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Reviewed, UniProtKB/Swiss-Prot Q61618 (AA3R_MOUSE)

Last modified June 16, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenosine A3 receptor
Alternative name(s):
    A3AR
Gene names
Name: Adora3
Synonyms: Gpcr2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

Phosphorylation on Thr-317 and Thr-318 may be crucial for rapid desensitization. Phosphorylation on Thr-317 may be necessary for phosphorylation on Thr-318 to occur By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Adenosine A3 receptor
PRO_0000069011

Regions

Topological domain1 – 1515Extracellular By similarity
Transmembrane16 – 38231 By similarity
Topological domain39 – 4911Cytoplasmic By similarity
Transmembrane50 – 73242 By similarity
Topological domain74 – 8512Extracellular By similarity
Transmembrane86 – 107223 By similarity
Topological domain108 – 12720Cytoplasmic By similarity
Transmembrane128 – 149224 By similarity
Topological domain150 – 17829Extracellular By similarity
Transmembrane179 – 199215 By similarity
Topological domain200 – 23233Cytoplasmic By similarity
Transmembrane233 – 256246 By similarity
Topological domain257 – 2626Extracellular By similarity
Transmembrane263 – 285237 By similarity
Topological domain286 – 31934Cytoplasmic By similarity

Amino acid modifications

Modified residue3061Phosphothreonine By similarity
Modified residue3171Phosphothreonine By similarity
Modified residue3181Phosphothreonine By similarity
Lipidation3041S-palmitoyl cysteine Potential
Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation131N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Disulfide bond84 ↔ 167 By similarity

Experimental info

Sequence conflict1841I → V in AAA16851. Ref.2
Sequence conflict1961I → V in AAA16851. Ref.2
Sequence conflict2141T → S in AAA16851. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q61618-1 [UniParc].

Last modified March 5, 2002. Version 2.
Checksum: 6AD7F46A9F03D9CC

FASTA31936,449
        10         20         30         40         50         60 
MEADNTTETD WLNITYITME AAIGLCAVVG NMLVIWVVKL NPTLRTTTVY FIVSLALADI 

        70         80         90        100        110        120 
AVGVLVIPLA IAVSLQVKMH FYACLFMSCV LLIFTHASIM SLLAIAVHRY LRVKLTVRYR 

       130        140        150        160        170        180 
TVTTQRRIWL FLGLCWLVSF LVGLTPMFGW NRKATLASSQ NSSTLLCHFR SVVSLDYMVF 

       190        200        210        220        230        240 
FSFITWILVP LVVMCIIYLD IFYIIRNKLS QNLTGFRETR AFYGREFKTA KSLFLVLFLF 

       250        260        270        280        290        300 
ALCWLPLSII NFVSYFDVKI PDVAMCLGIL LSHANSMMNP IVYACKIKKF KETYFLILRA 

       310 
VRLCQTSDSL DSNMEQTTE

« Hide

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References

[1]"Characterization of the mouse A3 adenosine receptor gene: exon/intron organization and promoter activity."
Zhao Z., Francis C., Ravid K.
Genomics 57:152-155(1999) [PubMed: 10191095] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
Genomics 18:175-184(1993) [PubMed: 8288218] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 111-239.
Tissue: Testis.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF069778 Genomic DNA. Translation: AAC82643.1.
L20331 mRNA. Translation: AAA16851.1.
IPIIPI00123499.
PIRB48909.
UniGeneMm.235024

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ61618.

Genome annotation databases

EnsemblENSMUSG00000000562. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:104847. Adora3.

Phylogenomic databases

HOGENOMQ61618.
HOVERGENQ61618.

Gene expression databases

ArrayExpressQ61618.
BgeeQ61618.
CleanExMM_ADORA3.
GermOnlineENSMUSG00000000562. Mus musculus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameAA3R_MOUSE
AccessionPrimary (citable) accession number: Q61618
Secondary accession number(s): Q9R202
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 5, 2002
Last modified: June 16, 2009
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents