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Protein

Rab GDP dissociation inhibitor beta

Gene

Gdi2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

GO - Molecular functioni

GO - Biological processi

  • positive regulation of GTPase activity Source: GOC
  • protein transport Source: InterPro
  • small GTPase mediated signal transduction Source: MGI
  • vesicle-mediated transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitor beta
Short name:
Rab GDI beta
Alternative name(s):
GDI-3
Guanosine diphosphate dissociation inhibitor 2
Short name:
GDI-2
Gene namesi
Name:Gdi2
Synonyms:Gdi3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:99845. Gdi2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • focal adhesion Source: MGI
  • Golgi apparatus Source: MGI
  • membrane Source: UniProtKB-SubCell
  • myelin sheath Source: UniProtKB
  • vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Rab GDP dissociation inhibitor betaPRO_0000056680Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei57 – 571N6-succinyllysineCombined sources
Modified residuei112 – 1121N6-acetyllysineBy similarity
Modified residuei130 – 1301PhosphoserineBy similarity
Modified residuei269 – 2691N6-acetyllysineBy similarity
Modified residuei382 – 3821PhosphoserineBy similarity
Modified residuei427 – 4271PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ61598.
MaxQBiQ61598.
PaxDbiQ61598.
PRIDEiQ61598.

2D gel databases

REPRODUCTION-2DPAGEQ61598.

PTM databases

iPTMnetiQ61598.
PhosphoSiteiQ61598.
SwissPalmiQ61598.

Expressioni

Gene expression databases

BgeeiQ61598.
GenevisibleiQ61598. MM.

Interactioni

Subunit structurei

Interacts with RHOH.By similarity

Protein-protein interaction databases

BioGridi199892. 7 interactions.
DIPiDIP-348N.
IntActiQ61598. 2 interactions.
MINTiMINT-1868741.
STRINGi10090.ENSMUSP00000062996.

Structurei

3D structure databases

ProteinModelPortaliQ61598.
SMRiQ61598. Positions 1-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

eggNOGiKOG1439. Eukaryota.
COG5044. LUCA.
GeneTreeiENSGT00530000063044.
HOGENOMiHOG000163825.
HOVERGENiHBG000839.
InParanoidiQ61598.
KOiK17255.
OMAiMAVETIH.
OrthoDBiEOG7PP56D.
PhylomeDBiQ61598.
TreeFamiTF300449.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
[Graphical view]
PfamiPF00996. GDI. 1 hit.
[Graphical view]
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q61598-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDQNPYYG GESASITPLE
60 70 80 90 100
DLYKRFKLPG QPPASMGRGR DWNVDLIPKF LMANGQLVKM LLFTEVTRYM
110 120 130 140 150
DFKVIEGSFV YKGGKIYKVP STEAEALASS LMGLFEKRRF RKFLVYVANF
160 170 180 190 200
DEKDPRTFEG VDPKKTSMRD VYKKFDLGQD VIDFTGHSLA LYRTDDYLDQ
210 220 230 240 250
PCCETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPIEEIIV QNGKVVGVKS EGEIARCKQL ICDPSYVKDR VEKVGQVIRV
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISFA HNVAAQGKYI
360 370 380 390 400
AIVSTTVETK EPEKEIRPAL ELLEPIEQKF VSISDLFVPK DLGTDSQIFI
410 420 430 440
SRAYDATTHF ETTCDDIKDI YKRMTGSEFD FEEMKRKKND IYGED
Length:445
Mass (Da):50,537
Last modified:November 1, 1996 - v1
Checksum:i483B7C7456B30525
GO
Isoform 2 (identifier: Q61598-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-51: Missing.

Note: No experimental confirmation available.
Show »
Length:409
Mass (Da):46,658
Checksum:iB4E0C7F07AA73D0D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561R → K in BAC37725 (PubMed:16141072).Curated
Sequence conflicti298 – 2981I → N in BAB25321 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 5136Missing in isoform 2. 1 PublicationVSP_010579Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36314 mRNA. Translation: AAA78786.1.
AK007871 mRNA. Translation: BAB25321.1.
AK078144 mRNA. Translation: BAC37145.1.
AK079690 mRNA. Translation: BAC37725.1.
AK090083 mRNA. Translation: BAC41085.1.
AK143633 mRNA. Translation: BAE25473.1.
AK149958 mRNA. Translation: BAE29194.1.
AK152250 mRNA. Translation: BAE31072.1.
AK153381 mRNA. Translation: BAE31947.1.
AK159734 mRNA. Translation: BAE35328.1.
AK166317 mRNA. Translation: BAE38700.1.
AK169299 mRNA. Translation: BAE41055.1.
BC055341 mRNA. Translation: AAH55341.1.
CCDSiCCDS36581.1. [Q61598-1]
PIRiA56024.
C56956.
RefSeqiNP_032138.3. NM_008112.4. [Q61598-1]
UniGeneiMm.153226.
Mm.221609.

Genome annotation databases

EnsembliENSMUST00000059515; ENSMUSP00000062996; ENSMUSG00000021218. [Q61598-1]
GeneIDi14569.
KEGGimmu:14569.
UCSCiuc007piu.1. mouse. [Q61598-1]
uc011yvx.1. mouse. [Q61598-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36314 mRNA. Translation: AAA78786.1.
AK007871 mRNA. Translation: BAB25321.1.
AK078144 mRNA. Translation: BAC37145.1.
AK079690 mRNA. Translation: BAC37725.1.
AK090083 mRNA. Translation: BAC41085.1.
AK143633 mRNA. Translation: BAE25473.1.
AK149958 mRNA. Translation: BAE29194.1.
AK152250 mRNA. Translation: BAE31072.1.
AK153381 mRNA. Translation: BAE31947.1.
AK159734 mRNA. Translation: BAE35328.1.
AK166317 mRNA. Translation: BAE38700.1.
AK169299 mRNA. Translation: BAE41055.1.
BC055341 mRNA. Translation: AAH55341.1.
CCDSiCCDS36581.1. [Q61598-1]
PIRiA56024.
C56956.
RefSeqiNP_032138.3. NM_008112.4. [Q61598-1]
UniGeneiMm.153226.
Mm.221609.

3D structure databases

ProteinModelPortaliQ61598.
SMRiQ61598. Positions 1-430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199892. 7 interactions.
DIPiDIP-348N.
IntActiQ61598. 2 interactions.
MINTiMINT-1868741.
STRINGi10090.ENSMUSP00000062996.

PTM databases

iPTMnetiQ61598.
PhosphoSiteiQ61598.
SwissPalmiQ61598.

2D gel databases

REPRODUCTION-2DPAGEQ61598.

Proteomic databases

EPDiQ61598.
MaxQBiQ61598.
PaxDbiQ61598.
PRIDEiQ61598.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059515; ENSMUSP00000062996; ENSMUSG00000021218. [Q61598-1]
GeneIDi14569.
KEGGimmu:14569.
UCSCiuc007piu.1. mouse. [Q61598-1]
uc011yvx.1. mouse. [Q61598-2]

Organism-specific databases

CTDi2665.
MGIiMGI:99845. Gdi2.

Phylogenomic databases

eggNOGiKOG1439. Eukaryota.
COG5044. LUCA.
GeneTreeiENSGT00530000063044.
HOGENOMiHOG000163825.
HOVERGENiHBG000839.
InParanoidiQ61598.
KOiK17255.
OMAiMAVETIH.
OrthoDBiEOG7PP56D.
PhylomeDBiQ61598.
TreeFamiTF300449.

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiGdi2. mouse.
PROiQ61598.
SOURCEiSearch...

Gene expression databases

BgeeiQ61598.
GenevisibleiQ61598. MM.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
[Graphical view]
PfamiPF00996. GDI. 1 hit.
[Graphical view]
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6."
    Janoueix-Lerosey I., Jollivet F., Camonis J., Marche P.N., Goud B.
    J. Biol. Chem. 270:14801-14808(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Bone marrow, Colon, Liver, Mammary gland, Medulla oblongata, Pancreas, Spleen and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 143-156; 175-193 AND 222-240, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-57, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiGDIB_MOUSE
AccessioniPrimary (citable) accession number: Q61598
Secondary accession number(s): Q541Z9, Q8C530, Q9D8M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.