       190        200        210        220        230        240 
FLISKETLSV RMLDDSRDPT PLLKEIRDDK VSTIIIDANA SISHLVLRKA SELGMTSAFY 

       250        260        270        280        290        300 
KYILTTMDFP ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMSWRE NCEASTYPGP 

       310        320        330        340        350        360 
ALSAALMFDA VHVVVSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL RMVEYDGLTG 

       370        380        390        400        410        420 
RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN ATTLDINLSQ TLANKTLVVT 

       430        440        450        460        470        480 
TILENPYVMR RPNFQALSGN ERFEGFCVDM LRELAELLRF RYRLRLVEDG LYGAPEPNGS 

       490        500        510        520        530        540 
WTGMVGELIN RKADLAVAAF TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD 

       550        560        570        580        590        600 
PFSPAVWLFM LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSLWFPV 

       610        620        630        640        650        660 
GGFMQQGSEV MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV PVESADDLAD 

       670        680        690        700        710        720 
QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV FVKSTEEGIA RVLNSRYAFL 

       730        740        750        760        770        780 
LESTMNEYHR RLNCNLTQIG GLLDTKGYGI GMPLGSPFRD EITLAILQLQ ENNRLEILKR 

       790        800        810        820        830        840 
KWWEGGRCPK EEDHRAKGLG MENIGGIFVV LICGLIIAVF VAVMEFIWST RRSAESEEVS 

       850        860        870        880        890        900 
VCQEMLQELR HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG 

       910        920        930        940        950        960 
AHGGPQRLLD DPGPPGGPRP QAPTPCTHVR VCQECRRIQA LRASGAGAPP RGLGTPAEAT 

       970 
SPPRPRPGPT GPRELTEHE

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References

[1]"Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate."
Sakimura K., Morita T., Kushiya E., Mishina M.
Neuron 8:267-274(1992) [PubMed: 1310861] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Forebrain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D10011 mRNA. Translation: BAA00899.1.
IPIIPI00123538.
PIRJH0589.
UniGeneMm.2879.

3D structure databases

ProteinModelPortalQ61626.
SMRQ61626. Positions 22-829.
ModBaseSearch...

Protein-protein interaction databases

IntActQ61626. 1 interaction.
STRINGQ61626.

Proteomic databases

PRIDEQ61626.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:95818. Grik5.

Phylogenomic databases

HOGENOMHBG381523.
HOVERGENHBG051839.
InParanoidQ61626.
OrthoDBEOG4RV2QP.

Gene expression databases

ArrayExpressQ61626.
BgeeQ61626.
GenevestigatorQ61626.
GermOnlineENSMUSG00000003378. Mus musculus.

Family and domain databases

InterProIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
[Graphical view]
PfamPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSPR00177. NMDARECEPTOR.
SMARTSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameGRIK5_MOUSE
AccessionPrimary (citable) accession number: Q61626
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 19, 2011
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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