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Protein

D(1A) dopamine receptor

Gene

Drd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • dopamine binding Source: MGI
  • dopamine neurotransmitter receptor activity Source: MGI
  • dopamine neurotransmitter receptor activity, coupled via Gs Source: MGI
  • G-protein coupled receptor activity Source: MGI

GO - Biological processi

  • activation of adenylate cyclase activity Source: MGI
  • adenylate cyclase-activating dopamine receptor signaling pathway Source: MGI
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • adult walking behavior Source: MGI
  • associative learning Source: MGI
  • astrocyte development Source: MGI
  • behavioral fear response Source: MGI
  • behavioral response to cocaine Source: MGI
  • cellular response to catecholamine stimulus Source: MGI
  • cerebral cortex GABAergic interneuron migration Source: MGI
  • conditioned taste aversion Source: MGI
  • dentate gyrus development Source: MGI
  • dopamine receptor signaling pathway Source: MGI
  • dopamine transport Source: MGI
  • feeding behavior Source: MGI
  • glucose import Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: MGI
  • grooming behavior Source: MGI
  • habituation Source: MGI
  • hippocampus development Source: MGI
  • learning Source: MGI
  • locomotory behavior Source: MGI
  • long term synaptic depression Source: MGI
  • long-term synaptic potentiation Source: MGI
  • maternal behavior Source: MGI
  • mating behavior Source: MGI
  • memory Source: MGI
  • muscle contraction Source: MGI
  • neuronal action potential Source: MGI
  • operant conditioning Source: MGI
  • peristalsis Source: MGI
  • phospholipase C-activating dopamine receptor signaling pathway Source: MGI
  • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
  • positive regulation of cAMP biosynthetic process Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: MGI
  • positive regulation of release of sequestered calcium ion into cytosol Source: MGI
  • positive regulation of synaptic transmission, glutamatergic Source: MGI
  • protein import into nucleus Source: MGI
  • regulation of dopamine metabolic process Source: MGI
  • response to amphetamine Source: MGI
  • response to cocaine Source: MGI
  • response to drug Source: MGI
  • sensitization Source: MGI
  • striatum development Source: MGI
  • synaptic transmission, dopaminergic Source: MGI
  • temperature homeostasis Source: MGI
  • transmission of nerve impulse Source: MGI
  • vasodilation Source: InterPro
  • visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390651. Dopamine receptors.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
Gene namesi
Name:Drd1
Synonyms:Drd1a, Gpcr15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:99578. Drd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularSequence analysisAdd BLAST22
Transmembranei23 – 48Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini49 – 59CytoplasmicSequence analysisAdd BLAST11
Transmembranei60 – 86Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini87 – 95ExtracellularSequence analysis9
Transmembranei96 – 118Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 162Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini163 – 192ExtracellularSequence analysisAdd BLAST30
Transmembranei193 – 218Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini219 – 272CytoplasmicSequence analysisAdd BLAST54
Transmembranei273 – 299Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini300 – 312ExtracellularSequence analysisAdd BLAST13
Transmembranei313 – 337Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini338 – 446CytoplasmicSequence analysisAdd BLAST109

GO - Cellular componenti

  • ciliary membrane Source: MGI
  • endomembrane system Source: MGI
  • endoplasmic reticulum Source: MGI
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: InterPro
  • membrane Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3071.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693751 – 446D(1A) dopamine receptorAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 186PROSITE-ProRule annotation
Lipidationi347S-palmitoyl cysteineBy similarity1
Lipidationi351S-palmitoyl cysteineBy similarity1
Modified residuei441PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ61616.
PRIDEiQ61616.

PTM databases

iPTMnetiQ61616.
PhosphoSitePlusiQ61616.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021478.
CleanExiMM_DRD1A.
GenevisibleiQ61616. MM.

Interactioni

Subunit structurei

Interacts with DNAJC14 via its C-terminus. Interacts with DRD1IP.By similarity

Protein-protein interaction databases

BioGridi199305. 1 interactor.
STRINGi10090.ENSMUSP00000021932.

Structurei

3D structure databases

ProteinModelPortaliQ61616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ61616.
KOiK04144.
OMAiSSLNRMY.
OrthoDBiEOG091G06VI.
PhylomeDBiQ61616.
TreeFamiTF325181.

Family and domain databases

InterProiIPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPNTSTMDE TGLPVERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF
60 70 80 90 100
RHLRSKVTNF FVISLAVSDL LVAVLVMPWK AVAEIAGFWP FGSFCNIWVA
110 120 130 140 150
FDIMCSTASI LNLCVISVDR YWAISSPFQY ERKMTPKAAF ILISVAWTLS
160 170 180 190 200
VLISFIPVQL SWHKAKPTWP LDGNFTSLED AEDDNCDTRL SRTYAISSSL
210 220 230 240 250
ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN CQTTTGNGNP
260 270 280 290 300
VECSQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS
310 320 330 340 350
EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL
360 370 380 390 400
CPTTNNAIET VSINNNGAVM FSSHHEPRGS ISKDCNLVYL IPHAVGSSED
410 420 430 440
LKREEAGGIP KPLEKLSPAL SVILDYDTDV SLEKIQPVTH SGQHST
Length:446
Mass (Da):49,612
Last modified:May 30, 2003 - v2
Checksum:i509BA66F9DF82A74
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193 – 196TYAI → DIRH (PubMed:8288218).Curated4
Sequence conflicti240N → S in AAA16848 (PubMed:8288218).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044723 mRNA. Translation: BAC32050.1.
BC137641 mRNA. Translation: AAI37642.1.
BC137655 mRNA. Translation: AAI37656.1.
L20336 mRNA. Translation: AAA16848.1.
CCDSiCCDS26524.1.
RefSeqiNP_001278730.1. NM_001291801.1.
NP_034206.1. NM_010076.3.
UniGeneiMm.54161.

Genome annotation databases

EnsembliENSMUST00000021932; ENSMUSP00000021932; ENSMUSG00000021478.
GeneIDi13488.
KEGGimmu:13488.
UCSCiuc011yzm.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044723 mRNA. Translation: BAC32050.1.
BC137641 mRNA. Translation: AAI37642.1.
BC137655 mRNA. Translation: AAI37656.1.
L20336 mRNA. Translation: AAA16848.1.
CCDSiCCDS26524.1.
RefSeqiNP_001278730.1. NM_001291801.1.
NP_034206.1. NM_010076.3.
UniGeneiMm.54161.

3D structure databases

ProteinModelPortaliQ61616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199305. 1 interactor.
STRINGi10090.ENSMUSP00000021932.

Chemistry databases

ChEMBLiCHEMBL3071.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ61616.
PhosphoSitePlusiQ61616.

Proteomic databases

PaxDbiQ61616.
PRIDEiQ61616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021932; ENSMUSP00000021932; ENSMUSG00000021478.
GeneIDi13488.
KEGGimmu:13488.
UCSCiuc011yzm.3. mouse.

Organism-specific databases

CTDi1812.
MGIiMGI:99578. Drd1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ61616.
KOiK04144.
OMAiSSLNRMY.
OrthoDBiEOG091G06VI.
PhylomeDBiQ61616.
TreeFamiTF325181.

Enzyme and pathway databases

ReactomeiR-MMU-390651. Dopamine receptors.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ61616.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021478.
CleanExiMM_DRD1A.
GenevisibleiQ61616. MM.

Family and domain databases

InterProiIPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRD1_MOUSE
AccessioniPrimary (citable) accession number: Q61616
Secondary accession number(s): B2RPW8, Q8C8P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2003
Last modified: November 30, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.