Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 148

Gene

Znf148

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 148
Alternative name(s):
Beta enolase repressor factor 1
G-rich box-binding protein
Transcription factor BFCOL1
Transcription factor ZBP-89
Zinc finger DNA-binding protein 89
Gene namesi
Name:Znf148
Synonyms:Zbp89, Zfp148
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1332234. Zfp148.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474281 – 794Zinc finger protein 148Add BLAST794

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei51PhosphoserineCombined sources1
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki132Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei194PhosphothreonineBy similarity1
Modified residuei250PhosphoserineBy similarity1
Cross-linki291Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei301PhosphoserineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Cross-linki308Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki356Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki356Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki402Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei412PhosphoserineBy similarity1
Cross-linki421Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki424Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei607N6-acetyllysineBy similarity1
Modified residuei665PhosphoserineBy similarity1
Modified residuei784PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ61624.
MaxQBiQ61624.
PaxDbiQ61624.
PRIDEiQ61624.

PTM databases

iPTMnetiQ61624.
PhosphoSitePlusiQ61624.

Expressioni

Tissue specificityi

Strong expression detected in brain, lung, liver and kidney, with lower levels detected in spleen, skeletal muscle, testis and heart.1 Publication

Developmental stagei

Detected in embryos from E7 to E17. Expression decreases in developing skeletal muscles.2 Publications

Gene expression databases

BgeeiENSMUSG00000022811.
CleanExiMM_ZFP148.
ExpressionAtlasiQ61624. baseline and differential.
GenevisibleiQ61624. MM.

Interactioni

Subunit structurei

Interacts with HNRNPDL (By similarity). Interacts with the 5FMC complex; the interaction requires association with CHTOP (PubMed:22872859). Interacts with CAVIN1 (PubMed:10727401).By similarity2 Publications

Protein-protein interaction databases

BioGridi204640. 1 interactor.
IntActiQ61624. 1 interactor.
MINTiMINT-4140637.
STRINGi10090.ENSMUSP00000087106.

Structurei

3D structure databases

ProteinModelPortaliQ61624.
SMRiQ61624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063238.
HOGENOMiHOG000293204.
HOVERGENiHBG054247.
InParanoidiQ61624.
OMAiEMISHDE.
OrthoDBiEOG091G02EU.
PhylomeDBiQ61624.
TreeFamiTF331779.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 4 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q61624-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDDKLEGL FLKCGGIDEM QSSRAMVVMG GVSGQSAVSG ELQESVLQDR
60 70 80 90 100
SLPHQEILAA DEVLQESEMR QQDMISHDEL MVHEETVKND EEQMDTHERL
110 120 130 140 150
PQGLQYALNV PISVKQEITF TDVSEQLMRD KKQVREPVDL QKKKKRKQRS
160 170 180 190 200
PAKILTINED GSLGLKTPKS HVCEHCNAAF RTNYHLQRHV FIHTGEKPFQ
210 220 230 240 250
CSQCDMRFIQ KYLLQRHEKI HTGEKPFRCD ECGMRFIQKY HMERHKRTHS
260 270 280 290 300
GEKPYQCEYC LQYFSRTDRV LKHKRMCHEN HDKKLNRCAI KGGLLTSEED
310 320 330 340 350
SGFSTSPKDN SLPKKKRQKT EKKSSGMDKE SVLDKSDLKK DKNDYLPLYS
360 370 380 390 400
SSTKVKDEYM VAEYAVEMPH SSVGGSHLED ASGEIHPPKL VLKKINSKRS
410 420 430 440 450
LKQPLEQSQT ISPLSSYEDS KVSKYAFELV DKQALLDSEG SADIDQVDNL
460 470 480 490 500
QEGPSKPVHS STNYDDAMQF LKKKRYLQAA SNNSREYALN VGTIASQPSV
510 520 530 540 550
TQAAVASVID ESTTASILDS QALNVEIKSN HDKNVIPDEV LQTLLDHYSH
560 570 580 590 600
KPNGQHEISF SVADTEVTSS ISINSSDVPE VTQSENVGSS SQASSSDKAN
610 620 630 640 650
MLQEYSKFLQ QALDRTSQND AYLNSPSLNF VTDNQTLPNP PAFSSIDKQV
660 670 680 690 700
YAAMPINSFR SGMNSPLRTT PDKSHFGLIV GDSQHPFPFS GDETNHASAT
710 720 730 740 750
STADFLDQVT SQKKAEAQPV HQAYQMSSFE QPFRAPYHGS RAGIATQFST
760 770 780 790
ANGQVNLRGP GTSAEFSEFP LVNVNDNRAG MTSSPDATTG QTFG
Length:794
Mass (Da):88,751
Last modified:June 1, 1998 - v2
Checksum:i4CB1C2A1822703FD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti283K → N in AAB38507 (PubMed:9030551).Curated1
Sequence conflicti314K → P in AAB38507 (PubMed:9030551).Curated1
Sequence conflicti319K → Q in AAB38507 (PubMed:9030551).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98096 mRNA. Translation: CAA66725.1.
BC026144 mRNA. Translation: AAH26144.1.
U80078 mRNA. Translation: AAB38507.1.
CCDSiCCDS28130.1.
RefSeqiNP_035879.1. NM_011749.4.
XP_006522165.1. XM_006522102.3.
XP_017172469.1. XM_017316980.1.
UniGeneiMm.392667.

Genome annotation databases

EnsembliENSMUST00000089677; ENSMUSP00000087106; ENSMUSG00000022811.
ENSMUST00000165418; ENSMUSP00000126338; ENSMUSG00000022811.
GeneIDi22661.
KEGGimmu:22661.
UCSCiuc007zab.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiZN148_MOUSE
AccessioniPrimary (citable) accession number: Q61624
Secondary accession number(s): P97475
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 1, 1998
Last modified: August 30, 2017
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families