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Protein

Adenosine receptor A3

Gene

Adora3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.By similarity

GO - Molecular functioni

  • G-protein coupled adenosine receptor activity Source: MGI

GO - Biological processi

  • adenosine receptor signaling pathway Source: MGI
  • histamine secretion by mast cell Source: MGI
  • negative regulation of cell migration Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of NF-kappaB transcription factor activity Source: MGI
  • positive regulation of calcium-mediated signaling Source: MGI
  • positive regulation of inflammatory response Source: MGI
  • positive regulation of leukocyte migration Source: MGI
  • positive regulation of mast cell degranulation Source: MGI
  • positive regulation of mucus secretion Source: MGI
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A3
Alternative name(s):
A3AR
Gene namesi
Name:Adora3
Synonyms:Gpcr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104847 Adora3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15ExtracellularBy similarityAdd BLAST15
Transmembranei16 – 38Helical; Name=1By similarityAdd BLAST23
Topological domaini39 – 49CytoplasmicBy similarityAdd BLAST11
Transmembranei50 – 73Helical; Name=2By similarityAdd BLAST24
Topological domaini74 – 85ExtracellularBy similarityAdd BLAST12
Transmembranei86 – 107Helical; Name=3By similarityAdd BLAST22
Topological domaini108 – 127CytoplasmicBy similarityAdd BLAST20
Transmembranei128 – 149Helical; Name=4By similarityAdd BLAST22
Topological domaini150 – 178ExtracellularBy similarityAdd BLAST29
Transmembranei179 – 199Helical; Name=5By similarityAdd BLAST21
Topological domaini200 – 232CytoplasmicBy similarityAdd BLAST33
Transmembranei233 – 256Helical; Name=6By similarityAdd BLAST24
Topological domaini257 – 262ExtracellularBy similarity6
Transmembranei263 – 285Helical; Name=7By similarityAdd BLAST23
Topological domaini286 – 319CytoplasmicBy similarityAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075269
GuidetoPHARMACOLOGYi21

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690111 – 319Adenosine receptor A3Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi84 ↔ 167PROSITE-ProRule annotation
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi304S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

Phosphorylation on Thr-317 and Thr-318 may be crucial for rapid desensitization. Phosphorylation on Thr-317 may be necessary for phosphorylation on Thr-318 to occur.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ61618
PRIDEiQ61618

PTM databases

iPTMnetiQ61618
PhosphoSitePlusiQ61618

Expressioni

Gene expression databases

CleanExiMM_ADORA3

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000574

Chemistry databases

BindingDBiQ61618

Structurei

3D structure databases

ProteinModelPortaliQ61618
SMRiQ61618
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiQ61618
PhylomeDBiQ61618

Family and domain databases

InterProiView protein in InterPro
IPR000466 Adeno_A3_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00555 ADENOSINEA3R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q61618-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEADNTTETD WLNITYITME AAIGLCAVVG NMLVIWVVKL NPTLRTTTVY
60 70 80 90 100
FIVSLALADI AVGVLVIPLA IAVSLQVKMH FYACLFMSCV LLIFTHASIM
110 120 130 140 150
SLLAIAVHRY LRVKLTVRYR TVTTQRRIWL FLGLCWLVSF LVGLTPMFGW
160 170 180 190 200
NRKATLASSQ NSSTLLCHFR SVVSLDYMVF FSFITWILVP LVVMCIIYLD
210 220 230 240 250
IFYIIRNKLS QNLTGFRETR AFYGREFKTA KSLFLVLFLF ALCWLPLSII
260 270 280 290 300
NFVSYFDVKI PDVAMCLGIL LSHANSMMNP IVYACKIKKF KETYFLILRA
310
VRLCQTSDSL DSNMEQTTE
Length:319
Mass (Da):36,449
Last modified:March 5, 2002 - v2
Checksum:i6AD7F46A9F03D9CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184I → V in AAA16851 (PubMed:8288218).Curated1
Sequence conflicti196I → V in AAA16851 (PubMed:8288218).Curated1
Sequence conflicti214T → S in AAA16851 (PubMed:8288218).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069778 Genomic DNA Translation: AAC82643.1
L20331 mRNA Translation: AAA16851.1
CCDSiCCDS17712.1
PIRiB48909
UniGeneiMm.235024

Similar proteinsi

Entry informationi

Entry nameiAA3R_MOUSE
AccessioniPrimary (citable) accession number: Q61618
Secondary accession number(s): Q9R202
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 5, 2002
Last modified: February 28, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health