Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q61616 (DRD1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
Gene names
Name:Drd1
Synonyms:Drd1a, Gpcr15
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Subunit structure

Interacts with DNAJC14 via its C-terminus By similarity. Interacts with DRD1IP By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Note: Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14 By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Endoplasmic reticulum
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 14712229. Source: MGI

activation of adenylate cyclase activity

Inferred from direct assay PubMed 12488442. Source: MGI

adenylate cyclase-activating dopamine receptor signaling pathway

Inferred from direct assay PubMed 11923452PubMed 12665504PubMed 8738226. Source: MGI

adult walking behavior

Inferred from mutant phenotype PubMed 7954836. Source: MGI

associative learning

Inferred from mutant phenotype PubMed 9692749. Source: MGI

astrocyte development

Inferred from mutant phenotype PubMed 17360497. Source: MGI

behavioral fear response

Inferred from mutant phenotype PubMed 11172752PubMed 11409899. Source: MGI

behavioral response to cocaine

Inferred from mutant phenotype PubMed 16014726. Source: MGI

cellular response to catecholamine stimulus

Inferred from electronic annotation. Source: Ensembl

cerebral cortex GABAergic interneuron migration

Inferred from mutant phenotype PubMed 17409246. Source: MGI

conditioned taste aversion

Inferred from mutant phenotype PubMed 15932618. Source: MGI

dentate gyrus development

Inferred from mutant phenotype PubMed 17360497. Source: MGI

dopamine receptor signaling pathway

Inferred from mutant phenotype PubMed 16908842. Source: MGI

dopamine transport

Inferred from mutant phenotype PubMed 11404425. Source: MGI

feeding behavior

Inferred from genetic interaction PubMed 15272078. Source: MGI

glucose import

Inferred from mutant phenotype PubMed 11251190. Source: MGI

grooming behavior

Inferred from mutant phenotype PubMed 9749770PubMed 9988094. Source: MGI

habituation

Inferred from mutant phenotype PubMed 11985822. Source: MGI

hippocampus development

Inferred from mutant phenotype PubMed 17360497. Source: MGI

learning

Inferred from mutant phenotype PubMed 15684065. Source: MGI

locomotory behavior

Inferred from mutant phenotype PubMed 10222120PubMed 10661513PubMed 11251190PubMed 13679419PubMed 15684065PubMed 17360497PubMed 8001143PubMed 9261820PubMed 9692749. Source: MGI

long term synaptic depression

Inferred from mutant phenotype PubMed 14981263. Source: MGI

long-term synaptic potentiation

Inferred from mutant phenotype PubMed 13679419PubMed 14981263PubMed 9427321. Source: MGI

maternal behavior

Inferred from mutant phenotype PubMed 17360497PubMed 7809078. Source: MGI

mating behavior

Inferred from direct assay PubMed 9829800. Source: MGI

memory

Inferred from mutant phenotype PubMed 10585522. Source: MGI

muscle contraction

Inferred from mutant phenotype PubMed 17360497. Source: MGI

neuronal action potential

Inferred from mutant phenotype PubMed 16908842. Source: MGI

operant conditioning

Inferred from mutant phenotype PubMed 12603275. Source: MGI

peristalsis

Inferred from genetic interaction PubMed 15272078. Source: MGI

phospholipase C-activating dopamine receptor signaling pathway

Inferred from direct assay PubMed 15016423. Source: MGI

positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

positive regulation of cell migration

Inferred from mutant phenotype PubMed 17409246. Source: MGI

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of release of sequestered calcium ion into cytosol

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission, glutamatergic

Inferred from mutant phenotype PubMed 8795639. Source: MGI

protein import into nucleus

Inferred from mutant phenotype PubMed 18496528. Source: MGI

regulation of dopamine metabolic process

Inferred from mutant phenotype PubMed 11438590. Source: MGI

response to amphetamine

Inferred from mutant phenotype PubMed 10222120PubMed 10661513PubMed 16014726PubMed 18486343PubMed 9261820. Source: MGI

response to cocaine

Inferred from mutant phenotype PubMed 10222120PubMed 10661513PubMed 12354293PubMed 16908842PubMed 18045908PubMed 9387887. Source: MGI

response to drug

Inferred from direct assay PubMed 7549459. Source: MGI

sensitization

Inferred from genetic interaction PubMed 11823893. Source: MGI

striatum development

Inferred from mutant phenotype PubMed 17360497. Source: MGI

synaptic transmission, dopaminergic

Inferred from mutant phenotype PubMed 16908842. Source: MGI

temperature homeostasis

Inferred from mutant phenotype PubMed 18486343. Source: MGI

transmission of nerve impulse

Inferred from mutant phenotype PubMed 12867509. Source: MGI

vasodilation

Inferred from electronic annotation. Source: InterPro

visual learning

Inferred from mutant phenotype PubMed 10585522PubMed 10884517PubMed 15684065PubMed 9692749. Source: MGI

