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Q61625

- GRID2_MOUSE

UniProt

Q61625 - GRID2_MOUSE

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Protein
Glutamate receptor ionotropic, delta-2
Gene
Grid2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

GO - Molecular functioni

  1. PDZ domain binding Source: BHF-UCL
  2. extracellular-glutamate-gated ion channel activity Source: RefGenome
  3. ionotropic glutamate receptor activity Source: RefGenome
  4. protein binding Source: IntAct
  5. scaffold protein binding Source: BHF-UCL

GO - Biological processi

  1. cellular protein localization Source: BHF-UCL
  2. cerebellar granule cell differentiation Source: BHF-UCL
  3. heterophilic cell-cell adhesion Source: BHF-UCL
  4. ion transmembrane transport Source: RefGenome
  5. ionotropic glutamate receptor signaling pathway Source: RefGenome
  6. prepulse inhibition Source: MGI
  7. regulation of excitatory postsynaptic membrane potential Source: MGI
  8. regulation of neuron apoptotic process Source: MGI
  9. regulation of neuron projection development Source: MGI
  10. synaptic transmission, glutamatergic Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.10.1.8. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, delta-2
Short name:
GluD2
Short name:
GluR delta-2 subunit
Gene namesi
Name:Grid2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:95813. Grid2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 566543Extracellular Reviewed prediction
Add
BLAST
Transmembranei567 – 58721Helical; Reviewed prediction
Add
BLAST
Topological domaini588 – 63548Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei636 – 65621Helical; Reviewed prediction
Add
BLAST
Topological domaini657 – 830174Extracellular Reviewed prediction
Add
BLAST
Transmembranei831 – 85121Helical; Reviewed prediction
Add
BLAST
Topological domaini852 – 1007156Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dendritic spine Source: BHF-UCL
  3. ionotropic glutamate receptor complex Source: BHF-UCL
  4. membrane Source: MGI
  5. plasma membrane Source: BHF-UCL
  6. postsynaptic membrane Source: BHF-UCL
  7. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Defects in Grid2 are the cause of the Lurcher phenotype. Heterozygous animals display a characteristic swaying of the hind quarters and jerky up and down movements following cerebellar Purkinje cell degeneration during postnatal development. Homozygous animals die shortly after birth because of a massive loss of midbrain and hindbrain neurons during late embryogenesis.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi920 – 9201S → A: Abolishes interaction with SHANK1 and SHANK2. 1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 1007984Glutamate receptor ionotropic, delta-2
PRO_0000011565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi426 – 4261N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ61625.
PaxDbiQ61625.
PRIDEiQ61625.

PTM databases

PhosphoSiteiQ61625.

Expressioni

Tissue specificityi

Expressed selectively in cerebellar Purkinje cells where it is localized in dendritic spines.2 Publications

Gene expression databases

BgeeiQ61625.
CleanExiMM_GRID2.
GenevestigatoriQ61625.

Interactioni

Subunit structurei

Interacts with AIP1 and AP4M1. Interacts with EML2 By similarity. Interacts with BECN1, GOPC, GRID2IP, SHANK1 and SHANK2. Interacts with CBLN1 and CBLN2, but not with CBLN4. CBLN1-binding is calcium-independent.

Binary interactionsi

WithEntry#Exp.IntActNotes
Cbln1Q9R1718EBI-2794106,EBI-2794140
GopcQ8BH605EBI-2794106,EBI-296357

Protein-protein interaction databases

BioGridi200062. 3 interactions.
IntActiQ61625. 37 interactions.
MINTiMINT-126960.
STRINGi10090.ENSMUSP00000093536.

Structurei

3D structure databases

ProteinModelPortaliQ61625.
SMRiQ61625. Positions 26-426, 441-809.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni921 – 99171Interaction with AP4M1 By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1005 – 10073PDZ-binding

Domaini

The PDZ-binding motif mediates interaction with GOPC.1 Publication

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276334.
GeneTreeiENSGT00740000115107.
HOGENOMiHOG000264260.
HOVERGENiHBG051840.
InParanoidiA4QPG1.
KOiK05207.
OMAiHGNYAFV.
OrthoDBiEOG7KQ20V.
PhylomeDBiQ61625.
TreeFamiTF352434.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61625-1 [UniParc]FASTAAdd to Basket

