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Protein

Gamma-crystallin C

Gene

Crygc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

  • structural constituent of eye lens Source: MGI

GO - Biological processi

  • camera-type eye development Source: MGI
  • eye development Source: MGI
  • visual perception Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin C
Alternative name(s):
Gamma-C-crystallin
Gene namesi
Name:Crygc
Synonyms:Gammab-cry
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88523. Crygc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 174173Gamma-crystallin CPRO_0000057597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231S-methylcysteineBy similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ61597.
PRIDEiQ61597.

PTM databases

PhosphoSiteiQ61597.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025952.
CleanExiMM_CRYGC.
ExpressionAtlasiQ61597. baseline and differential.
GenevisibleiQ61597. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109698.

Structurei

Secondary structure

1
174
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 97Combined sources
Turni10 – 123Combined sources
Beta strandi13 – 219Combined sources
Turni27 – 293Combined sources
Beta strandi35 – 4814Combined sources
Turni49 – 513Combined sources
Beta strandi52 – 587Combined sources
Beta strandi60 – 656Combined sources
Helixi66 – 694Combined sources
Beta strandi72 – 743Combined sources
Beta strandi78 – 825Combined sources
Beta strandi89 – 957Combined sources
Helixi96 – 983Combined sources
Beta strandi99 – 1079Combined sources
Helixi112 – 1154Combined sources
Beta strandi123 – 1297Combined sources
Beta strandi131 – 1366Combined sources
Turni137 – 1393Combined sources
Beta strandi140 – 1467Combined sources
Beta strandi148 – 1536Combined sources
Helixi154 – 1563Combined sources
Beta strandi160 – 1634Combined sources
Beta strandi166 – 1694Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2V2UX-ray1.90A/B2-174[»]
ProteinModelPortaliQ61597.
SMRiQ61597. Positions 2-174.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ61597.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 4039Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
BLAST
Domaini41 – 8343Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
BLAST
Domaini88 – 12841Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
BLAST
Domaini129 – 17143Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 874Connecting peptide

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiQ61597.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR033483. CRYGC.
IPR011024. G_crystallin-rel.
[Graphical view]
PANTHERiPTHR11818:SF32. PTHR11818:SF32. 1 hit.
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKITFFEDR SFQGRCYECS SDCPNLQTYF SRCNSVRVDS GCWMLYERPN
60 70 80 90 100
YQGHQYFLRR GEYPDYQQWM GFSDSIRSCR LIPHAGSHRM RLYEKEDHKG
110 120 130 140 150
VMMELSEDCS CIQDRFHLSE VRSLQVLEGC WVLYEMPNYR GRQYLLRPQE
160 170
YRRFQDWGSV DAKAGSLRRV VDLY
Length:174
Mass (Da):20,917
Last modified:January 23, 2007 - v3
Checksum:iECEF819F051D431D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111S → G in strain: CD-1.
Natural varianti14 – 141G → A in strain: CD-1.
Natural varianti154 – 1552FQ → YH in strain: CD-1.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22574 Genomic DNA. Translation: CAA80297.1.
BC056454 mRNA. Translation: AAH56454.1.
M64544 mRNA. Translation: AAA53524.1.
CCDSiCCDS15012.1.
PIRiI48360. S33526.
I49614.
RefSeqiNP_031801.1. NM_007775.2.
UniGeneiMm.491115.

Genome annotation databases

EnsembliENSMUST00000027089; ENSMUSP00000027089; ENSMUSG00000025952.
GeneIDi12966.
KEGGimmu:12966.
UCSCiuc007bhi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22574 Genomic DNA. Translation: CAA80297.1.
BC056454 mRNA. Translation: AAH56454.1.
M64544 mRNA. Translation: AAA53524.1.
CCDSiCCDS15012.1.
PIRiI48360. S33526.
I49614.
RefSeqiNP_031801.1. NM_007775.2.
UniGeneiMm.491115.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2V2UX-ray1.90A/B2-174[»]
ProteinModelPortaliQ61597.
SMRiQ61597. Positions 2-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109698.

PTM databases

PhosphoSiteiQ61597.

Proteomic databases

PaxDbiQ61597.
PRIDEiQ61597.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027089; ENSMUSP00000027089; ENSMUSG00000025952.
GeneIDi12966.
KEGGimmu:12966.
UCSCiuc007bhi.2. mouse.

Organism-specific databases

CTDi1420.
MGIiMGI:88523. Crygc.

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiQ61597.

Miscellaneous databases

EvolutionaryTraceiQ61597.
PROiQ61597.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025952.
CleanExiMM_CRYGC.
ExpressionAtlasiQ61597. baseline and differential.
GenevisibleiQ61597. MM.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR033483. CRYGC.
IPR011024. G_crystallin-rel.
[Graphical view]
PANTHERiPTHR11818:SF32. PTHR11818:SF32. 1 hit.
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRGC_MOUSE
AccessioniPrimary (citable) accession number: Q61597
Secondary accession number(s): Q03739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are six different gamma crystallins identified in mouse lens.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.