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Q61614

- EDNRA_MOUSE

UniProt

Q61614 - EDNRA_MOUSE

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Protein
Endothelin-1 receptor
Gene
Ednra, Gpcr10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: MGI
  2. endothelin receptor activity Source: MGI
  3. protein binding Source: MGI

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: MGI
  2. Rho protein signal transduction Source: Ensembl
  3. aging Source: Ensembl
  4. artery smooth muscle contraction Source: Ensembl
  5. cellular response to mechanical stimulus Source: Ensembl
  6. endothelin receptor signaling pathway Source: GOC
  7. enteric nervous system development Source: InterPro
  8. fibroblast proliferation Source: Ensembl
  9. glomerular filtration Source: Ensembl
  10. glucose transport Source: MGI
  11. head development Source: MGI
  12. heart development Source: MGI
  13. histamine secretion Source: Ensembl
  14. in utero embryonic development Source: MGI
  15. maternal process involved in parturition Source: Ensembl
  16. negative regulation of apoptotic process Source: Ensembl
  17. negative regulation of cAMP biosynthetic process Source: MGI
  18. neural crest cell development Source: MGI
  19. patterning of blood vessels Source: MGI
  20. penile erection Source: Ensembl
  21. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  22. positive regulation of cell proliferation Source: Ensembl
  23. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  24. positive regulation of inflammatory response Source: Ensembl
  25. positive regulation of kidney development Source: Ensembl
  26. positive regulation of neutrophil chemotaxis Source: Ensembl
  27. positive regulation of odontogenesis Source: Ensembl
  28. positive regulation of protein phosphorylation Source: Ensembl
  29. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  30. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  31. regulation of blood pressure Source: InterPro
  32. regulation of epithelial cell proliferation Source: Ensembl
  33. respiratory gaseous exchange Source: MGI
  34. response to hypoxia Source: MGI
  35. response to lipopolysaccharide Source: Ensembl
  36. response to morphine Source: Ensembl
  37. sensory perception of pain Source: Ensembl
  38. smooth muscle cell proliferation Source: Ensembl
  39. vasoconstriction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1 receptor
Alternative name(s):
Endothelin A receptor
Short name:
ET-A
Short name:
ET-AR
Gene namesi
Name:Ednra
Synonyms:Gpcr10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:105923. Ednra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 8060Extracellular Reviewed prediction
Add
BLAST
Transmembranei81 – 10222Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini103 – 11210Cytoplasmic Reviewed prediction
Transmembranei113 – 13220Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini133 – 15927Extracellular Reviewed prediction
Add
BLAST
Transmembranei160 – 18122Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini182 – 20524Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei206 – 22924Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini230 – 25627Extracellular Reviewed prediction
Add
BLAST
Transmembranei257 – 27822Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini279 – 30628Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei307 – 32822Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini329 – 34719Extracellular Reviewed prediction
Add
BLAST
Transmembranei348 – 37225Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini373 – 42755Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. T-tubule Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. nuclear membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 427407Endothelin-1 receptor
PRO_0000012722Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi62 – 621N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi158 ↔ 239 By similarity
Glycosylationi242 – 2421N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ61614.

PTM databases

PhosphoSiteiQ61614.

Expressioni

Gene expression databases

BgeeiQ61614.
CleanExiMM_EDNRA.
GenevestigatoriQ61614.

Interactioni

Subunit structurei

Interacts with HDAC7 and KAT5 By similarity.

Protein-protein interaction databases

BioGridi199380. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ61614.
SMRiQ61614. Positions 80-381.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278704.
GeneTreeiENSGT00690000101856.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiQ61614.
KOiK04197.
OMAiSIQWKNQ.
OrthoDBiEOG7HHWS4.
PhylomeDBiQ61614.
TreeFamiTF331292.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61614-1 [UniParc]FASTAAdd to Basket

« Hide

MSIFCLAAYF WLTMVGGVMA DNPERYSANL SSHMEDFTPF PGTEINFLGT    50
THRPPNLALP SNGSMHGYCP QQTKITTAFK YINTVISCTI FIVGMVGNAT 100
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFDH 150
NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL 200
ITAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGELHRTCM LNATSKFMEF 250
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ 300
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM 350
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCHQ SKSLMTSVPM 400
NGTSIQWKNQ EQNNHNTERS SHKDSMN 427
Length:427
Mass (Da):48,578
Last modified:May 30, 2003 - v3
Checksum:i10142BE73B028233
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK043210 mRNA. Translation: BAC31493.1.
BC008277 mRNA. Translation: AAH08277.1.
AF039892 mRNA. Translation: AAB96671.1.
L20340 mRNA. Translation: AAA16845.1.
CCDSiCCDS22427.1.
PIRiB57508.
RefSeqiNP_034462.1. NM_010332.2.
UniGeneiMm.283168.
Mm.392296.

Genome annotation databases

EnsembliENSMUST00000034029; ENSMUSP00000034029; ENSMUSG00000031616.
GeneIDi13617.
KEGGimmu:13617.
UCSCiuc009mhv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK043210 mRNA. Translation: BAC31493.1 .
BC008277 mRNA. Translation: AAH08277.1 .
AF039892 mRNA. Translation: AAB96671.1 .
L20340 mRNA. Translation: AAA16845.1 .
CCDSi CCDS22427.1.
PIRi B57508.
RefSeqi NP_034462.1. NM_010332.2.
UniGenei Mm.283168.
Mm.392296.

3D structure databases

ProteinModelPortali Q61614.
SMRi Q61614. Positions 80-381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199380. 2 interactions.

Chemistry

BindingDBi Q61614.
ChEMBLi CHEMBL2286.
GuidetoPHARMACOLOGYi 219.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q61614.

Proteomic databases

PRIDEi Q61614.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034029 ; ENSMUSP00000034029 ; ENSMUSG00000031616 .
GeneIDi 13617.
KEGGi mmu:13617.
UCSCi uc009mhv.1. mouse.

Organism-specific databases

CTDi 1909.
MGIi MGI:105923. Ednra.

Phylogenomic databases

eggNOGi NOG278704.
GeneTreei ENSGT00690000101856.
HOGENOMi HOG000272623.
HOVERGENi HBG051443.
InParanoidi Q61614.
KOi K04197.
OMAi SIQWKNQ.
OrthoDBi EOG7HHWS4.
PhylomeDBi Q61614.
TreeFami TF331292.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 284284.
PROi Q61614.
SOURCEi Search...

Gene expression databases

Bgeei Q61614.
CleanExi MM_EDNRA.
Genevestigatori Q61614.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. Schoenfeld J.R., Lowe D.G.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-368.
    Strain: C57BL/6.
    Tissue: Lung.
  4. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
    Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
    Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 198-314.
    Tissue: Testis.

Entry informationi

Entry nameiEDNRA_MOUSE
AccessioniPrimary (citable) accession number: Q61614
Secondary accession number(s): O54993, Q91VV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2003
Last modified: September 3, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi