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Q61614

- EDNRA_MOUSE

UniProt

Q61614 - EDNRA_MOUSE

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Protein

Endothelin-1 receptor

Gene

Ednra

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).By similarity

GO - Molecular functioni

  1. endothelin receptor activity Source: MGI
  2. G-protein coupled receptor activity Source: MGI

GO - Biological processi

  1. aging Source: Ensembl
  2. artery smooth muscle contraction Source: Ensembl
  3. cellular response to mechanical stimulus Source: Ensembl
  4. endothelin receptor signaling pathway Source: GOC
  5. enteric nervous system development Source: InterPro
  6. fibroblast proliferation Source: Ensembl
  7. glomerular filtration Source: Ensembl
  8. glucose transport Source: MGI
  9. G-protein coupled receptor signaling pathway Source: MGI
  10. head development Source: MGI
  11. heart development Source: MGI
  12. histamine secretion Source: Ensembl
  13. in utero embryonic development Source: MGI
  14. maternal process involved in parturition Source: Ensembl
  15. negative regulation of apoptotic process Source: Ensembl
  16. negative regulation of cAMP biosynthetic process Source: MGI
  17. neural crest cell development Source: MGI
  18. patterning of blood vessels Source: MGI
  19. penile erection Source: Ensembl
  20. positive regulation of cell proliferation Source: Ensembl
  21. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  22. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  23. positive regulation of inflammatory response Source: Ensembl
  24. positive regulation of kidney development Source: Ensembl
  25. positive regulation of neutrophil chemotaxis Source: Ensembl
  26. positive regulation of odontogenesis Source: Ensembl
  27. positive regulation of protein phosphorylation Source: Ensembl
  28. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  29. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  30. regulation of blood pressure Source: InterPro
  31. regulation of epithelial cell proliferation Source: Ensembl
  32. respiratory gaseous exchange Source: MGI
  33. response to hypoxia Source: MGI
  34. response to lipopolysaccharide Source: Ensembl
  35. response to morphine Source: Ensembl
  36. Rho protein signal transduction Source: Ensembl
  37. sensory perception of pain Source: Ensembl
  38. smooth muscle cell proliferation Source: Ensembl
  39. vasoconstriction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1 receptor
Alternative name(s):
Endothelin A receptor
Short name:
ET-A
Short name:
ET-AR
Gene namesi
Name:Ednra
Synonyms:Gpcr10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:105923. Ednra.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nuclear membrane Source: Ensembl
  3. T-tubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 427407Endothelin-1 receptorPRO_0000012722Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi158 ↔ 239PROSITE-ProRule annotation
Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61614.
PRIDEiQ61614.

PTM databases

PhosphoSiteiQ61614.

Expressioni

Gene expression databases

BgeeiQ61614.
CleanExiMM_EDNRA.
GenevestigatoriQ61614.

Interactioni

Subunit structurei

Interacts with HDAC7 and KAT5.By similarity

Protein-protein interaction databases

BioGridi199380. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ61614.
SMRiQ61614. Positions 80-381.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 8060ExtracellularSequence AnalysisAdd
BLAST
Topological domaini103 – 11210CytoplasmicSequence Analysis
Topological domaini133 – 15927ExtracellularSequence AnalysisAdd
BLAST
Topological domaini182 – 20524CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini230 – 25627ExtracellularSequence AnalysisAdd
BLAST
Topological domaini279 – 30628CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini329 – 34719ExtracellularSequence AnalysisAdd
BLAST
Topological domaini373 – 42755CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei81 – 10222Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei113 – 13220Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei160 – 18122Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei206 – 22924Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei257 – 27822Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei307 – 32822Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei348 – 37225Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278704.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiQ61614.
KOiK04197.
OMAiSIQWKNQ.
OrthoDBiEOG7HHWS4.
PhylomeDBiQ61614.
TreeFamiTF331292.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61614-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIFCLAAYF WLTMVGGVMA DNPERYSANL SSHMEDFTPF PGTEINFLGT
60 70 80 90 100
THRPPNLALP SNGSMHGYCP QQTKITTAFK YINTVISCTI FIVGMVGNAT
110 120 130 140 150
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFDH
160 170 180 190 200
NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL
210 220 230 240 250
ITAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGELHRTCM LNATSKFMEF
260 270 280 290 300
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
310 320 330 340 350
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM
360 370 380 390 400
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCHQ SKSLMTSVPM
410 420
NGTSIQWKNQ EQNNHNTERS SHKDSMN
Length:427
Mass (Da):48,578
Last modified:May 30, 2003 - v3
Checksum:i10142BE73B028233
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK043210 mRNA. Translation: BAC31493.1.
BC008277 mRNA. Translation: AAH08277.1.
AF039892 mRNA. Translation: AAB96671.1.
L20340 mRNA. Translation: AAA16845.1.
CCDSiCCDS22427.1.
PIRiB57508.
RefSeqiNP_034462.1. NM_010332.2.
UniGeneiMm.283168.
Mm.392296.

Genome annotation databases

EnsembliENSMUST00000034029; ENSMUSP00000034029; ENSMUSG00000031616.
GeneIDi13617.
KEGGimmu:13617.
UCSCiuc009mhv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK043210 mRNA. Translation: BAC31493.1 .
BC008277 mRNA. Translation: AAH08277.1 .
AF039892 mRNA. Translation: AAB96671.1 .
L20340 mRNA. Translation: AAA16845.1 .
CCDSi CCDS22427.1.
PIRi B57508.
RefSeqi NP_034462.1. NM_010332.2.
UniGenei Mm.283168.
Mm.392296.

3D structure databases

ProteinModelPortali Q61614.
SMRi Q61614. Positions 80-381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199380. 2 interactions.

Chemistry

BindingDBi Q61614.
ChEMBLi CHEMBL2286.
GuidetoPHARMACOLOGYi 219.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q61614.

Proteomic databases

MaxQBi Q61614.
PRIDEi Q61614.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034029 ; ENSMUSP00000034029 ; ENSMUSG00000031616 .
GeneIDi 13617.
KEGGi mmu:13617.
UCSCi uc009mhv.1. mouse.

Organism-specific databases

CTDi 1909.
MGIi MGI:105923. Ednra.

Phylogenomic databases

eggNOGi NOG278704.
GeneTreei ENSGT00760000119177.
HOGENOMi HOG000272623.
HOVERGENi HBG051443.
InParanoidi Q61614.
KOi K04197.
OMAi SIQWKNQ.
OrthoDBi EOG7HHWS4.
PhylomeDBi Q61614.
TreeFami TF331292.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 284284.
PROi Q61614.
SOURCEi Search...

Gene expression databases

Bgeei Q61614.
CleanExi MM_EDNRA.
Genevestigatori Q61614.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. Schoenfeld J.R., Lowe D.G.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-368.
    Strain: C57BL/6.
    Tissue: Lung.
  4. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
    Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
    Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 198-314.
    Tissue: Testis.

Entry informationi

Entry nameiEDNRA_MOUSE
AccessioniPrimary (citable) accession number: Q61614
Secondary accession number(s): O54993, Q91VV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2003
Last modified: October 29, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3