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Q61602

- GLI3_MOUSE

UniProt

Q61602 - GLI3_MOUSE

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Protein
Transcriptional activator GLI3
Gene
Gli3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.5 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri480 – 50526C2H2-type 1
Add
BLAST
Zinc fingeri513 – 54028C2H2-type 2
Add
BLAST
Zinc fingeri546 – 57025C2H2-type 3
Add
BLAST
Zinc fingeri576 – 60126C2H2-type 4
Add
BLAST
Zinc fingeri607 – 63226C2H2-type 5
Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: UniProtKB
  4. sequence-specific DNA binding Source: MGI
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. T cell differentiation in thymus Source: BHF-UCL
  2. anatomical structure development Source: MGI
  3. anatomical structure formation involved in morphogenesis Source: MGI
  4. anterior semicircular canal development Source: MGI
  5. anterior/posterior pattern specification Source: MGI
  6. artery development Source: MGI
  7. axon guidance Source: MGI
  8. brain development Source: MGI
  9. branching involved in ureteric bud morphogenesis Source: MGI
  10. branching morphogenesis of an epithelial tube Source: MGI
  11. camera-type eye development Source: MGI
  12. camera-type eye morphogenesis Source: MGI
  13. cell differentiation involved in kidney development Source: MGI
  14. central nervous system development Source: MGI
  15. cerebral cortex radial glia guided migration Source: MGI
  16. developmental growth Source: MGI
  17. dorsal/ventral pattern formation Source: MGI
  18. embryonic digestive tract development Source: MGI
  19. embryonic digestive tract morphogenesis Source: MGI
  20. embryonic digit morphogenesis Source: MGI
  21. embryonic limb morphogenesis Source: MGI
  22. embryonic morphogenesis Source: MGI
  23. embryonic skeletal system morphogenesis Source: MGI
  24. forebrain development Source: MGI
  25. forebrain dorsal/ventral pattern formation Source: MGI
  26. forebrain radial glial cell differentiation Source: MGI
  27. frontal suture morphogenesis Source: MGI
  28. heart development Source: MGI
  29. hindgut morphogenesis Source: MGI
  30. hippocampus development Source: MGI
  31. in utero embryonic development Source: MGI
  32. inner ear development Source: MGI
  33. kidney development Source: MGI
  34. lambdoid suture morphogenesis Source: MGI
  35. lateral ganglionic eminence cell proliferation Source: MGI
  36. lateral semicircular canal development Source: MGI
  37. limb development Source: UniProtKB
  38. limb morphogenesis Source: MGI
  39. lung development Source: MGI
  40. mammary gland development Source: MGI
  41. mammary gland specification Source: MGI
  42. melanocyte differentiation Source: MGI
  43. metanephros development Source: MGI
  44. negative regulation of alpha-beta T cell differentiation Source: BHF-UCL
  45. negative regulation of apoptotic process Source: MGI
  46. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  47. negative regulation of cell differentiation Source: MGI
  48. negative regulation of cell proliferation Source: MGI
  49. negative regulation of neuron differentiation Source: MGI
  50. negative regulation of smoothened signaling pathway Source: BHF-UCL
  51. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  52. negative regulation of transcription, DNA-templated Source: UniProtKB
  53. negative thymic T cell selection Source: BHF-UCL
  54. neural tube development Source: MGI
  55. neuron fate commitment Source: MGI
  56. odontogenesis of dentin-containing tooth Source: MGI
  57. oligodendrocyte differentiation Source: MGI
  58. optic nerve morphogenesis Source: MGI
  59. palate development Source: MGI
  60. pallium development Source: MGI
  61. pattern specification process Source: MGI
  62. positive regulation of alpha-beta T cell differentiation Source: BHF-UCL
  63. positive regulation of chondrocyte differentiation Source: MGI
  64. positive regulation of neuroblast proliferation Source: MGI
  65. positive regulation of osteoblast differentiation Source: MGI
  66. positive regulation of protein import into nucleus Source: MGI
  67. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  68. positive regulation of transcription, DNA-templated Source: UniProtKB
  69. protein processing Source: MGI
  70. proximal/distal pattern formation Source: MGI
  71. regulation of apoptotic process Source: MGI
  72. regulation of cell differentiation Source: MGI
  73. regulation of cell proliferation Source: MGI
  74. regulation of gene expression Source: MGI
  75. regulation of transcription, DNA-templated Source: MGI
  76. response to estrogen Source: Ensembl
  77. sagittal suture morphogenesis Source: MGI
  78. smoothened signaling pathway Source: MGI
  79. smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGI
  80. smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: MGI
  81. smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: MGI
  82. spinal cord dorsal/ventral patterning Source: MGI
  83. spinal cord motor neuron differentiation Source: MGI
  84. subpallium development Source: MGI
  85. telencephalon development Source: MGI
  86. thymocyte apoptotic process Source: BHF-UCL
  87. tongue development Source: MGI
  88. transcription, DNA-templated Source: UniProtKB-KW
  89. tube development Source: MGI
  90. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator GLI3
Alternative name(s):
GLI3 form of 190 kDa
Short name:
GLI3-190
GLI3 full length protein
Short name:
GLI3FL
Cleaved into the following chain:
Alternative name(s):
GLI3 C-terminally truncated form
GLI3 form of 83 kDa
Short name:
GLI3-83
Gene namesi
Name:Gli3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:95729. Gli3.

