Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q61584

- FXR1_MOUSE

UniProt

Q61584 - FXR1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Fragile X mental retardation syndrome-related protein 1

Gene

Fxr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs.1 Publication

GO - Molecular functioni

  1. G-quadruplex RNA binding Source: MGI
  2. mRNA 3'-UTR binding Source: MGI

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. muscle organ development Source: MGI
  3. negative regulation of translation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fragile X mental retardation syndrome-related protein 1
Short name:
mFxr1p
Gene namesi
Name:Fxr1
Synonyms:Fxr1h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:104860. Fxr1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. costamere Source: MGI
  2. cytoplasm Source: MGI
  3. nucleus Source: MGI
  4. polysome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Death shortly after birth. Mice expressing low levels of Fxr1 show postnatal growth retardation with reduced increase in muscle mass and strength. They die within 3 weeks of birth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 677676Fragile X mental retardation syndrome-related protein 1PRO_0000050107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei68 – 681Phosphotyrosine1 Publication
Modified residuei435 – 4351Phosphoserine1 Publication
Modified residuei438 – 4381PhosphoserineBy similarity
Modified residuei449 – 4491Phosphoserine1 Publication
Modified residuei452 – 4521Phosphoserine1 Publication
Modified residuei474 – 4741Omega-N-methylated arginineBy similarity
Modified residuei514 – 5141PhosphoserineBy similarity
Modified residuei643 – 6431PhosphoserineBy similarity
Modified residuei667 – 6671PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ61584.
PaxDbiQ61584.
PRIDEiQ61584.

PTM databases

PhosphoSiteiQ61584.

Expressioni

Tissue specificityi

In early embryogenesis, highest expression in somites and central nervous system. Also expressed in spinal cord, surrounding mesenchymal tissue and undifferentiated gonad. In mid-embryogenesis, most prominent in gonad and muscle tissue. Also expressed in liver, retina, telencephalon and mesencephalon. In late embryogenesis, restricted to skeletal muscle and proliferative active layers of brain. After birth, highly expressed in postmeiotic spermatids. Intermediate levels are found in heart, liver and kidney with lower levels in brain and skeletal muscle. Isoform(s) containing the 27 amino acid pocket (residues 564-590) are present in adult heart and muscle.2 Publications

Gene expression databases

BgeeiQ61584.
ExpressionAtlasiQ61584. baseline and differential.
GenevestigatoriQ61584.

Interactioni

Subunit structurei

Interacts with FMR1 and FXR2. Interacts with TDRD3 (By similarity). Interacts with CYFIP2 but not with CYFIP1.By similarity1 Publication

Protein-protein interaction databases

BioGridi199772. 3 interactions.
IntActiQ61584. 4 interactions.
MINTiMINT-257148.

Structurei

3D structure databases

ProteinModelPortaliQ61584.
SMRiQ61584. Positions 3-121, 212-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 5047Agenet-like 1Add
BLAST
Domaini63 – 11553Agenet-like 2Add
BLAST
Domaini222 – 25130KH 1PROSITE-ProRule annotationAdd
BLAST
Domaini285 – 31430KH 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni471 – 48616RNA-binding RGG-boxAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 534Poly-Pro
Compositional biasi531 – 5399Poly-Arg

Domaini

The tandem Tudor domains preferentially recognize trimethylated histone peptides.By similarity

Sequence similaritiesi

Belongs to the FMR1 family.Curated
Contains 2 Agenet-like domains.Curated
Contains 2 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG75351.
GeneTreeiENSGT00390000017033.
HOVERGENiHBG005739.
InParanoidiQ61584.
KOiK15516.
OMAiGMVPFTF.
OrthoDBiEOG7NKKJT.
PhylomeDBiQ61584.
TreeFamiTF105427.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
InterProiIPR008395. Agenet-like_dom.
IPR022034. Frag_X_MRP_fam.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF05641. Agenet. 1 hit.
PF12235. FXR1P_C. 1 hit.
PF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS51641. AGENET_LIKE. 2 hits.
PS50084. KH_TYPE_1. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform E (identifier: Q61584-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP
60 70 80 90 100
PPPDIKKEIS EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD
110 120 130 140 150
ATYNEIVTFE RLRPVNQNKT VKKNTFFKCT VDVPEDLREA CANENAHKDF
160 170 180 190 200
KKAVGACRIF YHPETTQLMI LSASEATVKR VNILSDMHLR SIRTKLMLMS
210 220 230 240 250
RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN IQQARKVPGV
260 270 280 290 300
TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN
310 320 330 340 350
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL
360 370 380 390 400
LEYHIAYLKE VEQLRMERLQ IDEQLRQIGM GFRPSSTRGP EREKGYATDE
410 420 430 440 450
STVSSVQGSR SYSGRGRGRR GPNYTSGYGT NSELSNPSET ESERKDELSD
460 470 480 490 500
WSLAGEDDRE TRHQRDSRRR PGGRGRSVSG GRGRGGPRGG KSSISSVLKD
510 520 530 540 550
PDSNPYSLLD NTESDQTADT DASESHHSTN RRRRSRRRRT DEDAVLMDGL
560 570 580 590 600
TESDTASVNE NGLDDSEKKP QRRNRSRRRR FRGQAEDRQP VTVADYISRA
610 620 630 640 650
ESQSRQRNLP RETLAKNKKE MAKDVIEEHG PSEKAINGPT SASGDEIPKL
660 670
PRTLGEEKTK TLKEDSTQEA AVLNGVS
Length:677
Mass (Da):76,222
Last modified:March 1, 2001 - v2
Checksum:i908104FC95431A11
GO
Isoform A (identifier: Q61584-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-408: Missing.
     564-568: DDSEK → GKRCD
     569-677: Missing.

Show »
Length:539
Mass (Da):60,816
Checksum:i46FC7A21E1C1697C
GO
Isoform B (identifier: Q61584-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     564-568: DDSEK → GKRCD

Show »
Length:677
Mass (Da):76,207
Checksum:i189DF067FC611A20
GO
Isoform C (identifier: Q61584-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     564-590: Missing.

Show »
Length:650
Mass (Da):72,814
Checksum:i4E1E7192CF7A0E85
GO
Isoform D (identifier: Q61584-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-408: Missing.
     564-590: Missing.

Show »
Length:621
Mass (Da):69,715
Checksum:i92C675950981B238
GO
Isoform F (identifier: Q61584-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-408: Missing.

Show »
Length:648
Mass (Da):73,123
Checksum:iEF2F32D4150CF24E
GO
Isoform G (identifier: Q61584-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     430-455: Missing.

Show »
Length:651
Mass (Da):73,358
Checksum:i9E24A06DDB03FA63
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361D → H in AAH19139. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei380 – 40829Missing in isoform A, isoform D and isoform F. 3 PublicationsVSP_002836Add
BLAST
Alternative sequencei430 – 45526Missing in isoform G. 1 PublicationVSP_002837Add
BLAST
Alternative sequencei564 – 59027Missing in isoform C and isoform D. 1 PublicationVSP_002839Add
BLAST
Alternative sequencei564 – 5685DDSEK → GKRCD in isoform A and isoform B. 3 PublicationsVSP_002838
Alternative sequencei569 – 677109Missing in isoform A. 3 PublicationsVSP_002840Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90875 mRNA. Translation: CAA62383.1.
AF124385 mRNA. Translation: AAD30211.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30212.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30213.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30214.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30215.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30216.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30217.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30218.1.
BC019139 mRNA. Translation: AAH19139.1.
CCDSiCCDS50890.1. [Q61584-2]
CCDS50891.1. [Q61584-1]
RefSeqiNP_001106659.1. NM_001113188.1. [Q61584-1]
NP_001106660.1. NM_001113189.1. [Q61584-5]
NP_032079.1. NM_008053.2. [Q61584-2]
XP_006535463.1. XM_006535400.1. [Q61584-4]
XP_006535464.1. XM_006535401.1. [Q61584-6]
XP_006535465.1. XM_006535402.1.
UniGeneiMm.259021.

Genome annotation databases

EnsembliENSMUST00000001620; ENSMUSP00000001620; ENSMUSG00000027680. [Q61584-1]
ENSMUST00000167354; ENSMUSP00000130216; ENSMUSG00000027680. [Q61584-2]
GeneIDi14359.
KEGGimmu:14359.
UCSCiuc008oxk.2. mouse. [Q61584-2]
uc008oxl.2. mouse. [Q61584-5]
uc008oxn.2. mouse. [Q61584-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90875 mRNA. Translation: CAA62383.1 .
AF124385 mRNA. Translation: AAD30211.1 .
AF124394
, AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30212.1 .
AF124394
, AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30213.1 .
AF124394
, AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30214.1 .
AF124394
, AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30215.1 .
AF124394
, AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30216.1 .
AF124394
, AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30217.1 .
AF124394
, AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30218.1 .
BC019139 mRNA. Translation: AAH19139.1 .
CCDSi CCDS50890.1. [Q61584-2 ]
CCDS50891.1. [Q61584-1 ]
RefSeqi NP_001106659.1. NM_001113188.1. [Q61584-1 ]
NP_001106660.1. NM_001113189.1. [Q61584-5 ]
NP_032079.1. NM_008053.2. [Q61584-2 ]
XP_006535463.1. XM_006535400.1. [Q61584-4 ]
XP_006535464.1. XM_006535401.1. [Q61584-6 ]
XP_006535465.1. XM_006535402.1.
UniGenei Mm.259021.

3D structure databases

ProteinModelPortali Q61584.
SMRi Q61584. Positions 3-121, 212-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199772. 3 interactions.
IntActi Q61584. 4 interactions.
MINTi MINT-257148.

PTM databases

PhosphoSitei Q61584.

Proteomic databases

MaxQBi Q61584.
PaxDbi Q61584.
PRIDEi Q61584.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001620 ; ENSMUSP00000001620 ; ENSMUSG00000027680 . [Q61584-1 ]
ENSMUST00000167354 ; ENSMUSP00000130216 ; ENSMUSG00000027680 . [Q61584-2 ]
GeneIDi 14359.
KEGGi mmu:14359.
UCSCi uc008oxk.2. mouse. [Q61584-2 ]
uc008oxl.2. mouse. [Q61584-5 ]
uc008oxn.2. mouse. [Q61584-1 ]

Organism-specific databases

CTDi 8087.
MGIi MGI:104860. Fxr1.

Phylogenomic databases

eggNOGi NOG75351.
GeneTreei ENSGT00390000017033.
HOVERGENi HBG005739.
InParanoidi Q61584.
KOi K15516.
OMAi GMVPFTF.
OrthoDBi EOG7NKKJT.
PhylomeDBi Q61584.
TreeFami TF105427.

Miscellaneous databases

NextBioi 285817.
PROi Q61584.
SOURCEi Search...

Gene expression databases

Bgeei Q61584.
ExpressionAtlasi Q61584. baseline and differential.
Genevestigatori Q61584.

Family and domain databases

Gene3Di 3.30.1370.10. 2 hits.
InterProi IPR008395. Agenet-like_dom.
IPR022034. Frag_X_MRP_fam.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view ]
Pfami PF05641. Agenet. 1 hit.
PF12235. FXR1P_C. 1 hit.
PF00013. KH_1. 2 hits.
[Graphical view ]
SMARTi SM00322. KH. 2 hits.
[Graphical view ]
SUPFAMi SSF54791. SSF54791. 2 hits.
PROSITEi PS51641. AGENET_LIKE. 2 hits.
PS50084. KH_TYPE_1. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Highly conserved 3' UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1."
    Coy J.F., Sedlacek Z., Baechner D., Hameister H., Joos S., Lichter P., Delius H., Poustka A.
    Hum. Mol. Genet. 4:2209-2218(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Tissue: Fetal brain.
  2. "Alternative splicing in the murine and human FXR1 genes."
    Kirkpatrick L.L., McIlwain K.A., Nelson D.L.
    Genomics 59:193-202(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A; B; C; D; E; F AND G), TISSUE SPECIFICITY.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Tissue: Kidney.
  4. "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P."
    Schenck A., Bardoni B., Moro A., Bagni C., Mandel J.-L.
    Proc. Natl. Acad. Sci. U.S.A. 98:8844-8849(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CYFIP2.
  5. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  6. "The RNA-binding protein Fragile X-related 1 regulates somite formation in Xenopus laevis."
    Huot M.-E., Bisson N., Davidovic L., Mazroui R., Labelle Y., Moss T., Khandjian E.W.
    Mol. Biol. Cell 16:4350-4361(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  9. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-68, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435; SER-449 AND SER-452, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFXR1_MOUSE
AccessioniPrimary (citable) accession number: Q61584
Secondary accession number(s): Q8VCU4
, Q9R1E2, Q9R1E3, Q9R1E4, Q9R1E5, Q9WUA7, Q9WUA8, Q9WUA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3