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Q61616

- DRD1_MOUSE

UniProt

Q61616 - DRD1_MOUSE

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Protein

D(1A) dopamine receptor

Gene

Drd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. dopamine binding Source: Ensembl
  2. dopamine neurotransmitter receptor activity Source: MGI
  3. dopamine neurotransmitter receptor activity, coupled via Gs Source: MGI
  4. G-protein coupled receptor activity Source: MGI

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. adenylate cyclase-activating dopamine receptor signaling pathway Source: MGI
  3. adult walking behavior Source: MGI
  4. associative learning Source: MGI
  5. astrocyte development Source: MGI
  6. behavioral fear response Source: MGI
  7. behavioral response to cocaine Source: MGI
  8. cellular response to catecholamine stimulus Source: Ensembl
  9. cerebral cortex GABAergic interneuron migration Source: MGI
  10. conditioned taste aversion Source: MGI
  11. dentate gyrus development Source: MGI
  12. dopamine receptor signaling pathway Source: MGI
  13. dopamine transport Source: MGI
  14. feeding behavior Source: MGI
  15. glucose import Source: MGI
  16. G-protein coupled receptor signaling pathway Source: MGI
  17. grooming behavior Source: MGI
  18. habituation Source: MGI
  19. hippocampus development Source: MGI
  20. learning Source: MGI
  21. locomotory behavior Source: MGI
  22. long term synaptic depression Source: MGI
  23. long-term synaptic potentiation Source: MGI
  24. maternal behavior Source: MGI
  25. mating behavior Source: MGI
  26. memory Source: MGI
  27. muscle contraction Source: MGI
  28. neuronal action potential Source: MGI
  29. operant conditioning Source: MGI
  30. peristalsis Source: MGI
  31. phospholipase C-activating dopamine receptor signaling pathway Source: MGI
  32. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: InterPro
  33. positive regulation of cell migration Source: MGI
  34. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  35. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  36. positive regulation of synaptic transmission, glutamatergic Source: MGI
  37. protein import into nucleus Source: MGI
  38. regulation of dopamine metabolic process Source: MGI
  39. response to amphetamine Source: MGI
  40. response to cocaine Source: MGI
  41. response to drug Source: MGI
  42. sensitization Source: MGI
  43. striatum development Source: MGI
  44. synaptic transmission, dopaminergic Source: MGI
  45. temperature homeostasis Source: MGI
  46. transmission of nerve impulse Source: MGI
  47. vasodilation Source: InterPro
  48. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
Gene namesi
Name:Drd1
Synonyms:Drd1a, Gpcr15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:99578. Drd1a.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Note: Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of plasma membrane Source: InterPro
  3. membrane Source: MGI
  4. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446D(1A) dopamine receptorPRO_0000069375Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 186PROSITE-ProRule annotation
Lipidationi347 – 3471S-palmitoyl cysteineBy similarity
Lipidationi351 – 3511S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ61616.
PRIDEiQ61616.

PTM databases

PhosphoSiteiQ61616.

Expressioni

Gene expression databases

BgeeiQ61616.
CleanExiMM_DRD1A.
ExpressionAtlasiQ61616. baseline and differential.
GenevestigatoriQ61616.

