Fragile X mental retardation syndrome-related protein 1

Preferred order of sections

Names and origin

Protein names

Recommended name:
Fragile X mental retardation syndrome-related protein 1
Short name=mFxr1p

Gene names

Name:	Fxr1
Synonyms:	Fxr1h

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	677 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. Ref.5
Subunit structure	Interacts with FMR1 and FXR2. Interacts with TDRD3 By similarity. Interacts with CYFIP2 but not with CYFIP1. Ref.4
Subcellular location	Cytoplasm By similarity.
Tissue specificity	In early embryogenesis, highest expression in somites and central nervous system. Also expressed in spinal cord, surrounding mesenchymal tissue and undifferentiated gonad. In mid-embryogenesis, most prominent in gonad and muscle tissue. Also expressed in liver, retina, telencephalon and mesencephalon. In late embryogenesis, restricted to skeletal muscle and proliferative active layers of brain. After birth, highly expressed in postmeiotic spermatids. Intermediate levels are found in heart, liver and kidney with lower levels in brain and skeletal muscle. Isoform(s) containing the 27 amino acid pocket (residues 564-590) are present in adult heart and muscle. Ref.2 Ref.6
Domain	The tandem Tudor domains preferentially recognize trimethylated histone peptides By similarity.
Disruption phenotype	Death shortly after birth. Mice expressing low levels of Fxr1 show postnatal growth retardation with reduced increase in muscle mass and strength. They die within 3 weeks of birth. Ref.5
Sequence similarities	Belongs to the FMR1 family. Contains 2 Agenet-like domains. Contains 2 KH domains.

Ontologies

Keywords
Biological process	Differentiation Myogenesis
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	RNA-binding
Molecular function	Developmental protein
PTM	Acetylation Methylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW muscle organ development Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of translation Inferred from direct assay PubMed 15548538. Source: MGI
Cellular_component	costamere Inferred from direct assay Ref.5. Source: MGI cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay PubMed 11178106. Source: MGI polysome Inferred from direct assay PubMed 11178106. Source: MGI
Molecular_function	G-quadruplex RNA binding Inferred from direct assay PubMed 17170008. Source: MGI RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA 3'-UTR binding Inferred from direct assay PubMed 15548538. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform E (identifier: Q61584-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A (identifier: Q61584-2) The sequence of this isoform differs from the canonical sequence as follows: 380-408: Missing. 564-568: DDSEK → GKRCD 569-677: Missing.

Isoform B (identifier: Q61584-3) The sequence of this isoform differs from the canonical sequence as follows: 564-568: DDSEK → GKRCD

Isoform C (identifier: Q61584-4) The sequence of this isoform differs from the canonical sequence as follows: 564-590: Missing.

Isoform D (identifier: Q61584-5) The sequence of this isoform differs from the canonical sequence as follows: 380-408: Missing. 564-590: Missing.

Isoform F (identifier: Q61584-6) The sequence of this isoform differs from the canonical sequence as follows: 380-408: Missing.

Isoform G (identifier: Q61584-7) The sequence of this isoform differs from the canonical sequence as follows: 430-455: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed By similarity

Chain

2 – 677

676

Fragile X mental retardation syndrome-related protein 1

PRO_0000050107

Regions

Domain

4 – 50

47

Agenet-like 1

Domain

63 – 115

53

Agenet-like 2

Domain

222 – 251

30

KH 1

Domain

285 – 314

30

KH 2

Region

471 – 486

16

RNA-binding RGG-box

Compositional bias

50 – 53

4

Poly-Pro

Compositional bias

531 – 539

9

Poly-Arg

Amino acid modifications

Modified residue

2

1

N-acetylalanine By similarity

Modified residue

68

1

Phosphotyrosine Ref.7

Modified residue

435

1

Phosphoserine Ref.8

Modified residue

438

1

Phosphoserine By similarity

Modified residue

449

1

Phosphoserine By similarity

Modified residue

452

1

Phosphoserine By similarity

Modified residue

474

1

Omega-N-methylated arginine By similarity

Modified residue

514

1

Phosphoserine By similarity

Modified residue

641

1

Phosphoserine Ref.9

Modified residue

643

1

Phosphoserine By similarity

Modified residue

667

1

Phosphothreonine By similarity

Natural variations

Alternative sequence

380 – 408

29

Missing in isoform A, isoform D and isoform F.

VSP_002836

Alternative sequence

430 – 455

26

Missing in isoform G.

VSP_002837

Alternative sequence

564 – 590

27

Missing in isoform C and isoform D.

VSP_002839

Alternative sequence

564 – 568

5

DDSEK → GKRCD in isoform A and isoform B.