Subcellular locationi

Nucleus. Cytoplasm. Cell projectioncilium
Note: Translocation to the nucleus is promoted by interaction with ZIC1 By similarity. GLI3FL is localized predominantly in the cytoplasm while GLI3R resides mainly in the nucleus. Ciliary accumulation requires the presence of KIF7 and SMO.1 Publication

GO - Cellular componenti

  1. cilium Source: MGI
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: Ensembl
  4. mediator complex Source: Ensembl
  5. nuclear speck Source: MGI
  6. nucleolus Source: Ensembl
  7. nucleus Source: UniProtKB
  8. primary cilium Source: BHF-UCL
  9. transcriptional repressor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Several mutations result in developmental defects of cranofacial and limb structures. In particular the add (anterior digit-pattern deformity) and pdn (polydactyly Nagoya) alleles.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15831583Transcriptional activator GLI3
PRO_0000047203Add
BLAST
Chaini1 – ?Transcriptional repressor GLI3RPRO_0000406138

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei664 – 6641Phosphoserine By similarity
Cross-linki773 – 773Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Cross-linki779 – 779Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Cross-linki784 – 784Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Cross-linki800 – 800Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Modified residuei849 – 8491Phosphoserine; by PKA By similarity
Modified residuei865 – 8651Phosphoserine; by PKA By similarity
Modified residuei877 – 8771Phosphoserine; by PKA By similarity
Modified residuei907 – 9071Phosphoserine; by PKA By similarity
Modified residuei980 – 9801Phosphoserine; by PKA By similarity
Modified residuei1006 – 10061Phosphoserine; by PKA By similarity

Post-translational modificationi

Phosphorylated by DYRK2 (in vitro) By similarity. Phosphorylated on multiple sites by protein kinase A (PKA) and phosphorylation by PKA primes further phosphorylation by CK1 and GSK3. Phosphorylation is essential for its proteolytic processing.1 Publication
Transcriptional repressor GLI3R, a C-terminally truncated form, is generated from the full-length GLI3 protein (GLI3FL/GLI3-190) through proteolytic processing. This process requires PKA-primed phosphorylation of GLI3, ubiquitination of GLI3 and the presence of BTRC. GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. GLI3R formation leads to its dissociation from SUFU, allowing it to translocate into the nucleus, and repress Hh target genes. When Hh signaling is initiated, SUFU dissociates from GLI3FL and this has two consequences. First, GLI3R production is halted. Second, free GLI3FL translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Phosphorylated in vitro by ULK3.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ61602.
PRIDEiQ61602.

PTM databases

PhosphoSiteiQ61602.

Expressioni

Gene expression databases

ArrayExpressiQ61602.
BgeeiQ61602.
CleanExiMM_GLI3.
GenevestigatoriQ61602.

Interactioni

Subunit structurei

The phosphorylated form interacts with BTRC By similarity. The full-length GLI3 form (GLI3FL) interacts with SUFU and this interaction regulates the formation of either repressor or activator forms of GLI3. Its association with SUFU is regulated by Hh signaling and dissociation of the SUFU-GLI3 interaction requires the presence of the ciliary motor KIF3A. Interacts with KIF7. The activator form of GLI3 (GLI3A) but not the repressor form (GLI3R) can interact with TRPS1. Interacts with ZIC1. Interacts with ZIC3 (via C2H2-type domains 3, 4 and 5); the interaction enhances its transcriptional activity By similarity.3 Publications

Protein-protein interaction databases

BioGridi199944. 7 interactions.
STRINGi10090.ENSMUSP00000106137.