Interactioni

Subunit structurei

Interacts with DNAJC14 via its C-terminus. Interacts with DRD1IP.By similarity

Protein-protein interaction databases

BioGridi199305. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ61616.
SMRiQ61616. Positions 28-346.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularSequence AnalysisAdd
BLAST
Topological domaini49 – 5911CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini87 – 959ExtracellularSequence Analysis
Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini163 – 19230ExtracellularSequence AnalysisAdd
BLAST
Topological domaini219 – 27254CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini300 – 31213ExtracellularSequence AnalysisAdd
BLAST
Topological domaini338 – 446109CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4826Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei60 – 8627Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei96 – 11823Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei138 – 16225Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei193 – 21826Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei273 – 29927Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei313 – 33725Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262978.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ61616.
KOiK04144.
OMAiSPTTFDV.
OrthoDBiEOG780RMN.
PhylomeDBiQ61616.
TreeFamiTF325181.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61616-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPNTSTMDE TGLPVERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF
60 70 80 90 100
RHLRSKVTNF FVISLAVSDL LVAVLVMPWK AVAEIAGFWP FGSFCNIWVA
110 120 130 140 150
FDIMCSTASI LNLCVISVDR YWAISSPFQY ERKMTPKAAF ILISVAWTLS
160 170 180 190 200
VLISFIPVQL SWHKAKPTWP LDGNFTSLED AEDDNCDTRL SRTYAISSSL
210 220 230 240 250
ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN CQTTTGNGNP
260 270 280 290 300
VECSQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS
310 320 330 340 350
EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL
360 370 380 390 400
CPTTNNAIET VSINNNGAVM FSSHHEPRGS ISKDCNLVYL IPHAVGSSED
410 420 430 440
LKREEAGGIP KPLEKLSPAL SVILDYDTDV SLEKIQPVTH SGQHST
Length:446
Mass (Da):49,612
Last modified:May 30, 2003 - v2
Checksum:i509BA66F9DF82A74
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti193 – 1964TYAI → DIRH(PubMed:8288218)Curated
Sequence conflicti240 – 2401N → S in AAA16848. (PubMed:8288218)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK044723 mRNA. Translation: BAC32050.1.
BC137641 mRNA. Translation: AAI37642.1.
BC137655 mRNA. Translation: AAI37656.1.
L20336 mRNA. Translation: AAA16848.1.
CCDSiCCDS26524.1.
RefSeqiNP_001278730.1. NM_001291801.1.
NP_034206.1. NM_010076.3.
UniGeneiMm.54161.

Genome annotation databases

EnsembliENSMUST00000021932; ENSMUSP00000021932; ENSMUSG00000021478.
GeneIDi13488.
KEGGimmu:13488.
UCSCiuc011yzm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK044723 mRNA. Translation: BAC32050.1 .
BC137641 mRNA. Translation: AAI37642.1 .
BC137655 mRNA. Translation: AAI37656.1 .
L20336 mRNA. Translation: AAA16848.1 .
CCDSi CCDS26524.1.
RefSeqi NP_001278730.1. NM_001291801.1.
NP_034206.1. NM_010076.3.
UniGenei Mm.54161.

3D structure databases

ProteinModelPortali Q61616.
SMRi Q61616. Positions 28-346.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199305. 1 interaction.

Chemistry

BindingDBi Q61616.
ChEMBLi CHEMBL3071.
GuidetoPHARMACOLOGYi 214.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q61616.

Proteomic databases

PaxDbi Q61616.
PRIDEi Q61616.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021932 ; ENSMUSP00000021932 ; ENSMUSG00000021478 .
GeneIDi 13488.
KEGGi mmu:13488.
UCSCi uc011yzm.2. mouse.

Organism-specific databases

CTDi 13488.
MGIi MGI:99578. Drd1a.

Phylogenomic databases

eggNOGi NOG262978.
GeneTreei ENSGT00760000118774.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi Q61616.
KOi K04144.
OMAi SPTTFDV.
OrthoDBi EOG780RMN.
PhylomeDBi Q61616.
TreeFami TF325181.

Miscellaneous databases

NextBioi 283997.
PROi Q61616.
SOURCEi Search...

Gene expression databases

Bgeei Q61616.
CleanExi MM_DRD1A.
ExpressionAtlasi Q61616. baseline and differential.
Genevestigatori Q61616.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
    Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
    Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 193-279.
    Tissue: Testis.

Entry informationi

Entry nameiDRD1_MOUSE
AccessioniPrimary (citable) accession number: Q61616
Secondary accession number(s): B2RPW8, Q8C8P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2003
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3