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Q61584

- FXR1_MOUSE

UniProt

Q61584 - FXR1_MOUSE

Protein

Fragile X mental retardation syndrome-related protein 1

Gene

Fxr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 2 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs.1 Publication

    GO - Molecular functioni

    1. G-quadruplex RNA binding Source: MGI
    2. mRNA 3'-UTR binding Source: MGI
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. muscle organ development Source: MGI
    3. negative regulation of translation Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Myogenesis

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fragile X mental retardation syndrome-related protein 1
    Short name:
    mFxr1p
    Gene namesi
    Name:Fxr1
    Synonyms:Fxr1h
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:104860. Fxr1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. costamere Source: MGI
    2. cytoplasm Source: MGI
    3. nucleus Source: MGI
    4. polysome Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Disruption phenotypei

    Death shortly after birth. Mice expressing low levels of Fxr1 show postnatal growth retardation with reduced increase in muscle mass and strength. They die within 3 weeks of birth.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 677676Fragile X mental retardation syndrome-related protein 1PRO_0000050107Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei68 – 681Phosphotyrosine1 Publication
    Modified residuei435 – 4351Phosphoserine1 Publication
    Modified residuei438 – 4381PhosphoserineBy similarity
    Modified residuei449 – 4491Phosphoserine1 Publication
    Modified residuei452 – 4521Phosphoserine1 Publication
    Modified residuei474 – 4741Omega-N-methylated arginineBy similarity
    Modified residuei514 – 5141PhosphoserineBy similarity
    Modified residuei643 – 6431PhosphoserineBy similarity
    Modified residuei667 – 6671PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Methylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ61584.
    PaxDbiQ61584.
    PRIDEiQ61584.

    PTM databases

    PhosphoSiteiQ61584.

    Expressioni

    Tissue specificityi

    In early embryogenesis, highest expression in somites and central nervous system. Also expressed in spinal cord, surrounding mesenchymal tissue and undifferentiated gonad. In mid-embryogenesis, most prominent in gonad and muscle tissue. Also expressed in liver, retina, telencephalon and mesencephalon. In late embryogenesis, restricted to skeletal muscle and proliferative active layers of brain. After birth, highly expressed in postmeiotic spermatids. Intermediate levels are found in heart, liver and kidney with lower levels in brain and skeletal muscle. Isoform(s) containing the 27 amino acid pocket (residues 564-590) are present in adult heart and muscle.2 Publications

    Gene expression databases

    ArrayExpressiQ61584.
    BgeeiQ61584.
    GenevestigatoriQ61584.

    Interactioni

    Subunit structurei

    Interacts with FMR1 and FXR2. Interacts with TDRD3 By similarity. Interacts with CYFIP2 but not with CYFIP1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi199772. 3 interactions.
    IntActiQ61584. 4 interactions.
    MINTiMINT-257148.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61584.
    SMRiQ61584. Positions 3-121, 212-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 5047Agenet-like 1Add
    BLAST
    Domaini63 – 11553Agenet-like 2Add
    BLAST
    Domaini222 – 25130KH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini285 – 31430KH 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni471 – 48616RNA-binding RGG-boxAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi50 – 534Poly-Pro
    Compositional biasi531 – 5399Poly-Arg

    Domaini

    The tandem Tudor domains preferentially recognize trimethylated histone peptides.By similarity

    Sequence similaritiesi

    Belongs to the FMR1 family.Curated
    Contains 2 Agenet-like domains.Curated
    Contains 2 KH domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG75351.
    GeneTreeiENSGT00390000017033.
    HOVERGENiHBG005739.
    InParanoidiQ61584.
    KOiK15516.
    OMAiGMVPFTF.
    OrthoDBiEOG7NKKJT.
    PhylomeDBiQ61584.
    TreeFamiTF105427.

    Family and domain databases

    Gene3Di3.30.1370.10. 2 hits.
    InterProiIPR008395. Agenet-like_dom.
    IPR022034. Frag_X_MRP_fam.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view]
    PfamiPF05641. Agenet. 1 hit.
    PF12235. FXR1P_C. 1 hit.
    PF00013. KH_1. 2 hits.
    [Graphical view]
    SMARTiSM00322. KH. 2 hits.
    [Graphical view]
    SUPFAMiSSF54791. SSF54791. 2 hits.
    PROSITEiPS51641. AGENET_LIKE. 2 hits.
    PS50084. KH_TYPE_1. 2 hits.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform E (identifier: Q61584-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP    50
    PPPDIKKEIS EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD 100
    ATYNEIVTFE RLRPVNQNKT VKKNTFFKCT VDVPEDLREA CANENAHKDF 150
    KKAVGACRIF YHPETTQLMI LSASEATVKR VNILSDMHLR SIRTKLMLMS 200
    RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN IQQARKVPGV 250
    TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN 300
    GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL 350
    LEYHIAYLKE VEQLRMERLQ IDEQLRQIGM GFRPSSTRGP EREKGYATDE 400
    STVSSVQGSR SYSGRGRGRR GPNYTSGYGT NSELSNPSET ESERKDELSD 450
    WSLAGEDDRE TRHQRDSRRR PGGRGRSVSG GRGRGGPRGG KSSISSVLKD 500
    PDSNPYSLLD NTESDQTADT DASESHHSTN RRRRSRRRRT DEDAVLMDGL 550
    TESDTASVNE NGLDDSEKKP QRRNRSRRRR FRGQAEDRQP VTVADYISRA 600
    ESQSRQRNLP RETLAKNKKE MAKDVIEEHG PSEKAINGPT SASGDEIPKL 650
    PRTLGEEKTK TLKEDSTQEA AVLNGVS 677
    Length:677
    Mass (Da):76,222
    Last modified:March 1, 2001 - v2
    Checksum:i908104FC95431A11
    GO
    Isoform A (identifier: Q61584-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         380-408: Missing.
         564-568: DDSEK → GKRCD
         569-677: Missing.

    Show »
    Length:539
    Mass (Da):60,816
    Checksum:i46FC7A21E1C1697C
    GO
    Isoform B (identifier: Q61584-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         564-568: DDSEK → GKRCD

    Show »
    Length:677
    Mass (Da):76,207
    Checksum:i189DF067FC611A20
    GO
    Isoform C (identifier: Q61584-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         564-590: Missing.

    Show »
    Length:650
    Mass (Da):72,814
    Checksum:i4E1E7192CF7A0E85
    GO
    Isoform D (identifier: Q61584-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         380-408: Missing.
         564-590: Missing.

    Show »
    Length:621
    Mass (Da):69,715
    Checksum:i92C675950981B238
    GO
    Isoform F (identifier: Q61584-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         380-408: Missing.

    Show »
    Length:648
    Mass (Da):73,123
    Checksum:iEF2F32D4150CF24E
    GO
    Isoform G (identifier: Q61584-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         430-455: Missing.

    Show »
    Length:651
    Mass (Da):73,358
    Checksum:i9E24A06DDB03FA63
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti136 – 1361D → H in AAH19139. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei380 – 40829Missing in isoform A, isoform D and isoform F. 3 PublicationsVSP_002836Add
    BLAST
    Alternative sequencei430 – 45526Missing in isoform G. 1 PublicationVSP_002837Add
    BLAST
    Alternative sequencei564 – 59027Missing in isoform C and isoform D. 1 PublicationVSP_002839Add
    BLAST
    Alternative sequencei564 – 5685DDSEK → GKRCD in isoform A and isoform B. 3 PublicationsVSP_002838
    Alternative sequencei569 – 677109Missing in isoform A. 3 PublicationsVSP_002840Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90875 mRNA. Translation: CAA62383.1.
    AF124385 mRNA. Translation: AAD30211.1.
    AF124394
    , AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30212.1.
    AF124394
    , AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30213.1.
    AF124394
    , AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30214.1.
    AF124394
    , AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30215.1.
    AF124394
    , AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30216.1.
    AF124394
    , AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30217.1.
    AF124394
    , AF124386, AF124387, AF124388, AF124389, AF124390, AF124391, AF124392, AF124393 Genomic DNA. Translation: AAD30218.1.
    BC019139 mRNA. Translation: AAH19139.1.
    CCDSiCCDS50890.1. [Q61584-2]
    CCDS50891.1. [Q61584-1]
    RefSeqiNP_001106659.1. NM_001113188.1. [Q61584-1]
    NP_001106660.1. NM_001113189.1. [Q61584-5]
    NP_032079.1. NM_008053.2. [Q61584-2]
    XP_006535463.1. XM_006535400.1. [Q61584-4]
    XP_006535464.1. XM_006535401.1. [Q61584-6]
    XP_006535465.1. XM_006535402.1.
    UniGeneiMm.259021.

    Genome annotation databases

    EnsembliENSMUST00000001620; ENSMUSP00000001620; ENSMUSG00000027680. [Q61584-1]
    ENSMUST00000167354; ENSMUSP00000130216; ENSMUSG00000027680. [Q61584-2]
    GeneIDi14359.
    KEGGimmu:14359.
    UCSCiuc008oxk.2. mouse. [Q61584-2]
    uc008oxl.2. mouse. [Q61584-5]
    uc008oxn.2. mouse. [Q61584-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90875 mRNA. Translation: CAA62383.1 .
    AF124385 mRNA. Translation: AAD30211.1 .
    AF124394
    , AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30212.1 .
    AF124394
    , AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30213.1 .
    AF124394
    , AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30214.1 .
    AF124394
    , AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30215.1 .
    AF124394
    , AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30216.1 .
    AF124394
    , AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30217.1 .
    AF124394
    , AF124386 , AF124387 , AF124388 , AF124389 , AF124390 , AF124391 , AF124392 , AF124393 Genomic DNA. Translation: AAD30218.1 .
    BC019139 mRNA. Translation: AAH19139.1 .
    CCDSi CCDS50890.1. [Q61584-2 ]
    CCDS50891.1. [Q61584-1 ]
    RefSeqi NP_001106659.1. NM_001113188.1. [Q61584-1 ]
    NP_001106660.1. NM_001113189.1. [Q61584-5 ]
    NP_032079.1. NM_008053.2. [Q61584-2 ]
    XP_006535463.1. XM_006535400.1. [Q61584-4 ]
    XP_006535464.1. XM_006535401.1. [Q61584-6 ]
    XP_006535465.1. XM_006535402.1.
    UniGenei Mm.259021.

    3D structure databases

    ProteinModelPortali Q61584.
    SMRi Q61584. Positions 3-121, 212-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199772. 3 interactions.
    IntActi Q61584. 4 interactions.
    MINTi MINT-257148.

    PTM databases

    PhosphoSitei Q61584.

    Proteomic databases

    MaxQBi Q61584.
    PaxDbi Q61584.
    PRIDEi Q61584.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001620 ; ENSMUSP00000001620 ; ENSMUSG00000027680 . [Q61584-1 ]
    ENSMUST00000167354 ; ENSMUSP00000130216 ; ENSMUSG00000027680 . [Q61584-2 ]
    GeneIDi 14359.
    KEGGi mmu:14359.
    UCSCi uc008oxk.2. mouse. [Q61584-2 ]
    uc008oxl.2. mouse. [Q61584-5 ]
    uc008oxn.2. mouse. [Q61584-1 ]

    Organism-specific databases

    CTDi 8087.
    MGIi MGI:104860. Fxr1.

    Phylogenomic databases

    eggNOGi NOG75351.
    GeneTreei ENSGT00390000017033.
    HOVERGENi HBG005739.
    InParanoidi Q61584.
    KOi K15516.
    OMAi GMVPFTF.
    OrthoDBi EOG7NKKJT.
    PhylomeDBi Q61584.
    TreeFami TF105427.

    Miscellaneous databases

    NextBioi 285817.
    PROi Q61584.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61584.
    Bgeei Q61584.
    Genevestigatori Q61584.

    Family and domain databases

    Gene3Di 3.30.1370.10. 2 hits.
    InterProi IPR008395. Agenet-like_dom.
    IPR022034. Frag_X_MRP_fam.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view ]
    Pfami PF05641. Agenet. 1 hit.
    PF12235. FXR1P_C. 1 hit.
    PF00013. KH_1. 2 hits.
    [Graphical view ]
    SMARTi SM00322. KH. 2 hits.
    [Graphical view ]
    SUPFAMi SSF54791. SSF54791. 2 hits.
    PROSITEi PS51641. AGENET_LIKE. 2 hits.
    PS50084. KH_TYPE_1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Highly conserved 3' UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1."
      Coy J.F., Sedlacek Z., Baechner D., Hameister H., Joos S., Lichter P., Delius H., Poustka A.
      Hum. Mol. Genet. 4:2209-2218(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
      Tissue: Fetal brain.
    2. "Alternative splicing in the murine and human FXR1 genes."
      Kirkpatrick L.L., McIlwain K.A., Nelson D.L.
      Genomics 59:193-202(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A; B; C; D; E; F AND G), TISSUE SPECIFICITY.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Tissue: Kidney.
    4. "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P."
      Schenck A., Bardoni B., Moro A., Bagni C., Mandel J.-L.
      Proc. Natl. Acad. Sci. U.S.A. 98:8844-8849(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CYFIP2.
    5. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    6. "The RNA-binding protein Fragile X-related 1 regulates somite formation in Xenopus laevis."
      Huot M.-E., Bisson N., Davidovic L., Mazroui R., Labelle Y., Moss T., Khandjian E.W.
      Mol. Biol. Cell 16:4350-4361(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    9. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-68, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Mast cell.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435; SER-449 AND SER-452, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiFXR1_MOUSE
    AccessioniPrimary (citable) accession number: Q61584
    Secondary accession number(s): Q8VCU4
    , Q9R1E2, Q9R1E3, Q9R1E4, Q9R1E5, Q9WUA7, Q9WUA8, Q9WUA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 134 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3