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Protein

Fragile X mental retardation syndrome-related protein 1

Gene

Fxr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • muscle organ development Source: MGI
  • negative regulation of translation Source: MGI
  • positive regulation of gene silencing by miRNA Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fragile X mental retardation syndrome-related protein 1
Short name:
mFxr1p
Gene namesi
Name:Fxr1
Synonyms:Fxr1h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:104860. Fxr1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: MGI
  • costamere Source: MGI
  • cytoplasm Source: MGI
  • dendrite Source: MGI
  • dendritic spine Source: MGI
  • membrane Source: MGI
  • nucleus Source: MGI
  • perinuclear region of cytoplasm Source: MGI
  • polysome Source: MGI
  • ribonucleoprotein granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Death shortly after birth. Mice expressing low levels of Fxr1 show postnatal growth retardation with reduced increase in muscle mass and strength. They die within 3 weeks of birth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000501072 – 677Fragile X mental retardation syndrome-related protein 1Add BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei68PhosphotyrosineCombined sources1
Modified residuei398PhosphothreonineBy similarity1
Modified residuei430PhosphothreonineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei435PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei449PhosphoserineCombined sources1
Modified residuei452PhosphoserineBy similarity1
Modified residuei474Omega-N-methylated arginineBy similarity1
Modified residuei512PhosphothreonineCombined sources1
Modified residuei514PhosphoserineBy similarity1
Modified residuei553PhosphoserineBy similarity1
Modified residuei643PhosphoserineCombined sources1
Modified residuei667PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ61584.
PeptideAtlasiQ61584.
PRIDEiQ61584.

PTM databases

iPTMnetiQ61584.
PhosphoSitePlusiQ61584.

Expressioni

Tissue specificityi

In early embryogenesis, highest expression in somites and central nervous system. Also expressed in spinal cord, surrounding mesenchymal tissue and undifferentiated gonad. In mid-embryogenesis, most prominent in gonad and muscle tissue. Also expressed in liver, retina, telencephalon and mesencephalon. In late embryogenesis, restricted to skeletal muscle and proliferative active layers of brain. After birth, highly expressed in postmeiotic spermatids. Intermediate levels are found in heart, liver and kidney with lower levels in brain and skeletal muscle. Isoform(s) containing the 27 amino acid pocket (residues 564-590) are present in adult heart and muscle.2 Publications

Gene expression databases

BgeeiENSMUSG00000027680.
ExpressionAtlasiQ61584. baseline and differential.
GenevisibleiQ61584. MM.

Interactioni

Subunit structurei

Interacts with FMR1 (By similarity). Interacts with FRX2 (By similarity). Interacts with TDRD3 (By similarity). Interacts with CYFIP2 but not with CYFIP1 (PubMed:11438699).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199772. 4 interactors.
IntActiQ61584. 4 interactors.
MINTiMINT-257148.
STRINGi10090.ENSMUSP00000001620.

Structurei

3D structure databases

ProteinModelPortaliQ61584.
SMRiQ61584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 50Agenet-like 1PROSITE-ProRule annotationAdd BLAST47
Domaini63 – 115Agenet-like 2PROSITE-ProRule annotationAdd BLAST53
Domaini222 – 251KH 1PROSITE-ProRule annotationAdd BLAST30
Domaini285 – 314KH 2PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni471 – 486RNA-binding RGG-boxAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi50 – 53Poly-Pro4
Compositional biasi531 – 539Poly-Arg9

Domaini

The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.By similarity

Sequence similaritiesi

Belongs to the FMR1 family.Curated
Contains 2 Agenet-like domains.PROSITE-ProRule annotation
Contains 2 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF9J. Eukaryota.
ENOG410ZDJG. LUCA.
GeneTreeiENSGT00390000017033.
HOVERGENiHBG005739.
InParanoidiQ61584.
KOiK15516.
OMAiPRDHEDN.
OrthoDBiEOG091G08EZ.
PhylomeDBiQ61584.
TreeFamiTF105427.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
InterProiIPR008395. Agenet-like_dom.
IPR022034. FXMRP1_C_core.
IPR032172. FXR_C1.
IPR032177. FXR_C3.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF05641. Agenet. 2 hits.
PF12235. FXMRP1_C_core. 1 hit.
PF16096. FXR_C1. 1 hit.
PF16097. FXR_C3. 1 hit.
PF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS51641. AGENET_LIKE. 2 hits.
PS50084. KH_TYPE_1. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform E (identifier: Q61584-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP
60 70 80 90 100
PPPDIKKEIS EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD
110 120 130 140 150
ATYNEIVTFE RLRPVNQNKT VKKNTFFKCT VDVPEDLREA CANENAHKDF
160 170 180 190 200
KKAVGACRIF YHPETTQLMI LSASEATVKR VNILSDMHLR SIRTKLMLMS
210 220 230 240 250
RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN IQQARKVPGV
260 270 280 290 300
TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN
310 320 330 340 350
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL
360 370 380 390 400
LEYHIAYLKE VEQLRMERLQ IDEQLRQIGM GFRPSSTRGP EREKGYATDE
410 420 430 440 450
STVSSVQGSR SYSGRGRGRR GPNYTSGYGT NSELSNPSET ESERKDELSD
460 470 480 490 500
WSLAGEDDRE TRHQRDSRRR PGGRGRSVSG GRGRGGPRGG KSSISSVLKD
510 520 530 540 550
PDSNPYSLLD NTESDQTADT DASESHHSTN RRRRSRRRRT DEDAVLMDGL
560 570 580 590 600
TESDTASVNE NGLDDSEKKP QRRNRSRRRR FRGQAEDRQP VTVADYISRA
610 620 630 640 650
ESQSRQRNLP RETLAKNKKE MAKDVIEEHG PSEKAINGPT SASGDEIPKL
660 670
PRTLGEEKTK TLKEDSTQEA AVLNGVS
Length:677
Mass (Da):76,222
Last modified:March 1, 2001 - v2
Checksum:i908104FC95431A11
GO
Isoform A (identifier: Q61584-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-408: Missing.
     564-568: DDSEK → GKRCD
     569-677: Missing.

Show »
Length:539
Mass (Da):60,816
Checksum:i46FC7A21E1C1697C
GO
Isoform B (identifier: Q61584-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     564-568: DDSEK → GKRCD

Show »
Length:677
Mass (Da):76,207
Checksum:i189DF067FC611A20
GO
Isoform C (identifier: Q61584-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     564-590: Missing.

Show »
Length:650
Mass (Da):72,814
Checksum:i4E1E7192CF7A0E85
GO
Isoform D (identifier: Q61584-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-408: Missing.
     564-590: Missing.

Show »
Length:621
Mass (Da):69,715
Checksum:i92C675950981B238
GO
Isoform F (identifier: Q61584-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-408: Missing.

Show »
Length:648
Mass (Da):73,123
Checksum:iEF2F32D4150CF24E
GO
Isoform G (identifier: Q61584-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     430-455: Missing.

Show »
Length:651
Mass (Da):73,358
Checksum:i9E24A06DDB03FA63
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136D → H in AAH19139 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002836380 – 408Missing in isoform A, isoform D and isoform F. 3 PublicationsAdd BLAST29
Alternative sequenceiVSP_002837430 – 455Missing in isoform G. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_002839564 – 590Missing in isoform C and isoform D. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_002838564 – 568DDSEK → GKRCD in isoform A and isoform B. 3 Publications5
Alternative sequenceiVSP_002840569 – 677Missing in isoform A. 3 PublicationsAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90875 mRNA. Translation: CAA62383.1.
AF124385 mRNA. Translation: AAD30211.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30212.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30213.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30214.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30215.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30216.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30217.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30218.1.
BC019139 mRNA. Translation: AAH19139.1.
CCDSiCCDS50890.1. [Q61584-2]
CCDS50891.1. [Q61584-1]
CCDS79896.1. [Q61584-5]
RefSeqiNP_001106659.1. NM_001113188.1. [Q61584-1]
NP_001106660.1. NM_001113189.1. [Q61584-5]
NP_032079.1. NM_008053.2. [Q61584-2]
XP_006535463.1. XM_006535400.1. [Q61584-4]
XP_006535464.1. XM_006535401.1. [Q61584-6]
XP_006535465.1. XM_006535402.1.
UniGeneiMm.259021.

Genome annotation databases

EnsembliENSMUST00000001620; ENSMUSP00000001620; ENSMUSG00000027680. [Q61584-1]
ENSMUST00000197694; ENSMUSP00000142441; ENSMUSG00000027680. [Q61584-5]
ENSMUST00000200392; ENSMUSP00000143392; ENSMUSG00000027680. [Q61584-2]
GeneIDi14359.
KEGGimmu:14359.
UCSCiuc008oxk.2. mouse. [Q61584-2]
uc008oxl.2. mouse. [Q61584-5]
uc008oxn.2. mouse. [Q61584-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90875 mRNA. Translation: CAA62383.1.
AF124385 mRNA. Translation: AAD30211.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30212.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30213.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30214.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30215.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30216.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30217.1.
AF124394
, AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30218.1.
BC019139 mRNA. Translation: AAH19139.1.
CCDSiCCDS50890.1. [Q61584-2]
CCDS50891.1. [Q61584-1]
CCDS79896.1. [Q61584-5]
RefSeqiNP_001106659.1. NM_001113188.1. [Q61584-1]
NP_001106660.1. NM_001113189.1. [Q61584-5]
NP_032079.1. NM_008053.2. [Q61584-2]
XP_006535463.1. XM_006535400.1. [Q61584-4]
XP_006535464.1. XM_006535401.1. [Q61584-6]
XP_006535465.1. XM_006535402.1.
UniGeneiMm.259021.

3D structure databases

ProteinModelPortaliQ61584.
SMRiQ61584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199772. 4 interactors.
IntActiQ61584. 4 interactors.
MINTiMINT-257148.
STRINGi10090.ENSMUSP00000001620.

PTM databases

iPTMnetiQ61584.
PhosphoSitePlusiQ61584.

Proteomic databases

PaxDbiQ61584.
PeptideAtlasiQ61584.
PRIDEiQ61584.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001620; ENSMUSP00000001620; ENSMUSG00000027680. [Q61584-1]
ENSMUST00000197694; ENSMUSP00000142441; ENSMUSG00000027680. [Q61584-5]
ENSMUST00000200392; ENSMUSP00000143392; ENSMUSG00000027680. [Q61584-2]
GeneIDi14359.
KEGGimmu:14359.
UCSCiuc008oxk.2. mouse. [Q61584-2]
uc008oxl.2. mouse. [Q61584-5]
uc008oxn.2. mouse. [Q61584-1]

Organism-specific databases

CTDi8087.
MGIiMGI:104860. Fxr1.

Phylogenomic databases

eggNOGiENOG410IF9J. Eukaryota.
ENOG410ZDJG. LUCA.
GeneTreeiENSGT00390000017033.
HOVERGENiHBG005739.
InParanoidiQ61584.
KOiK15516.
OMAiPRDHEDN.
OrthoDBiEOG091G08EZ.
PhylomeDBiQ61584.
TreeFamiTF105427.

Miscellaneous databases

PROiQ61584.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027680.
ExpressionAtlasiQ61584. baseline and differential.
GenevisibleiQ61584. MM.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
InterProiIPR008395. Agenet-like_dom.
IPR022034. FXMRP1_C_core.
IPR032172. FXR_C1.
IPR032177. FXR_C3.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF05641. Agenet. 2 hits.
PF12235. FXMRP1_C_core. 1 hit.
PF16096. FXR_C1. 1 hit.
PF16097. FXR_C3. 1 hit.
PF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS51641. AGENET_LIKE. 2 hits.
PS50084. KH_TYPE_1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXR1_MOUSE
AccessioniPrimary (citable) accession number: Q61584
Secondary accession number(s): Q8VCU4
, Q9R1E2, Q9R1E3, Q9R1E4, Q9R1E5, Q9WUA7, Q9WUA8, Q9WUA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.