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Q61606 (GLR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucagon receptor
Short name=GL-R
Gene names
Name:Gcgr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed predominantly in liver, kidney, adrenal, lung and stomach, while lower levels of expression are detected in brown and white adipose tissue, cerebellum, duodenum and heart.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 485459Glucagon receptor
PRO_0000012833

Regions

Topological domain27 – 143117Extracellular Potential
Transmembrane144 – 16724Helical; Name=1; Potential
Topological domain168 – 1747Cytoplasmic Potential
Transmembrane175 – 19420Helical; Name=2; Potential
Topological domain195 – 22632Extracellular Potential
Transmembrane227 – 25024Helical; Name=3; Potential
Topological domain251 – 26414Cytoplasmic Potential
Transmembrane265 – 28622Helical; Name=4; Potential
Topological domain287 – 30418Extracellular Potential
Transmembrane305 – 32723Helical; Name=5; Potential
Topological domain328 – 35124Cytoplasmic Potential
Transmembrane352 – 37019Helical; Name=6; Potential
Topological domain371 – 38212Extracellular Potential
Transmembrane383 – 40523Helical; Name=7; Potential
Topological domain406 – 48580Cytoplasmic Potential

Amino acid modifications

Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation1181N-linked (GlcNAc...) Potential
Disulfide bond44 ↔ 68 By similarity
Disulfide bond59 ↔ 101 By similarity
Disulfide bond82 ↔ 122 By similarity

Experimental info

Sequence conflict651K → N in AAA88244. Ref.1
Sequence conflict891Y → C in AAA88244. Ref.1
Sequence conflict2381A → P in AAA88244. Ref.1
Sequence conflict3251H → R in AAB30529. Ref.3
Sequence conflict3281H → Q in AAA88244. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61606 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 578EB30BF281E67A

FASTA48554,929
        10         20         30         40         50         60 
MPLTQLHCPH LLLLLLVLSC LPEAPSAQVM DFLFEKWKLY SDQCHHNLSL LPPPTELVCN 

        70         80         90        100        110        120 
RTFDKYSCWP DTPPNTTANI SCPWYLPWYH KVQHRLVFKR CGPDGQWVRG PRGQPWRNAS 

       130        140        150        160        170        180 
QCQLDDEEIE VQKGVAKMYS SQQVMYTVGY SLSLGALLLA LVILLGLRKL HCTRNYIHGN 

       190        200        210        220        230        240 
LFASFVLKAG SVLVIDWLLK TRYSQKIGDD LSVSVWLSDG AMAGCRVATV IMQYGIIANY 

       250        260        270        280        290        300 
CWLLVEGVYL YSLLSLATFS ERSFFSLYLG IGWGAPLLFV IPWVVVKCLF ENVQCWTSND 

       310        320        330        340        350        360 
NMGFWWILRI PVFLALLINF FIFVHIIHLL VAKLRAHQMH YADYKFRLAR STLTLIPLLG 

       370        380        390        400        410        420 
VHEVVFAFVT DEHAQGTLRS TKLFFDLFLS SFQGLLVAVL YCFLNKEVQA ELMRRWRQWQ 

       430        440        450        460        470        480 
EGKALQEERL ASSHGSHMAP AGPCHGDPCE KLQLMSAGSS SGTGCVPSME TSLASSLPRL 


ADSPT

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequence analysis of the murine glucagon receptor-encoding gene."
Burcelin R., Li J., Charron M.J.
Gene 164:305-310(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
[5]"Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse."
Campos R.V., Lee Y.C., Drucker D.J.
Endocrinology 134:2156-2164(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 324-458.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L38613 mRNA. Translation: AAA88244.1.
AL669855 Genomic DNA. Translation: CAM27053.1.
CH466558 Genomic DNA. Translation: EDL34761.1.
BC031885 mRNA. Translation: AAH31885.1.
BC057988 mRNA. Translation: AAH57988.1.
S69384 mRNA. Translation: AAB30529.2.
IPIIPI00123442.
PIRJC4363.
RefSeqNP_032127.2. NM_008101.2.
UniGeneMm.22329.

3D structure databases

ProteinModelPortalQ61606.
SMRQ61606. Positions 29-124.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000026119.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ61606.

Proteomic databases

PRIDEQ61606.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026119; ENSMUSP00000026119; ENSMUSG00000025127.
GeneID14527.
KEGGmmu:14527.
UCSCuc007mtc.2. mouse.

Organism-specific databases

CTD2642.
MGIMGI:99572. Gcgr.

Phylogenomic databases

eggNOGNOG263329.
GeneTreeENSGT00580000081498.
HOGENOMHOG000008250.
HOVERGENHBG008318.
InParanoidQ8K0B5.
KOK04583.
OMAVAKMYSS.
OrthoDBEOG473PRN.

Gene expression databases

BgeeQ61606.
CleanExMM_GCGR.
GenevestigatorQ61606.
GermOnlineENSMUSG00000025127. Mus musculus.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003291. GPCR_2_glucagon_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERPTHR12011:SF71. PTHR12011:SF71. 1 hit.
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR01353. GLUCAGNFAMLY.
PR01354. GLUCAGONR.
PR00249. GPCRSECRETIN.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBQ61606.
ChEMBLCHEMBL4773.
ChiTaRSGCGR. mouse.
NextBio286172.
SOURCESearch...

Entry information

Entry nameGLR_MOUSE
AccessionPrimary (citable) accession number: Q61606
Secondary accession number(s): Q63960, Q8K0B5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: May 29, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents