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Q61599

- GDIR2_MOUSE

UniProt

Q61599 - GDIR2_MOUSE

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Protein

Rho GDP-dissociation inhibitor 2

Gene

Arhgdib

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
  2. Rho GDP-dissociation inhibitor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_210090. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GDP-dissociation inhibitor 2
Short name:
Rho GDI 2
Alternative name(s):
D4
Rho-GDI beta
Gene namesi
Name:Arhgdib
Synonyms:Gdid4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:101940. Arhgdib.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 200199Rho GDP-dissociation inhibitor 2PRO_0000219017Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Modified residuei20 – 201N6-acetyllysineBy similarity
Modified residuei23 – 231PhosphotyrosineBy similarity
Modified residuei24 – 241N6-acetyllysineBy similarity
Modified residuei39 – 391N6-acetyllysineBy similarity
Modified residuei46 – 461N6-acetyllysineBy similarity
Modified residuei101 – 1011N6-acetyllysineBy similarity
Modified residuei123 – 1231N6-acetyllysineBy similarity
Modified residuei144 – 1441PhosphoserineBy similarity
Modified residuei174 – 1741N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ61599.
PaxDbiQ61599.
PRIDEiQ61599.

2D gel databases

COMPLUYEAST-2DPAGEQ61599.

PTM databases

PhosphoSiteiQ61599.

Expressioni

Tissue specificityi

Preferentially expressed in hematopoietic cells.

Gene expression databases

BgeeiQ61599.
CleanExiMM_ARHGDIB.
ExpressionAtlasiQ61599. baseline and differential.
GenevestigatoriQ61599.

Interactioni

Subunit structurei

Interacts with RHOA.By similarity

Protein-protein interaction databases

BioGridi198201. 6 interactions.
IntActiQ61599. 3 interactions.
MINTiMINT-1613948.

Structurei

3D structure databases

ProteinModelPortaliQ61599.
SMRiQ61599. Positions 22-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho GDI family.Curated

Phylogenomic databases

eggNOGiNOG253438.
GeneTreeiENSGT00390000006233.
HOGENOMiHOG000175765.
HOVERGENiHBG000206.
InParanoidiQ61599.
KOiK12462.
OMAiQDHLTWE.
OrthoDBiEOG72JWH9.
PhylomeDBiQ61599.
TreeFamiTF105387.

Family and domain databases

Gene3Di2.70.50.30. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
[Graphical view]
PANTHERiPTHR10980. PTHR10980. 1 hit.
PfamiPF02115. Rho_GDI. 1 hit.
[Graphical view]
PRINTSiPR00492. RHOGDI.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61599-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEKDAQPQL EEADDDLDSK LNYKPPPQKS LKELQEMDKD DESLTKYKKT
60 70 80 90 100
LLGDVPVVAD PTVPNVTVTR LSLVCDSAPG PITMDLTGDL EALKKDTFVL
110 120 130 140 150
KEGIEYRVKI NFKVNKDIVS GLKYVQHTYR TGMRVDKATF MVGSYGPRPE
160 170 180 190 200
EYEFLTPVEE APKGMLARGT YHNKSFFTDD DKQDHLTWEW NLAIKKDWTE
Length:200
Mass (Da):22,851
Last modified:January 23, 2007 - v3
Checksum:iEA78C965F1AB6F5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07918 mRNA. Translation: AAA61613.1.
AK002516 mRNA. Translation: BAB22155.1.
AK169733 mRNA. Translation: BAE41335.1.
BC031763 mRNA. Translation: AAH31763.1.
CCDSiCCDS20661.1.
PIRiI49687.
RefSeqiNP_031512.1. NM_007486.5.
XP_006505467.1. XM_006505404.1.
XP_006505468.1. XM_006505405.1.
UniGeneiMm.2241.

Genome annotation databases

EnsembliENSMUST00000032344; ENSMUSP00000032344; ENSMUSG00000030220.
ENSMUST00000111891; ENSMUSP00000107522; ENSMUSG00000030220.
ENSMUST00000111892; ENSMUSP00000107523; ENSMUSG00000030220.
GeneIDi11857.
KEGGimmu:11857.
UCSCiuc009emo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07918 mRNA. Translation: AAA61613.1 .
AK002516 mRNA. Translation: BAB22155.1 .
AK169733 mRNA. Translation: BAE41335.1 .
BC031763 mRNA. Translation: AAH31763.1 .
CCDSi CCDS20661.1.
PIRi I49687.
RefSeqi NP_031512.1. NM_007486.5.
XP_006505467.1. XM_006505404.1.
XP_006505468.1. XM_006505405.1.
UniGenei Mm.2241.

3D structure databases

ProteinModelPortali Q61599.
SMRi Q61599. Positions 22-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198201. 6 interactions.
IntActi Q61599. 3 interactions.
MINTi MINT-1613948.

PTM databases

PhosphoSitei Q61599.

2D gel databases

COMPLUYEAST-2DPAGE Q61599.

Proteomic databases

MaxQBi Q61599.
PaxDbi Q61599.
PRIDEi Q61599.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032344 ; ENSMUSP00000032344 ; ENSMUSG00000030220 .
ENSMUST00000111891 ; ENSMUSP00000107522 ; ENSMUSG00000030220 .
ENSMUST00000111892 ; ENSMUSP00000107523 ; ENSMUSG00000030220 .
GeneIDi 11857.
KEGGi mmu:11857.
UCSCi uc009emo.1. mouse.

Organism-specific databases

CTDi 397.
MGIi MGI:101940. Arhgdib.

Phylogenomic databases

eggNOGi NOG253438.
GeneTreei ENSGT00390000006233.
HOGENOMi HOG000175765.
HOVERGENi HBG000206.
InParanoidi Q61599.
KOi K12462.
OMAi QDHLTWE.
OrthoDBi EOG72JWH9.
PhylomeDBi Q61599.
TreeFami TF105387.

Enzyme and pathway databases

Reactomei REACT_210090. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSi ARHGDIB. mouse.
NextBioi 279847.
PROi Q61599.
SOURCEi Search...

Gene expression databases

Bgeei Q61599.
CleanExi MM_ARHGDIB.
ExpressionAtlasi Q61599. baseline and differential.
Genevestigatori Q61599.

Family and domain databases

Gene3Di 2.70.50.30. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
[Graphical view ]
PANTHERi PTHR10980. PTHR10980. 1 hit.
Pfami PF02115. Rho_GDI. 1 hit.
[Graphical view ]
PRINTSi PR00492. RHOGDI.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I."
    Adra C.N., Ko J., Leonard D., Wirth L.J., Cerione R.A., Lim B.
    Genes Chromosomes Cancer 8:253-261(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Kidney and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiGDIR2_MOUSE
AccessioniPrimary (citable) accession number: Q61599
Secondary accession number(s): Q3TEB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3