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Protein

Adenosine receptor A3

Gene

Adora3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.

GO - Molecular functioni

  • G-protein coupled adenosine receptor activity Source: MGI

GO - Biological processi

  • adenosine receptor signaling pathway Source: MGI
  • histamine secretion by mast cell Source: MGI
  • positive regulation of calcium-mediated signaling Source: MGI
  • positive regulation of inflammatory response Source: MGI
  • positive regulation of leukocyte migration Source: MGI
  • positive regulation of mast cell degranulation Source: MGI
  • positive regulation of mucus secretion Source: MGI
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A3
Alternative name(s):
A3AR
Gene namesi
Name:Adora3
Synonyms:Gpcr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104847. Adora3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515ExtracellularBy similarityAdd
BLAST
Transmembranei16 – 3823Helical; Name=1By similarityAdd
BLAST
Topological domaini39 – 4911CytoplasmicBy similarityAdd
BLAST
Transmembranei50 – 7324Helical; Name=2By similarityAdd
BLAST
Topological domaini74 – 8512ExtracellularBy similarityAdd
BLAST
Transmembranei86 – 10722Helical; Name=3By similarityAdd
BLAST
Topological domaini108 – 12720CytoplasmicBy similarityAdd
BLAST
Transmembranei128 – 14922Helical; Name=4By similarityAdd
BLAST
Topological domaini150 – 17829ExtracellularBy similarityAdd
BLAST
Transmembranei179 – 19921Helical; Name=5By similarityAdd
BLAST
Topological domaini200 – 23233CytoplasmicBy similarityAdd
BLAST
Transmembranei233 – 25624Helical; Name=6By similarityAdd
BLAST
Topological domaini257 – 2626ExtracellularBy similarity
Transmembranei263 – 28523Helical; Name=7By similarityAdd
BLAST
Topological domaini286 – 31934CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
  • mast cell granule Source: GOC
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1075269.
GuidetoPHARMACOLOGYi21.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Adenosine receptor A3PRO_0000069011Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence analysis
Disulfide bondi84 ↔ 167PROSITE-ProRule annotation
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence analysis
Lipidationi304 – 3041S-palmitoyl cysteineSequence analysis

Post-translational modificationi

Phosphorylation on Thr-317 and Thr-318 may be crucial for rapid desensitization. Phosphorylation on Thr-317 may be necessary for phosphorylation on Thr-318 to occur (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ61618.
PRIDEiQ61618.

PTM databases

PhosphoSiteiQ61618.

Expressioni

Gene expression databases

CleanExiMM_ADORA3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000574.

Chemistry

BindingDBiQ61618.

Structurei

3D structure databases

ProteinModelPortaliQ61618.
SMRiQ61618. Positions 16-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiQ61618.
PhylomeDBiQ61618.

Family and domain databases

InterProiIPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61618-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEADNTTETD WLNITYITME AAIGLCAVVG NMLVIWVVKL NPTLRTTTVY
60 70 80 90 100
FIVSLALADI AVGVLVIPLA IAVSLQVKMH FYACLFMSCV LLIFTHASIM
110 120 130 140 150
SLLAIAVHRY LRVKLTVRYR TVTTQRRIWL FLGLCWLVSF LVGLTPMFGW
160 170 180 190 200
NRKATLASSQ NSSTLLCHFR SVVSLDYMVF FSFITWILVP LVVMCIIYLD
210 220 230 240 250
IFYIIRNKLS QNLTGFRETR AFYGREFKTA KSLFLVLFLF ALCWLPLSII
260 270 280 290 300
NFVSYFDVKI PDVAMCLGIL LSHANSMMNP IVYACKIKKF KETYFLILRA
310
VRLCQTSDSL DSNMEQTTE
Length:319
Mass (Da):36,449
Last modified:March 5, 2002 - v2
Checksum:i6AD7F46A9F03D9CC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841I → V in AAA16851 (PubMed:8288218).Curated
Sequence conflicti196 – 1961I → V in AAA16851 (PubMed:8288218).Curated
Sequence conflicti214 – 2141T → S in AAA16851 (PubMed:8288218).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069778 Genomic DNA. Translation: AAC82643.1.
L20331 mRNA. Translation: AAA16851.1.
CCDSiCCDS17712.1.
PIRiB48909.
UniGeneiMm.235024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069778 Genomic DNA. Translation: AAC82643.1.
L20331 mRNA. Translation: AAA16851.1.
CCDSiCCDS17712.1.
PIRiB48909.
UniGeneiMm.235024.

3D structure databases

ProteinModelPortaliQ61618.
SMRiQ61618. Positions 16-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000574.

Chemistry

BindingDBiQ61618.
ChEMBLiCHEMBL1075269.
GuidetoPHARMACOLOGYi21.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ61618.

Proteomic databases

PaxDbiQ61618.
PRIDEiQ61618.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:104847. Adora3.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiQ61618.
PhylomeDBiQ61618.

Miscellaneous databases

PROiQ61618.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ADORA3.

Family and domain databases

InterProiIPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the mouse A3 adenosine receptor gene: exon/intron organization and promoter activity."
    Zhao Z., Francis C., Ravid K.
    Genomics 57:152-155(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
    Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
    Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 111-239.
    Tissue: Testis.

Entry informationi

Entry nameiAA3R_MOUSE
AccessioniPrimary (citable) accession number: Q61618
Secondary accession number(s): Q9R202
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 5, 2002
Last modified: February 17, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.