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Protein

Growth arrest-specific protein 6

Gene

Gas6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi326CalciumBy similarity1
Metal bindingi328Calcium; via carbonyl oxygenBy similarity1
Metal bindingi437Calcium; via carbonyl oxygenBy similarity1
Metal bindingi652CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Growth regulation

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-MMU-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.
R-MMU-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 6
Short name:
GAS-6
Alternative name(s):
AXL receptor tyrosine kinase ligand
Gene namesi
Name:Gas6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:95660. Gas6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000759028 – 674Growth arrest-specific protein 6Add BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 67By similarity
Modified residuei68PhosphoserineBy similarity1
Disulfide bondi117 ↔ 130By similarity
Disulfide bondi122 ↔ 139By similarity
Disulfide bondi141 ↔ 150By similarity
Disulfide bondi157 ↔ 168By similarity
Disulfide bondi164 ↔ 177By similarity
Disulfide bondi179 ↔ 192By similarity
Disulfide bondi198 ↔ 209By similarity
Disulfide bondi204 ↔ 218By similarity
Disulfide bondi220 ↔ 233By similarity
Disulfide bondi239 ↔ 248By similarity
Disulfide bondi244 ↔ 257By similarity
Disulfide bondi259 ↔ 274By similarity
Disulfide bondi280 ↔ 566By similarity
Glycosylationi417N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi441 ↔ 467By similarity
Glycosylationi488N-linked (GlcNAc...)Sequence analysis1
Modified residuei609PhosphothreonineBy similarity1
Modified residuei614PhosphoserineBy similarity1
Modified residuei617PhosphothreonineBy similarity1
Modified residuei633PhosphothreonineBy similarity1
Modified residuei636PhosphotyrosineBy similarity1
Disulfide bondi639 ↔ 666By similarity

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61592.
PaxDbiQ61592.
PRIDEiQ61592.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031451.
CleanExiMM_GAS6.
GenevisibleiQ61592. MM.

Interactioni

Subunit structurei

Heterodimer and heterotetramer with AXL.

GO - Molecular functioni

  • receptor agonist activity Source: MGI
  • receptor binding Source: UniProtKB
  • receptor tyrosine kinase binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033828.

Structurei

3D structure databases

ProteinModelPortaliQ61592.
SMRiQ61592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 91GlaPROSITE-ProRule annotationAdd BLAST42
Domaini113 – 151EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini153 – 193EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini194 – 234EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini235 – 275EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini295 – 467Laminin G-like 1PROSITE-ProRule annotationAdd BLAST173
Domaini474 – 666Laminin G-like 2PROSITE-ProRule annotationAdd BLAST193

Sequence similaritiesi

Contains 4 EGF-like domains.PROSITE-ProRule annotation
Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation
Contains 2 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IGK1. Eukaryota.
ENOG410ZPM2. LUCA.
GeneTreeiENSGT00530000063339.
HOGENOMiHOG000065758.
HOVERGENiHBG051702.
InParanoidiQ61592.
KOiK05464.
OMAiPVIRLRF.
OrthoDBiEOG091G034Z.
PhylomeDBiQ61592.
TreeFamiTF352157.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF07645. EGF_CA. 2 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPPGPAAA LGTALLLLLL ASESSHTVLL RAREAAQFLR PRQRRAYQVF
60 70 80 90 100
EEAKQGHLER ECVEEVCSKE EAREVFENDP ETEYFYPRYQ ECMRKYGRPE
110 120 130 140 150
EKNPDFAKCV QNLPDQCTPN PCDKKGTHIC QDLMGNFFCV CTDGWGGRLC
160 170 180 190 200
DKDVNECVQK NGGCSQVCHN KPGSFQCACH SGFSLASDGQ TCQDIDECTD
210 220 230 240 250
SDTCGDARCK NLPGSYSCLC DEGYTYSSKE KTCQDVDECQ QDRCEQTCVN
260 270 280 290 300
SPGSYTCHCD GRGGLKLSPD MDTCEDILPC VPFSMAKSVK SLYLGRMFSG
310 320 330 340 350
TPVIRLRFKR LQPTRLLAEF DFRTFDPEGV LFFAGGRSDS TWIVLGLRAG
360 370 380 390 400
RLELQLRYNG VGRITSSGPT INHGMWQTIS VEELERNLVI KVNKDAVMKI
410 420 430 440 450
AVAGELFQLE RGLYHLNLTV GGIPFKESEL VQPINPRLDG CMRSWNWLNG
460 470 480 490 500
EDSAIQETVK ANTKMQCFSV TERGSFFPGN GFATYRLNYT RTSLDVGTET
510 520 530 540 550
TWEVKVVARI RPATDTGVLL ALVGDDDVVP ISVALVDYHS TKKLKKQLVV
560 570 580 590 600
LAVEDVALAL MEIKVCDSQE HTVTVSLREG EATLEVDGTK GQSEVSTAQL
610 620 630 640 650
QERLDTLKTH LQGSVHTYVG GLPEVSVISA PVTAFYRGCM TLEVNGKILD
660 670
LDTASYKHSD ITSHSCPPVE HATP
Length:674
Mass (Da):74,610
Last modified:June 7, 2004 - v2
Checksum:i7C41F7693903F401
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti530Missing in CAA42507 (PubMed:8336730).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59846 mRNA. Translation: CAA42507.1.
BC005444 mRNA. Translation: AAH05444.1.
CCDSiCCDS40232.1.
PIRiA48089.
RefSeqiNP_062394.2. NM_019521.2.
UniGeneiMm.3982.

Genome annotation databases

EnsembliENSMUST00000033828; ENSMUSP00000033828; ENSMUSG00000031451.
GeneIDi14456.
KEGGimmu:14456.
UCSCiuc009kya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59846 mRNA. Translation: CAA42507.1.
BC005444 mRNA. Translation: AAH05444.1.
CCDSiCCDS40232.1.
PIRiA48089.
RefSeqiNP_062394.2. NM_019521.2.
UniGeneiMm.3982.

3D structure databases

ProteinModelPortaliQ61592.
SMRiQ61592.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033828.

Proteomic databases

MaxQBiQ61592.
PaxDbiQ61592.
PRIDEiQ61592.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033828; ENSMUSP00000033828; ENSMUSG00000031451.
GeneIDi14456.
KEGGimmu:14456.
UCSCiuc009kya.1. mouse.

Organism-specific databases

CTDi2621.
MGIiMGI:95660. Gas6.

Phylogenomic databases

eggNOGiENOG410IGK1. Eukaryota.
ENOG410ZPM2. LUCA.
GeneTreeiENSGT00530000063339.
HOGENOMiHOG000065758.
HOVERGENiHBG051702.
InParanoidiQ61592.
KOiK05464.
OMAiPVIRLRF.
OrthoDBiEOG091G034Z.
PhylomeDBiQ61592.
TreeFamiTF352157.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-MMU-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.
R-MMU-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

ChiTaRSiGas6. mouse.
PROiQ61592.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031451.
CleanExiMM_GAS6.
GenevisibleiQ61592. MM.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF07645. EGF_CA. 2 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAS6_MOUSE
AccessioniPrimary (citable) accession number: Q61592
Secondary accession number(s): Q99K57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 2, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

GAS6 deficient mice show protection against thrombosis, but no spontaneous bleeding.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.