SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q61603

- GLRA4_MOUSE

UniProt

Q61603 - GLRA4_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glycine receptor subunit alpha-4
Gene
Glra4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). May play a role in the maturation of reproductive organs.1 Publication

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. extracellular ligand-gated ion channel activity Source: InterPro
  3. glycine binding Source: InterPro
  4. transmitter-gated ion channel activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine receptor subunit alpha-4
    Gene namesi
    Name:Glra4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:95750. Glra4.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 257230Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei258 – 27821Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini279 – 31537Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei316 – 33621Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini337 – 42690Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei427 – 44721Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini448 – 4569Cytoplasmic Reviewed prediction

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. integral component of plasma membrane Source: InterPro
    4. postsynaptic membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727 Reviewed prediction
    Add
    BLAST
    Chaini28 – 456429Glycine receptor subunit alpha-4
    PRO_0000000422Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi171 ↔ 185 By similarity
    Disulfide bondi232 ↔ 243 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ61603.

    PTM databases

    PhosphoSiteiQ61603.

    Expressioni

    Gene expression databases

    BgeeiQ61603.
    CleanExiMM_GLRA4.
    GenevestigatoriQ61603.

    Interactioni

    Subunit structurei

    Pentamer composed of alpha and beta subunits By similarity.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61603.
    SMRiQ61603. Positions 54-451.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG265706.
    GeneTreeiENSGT00550000074453.
    HOGENOMiHOG000231336.
    HOVERGENiHBG051707.
    InParanoidiA2AEA9.
    KOiK05271.
    OMAiSYREYPD.
    OrthoDBiEOG712TVZ.
    PhylomeDBiQ61603.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR008127. Glycine_rcpt_A.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00253. GABAARECEPTR.
    PR01673. GLYRALPHA.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61603-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTLVPASLF LLLWTLPGKV LLSVALAKED VKSGLKGSQP MSPSDFLDKL    50
    MGRTSGYDAR IRPNFKGPPV NVTCNIFINS FGSVTETTMD YRVNVFLRQQ 100
    WNDPRLAYRE YPDDSLDLDP SMLDSIWKPD LFFANEKGAN FHEVTTDNKL 150
    LRIFKNGNVL YSIRLTLILS CPMDLKNFPM DIQTCTMQLE SFGYTMNDLM 200
    FEWLEDAPAV QVAEGLTLPQ FILRDEKDLG YCTKHYNTGK FTCIEVKFHL 250
    ERQMGYYLIQ MYIPSLLIVI LSWVSFWINM DAAPARVGLG ITTVLTMTTQ 300
    SSGSRASLPK VSYVKAIDIW MAVCLLFVFA ALLEYAAVNF VSRQHKEFMR 350
    LRRRQRRQRM EEDIIRESRF YFRGYGLGHC LQARDGGPME GSSIYSPQPP 400
    TPLLKEGETM RKLYVDRAKR IDTISRAVFP FTFLVFNIFY WVVYKVLRSE 450
    DIHQAL 456
    Length:456
    Mass (Da):52,514
    Last modified:October 25, 2005 - v3
    Checksum:i4199CB8404E05BEA
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti119 – 1191D → N in AAL69899. 1 Publication
    Sequence conflicti124 – 1241D → E in AAL69899. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ109809 mRNA. Translation: AAZ17380.1.
    AL671887 Genomic DNA. Translation: CAM17223.1.
    X75850
    , X75851, X75852, X75853 Genomic DNA. Translation: CAA53468.1.
    AF462147 mRNA. Translation: AAL69899.1.
    CCDSiCCDS53195.1.
    PIRiA49970.
    RefSeqiNP_034427.2. NM_010297.2.
    XP_006528569.1. XM_006528506.1.
    UniGeneiMm.215168.

    Genome annotation databases

    EnsembliENSMUST00000018739; ENSMUSP00000018739; ENSMUSG00000018595.
    GeneIDi14657.
    KEGGimmu:14657.
    UCSCiuc009uiz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ109809 mRNA. Translation: AAZ17380.1 .
    AL671887 Genomic DNA. Translation: CAM17223.1 .
    X75850
    , X75851 , X75852 , X75853 Genomic DNA. Translation: CAA53468.1 .
    AF462147 mRNA. Translation: AAL69899.1 .
    CCDSi CCDS53195.1.
    PIRi A49970.
    RefSeqi NP_034427.2. NM_010297.2.
    XP_006528569.1. XM_006528506.1.
    UniGenei Mm.215168.

    3D structure databases

    ProteinModelPortali Q61603.
    SMRi Q61603. Positions 54-451.
    ModBasei Search...

    Chemistry

    BindingDBi Q61603.
    ChEMBLi CHEMBL3500.
    GuidetoPHARMACOLOGYi 426.

    PTM databases

    PhosphoSitei Q61603.

    Proteomic databases

    PRIDEi Q61603.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018739 ; ENSMUSP00000018739 ; ENSMUSG00000018595 .
    GeneIDi 14657.
    KEGGi mmu:14657.
    UCSCi uc009uiz.2. mouse.

    Organism-specific databases

    CTDi 441509.
    MGIi MGI:95750. Glra4.

    Phylogenomic databases

    eggNOGi NOG265706.
    GeneTreei ENSGT00550000074453.
    HOGENOMi HOG000231336.
    HOVERGENi HBG051707.
    InParanoidi A2AEA9.
    KOi K05271.
    OMAi SYREYPD.
    OrthoDBi EOG712TVZ.
    PhylomeDBi Q61603.
    TreeFami TF315453.

    Miscellaneous databases

    NextBioi 286518.
    PROi Q61603.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61603.
    CleanExi MM_GLRA4.
    Genevestigatori Q61603.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR008127. Glycine_rcpt_A.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00253. GABAARECEPTR.
    PR01673. GLYRALPHA.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Glycine receptors containing the alpha4 subunit in the embryonic sympathetic nervous system, spinal cord and male genital ridge."
      Harvey R.J., Schmieden V., Von Holst A., Laube B., Rohrer H., Betz H.
      Eur. J. Neurosci. 12:994-1001(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: C57BL/6J.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant."
      Matzenbach B., Maulet Y., Sefton L., Courtier B., Avner P., Guenet J.-L., Betz H.
      J. Biol. Chem. 269:2607-2612(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-360.
      Strain: BALB/c.
    4. "Localization of different glycine receptor isoforms in murine spinal cord."
      Groemer T.-W., Becker C.-M., Becker K.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-456.
      Strain: B6C3/Fe.
      Tissue: Spinal cord.

    Entry informationi

    Entry nameiGLRA4_MOUSE
    AccessioniPrimary (citable) accession number: Q61603
    Secondary accession number(s): A2AEA9, Q45V76, Q8VHF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: October 25, 2005
    Last modified: July 9, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The alpha subunit binds strychnine.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi