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Protein

Endothelin-1 receptor

Gene

Ednra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).By similarity

GO - Molecular functioni

  • endothelin receptor activity Source: MGI
  • G-protein coupled receptor activity Source: MGI

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
  • artery smooth muscle contraction Source: MGI
  • branching involved in blood vessel morphogenesis Source: MGI
  • enteric nervous system development Source: InterPro
  • G-protein coupled receptor signaling pathway Source: MGI
  • head development Source: MGI
  • heart development Source: MGI
  • in utero embryonic development Source: MGI
  • neural crest cell development Source: MGI
  • regulation of blood pressure Source: InterPro
  • respiratory gaseous exchange Source: MGI
  • response to hypoxia Source: MGI
  • vasoconstriction Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1 receptorCurated
Alternative name(s):
Endothelin receptor type AImported
Short name:
ET-A
Short name:
ET-AR
Gene namesi
Name:EdnraImported
Synonyms:Gpcr10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:105923 Ednra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 80ExtracellularSequence analysisAdd BLAST60
Transmembranei81 – 102Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini103 – 112CytoplasmicSequence analysis10
Transmembranei113 – 132Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini133 – 159ExtracellularSequence analysisAdd BLAST27
Transmembranei160 – 181Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini182 – 205CytoplasmicSequence analysisAdd BLAST24
Transmembranei206 – 229Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini230 – 256ExtracellularSequence analysisAdd BLAST27
Transmembranei257 – 278Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini279 – 306CytoplasmicSequence analysisAdd BLAST28
Transmembranei307 – 328Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini329 – 347ExtracellularSequence analysisAdd BLAST19
Transmembranei348 – 372Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini373 – 427CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2286

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001272221 – 427Endothelin-1 receptorAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi158 ↔ 239PROSITE-ProRule annotation
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei425PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61614
PaxDbiQ61614
PRIDEiQ61614

PTM databases

iPTMnetiQ61614
PhosphoSitePlusiQ61614

Expressioni

Gene expression databases

BgeeiENSMUSG00000031616
CleanExiMM_EDNRA
GenevisibleiQ61614 MM

Interactioni

Subunit structurei

Interacts with HDAC7 and KAT5.By similarity

Protein-protein interaction databases

BioGridi199380, 2 interactors
STRINGi10090.ENSMUSP00000034029

Chemistry databases

BindingDBiQ61614

Structurei

3D structure databases

ProteinModelPortaliQ61614
SMRiQ61614
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119177
HOGENOMiHOG000272623
HOVERGENiHBG051443
InParanoidiQ61614
KOiK04197
OMAiNNHNTER
OrthoDBiEOG091G0CJV
PhylomeDBiQ61614
TreeFamiTF331292

Family and domain databases

InterProiView protein in InterPro
IPR000499 Endthln_rcpt
IPR002175 ETA_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00570 ENDOTHELINAR
PR00366 ENDOTHELINR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFCLAAYF WLTMVGGVMA DNPERYSANL SSHMEDFTPF PGTEINFLGT
60 70 80 90 100
THRPPNLALP SNGSMHGYCP QQTKITTAFK YINTVISCTI FIVGMVGNAT
110 120 130 140 150
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFDH
160 170 180 190 200
NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL
210 220 230 240 250
ITAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGELHRTCM LNATSKFMEF
260 270 280 290 300
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
310 320 330 340 350
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM
360 370 380 390 400
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCHQ SKSLMTSVPM
410 420
NGTSIQWKNQ EQNNHNTERS SHKDSMN
Length:427
Mass (Da):48,578
Last modified:May 30, 2003 - v3
Checksum:i10142BE73B028233
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043210 mRNA Translation: BAC31493.1
BC008277 mRNA Translation: AAH08277.1
AF039892 mRNA Translation: AAB96671.1
L20340 mRNA Translation: AAA16845.1
CCDSiCCDS22427.1
PIRiB57508
RefSeqiNP_034462.1, NM_010332.2
UniGeneiMm.283168
Mm.392296

Genome annotation databases

EnsembliENSMUST00000034029; ENSMUSP00000034029; ENSMUSG00000031616
GeneIDi13617
KEGGimmu:13617
UCSCiuc009mhv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiEDNRA_MOUSE
AccessioniPrimary (citable) accession number: Q61614
Secondary accession number(s): O54993, Q91VV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2003
Last modified: April 25, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health