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Q61626

- GRIK5_MOUSE

UniProt

Q61626 - GRIK5_MOUSE

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Protein

Glutamate receptor ionotropic, kainate 5

Gene

Grik5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate = glutamate >> AMPA.

GO - Molecular functioni

  1. extracellular-glutamate-gated ion channel activity Source: RefGenome
  2. kainate selective glutamate receptor activity Source: MGI

GO - Biological processi

  1. cellular response to glucose stimulus Source: Ensembl
  2. establishment of localization in cell Source: Ensembl
  3. ionotropic glutamate receptor signaling pathway Source: GOC
  4. ion transmembrane transport Source: GOC
  5. positive regulation of neuron apoptotic process Source: Ensembl
  6. protein retention in ER lumen Source: Ensembl
  7. receptor clustering Source: Ensembl
  8. regulation of excitatory postsynaptic membrane potential Source: MGI
  9. regulation of membrane potential Source: MGI
  10. regulation of synaptic vesicle fusion to presynaptic membrane Source: MGI
  11. synaptic transmission, glutamatergic Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198694. Activation of Ca-permeable Kainate Receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 5
Short name:
GluK5
Alternative name(s):
Glutamate receptor KA-2
Short name:
KA2
Glutamate receptor gamma-2
Short name:
GluR gamma-2
Gene namesi
Name:Grik5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:95818. Grik5.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dendrite Source: RefGenome
  3. endoplasmic reticulum Source: MGI
  4. kainate selective glutamate receptor complex Source: MGI
  5. membrane Source: MGI
  6. perikaryon Source: Ensembl
  7. postsynaptic density Source: Ensembl
  8. postsynaptic membrane Source: MGI
  9. presynaptic membrane Source: MGI
  10. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414Sequence AnalysisAdd
BLAST
Chaini15 – 979965Glutamate receptor ionotropic, kainate 5PRO_0000011553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 292By similarity
Disulfide bondi83 ↔ 334By similarity
Disulfide bondi165 ↔ 170By similarity
Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61626.
PRIDEiQ61626.

PTM databases

PhosphoSiteiQ61626.

Expressioni

Gene expression databases

ExpressionAtlasiQ61626. baseline and differential.
GenevestigatoriQ61626.

Interactioni

Subunit structurei

Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity By similarity.By similarity

Protein-protein interaction databases

IntActiQ61626. 1 interaction.
STRINGi10090.ENSMUSP00000003468.

Structurei

3D structure databases

ProteinModelPortaliQ61626.
SMRiQ61626. Positions 20-834.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini15 – 544530ExtracellularSequence AnalysisAdd
BLAST
Topological domaini566 – 62257CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini644 – 803160ExtracellularSequence AnalysisAdd
BLAST
Topological domaini825 – 979155CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei545 – 56521HelicalSequence AnalysisAdd
BLAST
Transmembranei623 – 64321HelicalSequence AnalysisAdd
BLAST
Transmembranei804 – 82421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi860 – 8667Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG316680.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiQ61626.
KOiK05205.
OMAiGLNCNLT.
OrthoDBiEOG71G9W6.
TreeFamiTF334668.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61626-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAELLLLLI VAFANPSCQV LSSLRMAAIL DDQTVCGRGE RLALALAREQ
60 70 80 90 100
INGIIEVPAK ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP
110 120 130 140 150
ASASTVSHIC GEKEIPHIKV GPEETPRLQY LRFASVSLYP SNEDVSLAVS
160 170 180 190 200
RILKSFNYPS ASLICAKAEC LLRLEELVRG FLISKETLSV RMLDDSRDPT
210 220 230 240 250
PLLKEIRDDK VSTIIIDANA SISHLVLRKA SELGMTSAFY KYILTTMDFP
260 270 280 290 300
ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMSWRE NCEASTYPGP
310 320 330 340 350
ALSAALMFDA VHVVVSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL
360 370 380 390 400
RMVEYDGLTG RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN
410 420 430 440 450
ATTLDINLSQ TLANKTLVVT TILENPYVMR RPNFQALSGN ERFEGFCVDM
460 470 480 490 500
LRELAELLRF RYRLRLVEDG LYGAPEPNGS WTGMVGELIN RKADLAVAAF
510 520 530 540 550
TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD PFSPAVWLFM
560 570 580 590 600
LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSLWFPV
610 620 630 640 650
GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV
660 670 680 690 700
PVESADDLAD QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV
710 720 730 740 750
FVKSTEEGIA RVLNSRYAFL LESTMNEYHR RLNCNLTQIG GLLDTKGYGI
760 770 780 790 800
GMPLGSPFRD EITLAILQLQ ENNRLEILKR KWWEGGRCPK EEDHRAKGLG
810 820 830 840 850
MENIGGIFVV LICGLIIAVF VAVMEFIWST RRSAESEEVS VCQEMLQELR
860 870 880 890 900
HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG
910 920 930 940 950
AHGGPQRLLD DPGPPGGPRP QAPTPCTHVR VCQECRRIQA LRASGAGAPP
960 970
RGLGTPAEAT SPPRPRPGPT GPRELTEHE
Length:979
Mass (Da):109,276
Last modified:October 3, 2012 - v2
Checksum:i313E2862746474B1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti610 – 6101I → V in BAA00899. (PubMed:1310861)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10011 mRNA. Translation: BAA00899.1.
AC125468 Genomic DNA. No translation available.
CH466593 Genomic DNA. Translation: EDL24295.1.
CCDSiCCDS20970.1.
PIRiJH0589.
RefSeqiNP_032194.2. NM_008168.2.
UniGeneiMm.2879.

Genome annotation databases

EnsembliENSMUST00000003468; ENSMUSP00000003468; ENSMUSG00000003378.
GeneIDi14809.
KEGGimmu:14809.
UCSCiuc009frh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10011 mRNA. Translation: BAA00899.1 .
AC125468 Genomic DNA. No translation available.
CH466593 Genomic DNA. Translation: EDL24295.1 .
CCDSi CCDS20970.1.
PIRi JH0589.
RefSeqi NP_032194.2. NM_008168.2.
UniGenei Mm.2879.

3D structure databases

ProteinModelPortali Q61626.
SMRi Q61626. Positions 20-834.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61626. 1 interaction.
STRINGi 10090.ENSMUSP00000003468.

Chemistry

GuidetoPHARMACOLOGYi 454.

PTM databases

PhosphoSitei Q61626.

Proteomic databases

PaxDbi Q61626.
PRIDEi Q61626.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003468 ; ENSMUSP00000003468 ; ENSMUSG00000003378 .
GeneIDi 14809.
KEGGi mmu:14809.
UCSCi uc009frh.2. mouse.

Organism-specific databases

CTDi 2901.
MGIi MGI:95818. Grik5.

Phylogenomic databases

eggNOGi NOG316680.
GeneTreei ENSGT00760000118920.
HOGENOMi HOG000234371.
HOVERGENi HBG051839.
InParanoidi Q61626.
KOi K05205.
OMAi GLNCNLT.
OrthoDBi EOG71G9W6.
TreeFami TF334668.

Enzyme and pathway databases

Reactomei REACT_198694. Activation of Ca-permeable Kainate Receptor.

Miscellaneous databases

ChiTaRSi GRIK5. mouse.
NextBioi 286991.
PROi Q61626.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi Q61626. baseline and differential.
Genevestigatori Q61626.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate."
    Sakimura K., Morita T., Kushiya E., Mishina M.
    Neuron 8:267-274(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Forebrain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGRIK5_MOUSE
AccessioniPrimary (citable) accession number: Q61626
Secondary accession number(s): G5E822
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3