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Q61609

- S20A1_MOUSE

UniProt

Q61609 - S20A1_MOUSE

Protein

Sodium-dependent phosphate transporter 1

Gene

Slc20a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor but do not confer infection susceptibility to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B).5 Publications

    GO - Molecular functioni

    1. high-affinity inorganic phosphate:sodium symporter activity Source: Ensembl
    2. inorganic phosphate transmembrane transporter activity Source: InterPro
    3. signal transducer activity Source: Ensembl

    GO - Biological processi

    1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Phosphate transport, Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent phosphate transporter 1
    Alternative name(s):
    Gibbon ape leukemia virus receptor 1
    Short name:
    GLVR-1
    Leukemia virus receptor 1 homolog
    Phosphate transporter 1
    Short name:
    PiT-1
    Solute carrier family 20 member 1
    Gene namesi
    Name:Slc20a1
    Synonyms:Glvr1, Pit1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:108392. Slc20a1.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi553 – 5608KQEASTKA → DTGDVSSKV: Confers virus infectibility. 1 Publication
    Mutagenesisi553 – 5553KQE → DTGD: Confers virus infectibility. 1 Publication
    Mutagenesisi553 – 5531K → DT: Confers virus infectibility. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 681681Sodium-dependent phosphate transporter 1PRO_0000080772Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei269 – 2691Phosphoserine1 Publication
    Modified residuei273 – 2731Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ61609.
    PRIDEiQ61609.

    PTM databases

    PhosphoSiteiQ61609.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Developmental stagei

    Detected at E17 of embryonic development in a subpopulation of early hypertrophic chondrocytes in bone, but not when fully differentiated.1 Publication

    Inductioni

    By growth hormone.1 Publication

    Gene expression databases

    ArrayExpressiQ61609.
    BgeeiQ61609.
    CleanExiMM_SLC20A1.
    GenevestigatoriQ61609.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61609.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini46 – 6520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini87 – 10519ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 16135CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini183 – 20018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini222 – 23312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini255 – 513259ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini535 – 56026CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini582 – 60120ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini623 – 65129CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini673 – 6819ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei514 – 53421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei561 – 58121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei602 – 62221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei652 – 67221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni553 – 5608A

    Domaini

    Region A does not confer susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0306.
    GeneTreeiENSGT00390000014879.
    HOGENOMiHOG000231892.
    HOVERGENiHBG053358.
    InParanoidiQ61609.
    KOiK14640.
    OMAiDIENRNP.
    OrthoDBiEOG79KPDT.
    PhylomeDBiQ61609.
    TreeFamiTF314426.

    Family and domain databases

    InterProiIPR001204. Phos_transporter.
    [Graphical view]
    PANTHERiPTHR11101. PTHR11101. 1 hit.
    PfamiPF01384. PHO4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61609-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESTVATITS TLAAVTASAP PKYDNLWMLI LGFIIAFVLA FSVGANDVAN    50
    SFGTAVGSGV VTLKQACILA SIFETVGSAL LGAKVSETIR NGLIDVELYN 100
    ETQDLLMAGS VSAMFGSAVW QLVASFLKLP ISGTHCIVGA TIGFSLVANG 150
    QKGVKWSELI KIVMSWFVSP LLSGIMSGIL FFLVRAFILR KADPVPNGLR 200
    ALPIFYACTI GINLFSIMYT GAPLLGFDKL PLWGTILISV GCAVFCALIV 250
    WFFVCPRMKR KIEREVKSSP SESPLMEKKS NLKEDHEETK MAPGDVEHRN 300
    PVSEVVCATG PLRAVVEERT VSFKLGDLEE APERERLPMD LKEETSIDST 350
    INGAVQLPNG NLVQFSQTVS NQINSSGHYQ YHTVHKDSGL YKELLHKLHL 400
    AKVGDCMGDS GDKPLRRNNS YTSYTMAICG MPLDSFRAKE GEQKGDEMET 450
    LTWPNADTKK RIRMDSYTSY CNAVSDLHSE SEMDMSVKAE MGLGDRKGSS 500
    GSLEEWYDQD KPEVSLLFQF LQILTACFGS FAHGGNDVSN AIGPLVALYL 550
    VYKQEASTKA ATPIWLLLYG GVGICMGLWV WGRRVIQTMG KDLTPITPSS 600
    GFSIELASAL TVVIASNIGL PISTTHCKVG SVVSVGWLRS KKAVDWRLFR 650
    NIFMAWFVTV PISGVISAAI MAVFKYIILP V 681
    Length:681
    Mass (Da):74,153
    Last modified:November 1, 1996 - v1
    Checksum:iF337B0982B5A297D
    GO

    Sequence cautioni

    The sequence BAC29234.1 differs from that shown. Reason: Intron retention. The sequence differs at the 3'end due to intron retention.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti190 – 1901R → H(PubMed:8046392)Curated
    Sequence conflicti368 – 3681T → A(PubMed:8046392)Curated
    Sequence conflicti446 – 4461D → E(PubMed:8046392)Curated
    Sequence conflicti490 – 4901E → G in AAH15085. (PubMed:15489334)Curated
    Sequence conflicti568 – 5681L → P in BAE33298. (PubMed:16141072)Curated
    Sequence conflicti569 – 5691Y → T(PubMed:8046392)Curated
    Sequence conflicti639 – 6391R → I(PubMed:8046392)Curated
    Sequence conflicti672 – 6721A → AA(PubMed:8046392)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73696 mRNA. Translation: AAA74887.1.
    AF172634
    , AF172628, AF172629, AF172630, AF172631, AF172632, AF172633 Genomic DNA. Translation: AAF45041.1.
    AK035898 mRNA. Translation: BAC29234.1. Sequence problems.
    AK155506 mRNA. Translation: BAE33298.1.
    AL772347 Genomic DNA. Translation: CAM15802.1.
    BC015085 mRNA. Translation: AAH15085.1.
    CCDSiCCDS16722.1.
    PIRiS27868.
    RefSeqiNP_001153065.1. NM_001159593.1.
    NP_056562.1. NM_015747.2.
    XP_006499111.1. XM_006499048.1.
    UniGeneiMm.272675.

    Genome annotation databases

    EnsembliENSMUST00000028880; ENSMUSP00000028880; ENSMUSG00000027397.
    ENSMUST00000110315; ENSMUSP00000105944; ENSMUSG00000027397.
    GeneIDi20515.
    KEGGimmu:20515.
    UCSCiuc008mhl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73696 mRNA. Translation: AAA74887.1 .
    AF172634
    , AF172628 , AF172629 , AF172630 , AF172631 , AF172632 , AF172633 Genomic DNA. Translation: AAF45041.1 .
    AK035898 mRNA. Translation: BAC29234.1 . Sequence problems.
    AK155506 mRNA. Translation: BAE33298.1 .
    AL772347 Genomic DNA. Translation: CAM15802.1 .
    BC015085 mRNA. Translation: AAH15085.1 .
    CCDSi CCDS16722.1.
    PIRi S27868.
    RefSeqi NP_001153065.1. NM_001159593.1.
    NP_056562.1. NM_015747.2.
    XP_006499111.1. XM_006499048.1.
    UniGenei Mm.272675.

    3D structure databases

    ProteinModelPortali Q61609.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q61609.

    Proteomic databases

    PaxDbi Q61609.
    PRIDEi Q61609.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028880 ; ENSMUSP00000028880 ; ENSMUSG00000027397 .
    ENSMUST00000110315 ; ENSMUSP00000105944 ; ENSMUSG00000027397 .
    GeneIDi 20515.
    KEGGi mmu:20515.
    UCSCi uc008mhl.2. mouse.

    Organism-specific databases

    CTDi 6574.
    MGIi MGI:108392. Slc20a1.

    Phylogenomic databases

    eggNOGi COG0306.
    GeneTreei ENSGT00390000014879.
    HOGENOMi HOG000231892.
    HOVERGENi HBG053358.
    InParanoidi Q61609.
    KOi K14640.
    OMAi DIENRNP.
    OrthoDBi EOG79KPDT.
    PhylomeDBi Q61609.
    TreeFami TF314426.

    Miscellaneous databases

    ChiTaRSi SLC20A1. mouse.
    NextBioi 298723.
    PROi Q61609.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61609.
    Bgeei Q61609.
    CleanExi MM_SLC20A1.
    Genevestigatori Q61609.

    Family and domain databases

    InterProi IPR001204. Phos_transporter.
    [Graphical view ]
    PANTHERi PTHR11101. PTHR11101. 1 hit.
    Pfami PF01384. PHO4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus."
      Johann S.V., Gibbons J.J., O'Hara B.
      J. Virol. 66:1635-1640(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "Comparison of cDNAs encoding the gibbon ape leukaemia virus receptor from susceptible and non-susceptible murine cells."
      Wilson C.A., Farrell K.B., Eiden M.V.
      J. Gen. Virol. 75:1901-1908(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Structure of the murine Pit1 phosphate transporter/retrovirus receptor gene and functional characterization of its promoter region."
      Palmer G., Manen D., Bonjour J.-P., Caverzasio J.
      Gene 244:35-45(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    7. "Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus."
      Takeuchi Y., Vile R.G., Simpson G., O'Hara B., Collins M.K., Weiss R.A.
      J. Virol. 66:1219-1222(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species."
      Johann S.V., van Zeijl M., Cekleniak J., O'Hara B.
      J. Virol. 67:6733-6736(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF 553-LYS--ALA-560; 553-LYS--GLU-555 AND LYS-553, REGION.
    9. "Differential expression, abundance, and regulation of Na+-phosphate cotransporter genes in murine kidney."
      Tenenhouse H.S., Roy S., Martel J., Gauthier C.
      Am. J. Physiol. 275:F527-F534(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    10. "In vivo expression of transcripts encoding the Glvr-1 phosphate transporter/retrovirus receptor during bone development."
      Palmer G., Zhao J., Bonjour J.-P., Hofstetter W., Caverzasio J.
      Bone 24:1-7(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    11. "Reassessing the role of region A in Pit1-mediated viral entry."
      Farrell K.B., Russ J.L., Murthy R.K., Eiden M.V.
      J. Virol. 76:7683-7693(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, REGION.
    12. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269 AND SER-273, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS20A1_MOUSE
    AccessioniPrimary (citable) accession number: Q61609
    Secondary accession number(s): A2AKR9
    , Q3U244, Q8CBJ1, Q91YQ9, Q9QVW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3