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Protein

Sodium-dependent phosphate transporter 1

Gene

Slc20a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor but do not confer infection susceptibility to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B).5 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Phosphate transport, Symport, Transport

Enzyme and pathway databases

BRENDAi3.6.3.27. 3474.
ReactomeiR-MMU-427652. Sodium-coupled phosphate cotransporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 1
Alternative name(s):
Gibbon ape leukemia virus receptor 1
Short name:
GLVR-1
Leukemia virus receptor 1 homolog
Phosphate transporter 1
Short name:
PiT-1
Solute carrier family 20 member 1
Gene namesi
Name:Slc20a1
Synonyms:Glvr1, Pit1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:108392. Slc20a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 65CytoplasmicSequence analysisAdd BLAST20
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 105ExtracellularSequence analysisAdd BLAST19
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 161CytoplasmicSequence analysisAdd BLAST35
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 200ExtracellularSequence analysisAdd BLAST18
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 233CytoplasmicSequence analysisAdd BLAST12
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 513ExtracellularSequence analysisAdd BLAST259
Transmembranei514 – 534HelicalSequence analysisAdd BLAST21
Topological domaini535 – 560CytoplasmicSequence analysisAdd BLAST26
Transmembranei561 – 581HelicalSequence analysisAdd BLAST21
Topological domaini582 – 601ExtracellularSequence analysisAdd BLAST20
Transmembranei602 – 622HelicalSequence analysisAdd BLAST21
Topological domaini623 – 651CytoplasmicSequence analysisAdd BLAST29
Transmembranei652 – 672HelicalSequence analysisAdd BLAST21
Topological domaini673 – 681ExtracellularSequence analysis9

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi553 – 560KQEASTKA → DTGDVSSKV: Confers virus infectibility. 1 Publication8
Mutagenesisi553 – 555KQE → DTGD: Confers virus infectibility. 1 Publication3
Mutagenesisi553K → DT: Confers virus infectibility. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000807721 – 681Sodium-dependent phosphate transporter 1Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ61609.
PaxDbiQ61609.
PeptideAtlasiQ61609.
PRIDEiQ61609.

PTM databases

iPTMnetiQ61609.
PhosphoSitePlusiQ61609.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Developmental stagei

Detected at E17 of embryonic development in a subpopulation of early hypertrophic chondrocytes in bone, but not when fully differentiated.1 Publication

Inductioni

By growth hormone.1 Publication

Gene expression databases

BgeeiENSMUSG00000027397.
CleanExiMM_SLC20A1.
ExpressionAtlasiQ61609. baseline and differential.
GenevisibleiQ61609. MM.

Interactioni

Protein-protein interaction databases

BioGridi203294. 1 interactor.
STRINGi10090.ENSMUSP00000028880.

Structurei

3D structure databases

ProteinModelPortaliQ61609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni553 – 560A8

Domaini

Region A does not confer susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2493. Eukaryota.
COG0306. LUCA.
GeneTreeiENSGT00390000014879.
HOGENOMiHOG000231892.
HOVERGENiHBG053358.
InParanoidiQ61609.
KOiK14640.
OMAiWINLATW.
OrthoDBiEOG091G07J5.
PhylomeDBiQ61609.
TreeFamiTF314426.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 2 hits.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTVATITS TLAAVTASAP PKYDNLWMLI LGFIIAFVLA FSVGANDVAN
60 70 80 90 100
SFGTAVGSGV VTLKQACILA SIFETVGSAL LGAKVSETIR NGLIDVELYN
110 120 130 140 150
ETQDLLMAGS VSAMFGSAVW QLVASFLKLP ISGTHCIVGA TIGFSLVANG
160 170 180 190 200
QKGVKWSELI KIVMSWFVSP LLSGIMSGIL FFLVRAFILR KADPVPNGLR
210 220 230 240 250
ALPIFYACTI GINLFSIMYT GAPLLGFDKL PLWGTILISV GCAVFCALIV
260 270 280 290 300
WFFVCPRMKR KIEREVKSSP SESPLMEKKS NLKEDHEETK MAPGDVEHRN
310 320 330 340 350
PVSEVVCATG PLRAVVEERT VSFKLGDLEE APERERLPMD LKEETSIDST
360 370 380 390 400
INGAVQLPNG NLVQFSQTVS NQINSSGHYQ YHTVHKDSGL YKELLHKLHL
410 420 430 440 450
AKVGDCMGDS GDKPLRRNNS YTSYTMAICG MPLDSFRAKE GEQKGDEMET
460 470 480 490 500
LTWPNADTKK RIRMDSYTSY CNAVSDLHSE SEMDMSVKAE MGLGDRKGSS
510 520 530 540 550
GSLEEWYDQD KPEVSLLFQF LQILTACFGS FAHGGNDVSN AIGPLVALYL
560 570 580 590 600
VYKQEASTKA ATPIWLLLYG GVGICMGLWV WGRRVIQTMG KDLTPITPSS
610 620 630 640 650
GFSIELASAL TVVIASNIGL PISTTHCKVG SVVSVGWLRS KKAVDWRLFR
660 670 680
NIFMAWFVTV PISGVISAAI MAVFKYIILP V
Length:681
Mass (Da):74,153
Last modified:November 1, 1996 - v1
Checksum:iF337B0982B5A297D
GO