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of plasma membrane

Inferred from electronic annotation. Source: InterPro

membrane

Inferred from direct assay PubMed 7809078PubMed 8738226PubMed 9016340. Source: MGI

nucleus

Inferred from direct assay PubMed 9387887. Source: MGI

   Molecular_functionG-protein coupled receptor activity

Inferred from direct assay PubMed 14712229. Source: MGI

dopamine binding

Inferred from electronic annotation. Source: Ensembl

dopamine neurotransmitter receptor activity

Inferred from direct assay PubMed 18671743. Source: MGI

dopamine neurotransmitter receptor activity, coupled via Gs

Inferred from direct assay PubMed 11069937PubMed 12097513PubMed 12930822PubMed 16962565PubMed 7566118PubMed 7954836PubMed 8294904PubMed 8738226. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446D(1A) dopamine receptor
PRO_0000069375

Regions

Topological domain1 – 2222Extracellular Potential
Transmembrane23 – 4826Helical; Name=1; Potential
Topological domain49 – 5911Cytoplasmic Potential
Transmembrane60 – 8627Helical; Name=2; Potential
Topological domain87 – 959Extracellular Potential
Transmembrane96 – 11823Helical; Name=3; Potential
Topological domain119 – 13719Cytoplasmic Potential
Transmembrane138 – 16225Helical; Name=4; Potential
Topological domain163 – 19230Extracellular Potential
Transmembrane193 – 21826Helical; Name=5; Potential
Topological domain219 – 27254Cytoplasmic Potential
Transmembrane273 – 29927Helical; Name=6; Potential
Topological domain300 – 31213Extracellular Potential
Transmembrane313 – 33725Helical; Name=7; Potential
Topological domain338 – 446109Cytoplasmic Potential

Amino acid modifications

Lipidation3471S-palmitoyl cysteine By similarity
Lipidation3511S-palmitoyl cysteine By similarity
Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 186 By similarity

Experimental info

Sequence conflict193 – 1964TYAI → DIRH Ref.3
Sequence conflict2401N → S in AAA16848. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q61616 [UniParc].

Last modified May 30, 2003. Version 2.
Checksum: 509BA66F9DF82A74

FASTA44649,612
        10         20         30         40         50         60 
MAPNTSTMDE TGLPVERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF RHLRSKVTNF 

        70         80         90        100        110        120 
FVISLAVSDL LVAVLVMPWK AVAEIAGFWP FGSFCNIWVA FDIMCSTASI LNLCVISVDR 

       130        140        150        160        170        180 
YWAISSPFQY ERKMTPKAAF ILISVAWTLS VLISFIPVQL SWHKAKPTWP LDGNFTSLED 

       190        200        210        220        230        240 
AEDDNCDTRL SRTYAISSSL ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN 

       250        260        270        280        290        300 
CQTTTGNGNP VECSQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS 

       310        320        330        340        350        360 
EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL CPTTNNAIET 

       370        380        390        400        410        420 
VSINNNGAVM FSSHHEPRGS ISKDCNLVYL IPHAVGSSED LKREEAGGIP KPLEKLSPAL 

       430        440 
SVILDYDTDV SLEKIQPVTH SGQHST 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Retina.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 193-279.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK044723 mRNA. Translation: BAC32050.1.
BC137641 mRNA. Translation: AAI37642.1.
BC137655 mRNA. Translation: AAI37656.1.
L20336 mRNA. Translation: AAA16848.1.
RefSeqNP_034206.1. NM_010076.3.
XP_006516911.1. XM_006516848.1.
UniGeneMm.54161.

3D structure databases

ProteinModelPortalQ61616.
SMRQ61616. Positions 28-346.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199305. 1 interaction.

Chemistry

BindingDBQ61616.
ChEMBLCHEMBL3071.
GuidetoPHARMACOLOGY214.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ61616.

Proteomic databases

PaxDbQ61616.
PRIDEQ61616.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021932; ENSMUSP00000021932; ENSMUSG00000021478.
GeneID13488.
KEGGmmu:13488.
UCSCuc011yzm.2. mouse.

Organism-specific databases

CTD13488.
MGIMGI:99578. Drd1a.

Phylogenomic databases

eggNOGNOG262978.
GeneTreeENSGT00750000117368.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidB2RPW8.
KOK04144.
OMASPTTFDV.
OrthoDBEOG780RMN.
PhylomeDBQ61616.
TreeFamTF325181.

Gene expression databases

BgeeQ61616.
CleanExMM_DRD1A.
GenevestigatorQ61616.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001413. Dopamine_D1_rcpt.
IPR000497. Dopamine_D5_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24249:SF45. PTHR24249:SF45. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283997.
PROQ61616.
SOURCESearch...

Entry information

Entry nameDRD1_MOUSE
AccessionPrimary (citable) accession number: Q61616
Secondary accession number(s): B2RPW8, Q8C8P8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2003
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries