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Q61592

- GAS6_MOUSE

UniProt

Q61592 - GAS6_MOUSE

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Protein
Growth arrest-specific protein 6
Gene
Gas6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi326 – 3261Calcium By similarity
Metal bindingi328 – 3281Calcium; via carbonyl oxygen By similarity
Metal bindingi437 – 4371Calcium; via carbonyl oxygen By similarity
Metal bindingi652 – 6521Calcium By similarity

GO - Molecular functioni

  1. binding, bridging Source: UniProtKB
  2. calcium ion binding Source: InterPro
  3. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  4. phosphatidylserine binding Source: UniProtKB
  5. protein tyrosine kinase activator activity Source: UniProtKB
  6. receptor agonist activity Source: MGI
  7. receptor binding Source: UniProtKB
  8. voltage-gated calcium channel activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. B cell chemotaxis Source: UniProtKB
  2. activation of protein kinase B activity Source: UniProtKB
  3. apoptotic cell clearance Source: MGI
  4. blood coagulation Source: MGI
  5. cell-substrate adhesion Source: MGI
  6. cellular response to drug Source: UniProtKB
  7. cellular response to glucose stimulus Source: UniProtKB
  8. cellular response to growth factor stimulus Source: MGI
  9. cellular response to interferon-alpha Source: UniProtKB
  10. cellular response to starvation Source: MGI
  11. cellular response to vitamin K Source: UniProtKB
  12. dendritic cell differentiation Source: Ensembl
  13. enzyme linked receptor protein signaling pathway Source: MGI
  14. extracellular matrix assembly Source: UniProtKB
  15. fusion of virus membrane with host plasma membrane Source: UniProtKB
  16. hematopoietic stem cell migration to bone marrow Source: UniProtKB
  17. macrophage cytokine production Source: MGI
  18. negative regulation of apoptotic process Source: UniProtKB
  19. negative regulation of biomineral tissue development Source: UniProtKB
  20. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  21. negative regulation of dendritic cell apoptotic process Source: UniProtKB
  22. negative regulation of endothelial cell apoptotic process Source: UniProtKB
  23. negative regulation of fibroblast apoptotic process Source: UniProtKB
  24. negative regulation of interferon-gamma production Source: UniProtKB
  25. negative regulation of interleukin-1 secretion Source: UniProtKB
  26. negative regulation of interleukin-6 production Source: Ensembl
  27. negative regulation of interleukin-6 secretion Source: UniProtKB
  28. negative regulation of oligodendrocyte apoptotic process Source: Ensembl
  29. negative regulation of protein import into nucleus, translocation Source: UniProtKB
  30. negative regulation of renal albumin absorption Source: UniProtKB
  31. negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  32. negative regulation of transcription, DNA-templated Source: UniProtKB
  33. negative regulation of tumor necrosis factor production Source: UniProtKB
  34. negative regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
  35. neuron migration Source: MGI
  36. organ regeneration Source: Ensembl
  37. peptidyl-serine phosphorylation Source: UniProtKB
  38. phagocytosis Source: UniProtKB
  39. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  40. positive regulation of TOR signaling Source: UniProtKB
  41. positive regulation of cytokine-mediated signaling pathway Source: UniProtKB
  42. positive regulation of dendritic cell chemotaxis Source: Ensembl
  43. positive regulation of fibroblast proliferation Source: UniProtKB
  44. positive regulation of gene expression Source: UniProtKB
  45. positive regulation of glomerular filtration Source: UniProtKB
  46. positive regulation of natural killer cell differentiation Source: UniProtKB
  47. positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
  48. positive regulation of phagocytosis Source: UniProtKB
  49. positive regulation of protein export from nucleus Source: UniProtKB
  50. positive regulation of protein kinase B signaling Source: UniProtKB
  51. positive regulation of protein kinase activity Source: UniProtKB
  52. positive regulation of protein phosphorylation Source: UniProtKB
  53. positive regulation of protein tyrosine kinase activity Source: UniProtKB
  54. protein kinase B signaling Source: MGI
  55. protein phosphorylation Source: UniProtKB
  56. protein targeting to plasma membrane Source: UniProtKB
  57. receptor-mediated virion attachment to host cell Source: UniProtKB
  58. regulation of growth Source: UniProtKB-KW
  59. viral entry into host cell Source: UniProtKB
  60. viral genome replication Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Growth regulation

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_225233. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 6
Short name:
GAS-6
Alternative name(s):
AXL receptor tyrosine kinase ligand
Gene namesi
Name:Gas6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:95660. Gas6.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 674647Growth arrest-specific protein 6
PRO_0000007590Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi62 ↔ 67 By similarity
Disulfide bondi117 ↔ 130 By similarity
Disulfide bondi122 ↔ 139 By similarity
Disulfide bondi141 ↔ 150 By similarity
Disulfide bondi157 ↔ 168 By similarity
Disulfide bondi164 ↔ 177 By similarity
Disulfide bondi179 ↔ 192 By similarity
Disulfide bondi198 ↔ 209 By similarity
Disulfide bondi204 ↔ 218 By similarity
Disulfide bondi220 ↔ 233 By similarity
Disulfide bondi239 ↔ 248 By similarity
Disulfide bondi244 ↔ 257 By similarity
Disulfide bondi259 ↔ 274 By similarity
Disulfide bondi280 ↔ 566 By similarity
Glycosylationi417 – 4171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi441 ↔ 467 By similarity
Glycosylationi488 – 4881N-linked (GlcNAc...) Reviewed prediction
Modified residuei609 – 6091Phosphothreonine By similarity
Modified residuei614 – 6141Phosphoserine By similarity
Modified residuei617 – 6171Phosphothreonine By similarity
Modified residuei633 – 6331Phosphothreonine By similarity
Modified residuei636 – 6361Phosphotyrosine By similarity
Disulfide bondi639 ↔ 666 By similarity

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium By similarity.

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ61592.
PRIDEiQ61592.

Expressioni

Gene expression databases

BgeeiQ61592.
CleanExiMM_GAS6.
GenevestigatoriQ61592.

Interactioni

Subunit structurei

Heterodimer and heterotetramer with AXL.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033828.

Structurei

3D structure databases

ProteinModelPortaliQ61592.
SMRiQ61592. Positions 50-672.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 9142Gla
Add
BLAST
Domaini113 – 15139EGF-like 1; calcium-binding Reviewed prediction
Add
BLAST
Domaini153 – 19341EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini194 – 23441EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini235 – 27541EGF-like 4; calcium-binding Reviewed prediction
Add
BLAST
Domaini295 – 467173Laminin G-like 1
Add
BLAST
Domaini474 – 666193Laminin G-like 2
Add
BLAST

Sequence similaritiesi

Contains 4 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG149502.
GeneTreeiENSGT00530000063339.
HOGENOMiHOG000065758.
HOVERGENiHBG051702.
InParanoidiQ61592.
KOiK05464.
OMAiVDYHSTK.
OrthoDBiEOG7F5119.
PhylomeDBiQ61592.
TreeFamiTF352157.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF07645. EGF_CA. 1 hit.
PF00594. Gla. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61592-1 [UniParc]FASTAAdd to Basket

« Hide

MPPPPGPAAA LGTALLLLLL ASESSHTVLL RAREAAQFLR PRQRRAYQVF    50
EEAKQGHLER ECVEEVCSKE EAREVFENDP ETEYFYPRYQ ECMRKYGRPE 100
EKNPDFAKCV QNLPDQCTPN PCDKKGTHIC QDLMGNFFCV CTDGWGGRLC 150
DKDVNECVQK NGGCSQVCHN KPGSFQCACH SGFSLASDGQ TCQDIDECTD 200
SDTCGDARCK NLPGSYSCLC DEGYTYSSKE KTCQDVDECQ QDRCEQTCVN 250
SPGSYTCHCD GRGGLKLSPD MDTCEDILPC VPFSMAKSVK SLYLGRMFSG 300
TPVIRLRFKR LQPTRLLAEF DFRTFDPEGV LFFAGGRSDS TWIVLGLRAG 350
RLELQLRYNG VGRITSSGPT INHGMWQTIS VEELERNLVI KVNKDAVMKI 400
AVAGELFQLE RGLYHLNLTV GGIPFKESEL VQPINPRLDG CMRSWNWLNG 450
EDSAIQETVK ANTKMQCFSV TERGSFFPGN GFATYRLNYT RTSLDVGTET 500
TWEVKVVARI RPATDTGVLL ALVGDDDVVP ISVALVDYHS TKKLKKQLVV 550
LAVEDVALAL MEIKVCDSQE HTVTVSLREG EATLEVDGTK GQSEVSTAQL 600
QERLDTLKTH LQGSVHTYVG GLPEVSVISA PVTAFYRGCM TLEVNGKILD 650
LDTASYKHSD ITSHSCPPVE HATP 674
Length:674
Mass (Da):74,610
Last modified:June 7, 2004 - v2
Checksum:i7C41F7693903F401
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti530 – 5301Missing in CAA42507. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59846 mRNA. Translation: CAA42507.1.
BC005444 mRNA. Translation: AAH05444.1.
CCDSiCCDS40232.1.
PIRiA48089.
RefSeqiNP_062394.2. NM_019521.2.
UniGeneiMm.3982.

Genome annotation databases

EnsembliENSMUST00000033828; ENSMUSP00000033828; ENSMUSG00000031451.
GeneIDi14456.
KEGGimmu:14456.
UCSCiuc009kya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59846 mRNA. Translation: CAA42507.1 .
BC005444 mRNA. Translation: AAH05444.1 .
CCDSi CCDS40232.1.
PIRi A48089.
RefSeqi NP_062394.2. NM_019521.2.
UniGenei Mm.3982.

3D structure databases

ProteinModelPortali Q61592.
SMRi Q61592. Positions 50-672.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000033828.

Proteomic databases

PaxDbi Q61592.
PRIDEi Q61592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033828 ; ENSMUSP00000033828 ; ENSMUSG00000031451 .
GeneIDi 14456.
KEGGi mmu:14456.
UCSCi uc009kya.1. mouse.

Organism-specific databases

CTDi 2621.
MGIi MGI:95660. Gas6.

Phylogenomic databases

eggNOGi NOG149502.
GeneTreei ENSGT00530000063339.
HOGENOMi HOG000065758.
HOVERGENi HBG051702.
InParanoidi Q61592.
KOi K05464.
OMAi VDYHSTK.
OrthoDBi EOG7F5119.
PhylomeDBi Q61592.
TreeFami TF352157.

Enzyme and pathway databases

Reactomei REACT_225233. Cell surface interactions at the vascular wall.

Miscellaneous databases

ChiTaRSi GAS6. mouse.
NextBioi 286080.
PROi Q61592.
SOURCEi Search...

Gene expression databases

Bgeei Q61592.
CleanExi MM_GAS6.
Genevestigatori Q61592.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
4.10.740.10. 1 hit.
InterProi IPR017857. Coagulation_fac_subgr_Gla_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF07645. EGF_CA. 1 hit.
PF00594. Gla. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view ]
PRINTSi PR00001. GLABLOOD.
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade."
    Manfioletti G., Brancolini C., Avanzi G., Schneider C.
    Mol. Cell. Biol. 13:4976-4985(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis."
    Angelillo-Scherrer A., de Frutos P., Aparicio C., Melis E., Savi P., Lupu F., Arnout J., Dewerchin M., Hoylaerts M., Herbert J., Collen D., Dahlback B., Carmeliet P.
    Nat. Med. 7:215-221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGAS6_MOUSE
AccessioniPrimary (citable) accession number: Q61592
Secondary accession number(s): Q99K57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 3, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

GAS6 deficient mice show protection against thrombosis, but no spontaneous bleeding.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi