Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q61614 (EDNRA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin-1 receptor
Alternative name(s):
Endothelin A receptor
Short name=ET-A
Short name=ET-AR
Gene names
Name:Ednra
Synonyms:Gpcr10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 By similarity.

Subunit structure

Interacts with HDAC7 and KAT5 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement PubMed 11546805. Source: MGI

Rho protein signal transduction

Inferred from electronic annotation. Source: Ensembl

aging

Inferred from electronic annotation. Source: Ensembl

artery smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

endothelin receptor signaling pathway

Inferred from mutant phenotype PubMed 9449664. Source: GOC

enteric nervous system development

Inferred from electronic annotation. Source: InterPro

fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

glomerular filtration

Inferred from electronic annotation. Source: Ensembl

glucose transport

Inferred from direct assay PubMed 11546805. Source: MGI

head development

Inferred from mutant phenotype PubMed 15306564. Source: MGI

heart development

Inferred from genetic interaction PubMed 15664398. Source: MGI

histamine secretion

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from mutant phenotype PubMed 15327783. Source: MGI

maternal process involved in parturition

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cAMP biosynthetic process

Inferred from genetic interaction PubMed 15928212. Source: MGI

neural crest cell development

Inferred from mutant phenotype PubMed 15306564PubMed 15327783PubMed 9449664. Source: MGI

patterning of blood vessels

Inferred from genetic interaction PubMed 15664398. Source: MGI

penile erection

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

positive regulation of kidney development

Inferred from electronic annotation. Source: Ensembl

positive regulation of neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of odontogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of release of sequestered calcium ion into cytosol

Inferred from electronic annotation. Source: Ensembl

protein kinase C-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

regulation of blood pressure

Inferred from electronic annotation. Source: InterPro

regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

respiratory gaseous exchange

Inferred from mutant phenotype PubMed 10626068PubMed 9449664. Source: MGI

response to hypoxia

Inferred from mutant phenotype PubMed 9449664. Source: MGI

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to morphine

Inferred from electronic annotation. Source: Ensembl

sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

vasoconstriction

Inferred from mutant phenotype PubMed 9826706. Source: MGI

   Cellular_componentT-tubule

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

nuclear membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionG-protein coupled receptor activity

Traceable author statement PubMed 11546805. Source: MGI

endothelin receptor activity

Inferred from mutant phenotype PubMed 9449664. Source: MGI

protein binding

Inferred from physical interaction PubMed 11546805PubMed 9449664. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 427407Endothelin-1 receptor
PRO_0000012722

Regions

Topological domain21 – 8060Extracellular Potential
Transmembrane81 – 10222Helical; Name=1; Potential
Topological domain103 – 11210Cytoplasmic Potential
Transmembrane113 – 13220Helical; Name=2; Potential
Topological domain133 – 15927Extracellular Potential
Transmembrane160 – 18122Helical; Name=3; Potential
Topological domain182 – 20524Cytoplasmic Potential
Transmembrane206 – 22924Helical; Name=4; Potential
Topological domain230 – 25627Extracellular Potential
Transmembrane257 – 27822Helical; Name=5; Potential
Topological domain279 – 30628Cytoplasmic Potential
Transmembrane307 – 32822Helical; Name=6; Potential
Topological domain329 – 34719Extracellular Potential
Transmembrane348 – 37225Helical; Name=7; Potential
Topological domain373 – 42755Cytoplasmic Potential

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation621N-linked (GlcNAc...) Potential
Glycosylation2421N-linked (GlcNAc...) Potential
Disulfide bond158 ↔ 239 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q61614 [UniParc].

Last modified May 30, 2003. Version 3.
Checksum: 10142BE73B028233

FASTA42748,578
        10         20         30         40         50         60 
MSIFCLAAYF WLTMVGGVMA DNPERYSANL SSHMEDFTPF PGTEINFLGT THRPPNLALP 

        70         80         90        100        110        120 
SNGSMHGYCP QQTKITTAFK YINTVISCTI FIVGMVGNAT LLRIIYQNKC MRNGPNALIA 

       130        140        150        160        170        180 
SLALGDLIYV VIDLPINVFK LLAGRWPFDH NDFGVFLCKL FPFLQKSSVG ITVLNLCALS 

       190        200        210        220        230        240 
VDRYRAVASW SRVQGIGIPL ITAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGELHRTCM 

       250        260        270        280        290        300 
LNATSKFMEF YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ 

       310        320        330        340        350        360 
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM DYIGINLATM 

       370        380        390        400        410        420 
NSCINPIALY FVSKKFKNCF QSCLCCCCHQ SKSLMTSVPM NGTSIQWKNQ EQNNHNTERS 


SHKDSMN 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[3]Schoenfeld J.R., Lowe D.G.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-368.
Strain: C57BL/6.
Tissue: Lung.
[4]"Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 198-314.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK043210 mRNA. Translation: BAC31493.1.
BC008277 mRNA. Translation: AAH08277.1.
AF039892 mRNA. Translation: AAB96671.1.
L20340 mRNA. Translation: AAA16845.1.
CCDSCCDS22427.1.
PIRB57508.
RefSeqNP_034462.1. NM_010332.2.
UniGeneMm.283168.
Mm.392296.

3D structure databases

ProteinModelPortalQ61614.
SMRQ61614. Positions 80-381.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199380. 2 interactions.

Chemistry

BindingDBQ61614.
ChEMBLCHEMBL2286.
GuidetoPHARMACOLOGY219.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ61614.

Proteomic databases

PRIDEQ61614.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034029; ENSMUSP00000034029; ENSMUSG00000031616.
GeneID13617.
KEGGmmu:13617.
UCSCuc009mhv.1. mouse.

Organism-specific databases

CTD1909.
MGIMGI:105923. Ednra.

Phylogenomic databases

eggNOGNOG278704.
GeneTreeENSGT00690000101856.
HOGENOMHOG000272623.
HOVERGENHBG051443.
InParanoidQ61614.
KOK04197.
OMASIQWKNQ.
OrthoDBEOG7HHWS4.
PhylomeDBQ61614.
TreeFamTF331292.

Gene expression databases

BgeeQ61614.
CleanExMM_EDNRA.
GenevestigatorQ61614.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284284.
PROQ61614.
SOURCESearch...

Entry information

Entry nameEDNRA_MOUSE
AccessionPrimary (citable) accession number: Q61614
Secondary accession number(s): O54993, Q91VV2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2003
Last modified: July 9, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries