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Q61609

- S20A1_MOUSE

UniProt

Q61609 - S20A1_MOUSE

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Protein
Sodium-dependent phosphate transporter 1
Gene
Slc20a1, Glvr1, Pit1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor but do not confer infection susceptibility to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B).5 Publications

GO - Molecular functioni

  1. high affinity inorganic phosphate:sodium symporter activity Source: Ensembl
  2. inorganic phosphate transmembrane transporter activity Source: InterPro
  3. signal transducer activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Phosphate transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 1
Alternative name(s):
Gibbon ape leukemia virus receptor 1
Short name:
GLVR-1
Leukemia virus receptor 1 homolog
Phosphate transporter 1
Short name:
PiT-1
Solute carrier family 20 member 1
Gene namesi
Name:Slc20a1
Synonyms:Glvr1, Pit1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:108392. Slc20a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424Extracellular Reviewed prediction
Add
BLAST
Transmembranei25 – 4521Helical; Reviewed prediction
Add
BLAST
Topological domaini46 – 6520Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei66 – 8621Helical; Reviewed prediction
Add
BLAST
Topological domaini87 – 10519Extracellular Reviewed prediction
Add
BLAST
Transmembranei106 – 12621Helical; Reviewed prediction
Add
BLAST
Topological domaini127 – 16135Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei162 – 18221Helical; Reviewed prediction
Add
BLAST
Topological domaini183 – 20018Extracellular Reviewed prediction
Add
BLAST
Transmembranei201 – 22121Helical; Reviewed prediction
Add
BLAST
Topological domaini222 – 23312Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei234 – 25421Helical; Reviewed prediction
Add
BLAST
Topological domaini255 – 513259Extracellular Reviewed prediction
Add
BLAST
Transmembranei514 – 53421Helical; Reviewed prediction
Add
BLAST
Topological domaini535 – 56026Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei561 – 58121Helical; Reviewed prediction
Add
BLAST
Topological domaini582 – 60120Extracellular Reviewed prediction
Add
BLAST
Transmembranei602 – 62221Helical; Reviewed prediction
Add
BLAST
Topological domaini623 – 65129Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei652 – 67221Helical; Reviewed prediction
Add
BLAST
Topological domaini673 – 6819Extracellular Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi553 – 5608KQEASTKA → DTGDVSSKV: Confers virus infectibility. 1 Publication
Mutagenesisi553 – 5553KQE → DTGD: Confers virus infectibility. 1 Publication
Mutagenesisi553 – 5531K → DT: Confers virus infectibility. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 681681Sodium-dependent phosphate transporter 1
PRO_0000080772Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691Phosphoserine1 Publication
Modified residuei273 – 2731Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ61609.
PRIDEiQ61609.

PTM databases

PhosphoSiteiQ61609.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Developmental stagei

Detected at E17 of embryonic development in a subpopulation of early hypertrophic chondrocytes in bone, but not when fully differentiated.1 Publication

Inductioni

By growth hormone.1 Publication

Gene expression databases

ArrayExpressiQ61609.
BgeeiQ61609.
CleanExiMM_SLC20A1.
GenevestigatoriQ61609.

Structurei

3D structure databases

ProteinModelPortaliQ61609.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni553 – 5608A

Domaini

Region A does not confer susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0306.
GeneTreeiENSGT00390000014879.
HOGENOMiHOG000231892.
HOVERGENiHBG053358.
InParanoidiQ61609.
KOiK14640.
OMAiDIENRNP.
OrthoDBiEOG79KPDT.
PhylomeDBiQ61609.
TreeFamiTF314426.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61609-1 [UniParc]FASTAAdd to Basket

« Hide

MESTVATITS TLAAVTASAP PKYDNLWMLI LGFIIAFVLA FSVGANDVAN    50
SFGTAVGSGV VTLKQACILA SIFETVGSAL LGAKVSETIR NGLIDVELYN 100
ETQDLLMAGS VSAMFGSAVW QLVASFLKLP ISGTHCIVGA TIGFSLVANG 150
QKGVKWSELI KIVMSWFVSP LLSGIMSGIL FFLVRAFILR KADPVPNGLR 200
ALPIFYACTI GINLFSIMYT GAPLLGFDKL PLWGTILISV GCAVFCALIV 250
WFFVCPRMKR KIEREVKSSP SESPLMEKKS NLKEDHEETK MAPGDVEHRN 300
PVSEVVCATG PLRAVVEERT VSFKLGDLEE APERERLPMD LKEETSIDST 350
INGAVQLPNG NLVQFSQTVS NQINSSGHYQ YHTVHKDSGL YKELLHKLHL 400
AKVGDCMGDS GDKPLRRNNS YTSYTMAICG MPLDSFRAKE GEQKGDEMET 450
LTWPNADTKK RIRMDSYTSY CNAVSDLHSE SEMDMSVKAE MGLGDRKGSS 500
GSLEEWYDQD KPEVSLLFQF LQILTACFGS FAHGGNDVSN AIGPLVALYL 550
VYKQEASTKA ATPIWLLLYG GVGICMGLWV WGRRVIQTMG KDLTPITPSS 600
GFSIELASAL TVVIASNIGL PISTTHCKVG SVVSVGWLRS KKAVDWRLFR 650
NIFMAWFVTV PISGVISAAI MAVFKYIILP V 681
Length:681
Mass (Da):74,153
Last modified:November 1, 1996 - v1
Checksum:iF337B0982B5A297D
GO

Sequence cautioni

The sequence BAC29234.1 differs from that shown. Reason: Intron retention. The sequence differs at the 3'end due to intron retention.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti190 – 1901R → H1 Publication
Sequence conflicti368 – 3681T → A1 Publication
Sequence conflicti446 – 4461D → E1 Publication
Sequence conflicti490 – 4901E → G in AAH15085. 1 Publication
Sequence conflicti568 – 5681L → P in BAE33298. 1 Publication
Sequence conflicti569 – 5691Y → T1 Publication
Sequence conflicti639 – 6391R → I1 Publication
Sequence conflicti672 – 6721A → AA1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73696 mRNA. Translation: AAA74887.1.
AF172634
, AF172628, AF172629, AF172630, AF172631, AF172632, AF172633 Genomic DNA. Translation: AAF45041.1.
AK035898 mRNA. Translation: BAC29234.1. Sequence problems.
AK155506 mRNA. Translation: BAE33298.1.
AL772347 Genomic DNA. Translation: CAM15802.1.
BC015085 mRNA. Translation: AAH15085.1.
CCDSiCCDS16722.1.
PIRiS27868.
RefSeqiNP_001153065.1. NM_001159593.1.
NP_056562.1. NM_015747.2.
XP_006499111.1. XM_006499048.1.
UniGeneiMm.272675.

Genome annotation databases

EnsembliENSMUST00000028880; ENSMUSP00000028880; ENSMUSG00000027397.
ENSMUST00000110315; ENSMUSP00000105944; ENSMUSG00000027397.
GeneIDi20515.
KEGGimmu:20515.
UCSCiuc008mhl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73696 mRNA. Translation: AAA74887.1 .
AF172634
, AF172628 , AF172629 , AF172630 , AF172631 , AF172632 , AF172633 Genomic DNA. Translation: AAF45041.1 .
AK035898 mRNA. Translation: BAC29234.1 . Sequence problems.
AK155506 mRNA. Translation: BAE33298.1 .
AL772347 Genomic DNA. Translation: CAM15802.1 .
BC015085 mRNA. Translation: AAH15085.1 .
CCDSi CCDS16722.1.
PIRi S27868.
RefSeqi NP_001153065.1. NM_001159593.1.
NP_056562.1. NM_015747.2.
XP_006499111.1. XM_006499048.1.
UniGenei Mm.272675.

3D structure databases

ProteinModelPortali Q61609.
ModBasei Search...

PTM databases

PhosphoSitei Q61609.

Proteomic databases

PaxDbi Q61609.
PRIDEi Q61609.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028880 ; ENSMUSP00000028880 ; ENSMUSG00000027397 .
ENSMUST00000110315 ; ENSMUSP00000105944 ; ENSMUSG00000027397 .
GeneIDi 20515.
KEGGi mmu:20515.
UCSCi uc008mhl.2. mouse.

Organism-specific databases

CTDi 6574.
MGIi MGI:108392. Slc20a1.

Phylogenomic databases

eggNOGi COG0306.
GeneTreei ENSGT00390000014879.
HOGENOMi HOG000231892.
HOVERGENi HBG053358.
InParanoidi Q61609.
KOi K14640.
OMAi DIENRNP.
OrthoDBi EOG79KPDT.
PhylomeDBi Q61609.
TreeFami TF314426.

Miscellaneous databases

ChiTaRSi SLC20A1. mouse.
NextBioi 298723.
PROi Q61609.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61609.
Bgeei Q61609.
CleanExi MM_SLC20A1.
Genevestigatori Q61609.

Family and domain databases

InterProi IPR001204. Phos_transporter.
[Graphical view ]
PANTHERi PTHR11101. PTHR11101. 1 hit.
Pfami PF01384. PHO4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus."
    Johann S.V., Gibbons J.J., O'Hara B.
    J. Virol. 66:1635-1640(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "Comparison of cDNAs encoding the gibbon ape leukaemia virus receptor from susceptible and non-susceptible murine cells."
    Wilson C.A., Farrell K.B., Eiden M.V.
    J. Gen. Virol. 75:1901-1908(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structure of the murine Pit1 phosphate transporter/retrovirus receptor gene and functional characterization of its promoter region."
    Palmer G., Manen D., Bonjour J.-P., Caverzasio J.
    Gene 244:35-45(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  7. "Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus."
    Takeuchi Y., Vile R.G., Simpson G., O'Hara B., Collins M.K., Weiss R.A.
    J. Virol. 66:1219-1222(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species."
    Johann S.V., van Zeijl M., Cekleniak J., O'Hara B.
    J. Virol. 67:6733-6736(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF 553-LYS--ALA-560; 553-LYS--GLU-555 AND LYS-553, REGION.
  9. "Differential expression, abundance, and regulation of Na+-phosphate cotransporter genes in murine kidney."
    Tenenhouse H.S., Roy S., Martel J., Gauthier C.
    Am. J. Physiol. 275:F527-F534(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  10. "In vivo expression of transcripts encoding the Glvr-1 phosphate transporter/retrovirus receptor during bone development."
    Palmer G., Zhao J., Bonjour J.-P., Hofstetter W., Caverzasio J.
    Bone 24:1-7(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  11. "Reassessing the role of region A in Pit1-mediated viral entry."
    Farrell K.B., Russ J.L., Murthy R.K., Eiden M.V.
    J. Virol. 76:7683-7693(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, REGION.
  12. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269 AND SER-273, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS20A1_MOUSE
AccessioniPrimary (citable) accession number: Q61609
Secondary accession number(s): A2AKR9
, Q3U244, Q8CBJ1, Q91YQ9, Q9QVW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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