« Hide

MEVFPLLLFL SFCWSRTWDL ATADSIIHIG AIFDESAKKD DEVFRTAVGD     50
LNQNEEILQT EKITFSVTFV DGNNPFQAVQ EACELMNQGI LALVSSIGCT 100
SAGSLQSLAD AMHIPHLFIQ RSTAGTPRSG CGLTRSNRND DYTLSVRPPV 150
YLNEVILRVV TEYAWQKFII FYDSEYDIRG IQEFLDKVSQ QGMDVALQKV 200
ENNINKMITT LFDTMRIEEL NRYRDTLRRA ILVMNPATAK SFISEVVETN 250
LVAFDCHWII INEEINDVDV QELVRRSIGR LTIIRQTFPV PQNISQRCFR 300
GNHRISSSLC DPKDPFAQNM EISNLYIYDT VLLLANAFHK KLEDRKWHSM 350
ASLSCIRKNS KPWQGGRSML ETIKKGGVNG LTGDLEFGEN GGNPNVHFEI 400
LGTNYGEELG RGVRKLGCWN PVTGLNGSLT DKKLENNMRG VVLRVVTVLE 450
EPFVMVSENV LGKPKKYQGF SIDVLDALSN YLGFNYEIYV APDHKYGSPQ 500
EDGTWNGLVG ELVFKRADIG ISALTITPDR ENVVDFTTRY MDYSVGVLLR 550
RAEKTVDMFA CLAPFDLSLW ACIAGTVLLV GLLVYLLNWL NPPRLQMGSM 600
TSTTLYNSMW FVYGSFVQQG GEVPYTTLAT RMMMGAWWLF ALIVISSYTA 650
NLAAFLTITR IESSIQSLQD LSKQTDIPYG TVLDSAVYQH VRMKGLNPFE 700
RDSMYSQMWR MINRSNGSEN NVLESQAGIQ KVKYGNYAFV WDAAVLEYVA 750
INDPDCSFYT VGNTVADRGY GIALQHGSPY RDVFSQRILE LQQSGDMDIL 800
KHKWWPKNGQ CDLYSSVDAK QKGGALDIKS LAGVFCILAA GIVLSCLIAV 850
LETWWSRRKG SRVPSKEDDK EIDLEHLHRR VNSLCTDDDS PHKQFSTSSI 900
DLTPLDIDTL PTRQALEQIS DFRNTHITTT TFIPEQIQTL SRTLSAKAAS 950
GFAFGSVPEH RTGPFRHRAP NGGFFRSPIK TMSSIPYQPT PTLGLNLGND 1000
PDRGTSI 1007
Length:1,007
Mass (Da):113,082
Last modified:November 1, 1996 - v1
Checksum:iA456166CC782A44B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti654 – 6541A → T in Lurcher. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13266 mRNA. Translation: BAA02524.1.
BC139823 mRNA. Translation: AAI39824.1.
CCDSiCCDS20202.1.
PIRiPN0156.
RefSeqiNP_032193.1. NM_008167.2.
UniGeneiMm.439651.
Mm.447390.

Genome annotation databases

EnsembliENSMUST00000095852; ENSMUSP00000093536; ENSMUSG00000071424.
GeneIDi14804.
KEGGimmu:14804.
UCSCiuc009cdz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13266 mRNA. Translation: BAA02524.1 .
BC139823 mRNA. Translation: AAI39824.1 .
CCDSi CCDS20202.1.
PIRi PN0156.
RefSeqi NP_032193.1. NM_008167.2.
UniGenei Mm.439651.
Mm.447390.

3D structure databases

ProteinModelPortali Q61625.
SMRi Q61625. Positions 26-426, 441-809.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200062. 3 interactions.
IntActi Q61625. 37 interactions.
MINTi MINT-126960.
STRINGi 10090.ENSMUSP00000093536.

Chemistry

BindingDBi Q61625.
GuidetoPHARMACOLOGYi 449.

Protein family/group databases

TCDBi 1.A.10.1.8. the glutamate-gated ion channel (gic) family of neurotransmitter receptors.

PTM databases

PhosphoSitei Q61625.

Proteomic databases

MaxQBi Q61625.
PaxDbi Q61625.
PRIDEi Q61625.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095852 ; ENSMUSP00000093536 ; ENSMUSG00000071424 .
GeneIDi 14804.
KEGGi mmu:14804.
UCSCi uc009cdz.1. mouse.

Organism-specific databases

CTDi 2895.
MGIi MGI:95813. Grid2.

Phylogenomic databases

eggNOGi NOG276334.
GeneTreei ENSGT00740000115107.
HOGENOMi HOG000264260.
HOVERGENi HBG051840.
InParanoidi A4QPG1.
KOi K05207.
OMAi HGNYAFV.
OrthoDBi EOG7KQ20V.
PhylomeDBi Q61625.
TreeFami TF352434.

Miscellaneous databases

ChiTaRSi GRID2. mouse.
NextBioi 286973.
PROi Q61625.
SOURCEi Search...

Gene expression databases

Bgeei Q61625.
CleanExi MM_GRID2.
Genevestigatori Q61625.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Selective expression of the glutamate receptor channel delta 2 subunit in cerebellar Purkinje cells."
    Araki K., Meguro H., Kushiya E., Takayama C., Inoue Y., Mishina M.
    Biochem. Biophys. Res. Commun. 197:1267-1276(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: ICR.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice."
    Yue Z., Horton A., Bravin M., DeJager P.L., Selimi F., Heintz N.
    Neuron 35:921-933(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GOPC AND BECN1, DOMAIN.
  4. "Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells."
    Uemura T., Mori H., Mishina M.
    Mol. Cell. Neurosci. 26:330-341(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SHANK1 AND SHANK2, MUTAGENESIS OF SER-920, TISSUE SPECIFICITY.
  5. "Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA."
    Sonoda T., Mochizuki C., Yamashita T., Watanabe-Kaneko K., Miyagi Y., Shigeri Y., Yazama F., Okuda K., Kawamoto S.
    Biochem. Biophys. Res. Commun. 350:748-752(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRID2IP.
  6. "Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer."
    Matsuda K., Miura E., Miyazaki T., Kakegawa W., Emi K., Narumi S., Fukazawa Y., Ito-Ishida A., Kondo T., Shigemoto R., Watanabe M., Yuzaki M.
    Science 328:363-368(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CBLN1.
  7. "Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions."
    Matsuda K., Yuzaki M.
    Eur. J. Neurosci. 33:1447-1461(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CBLN1.
  8. "The Cbln family of proteins interact with multiple signaling pathways."
    Wei P., Pattarini R., Rong Y., Guo H., Bansal P.K., Kusnoor S.V., Deutch A.Y., Parris J., Morgan J.I.
    J. Neurochem. 121:717-729(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CBLN1 AND CBLN2.
  9. "Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene."
    Zuo J., De Jager P.L., Takahashi K.A., Jiang W., Linden D.J., Heintz N.
    Nature 388:769-773(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LURCHER THR-654.
    Tissue: Purkinje cell.

Entry informationi

Entry nameiGRID2_MOUSE
AccessioniPrimary (citable) accession number: Q61625
Secondary accession number(s): A4QPG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi