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Q61602

- GLI3_MOUSE

UniProt

Q61602 - GLI3_MOUSE

Protein

Transcriptional activator GLI3

Gene

Gli3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.5 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri480 – 50526C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri513 – 54028C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri546 – 57025C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri576 – 60126C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri607 – 63226C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB
    4. sequence-specific DNA binding Source: MGI
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. anatomical structure development Source: MGI
    2. anatomical structure formation involved in morphogenesis Source: MGI
    3. anterior/posterior pattern specification Source: MGI
    4. anterior semicircular canal development Source: MGI
    5. artery development Source: MGI
    6. axon guidance Source: MGI
    7. brain development Source: MGI
    8. branching involved in ureteric bud morphogenesis Source: MGI
    9. branching morphogenesis of an epithelial tube Source: MGI
    10. camera-type eye development Source: MGI
    11. camera-type eye morphogenesis Source: MGI
    12. cell differentiation involved in kidney development Source: MGI
    13. central nervous system development Source: MGI
    14. cerebral cortex radial glia guided migration Source: MGI
    15. developmental growth Source: MGI
    16. dorsal/ventral pattern formation Source: MGI
    17. embryonic digestive tract development Source: MGI
    18. embryonic digestive tract morphogenesis Source: MGI
    19. embryonic digit morphogenesis Source: MGI
    20. embryonic limb morphogenesis Source: MGI
    21. embryonic morphogenesis Source: MGI
    22. embryonic skeletal system morphogenesis Source: MGI
    23. forebrain development Source: MGI
    24. forebrain dorsal/ventral pattern formation Source: MGI
    25. forebrain radial glial cell differentiation Source: MGI
    26. frontal suture morphogenesis Source: MGI
    27. heart development Source: MGI
    28. hindgut morphogenesis Source: MGI
    29. hippocampus development Source: MGI
    30. inner ear development Source: MGI
    31. in utero embryonic development Source: MGI
    32. kidney development Source: MGI
    33. lambdoid suture morphogenesis Source: MGI
    34. lateral ganglionic eminence cell proliferation Source: MGI
    35. lateral semicircular canal development Source: MGI
    36. limb development Source: UniProtKB
    37. limb morphogenesis Source: MGI
    38. lung development Source: MGI
    39. mammary gland development Source: MGI
    40. mammary gland specification Source: MGI
    41. melanocyte differentiation Source: MGI
    42. metanephros development Source: MGI
    43. negative regulation of alpha-beta T cell differentiation Source: BHF-UCL
    44. negative regulation of apoptotic process Source: MGI
    45. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    46. negative regulation of cell differentiation Source: MGI
    47. negative regulation of cell proliferation Source: MGI
    48. negative regulation of neuron differentiation Source: MGI
    49. negative regulation of smoothened signaling pathway Source: BHF-UCL
    50. negative regulation of transcription, DNA-templated Source: UniProtKB
    51. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    52. negative thymic T cell selection Source: BHF-UCL
    53. neural tube development Source: MGI
    54. neuron fate commitment Source: MGI
    55. odontogenesis of dentin-containing tooth Source: MGI
    56. oligodendrocyte differentiation Source: MGI
    57. optic nerve morphogenesis Source: MGI
    58. palate development Source: MGI
    59. pallium development Source: MGI
    60. pattern specification process Source: MGI
    61. positive regulation of alpha-beta T cell differentiation Source: BHF-UCL
    62. positive regulation of chondrocyte differentiation Source: MGI
    63. positive regulation of neuroblast proliferation Source: MGI
    64. positive regulation of osteoblast differentiation Source: MGI
    65. positive regulation of protein import into nucleus Source: MGI
    66. positive regulation of transcription, DNA-templated Source: UniProtKB
    67. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    68. protein processing Source: MGI
    69. proximal/distal pattern formation Source: MGI
    70. regulation of apoptotic process Source: MGI
    71. regulation of cell differentiation Source: MGI
    72. regulation of cell proliferation Source: MGI
    73. regulation of gene expression Source: MGI
    74. regulation of transcription, DNA-templated Source: MGI
    75. response to estrogen Source: Ensembl
    76. sagittal suture morphogenesis Source: MGI
    77. smoothened signaling pathway Source: MGI
    78. smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGI
    79. smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: MGI
    80. smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: MGI
    81. spinal cord dorsal/ventral patterning Source: MGI
    82. spinal cord motor neuron differentiation Source: MGI
    83. subpallium development Source: MGI
    84. T cell differentiation in thymus Source: BHF-UCL
    85. telencephalon development Source: MGI
    86. thymocyte apoptotic process Source: BHF-UCL
    87. tongue development Source: MGI
    88. transcription, DNA-templated Source: UniProtKB-KW
    89. tube development Source: MGI
    90. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional activator GLI3
    Alternative name(s):
    GLI3 form of 190 kDa
    Short name:
    GLI3-190
    GLI3 full length protein
    Short name:
    GLI3FL
    Cleaved into the following chain:
    Alternative name(s):
    GLI3 C-terminally truncated form
    GLI3 form of 83 kDa
    Short name:
    GLI3-83
    Gene namesi
    Name:Gli3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:95729. Gli3.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication. Cell projectioncilium 1 Publication
    Note: Translocation to the nucleus is promoted by interaction with ZIC1 By similarity. GLI3FL is localized predominantly in the cytoplasm while GLI3R resides mainly in the nucleus. Ciliary accumulation requires the presence of KIF7 and SMO.By similarity

    GO - Cellular componenti

    1. cilium Source: MGI
    2. cytoplasm Source: UniProtKB
    3. cytosol Source: Ensembl
    4. mediator complex Source: Ensembl
    5. nuclear speck Source: MGI
    6. nucleolus Source: Ensembl
    7. nucleus Source: UniProtKB
    8. primary cilium Source: BHF-UCL
    9. transcriptional repressor complex Source: MGI

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Several mutations result in developmental defects of cranofacial and limb structures. In particular the add (anterior digit-pattern deformity) and pdn (polydactyly Nagoya) alleles.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15831583Transcriptional activator GLI3PRO_0000047203Add
    BLAST
    Chaini1 – ?Transcriptional repressor GLI3RPRO_0000406138

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei664 – 6641PhosphoserineBy similarity
    Cross-linki773 – 773Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki779 – 779Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki784 – 784Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki800 – 800Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei849 – 8491Phosphoserine; by PKABy similarity
    Modified residuei865 – 8651Phosphoserine; by PKABy similarity
    Modified residuei877 – 8771Phosphoserine; by PKABy similarity
    Modified residuei907 – 9071Phosphoserine; by PKABy similarity
    Modified residuei980 – 9801Phosphoserine; by PKABy similarity
    Modified residuei1006 – 10061Phosphoserine; by PKABy similarity

    Post-translational modificationi

    Phosphorylated by DYRK2 (in vitro) By similarity. Phosphorylated on multiple sites by protein kinase A (PKA) and phosphorylation by PKA primes further phosphorylation by CK1 and GSK3. Phosphorylation is essential for its proteolytic processing.By similarity1 Publication
    Transcriptional repressor GLI3R, a C-terminally truncated form, is generated from the full-length GLI3 protein (GLI3FL/GLI3-190) through proteolytic processing. This process requires PKA-primed phosphorylation of GLI3, ubiquitination of GLI3 and the presence of BTRC. GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. GLI3R formation leads to its dissociation from SUFU, allowing it to translocate into the nucleus, and repress Hh target genes. When Hh signaling is initiated, SUFU dissociates from GLI3FL and this has two consequences. First, GLI3R production is halted. Second, free GLI3FL translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Phosphorylated in vitro by ULK3.1 Publication

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ61602.
    PRIDEiQ61602.

    PTM databases

    PhosphoSiteiQ61602.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61602.
    BgeeiQ61602.
    CleanExiMM_GLI3.
    GenevestigatoriQ61602.

    Interactioni

    Subunit structurei

    The phosphorylated form interacts with BTRC By similarity. The full-length GLI3 form (GLI3FL) interacts with SUFU and this interaction regulates the formation of either repressor or activator forms of GLI3. Its association with SUFU is regulated by Hh signaling and dissociation of the SUFU-GLI3 interaction requires the presence of the ciliary motor KIF3A. Interacts with KIF7. The activator form of GLI3 (GLI3A) but not the repressor form (GLI3R) can interact with TRPS1. Interacts with ZIC1. Interacts with ZIC3 (via C2H2-type domains 3, 4 and 5); the interaction enhances its transcriptional activity By similarity.By similarity

    Protein-protein interaction databases

    BioGridi199944. 7 interactions.
    STRINGi10090.ENSMUSP00000106137.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61602.
    SMRiQ61602. Positions 479-633.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi120 – 19980Pro-richAdd
    BLAST
    Compositional biasi849 – 91062Ser-richAdd
    BLAST
    Compositional biasi1494 – 151421Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri480 – 50526C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri513 – 54028C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri546 – 57025C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri576 – 60126C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri607 – 63226C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00740000115106.
    HOGENOMiHOG000290688.
    HOVERGENiHBG005844.
    InParanoidiQ61602.
    KOiK06230.
    OMAiPRDSGSH.
    PhylomeDBiQ61602.
    TreeFamiTF350216.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61602-1 [UniParc]FASTAAdd to Basket