Structurei

3D structure databases

ProteinModelPortaliQ61602.
SMRiQ61602. Positions 479-633.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi120 – 19980Pro-rich
Add
BLAST
Compositional biasi849 – 91062Ser-rich
Add
BLAST
Compositional biasi1494 – 151421Asp/Glu-rich (acidic)
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00740000115106.
HOGENOMiHOG000290688.
HOVERGENiHBG005844.
InParanoidiQ61602.
KOiK06230.
OMAiPRDSGSH.
PhylomeDBiQ61602.
TreeFamiTF350216.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61602-1 [UniParc]FASTAAdd to Basket

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MEAQAHSSTA TERKKAENSI GKCPTRTDVS EKAVASSTTS NEDESPGQIY     50
HRERRNAITM QPQSVQGLNK ISEEPSTSSD ERASLIKKEI HGSLPHLAEP 100
SLPYRGTVFA MDPRNGYMEP HYHPPHLFPA FHPPVPIDAR HHEGRYHYDP 150
SPIPPLHVPS ALSSSPTYPD LPFIRISPHR NPTAASESPF SPPHPYINPY 200
MDYIRSLHSS PSLSMISAAR GLSPTDAPHA GVSPAEYYHQ MALLTGQRSP 250
YADILPSAAT AGAGAIHMEY LHAMDSTRFP SPRLSARPSR KRTLSISPLS 300
DHSFDLQTMI RTSPNSLVTI LNNSRSSSSA SGSYGHLSAS AISPALSFTY 350
PSAPVSLHMH QQILSRQQSL GSAFGHSPPL IHPAPTFPTQ RPIPGIPTVL 400
NPVQVSSGPS ESSQSKPTSE SAVSSTGDPM HNKRSKIKPD EDLPSPGSRG 450
QQEQPEGTTL VKEEADKDES KQEPEVIYET NCHWEGCTRE FDTQDQLVHH 500
INNDHIHGEK KEFVCRWLDC SREQKPFKAQ YMLVVHMRRH TGEKPHKCTF 550
EGCTKAYSRL ENLKTHLRSH TGEKPYVCEH EGCNKAFSNA SDRAKHQNRT 600
HSNEKPYVCK IPGCTKRYTD PSSLRKHVKT VHGPEAHVTK KQRGDMHPRP 650
PPPRDSGSHS QSRSPGRPTQ GAFGEQKELS NTTSKREECL QVKTVKAEKP 700
MTSQPSPGGQ SSCSSQQSPI SNYSNSGLEL PLTDGGSVAD LSAIDETPIM 750
DSTISTATTA LALQARRNPA GTKWMEHIKL ERLKQVNGMF PRLNPILPSK 800
APAVSPLIGN GTQSNNNYSS GGPGTLLPSR SDLSGVDFTV LNTLNRRDSN 850
TSTISSAYLS SRRSSGISPC FSSRRSSEAS QAEGRPQNVS VADSYDPIST 900
DASRRSSEAS QGDGLPSLLS LTPVQQYRLK AKYAAATGGP PPTPLPHMER 950
LSLKTKMALL GEGRDSGVTL PPVHPPRRCS DGGGHTYRGR HLMPHDALAN 1000
SVRRASDPVR TVSENMSLAR VQRFSSLNSF NPPNLPPSVE KRSLVLQNYT 1050
RQESSQPRYF QASPCPPSIT ENVALEALTM DADANLNDED LLPDDVVQYL 1100
NSQNQTGYGQ QLQSGISEDS KVAHEPEDLD LAGLPDSHVG QEYPALEQPC 1150
SEGSKTDLPI QWNEVSSGTS DLSSSKLKCG QQRPSAQQPR GFGLYNNMVV 1200
HPHNLWKVGT GPAGGYQTLG ENSSTYNGPE HFAIHSGDGL GTNGNTFHEQ 1250
PFKTQQYGSQ LNRQPLTSSA LDHACGTGIQ GSKLKGNSLQ ENGGLLDFSL 1300
SVAPNELAGN TVNGMQTQDQ MGQGYIAHQL LSGSMQHQGP SRPGQQVLGQ 1350
VGATSHINIY QGTESCLPGT QDNSSQPSSM AAIRGYQPCA SYGGNRRQAM 1400
PRGNLTLQQG QLSDMSQSSR VNSIKMEAQG QSQQLCSTVQ NYSGQFYDQT 1450
MGFSQQDRKA GSFSLSDANC LLQGNGTENS ELLSPGANQV TSTVDSFESH 1500
DLEGVQIDFD AIIDDGDHTS LMSGALSPSI IQNLSHSSSR LTTPRASLPF 1550
PSLSMGTTNM AIGDMSSLLT SLAEESKFLA VMQ 1583
Length:1,583
Mass (Da):171,655
Last modified:September 11, 2007 - v2
Checksum:i37ECC0C3ACF26C24
GO

Sequence cautioni

The sequence CAA64543.1 differs from that shown. Reason: Frameshift at position 1552.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091S → C in CAA64543. 1 Publication
Sequence conflicti428 – 4281D → G in CAA64543. 1 Publication
Sequence conflicti928 – 9281R → A in CAA64543. 1 Publication
Sequence conflicti936 – 9361A → P in CAA64543. 1 Publication
Sequence conflicti1005 – 10051A → D in CAA64543. 1 Publication
Sequence conflicti1185 – 11862SA → R in CAA64543. 1 Publication
Sequence conflicti1475 – 14762NG → TC in CAA64543. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95255 mRNA. Translation: CAA64543.1. Frameshift.
AC163610 Genomic DNA. No translation available.
AC173115 Genomic DNA. No translation available.
AC173210 Genomic DNA. No translation available.
CCDSiCCDS36603.1.
RefSeqiNP_032156.2. NM_008130.2.
XP_006516617.1. XM_006516554.1.
UniGeneiMm.5098.

Genome annotation databases

EnsembliENSMUST00000110510; ENSMUSP00000106137; ENSMUSG00000021318.
GeneIDi14634.
KEGGimmu:14634.
UCSCiuc007pns.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95255 mRNA. Translation: CAA64543.1 . Frameshift.
AC163610 Genomic DNA. No translation available.
AC173115 Genomic DNA. No translation available.
AC173210 Genomic DNA. No translation available.
CCDSi CCDS36603.1.
RefSeqi NP_032156.2. NM_008130.2.
XP_006516617.1. XM_006516554.1.
UniGenei Mm.5098.

3D structure databases

ProteinModelPortali Q61602.
SMRi Q61602. Positions 479-633.
ModBasei Search...

Protein-protein interaction databases

BioGridi 199944. 7 interactions.
STRINGi 10090.ENSMUSP00000106137.

PTM databases

PhosphoSitei Q61602.

Proteomic databases

PaxDbi Q61602.
PRIDEi Q61602.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000110510 ; ENSMUSP00000106137 ; ENSMUSG00000021318 .
GeneIDi 14634.
KEGGi mmu:14634.
UCSCi uc007pns.1. mouse.

Organism-specific databases

CTDi 2737.
MGIi MGI:95729. Gli3.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00740000115106.
HOGENOMi HOG000290688.
HOVERGENi HBG005844.
InParanoidi Q61602.
KOi K06230.
OMAi PRDSGSH.
PhylomeDBi Q61602.
TreeFami TF350216.

Miscellaneous databases

NextBioi 286490.
PROi Q61602.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61602.
Bgeei Q61602.
CleanExi MM_GLI3.
Genevestigatori Q61602.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of the murine Gli3 cDNA."
    Thien H., Buescher D., Ruether U.
    Biochim. Biophys. Acta 1307:267-269(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb."
    Wang B., Fallon J.F., Beachy P.A.
    Cell 100:423-434(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PROTEOLYTIC PROCESSING.
  4. "Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins."
    Mizugishi K., Aruga J., Nakata K., Mikoshiba K.
    J. Biol. Chem. 276:2180-2188(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.
  5. "The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning."
    Wang C., Ruther U., Wang B.
    Dev. Biol. 305:460-469(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development."
    Endoh-Yamagami S., Evangelista M., Wilson D., Wen X., Theunissen J.W., Phamluong K., Davis M., Scales S.J., Solloway M.J., de Sauvage F.J., Peterson A.S.
    Curr. Biol. 19:1320-1326(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING.
  7. "Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3."
    Wuelling M., Kaiser F.J., Buelens L.A., Braunholz D., Shivdasani R.A., Depping R., Vortkamp A.
    Dev. Biol. 328:40-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TRPS1.
  8. "The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling."
    Cheung H.O., Zhang X., Ribeiro A., Mo R., Makino S., Puviindran V., Law K.K., Briscoe J., Hui C.C.
    Sci. Signal. 2:RA29-RA29(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIF7.
  9. "The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins."
    Humke E.W., Dorn K.V., Milenkovic L., Scott M.P., Rohatgi R.
    Genes Dev. 24:670-682(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH SUFU.

Entry informationi

Entry nameiGLI3_MOUSE
AccessioniPrimary (citable) accession number: Q61602
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 11, 2007
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi