Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q61614

- EDNRA_MOUSE

UniProt

Q61614 - EDNRA_MOUSE

Protein

Endothelin-1 receptor

Gene

Ednra

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (30 May 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 By similarity.By similarity

    GO - Molecular functioni

    1. endothelin receptor activity Source: MGI
    2. G-protein coupled receptor activity Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. aging Source: Ensembl
    2. artery smooth muscle contraction Source: Ensembl
    3. cellular response to mechanical stimulus Source: Ensembl
    4. endothelin receptor signaling pathway Source: GOC
    5. enteric nervous system development Source: InterPro
    6. fibroblast proliferation Source: Ensembl
    7. glomerular filtration Source: Ensembl
    8. glucose transport Source: MGI
    9. G-protein coupled receptor signaling pathway Source: MGI
    10. head development Source: MGI
    11. heart development Source: MGI
    12. histamine secretion Source: Ensembl
    13. in utero embryonic development Source: MGI
    14. maternal process involved in parturition Source: Ensembl
    15. negative regulation of apoptotic process Source: Ensembl
    16. negative regulation of cAMP biosynthetic process Source: MGI
    17. neural crest cell development Source: MGI
    18. patterning of blood vessels Source: MGI
    19. penile erection Source: Ensembl
    20. positive regulation of cell proliferation Source: Ensembl
    21. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
    22. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    23. positive regulation of inflammatory response Source: Ensembl
    24. positive regulation of kidney development Source: Ensembl
    25. positive regulation of neutrophil chemotaxis Source: Ensembl
    26. positive regulation of odontogenesis Source: Ensembl
    27. positive regulation of protein phosphorylation Source: Ensembl
    28. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
    29. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    30. regulation of blood pressure Source: InterPro
    31. regulation of epithelial cell proliferation Source: Ensembl
    32. respiratory gaseous exchange Source: MGI
    33. response to hypoxia Source: MGI
    34. response to lipopolysaccharide Source: Ensembl
    35. response to morphine Source: Ensembl
    36. Rho protein signal transduction Source: Ensembl
    37. sensory perception of pain Source: Ensembl
    38. smooth muscle cell proliferation Source: Ensembl
    39. vasoconstriction Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-1 receptor
    Alternative name(s):
    Endothelin A receptor
    Short name:
    ET-A
    Short name:
    ET-AR
    Gene namesi
    Name:Ednra
    Synonyms:Gpcr10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:105923. Ednra.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. nuclear membrane Source: Ensembl
    3. T-tubule Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 427407Endothelin-1 receptorPRO_0000012722Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi158 ↔ 239PROSITE-ProRule annotation
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ61614.

    PTM databases

    PhosphoSiteiQ61614.

    Expressioni

    Gene expression databases

    BgeeiQ61614.
    CleanExiMM_EDNRA.
    GenevestigatoriQ61614.

    Interactioni

    Subunit structurei

    Interacts with HDAC7 and KAT5.By similarity

    Protein-protein interaction databases

    BioGridi199380. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61614.
    SMRiQ61614. Positions 80-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 8060ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 11210CytoplasmicSequence Analysis
    Topological domaini133 – 15927ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini182 – 20524CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini230 – 25627ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini279 – 30628CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini329 – 34719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini373 – 42755CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei81 – 10222Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13220Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei160 – 18122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22924Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27822Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei307 – 32822Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei348 – 37225Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG278704.
    GeneTreeiENSGT00690000101856.
    HOGENOMiHOG000272623.
    HOVERGENiHBG051443.
    InParanoidiQ61614.
    KOiK04197.
    OMAiSIQWKNQ.
    OrthoDBiEOG7HHWS4.
    PhylomeDBiQ61614.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000499. Endthln_rcpt.
    IPR002175. ETA_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00570. ENDOTHELINAR.
    PR00366. ENDOTHELINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61614-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIFCLAAYF WLTMVGGVMA DNPERYSANL SSHMEDFTPF PGTEINFLGT    50
    THRPPNLALP SNGSMHGYCP QQTKITTAFK YINTVISCTI FIVGMVGNAT 100
    LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFDH 150
    NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL 200
    ITAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGELHRTCM LNATSKFMEF 250
    YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ 300
    RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM 350
    DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCHQ SKSLMTSVPM 400
    NGTSIQWKNQ EQNNHNTERS SHKDSMN 427
    Length:427
    Mass (Da):48,578
    Last modified:May 30, 2003 - v3
    Checksum:i10142BE73B028233
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043210 mRNA. Translation: BAC31493.1.
    BC008277 mRNA. Translation: AAH08277.1.
    AF039892 mRNA. Translation: AAB96671.1.
    L20340 mRNA. Translation: AAA16845.1.
    CCDSiCCDS22427.1.
    PIRiB57508.
    RefSeqiNP_034462.1. NM_010332.2.
    UniGeneiMm.283168.
    Mm.392296.

    Genome annotation databases

    EnsembliENSMUST00000034029; ENSMUSP00000034029; ENSMUSG00000031616.
    GeneIDi13617.
    KEGGimmu:13617.
    UCSCiuc009mhv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043210 mRNA. Translation: BAC31493.1 .
    BC008277 mRNA. Translation: AAH08277.1 .
    AF039892 mRNA. Translation: AAB96671.1 .
    L20340 mRNA. Translation: AAA16845.1 .
    CCDSi CCDS22427.1.
    PIRi B57508.
    RefSeqi NP_034462.1. NM_010332.2.
    UniGenei Mm.283168.
    Mm.392296.

    3D structure databases

    ProteinModelPortali Q61614.
    SMRi Q61614. Positions 80-381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199380. 2 interactions.

    Chemistry

    BindingDBi Q61614.
    ChEMBLi CHEMBL2286.
    GuidetoPHARMACOLOGYi 219.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q61614.

    Proteomic databases

    PRIDEi Q61614.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034029 ; ENSMUSP00000034029 ; ENSMUSG00000031616 .
    GeneIDi 13617.
    KEGGi mmu:13617.
    UCSCi uc009mhv.1. mouse.

    Organism-specific databases

    CTDi 1909.
    MGIi MGI:105923. Ednra.

    Phylogenomic databases

    eggNOGi NOG278704.
    GeneTreei ENSGT00690000101856.
    HOGENOMi HOG000272623.
    HOVERGENi HBG051443.
    InParanoidi Q61614.
    KOi K04197.
    OMAi SIQWKNQ.
    OrthoDBi EOG7HHWS4.
    PhylomeDBi Q61614.
    TreeFami TF331292.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 284284.
    PROi Q61614.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61614.
    CleanExi MM_EDNRA.
    Genevestigatori Q61614.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000499. Endthln_rcpt.
    IPR002175. ETA_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00570. ENDOTHELINAR.
    PR00366. ENDOTHELINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    3. Schoenfeld J.R., Lowe D.G.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-368.
      Strain: C57BL/6.
      Tissue: Lung.
    4. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
      Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
      Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 198-314.
      Tissue: Testis.

    Entry informationi

    Entry nameiEDNRA_MOUSE
    AccessioniPrimary (citable) accession number: Q61614
    Secondary accession number(s): O54993, Q91VV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 30, 2003
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3