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    MEAQAHSSTA TERKKAENSI GKCPTRTDVS EKAVASSTTS NEDESPGQIY     50
    HRERRNAITM QPQSVQGLNK ISEEPSTSSD ERASLIKKEI HGSLPHLAEP 100
    SLPYRGTVFA MDPRNGYMEP HYHPPHLFPA FHPPVPIDAR HHEGRYHYDP 150
    SPIPPLHVPS ALSSSPTYPD LPFIRISPHR NPTAASESPF SPPHPYINPY 200
    MDYIRSLHSS PSLSMISAAR GLSPTDAPHA GVSPAEYYHQ MALLTGQRSP 250
    YADILPSAAT AGAGAIHMEY LHAMDSTRFP SPRLSARPSR KRTLSISPLS 300
    DHSFDLQTMI RTSPNSLVTI LNNSRSSSSA SGSYGHLSAS AISPALSFTY 350
    PSAPVSLHMH QQILSRQQSL GSAFGHSPPL IHPAPTFPTQ RPIPGIPTVL 400
    NPVQVSSGPS ESSQSKPTSE SAVSSTGDPM HNKRSKIKPD EDLPSPGSRG 450
    QQEQPEGTTL VKEEADKDES KQEPEVIYET NCHWEGCTRE FDTQDQLVHH 500
    INNDHIHGEK KEFVCRWLDC SREQKPFKAQ YMLVVHMRRH TGEKPHKCTF 550
    EGCTKAYSRL ENLKTHLRSH TGEKPYVCEH EGCNKAFSNA SDRAKHQNRT 600
    HSNEKPYVCK IPGCTKRYTD PSSLRKHVKT VHGPEAHVTK KQRGDMHPRP 650
    PPPRDSGSHS QSRSPGRPTQ GAFGEQKELS NTTSKREECL QVKTVKAEKP 700
    MTSQPSPGGQ SSCSSQQSPI SNYSNSGLEL PLTDGGSVAD LSAIDETPIM 750
    DSTISTATTA LALQARRNPA GTKWMEHIKL ERLKQVNGMF PRLNPILPSK 800
    APAVSPLIGN GTQSNNNYSS GGPGTLLPSR SDLSGVDFTV LNTLNRRDSN 850
    TSTISSAYLS SRRSSGISPC FSSRRSSEAS QAEGRPQNVS VADSYDPIST 900
    DASRRSSEAS QGDGLPSLLS LTPVQQYRLK AKYAAATGGP PPTPLPHMER 950
    LSLKTKMALL GEGRDSGVTL PPVHPPRRCS DGGGHTYRGR HLMPHDALAN 1000
    SVRRASDPVR TVSENMSLAR VQRFSSLNSF NPPNLPPSVE KRSLVLQNYT 1050
    RQESSQPRYF QASPCPPSIT ENVALEALTM DADANLNDED LLPDDVVQYL 1100
    NSQNQTGYGQ QLQSGISEDS KVAHEPEDLD LAGLPDSHVG QEYPALEQPC 1150
    SEGSKTDLPI QWNEVSSGTS DLSSSKLKCG QQRPSAQQPR GFGLYNNMVV 1200
    HPHNLWKVGT GPAGGYQTLG ENSSTYNGPE HFAIHSGDGL GTNGNTFHEQ 1250
    PFKTQQYGSQ LNRQPLTSSA LDHACGTGIQ GSKLKGNSLQ ENGGLLDFSL 1300
    SVAPNELAGN TVNGMQTQDQ MGQGYIAHQL LSGSMQHQGP SRPGQQVLGQ 1350
    VGATSHINIY QGTESCLPGT QDNSSQPSSM AAIRGYQPCA SYGGNRRQAM 1400
    PRGNLTLQQG QLSDMSQSSR VNSIKMEAQG QSQQLCSTVQ NYSGQFYDQT 1450
    MGFSQQDRKA GSFSLSDANC LLQGNGTENS ELLSPGANQV TSTVDSFESH 1500
    DLEGVQIDFD AIIDDGDHTS LMSGALSPSI IQNLSHSSSR LTTPRASLPF 1550
    PSLSMGTTNM AIGDMSSLLT SLAEESKFLA VMQ 1583
    Length:1,583
    Mass (Da):171,655
    Last modified:September 11, 2007 - v2
    Checksum:i37ECC0C3ACF26C24
    GO

    Sequence cautioni

    The sequence CAA64543.1 differs from that shown. Reason: Frameshift at position 1552.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti209 – 2091S → C in CAA64543. (PubMed:8688459)Curated
    Sequence conflicti428 – 4281D → G in CAA64543. (PubMed:8688459)Curated
    Sequence conflicti928 – 9281R → A in CAA64543. (PubMed:8688459)Curated
    Sequence conflicti936 – 9361A → P in CAA64543. (PubMed:8688459)Curated
    Sequence conflicti1005 – 10051A → D in CAA64543. (PubMed:8688459)Curated
    Sequence conflicti1185 – 11862SA → R in CAA64543. (PubMed:8688459)Curated
    Sequence conflicti1475 – 14762NG → TC in CAA64543. (PubMed:8688459)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95255 mRNA. Translation: CAA64543.1. Frameshift.
    AC163610 Genomic DNA. No translation available.
    AC173115 Genomic DNA. No translation available.
    AC173210 Genomic DNA. No translation available.
    CCDSiCCDS36603.1.
    RefSeqiNP_032156.2. NM_008130.2.
    XP_006516617.1. XM_006516554.1.
    UniGeneiMm.5098.

    Genome annotation databases

    EnsembliENSMUST00000110510; ENSMUSP00000106137; ENSMUSG00000021318.
    GeneIDi14634.
    KEGGimmu:14634.
    UCSCiuc007pns.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95255 mRNA. Translation: CAA64543.1 . Frameshift.
    AC163610 Genomic DNA. No translation available.
    AC173115 Genomic DNA. No translation available.
    AC173210 Genomic DNA. No translation available.
    CCDSi CCDS36603.1.
    RefSeqi NP_032156.2. NM_008130.2.
    XP_006516617.1. XM_006516554.1.
    UniGenei Mm.5098.

    3D structure databases

    ProteinModelPortali Q61602.
    SMRi Q61602. Positions 479-633.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199944. 7 interactions.
    STRINGi 10090.ENSMUSP00000106137.

    PTM databases

    PhosphoSitei Q61602.

    Proteomic databases

    PaxDbi Q61602.
    PRIDEi Q61602.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000110510 ; ENSMUSP00000106137 ; ENSMUSG00000021318 .
    GeneIDi 14634.
    KEGGi mmu:14634.
    UCSCi uc007pns.1. mouse.

    Organism-specific databases

    CTDi 2737.
    MGIi MGI:95729. Gli3.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00740000115106.
    HOGENOMi HOG000290688.
    HOVERGENi HBG005844.
    InParanoidi Q61602.
    KOi K06230.
    OMAi PRDSGSH.
    PhylomeDBi Q61602.
    TreeFami TF350216.

    Miscellaneous databases

    NextBioi 286490.
    PROi Q61602.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61602.
    Bgeei Q61602.
    CleanExi MM_GLI3.
    Genevestigatori Q61602.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of the murine Gli3 cDNA."
      Thien H., Buescher D., Ruether U.
      Biochim. Biophys. Acta 1307:267-269(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NIH Swiss.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb."
      Wang B., Fallon J.F., Beachy P.A.
      Cell 100:423-434(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PROTEOLYTIC PROCESSING.
    4. "Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins."
      Mizugishi K., Aruga J., Nakata K., Mikoshiba K.
      J. Biol. Chem. 276:2180-2188(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DNA-BINDING.
    5. "The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning."
      Wang C., Ruther U., Wang B.
      Dev. Biol. 305:460-469(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development."
      Endoh-Yamagami S., Evangelista M., Wilson D., Wen X., Theunissen J.W., Phamluong K., Davis M., Scales S.J., Solloway M.J., de Sauvage F.J., Peterson A.S.
      Curr. Biol. 19:1320-1326(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING.
    7. "Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3."
      Wuelling M., Kaiser F.J., Buelens L.A., Braunholz D., Shivdasani R.A., Depping R., Vortkamp A.
      Dev. Biol. 328:40-53(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TRPS1.
    8. "The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling."
      Cheung H.O., Zhang X., Ribeiro A., Mo R., Makino S., Puviindran V., Law K.K., Briscoe J., Hui C.C.
      Sci. Signal. 2:RA29-RA29(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KIF7.
    9. "The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins."
      Humke E.W., Dorn K.V., Milenkovic L., Scott M.P., Rohatgi R.
      Genes Dev. 24:670-682(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH SUFU.

    Entry informationi

    Entry nameiGLI3_MOUSE
    AccessioniPrimary (citable) accession number: Q61602
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3