Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q61592

- GAS6_MOUSE

UniProt

Q61592 - GAS6_MOUSE

Protein

Growth arrest-specific protein 6

Gene

Gas6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (07 Jun 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi326 – 3261CalciumBy similarity
    Metal bindingi328 – 3281Calcium; via carbonyl oxygenBy similarity
    Metal bindingi437 – 4371Calcium; via carbonyl oxygenBy similarity
    Metal bindingi652 – 6521CalciumBy similarity

    GO - Molecular functioni

    1. binding, bridging Source: UniProtKB
    2. calcium ion binding Source: InterPro
    3. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
    4. phosphatidylserine binding Source: UniProtKB
    5. protein tyrosine kinase activator activity Source: UniProtKB
    6. receptor agonist activity Source: MGI
    7. receptor binding Source: UniProtKB
    8. voltage-gated calcium channel activity Source: UniProtKB

    GO - Biological processi

    1. activation of protein kinase B activity Source: UniProtKB
    2. apoptotic cell clearance Source: MGI
    3. B cell chemotaxis Source: UniProtKB
    4. blood coagulation Source: MGI
    5. cell-substrate adhesion Source: MGI
    6. cellular response to drug Source: UniProtKB
    7. cellular response to glucose stimulus Source: UniProtKB
    8. cellular response to growth factor stimulus Source: MGI
    9. cellular response to interferon-alpha Source: UniProtKB
    10. cellular response to starvation Source: MGI
    11. cellular response to vitamin K Source: UniProtKB
    12. dendritic cell differentiation Source: Ensembl
    13. enzyme linked receptor protein signaling pathway Source: MGI
    14. extracellular matrix assembly Source: UniProtKB
    15. fusion of virus membrane with host plasma membrane Source: UniProtKB
    16. hematopoietic stem cell migration to bone marrow Source: UniProtKB
    17. macrophage cytokine production Source: MGI
    18. negative regulation of apoptotic process Source: UniProtKB
    19. negative regulation of biomineral tissue development Source: UniProtKB
    20. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    21. negative regulation of dendritic cell apoptotic process Source: UniProtKB
    22. negative regulation of endothelial cell apoptotic process Source: UniProtKB
    23. negative regulation of fibroblast apoptotic process Source: UniProtKB
    24. negative regulation of interferon-gamma production Source: UniProtKB
    25. negative regulation of interleukin-1 secretion Source: UniProtKB
    26. negative regulation of interleukin-6 production Source: Ensembl
    27. negative regulation of interleukin-6 secretion Source: UniProtKB
    28. negative regulation of oligodendrocyte apoptotic process Source: Ensembl
    29. negative regulation of protein import into nucleus, translocation Source: UniProtKB
    30. negative regulation of renal albumin absorption Source: UniProtKB
    31. negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    32. negative regulation of transcription, DNA-templated Source: UniProtKB
    33. negative regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
    34. negative regulation of tumor necrosis factor production Source: UniProtKB
    35. neuron migration Source: MGI
    36. organ regeneration Source: Ensembl
    37. peptidyl-serine phosphorylation Source: UniProtKB
    38. phagocytosis Source: UniProtKB
    39. positive regulation of cytokine-mediated signaling pathway Source: UniProtKB
    40. positive regulation of dendritic cell chemotaxis Source: Ensembl
    41. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    42. positive regulation of fibroblast proliferation Source: UniProtKB
    43. positive regulation of gene expression Source: UniProtKB
    44. positive regulation of glomerular filtration Source: UniProtKB
    45. positive regulation of natural killer cell differentiation Source: UniProtKB
    46. positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
    47. positive regulation of phagocytosis Source: UniProtKB
    48. positive regulation of protein export from nucleus Source: UniProtKB
    49. positive regulation of protein kinase activity Source: UniProtKB
    50. positive regulation of protein kinase B signaling Source: UniProtKB
    51. positive regulation of protein phosphorylation Source: UniProtKB
    52. positive regulation of protein tyrosine kinase activity Source: UniProtKB
    53. positive regulation of TOR signaling Source: UniProtKB
    54. protein kinase B signaling Source: MGI
    55. protein phosphorylation Source: UniProtKB
    56. protein targeting to plasma membrane Source: UniProtKB
    57. receptor-mediated virion attachment to host cell Source: UniProtKB
    58. regulation of growth Source: UniProtKB-KW
    59. viral entry into host cell Source: UniProtKB
    60. viral genome replication Source: UniProtKB

    Keywords - Biological processi

    Growth regulation

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_225233. Cell surface interactions at the vascular wall.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth arrest-specific protein 6
    Short name:
    GAS-6
    Alternative name(s):
    AXL receptor tyrosine kinase ligand
    Gene namesi
    Name:Gas6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:95660. Gas6.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 674647Growth arrest-specific protein 6PRO_0000007590Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi62 ↔ 67By similarity
    Disulfide bondi117 ↔ 130By similarity
    Disulfide bondi122 ↔ 139By similarity
    Disulfide bondi141 ↔ 150By similarity
    Disulfide bondi157 ↔ 168By similarity
    Disulfide bondi164 ↔ 177By similarity
    Disulfide bondi179 ↔ 192By similarity
    Disulfide bondi198 ↔ 209By similarity
    Disulfide bondi204 ↔ 218By similarity
    Disulfide bondi220 ↔ 233By similarity
    Disulfide bondi239 ↔ 248By similarity
    Disulfide bondi244 ↔ 257By similarity
    Disulfide bondi259 ↔ 274By similarity
    Disulfide bondi280 ↔ 566By similarity
    Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi441 ↔ 467By similarity
    Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
    Modified residuei609 – 6091PhosphothreonineBy similarity
    Modified residuei614 – 6141PhosphoserineBy similarity
    Modified residuei617 – 6171PhosphothreonineBy similarity
    Modified residuei633 – 6331PhosphothreonineBy similarity
    Modified residuei636 – 6361PhosphotyrosineBy similarity
    Disulfide bondi639 ↔ 666By similarity

    Post-translational modificationi

    Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ61592.
    PRIDEiQ61592.

    Expressioni

    Gene expression databases

    BgeeiQ61592.
    CleanExiMM_GAS6.
    GenevestigatoriQ61592.

    Interactioni

    Subunit structurei

    Heterodimer and heterotetramer with AXL.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000033828.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61592.
    SMRiQ61592. Positions 50-672.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 9142GlaPROSITE-ProRule annotationAdd
    BLAST
    Domaini113 – 15139EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini153 – 19341EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini194 – 23441EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini235 – 27541EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini295 – 467173Laminin G-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini474 – 666193Laminin G-like 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation
    Contains 2 laminin G-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG149502.
    GeneTreeiENSGT00530000063339.
    HOGENOMiHOG000065758.
    HOVERGENiHBG051702.
    InParanoidiQ61592.
    KOiK05464.
    OMAiVDYHSTK.
    OrthoDBiEOG7F5119.
    PhylomeDBiQ61592.
    TreeFamiTF352157.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    4.10.740.10. 1 hit.
    InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR000294. GLA_domain.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF07645. EGF_CA. 1 hit.
    PF00594. Gla. 1 hit.
    PF02210. Laminin_G_2. 2 hits.
    [Graphical view]
    PRINTSiPR00001. GLABLOOD.
    SMARTiSM00181. EGF. 1 hit.
    SM00179. EGF_CA. 3 hits.
    SM00069. GLA. 1 hit.
    SM00282. LamG. 2 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    SSF57184. SSF57184. 1 hit.
    SSF57630. SSF57630. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 3 hits.
    PS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61592-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPPPGPAAA LGTALLLLLL ASESSHTVLL RAREAAQFLR PRQRRAYQVF    50
    EEAKQGHLER ECVEEVCSKE EAREVFENDP ETEYFYPRYQ ECMRKYGRPE 100
    EKNPDFAKCV QNLPDQCTPN PCDKKGTHIC QDLMGNFFCV CTDGWGGRLC 150
    DKDVNECVQK NGGCSQVCHN KPGSFQCACH SGFSLASDGQ TCQDIDECTD 200
    SDTCGDARCK NLPGSYSCLC DEGYTYSSKE KTCQDVDECQ QDRCEQTCVN 250
    SPGSYTCHCD GRGGLKLSPD MDTCEDILPC VPFSMAKSVK SLYLGRMFSG 300
    TPVIRLRFKR LQPTRLLAEF DFRTFDPEGV LFFAGGRSDS TWIVLGLRAG 350
    RLELQLRYNG VGRITSSGPT INHGMWQTIS VEELERNLVI KVNKDAVMKI 400
    AVAGELFQLE RGLYHLNLTV GGIPFKESEL VQPINPRLDG CMRSWNWLNG 450
    EDSAIQETVK ANTKMQCFSV TERGSFFPGN GFATYRLNYT RTSLDVGTET 500
    TWEVKVVARI RPATDTGVLL ALVGDDDVVP ISVALVDYHS TKKLKKQLVV 550
    LAVEDVALAL MEIKVCDSQE HTVTVSLREG EATLEVDGTK GQSEVSTAQL 600
    QERLDTLKTH LQGSVHTYVG GLPEVSVISA PVTAFYRGCM TLEVNGKILD 650
    LDTASYKHSD ITSHSCPPVE HATP 674
    Length:674
    Mass (Da):74,610
    Last modified:June 7, 2004 - v2
    Checksum:i7C41F7693903F401
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti530 – 5301Missing in CAA42507. (PubMed:8336730)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59846 mRNA. Translation: CAA42507.1.
    BC005444 mRNA. Translation: AAH05444.1.
    CCDSiCCDS40232.1.
    PIRiA48089.
    RefSeqiNP_062394.2. NM_019521.2.
    UniGeneiMm.3982.

    Genome annotation databases

    EnsembliENSMUST00000033828; ENSMUSP00000033828; ENSMUSG00000031451.
    GeneIDi14456.
    KEGGimmu:14456.
    UCSCiuc009kya.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59846 mRNA. Translation: CAA42507.1 .
    BC005444 mRNA. Translation: AAH05444.1 .
    CCDSi CCDS40232.1.
    PIRi A48089.
    RefSeqi NP_062394.2. NM_019521.2.
    UniGenei Mm.3982.

    3D structure databases

    ProteinModelPortali Q61592.
    SMRi Q61592. Positions 50-672.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000033828.

    Proteomic databases

    PaxDbi Q61592.
    PRIDEi Q61592.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033828 ; ENSMUSP00000033828 ; ENSMUSG00000031451 .
    GeneIDi 14456.
    KEGGi mmu:14456.
    UCSCi uc009kya.1. mouse.

    Organism-specific databases

    CTDi 2621.
    MGIi MGI:95660. Gas6.

    Phylogenomic databases

    eggNOGi NOG149502.
    GeneTreei ENSGT00530000063339.
    HOGENOMi HOG000065758.
    HOVERGENi HBG051702.
    InParanoidi Q61592.
    KOi K05464.
    OMAi VDYHSTK.
    OrthoDBi EOG7F5119.
    PhylomeDBi Q61592.
    TreeFami TF352157.

    Enzyme and pathway databases

    Reactomei REACT_225233. Cell surface interactions at the vascular wall.

    Miscellaneous databases

    ChiTaRSi GAS6. mouse.
    NextBioi 286080.
    PROi Q61592.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61592.
    CleanExi MM_GAS6.
    Genevestigatori Q61592.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    4.10.740.10. 1 hit.
    InterProi IPR017857. Coagulation_fac_subgr_Gla_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR000294. GLA_domain.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF07645. EGF_CA. 1 hit.
    PF00594. Gla. 1 hit.
    PF02210. Laminin_G_2. 2 hits.
    [Graphical view ]
    PRINTSi PR00001. GLABLOOD.
    SMARTi SM00181. EGF. 1 hit.
    SM00179. EGF_CA. 3 hits.
    SM00069. GLA. 1 hit.
    SM00282. LamG. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    SSF57184. SSF57184. 1 hit.
    SSF57630. SSF57630. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 4 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 3 hits.
    PS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade."
      Manfioletti G., Brancolini C., Avanzi G., Schneider C.
      Mol. Cell. Biol. 13:4976-4985(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis."
      Angelillo-Scherrer A., de Frutos P., Aparicio C., Melis E., Savi P., Lupu F., Arnout J., Dewerchin M., Hoylaerts M., Herbert J., Collen D., Dahlback B., Carmeliet P.
      Nat. Med. 7:215-221(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiGAS6_MOUSE
    AccessioniPrimary (citable) accession number: Q61592
    Secondary accession number(s): Q99K57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    GAS6 deficient mice show protection against thrombosis, but no spontaneous bleeding.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3