Sequence cautioni

The sequence BAC29234 differs from that shown. Intron retention. The sequence differs at the 3'end due to intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190R → H (PubMed:8046392).Curated1
Sequence conflicti368T → A (PubMed:8046392).Curated1
Sequence conflicti446D → E (PubMed:8046392).Curated1
Sequence conflicti490E → G in AAH15085 (PubMed:15489334).Curated1
Sequence conflicti568L → P in BAE33298 (PubMed:16141072).Curated1
Sequence conflicti569Y → T (PubMed:8046392).Curated1
Sequence conflicti639R → I (PubMed:8046392).Curated1
Sequence conflicti672A → AA (PubMed:8046392).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73696 mRNA. Translation: AAA74887.1.
AF172634
, AF172628, AF172629, AF172630, AF172631, AF172632, AF172633 Genomic DNA. Translation: AAF45041.1.
AK035898 mRNA. Translation: BAC29234.1. Sequence problems.
AK155506 mRNA. Translation: BAE33298.1.
AL772347 Genomic DNA. Translation: CAM15802.1.
BC015085 mRNA. Translation: AAH15085.1.
CCDSiCCDS16722.1.
PIRiS27868.
RefSeqiNP_001153065.1. NM_001159593.1.
NP_056562.1. NM_015747.2.
UniGeneiMm.272675.

Genome annotation databases

EnsembliENSMUST00000028880; ENSMUSP00000028880; ENSMUSG00000027397.
ENSMUST00000110315; ENSMUSP00000105944; ENSMUSG00000027397.
GeneIDi20515.
KEGGimmu:20515.
UCSCiuc008mhl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73696 mRNA. Translation: AAA74887.1.
AF172634
, AF172628, AF172629, AF172630, AF172631, AF172632, AF172633 Genomic DNA. Translation: AAF45041.1.
AK035898 mRNA. Translation: BAC29234.1. Sequence problems.
AK155506 mRNA. Translation: BAE33298.1.
AL772347 Genomic DNA. Translation: CAM15802.1.
BC015085 mRNA. Translation: AAH15085.1.
CCDSiCCDS16722.1.
PIRiS27868.
RefSeqiNP_001153065.1. NM_001159593.1.
NP_056562.1. NM_015747.2.
UniGeneiMm.272675.

3D structure databases

ProteinModelPortaliQ61609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203294. 1 interactor.
STRINGi10090.ENSMUSP00000028880.

PTM databases

iPTMnetiQ61609.
PhosphoSitePlusiQ61609.

Proteomic databases

EPDiQ61609.
PaxDbiQ61609.
PeptideAtlasiQ61609.
PRIDEiQ61609.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028880; ENSMUSP00000028880; ENSMUSG00000027397.
ENSMUST00000110315; ENSMUSP00000105944; ENSMUSG00000027397.
GeneIDi20515.
KEGGimmu:20515.
UCSCiuc008mhl.2. mouse.

Organism-specific databases

CTDi6574.
MGIiMGI:108392. Slc20a1.

Phylogenomic databases

eggNOGiKOG2493. Eukaryota.
COG0306. LUCA.
GeneTreeiENSGT00390000014879.
HOGENOMiHOG000231892.
HOVERGENiHBG053358.
InParanoidiQ61609.
KOiK14640.
OMAiWINLATW.
OrthoDBiEOG091G07J5.
PhylomeDBiQ61609.
TreeFamiTF314426.

Enzyme and pathway databases

BRENDAi3.6.3.27. 3474.
ReactomeiR-MMU-427652. Sodium-coupled phosphate cotransporters.

Miscellaneous databases

ChiTaRSiSlc20a1. mouse.
PROiQ61609.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027397.
CleanExiMM_SLC20A1.
ExpressionAtlasiQ61609. baseline and differential.
GenevisibleiQ61609. MM.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 2 hits.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS20A1_MOUSE
AccessioniPrimary (citable) accession number: Q61609
Secondary accession number(s): A2AKR9
, Q3U244, Q8CBJ1, Q91YQ9, Q9QVW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.