VSP_002838

Alternative sequence

569 – 677

109

Missing in isoform A.

VSP_002840

Experimental info

Sequence conflict

136

1

D → H in AAH19139. Ref.3

Sequences

Sequence		Length	Mass (Da)
Isoform E [UniParc]. Last modified March 1, 2001. Version 2. Checksum: 908104FC95431A11 Show »	FASTA	677	76,222
10 20 30 40 50 60 MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS 70 80 90 100 110 120 EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT 130 140 150 160 170 180 VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR 190 200 210 220 230 240 VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN 250 260 270 280 290 300 IQQARKVPGV TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN 310 320 330 340 350 360 GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE 370 380 390 400 410 420 VEQLRMERLQ IDEQLRQIGM GFRPSSTRGP EREKGYATDE STVSSVQGSR SYSGRGRGRR 430 440 450 460 470 480 GPNYTSGYGT NSELSNPSET ESERKDELSD WSLAGEDDRE TRHQRDSRRR PGGRGRSVSG 490 500 510 520 530 540 GRGRGGPRGG KSSISSVLKD PDSNPYSLLD NTESDQTADT DASESHHSTN RRRRSRRRRT 550 560 570 580 590 600 DEDAVLMDGL TESDTASVNE NGLDDSEKKP QRRNRSRRRR FRGQAEDRQP VTVADYISRA 610 620 630 640 650 660 ESQSRQRNLP RETLAKNKKE MAKDVIEEHG PSEKAINGPT SASGDEIPKL PRTLGEEKTK 670 TLKEDSTQEA AVLNGVS « Hide
Isoform A [UniParc]. Checksum: 46FC7A21E1C1697C Show »	FASTA	539	60,816
10 20 30 40 50 60 MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS 70 80 90 100 110 120 EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT 130 140 150 160 170 180 VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR 190 200 210 220 230 240 VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN 250 260 270 280 290 300 IQQARKVPGV TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN 310 320 330 340 350 360 GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE 370 380 390 400 410 420 VEQLRMERLQ IDEQLRQIGS RSYSGRGRGR RGPNYTSGYG TNSELSNPSE TESERKDELS 430 440 450 460 470 480 DWSLAGEDDR ETRHQRDSRR RPGGRGRSVS GGRGRGGPRG GKSSISSVLK DPDSNPYSLL 490 500 510 520 530 DNTESDQTAD TDASESHHST NRRRRSRRRR TDEDAVLMDG LTESDTASVN ENGLGKRCD « Hide
Isoform B [UniParc]. Checksum: 189DF067FC611A20 Show »	FASTA	677	76,207
10 20 30 40 50 60 MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS 70 80 90 100 110 120 EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT 130 140 150 160 170 180 VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR 190 200 210 220 230 240 VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN 250 260 270 280 290 300 IQQARKVPGV TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN 310 320 330 340 350 360 GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE 370 380 390 400 410 420 VEQLRMERLQ IDEQLRQIGM GFRPSSTRGP EREKGYATDE STVSSVQGSR SYSGRGRGRR 430 440 450 460 470 480 GPNYTSGYGT NSELSNPSET ESERKDELSD WSLAGEDDRE TRHQRDSRRR PGGRGRSVSG 490 500 510 520 530 540 GRGRGGPRGG KSSISSVLKD PDSNPYSLLD NTESDQTADT DASESHHSTN RRRRSRRRRT 550 560 570 580 590 600 DEDAVLMDGL TESDTASVNE NGLGKRCDKP QRRNRSRRRR FRGQAEDRQP VTVADYISRA 610 620 630 640 650 660 ESQSRQRNLP RETLAKNKKE MAKDVIEEHG PSEKAINGPT SASGDEIPKL PRTLGEEKTK 670 TLKEDSTQEA AVLNGVS « Hide
Isoform C [UniParc]. Checksum: 4E1E7192CF7A0E85 Show »	FASTA	650	72,814
10 20 30 40 50 60 MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS 70 80 90 100 110 120 EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT 130 140 150 160 170 180 VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR 190 200 210 220 230 240 VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN 250 260 270 280 290 300 IQQARKVPGV TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN 310 320 330 340 350 360 GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE 370 380 390 400 410 420 VEQLRMERLQ IDEQLRQIGM GFRPSSTRGP EREKGYATDE STVSSVQGSR SYSGRGRGRR 430 440 450 460 470 480 GPNYTSGYGT NSELSNPSET ESERKDELSD WSLAGEDDRE TRHQRDSRRR PGGRGRSVSG 490 500 510 520 530 540 GRGRGGPRGG KSSISSVLKD PDSNPYSLLD NTESDQTADT DASESHHSTN RRRRSRRRRT 550 560 570 580 590 600 DEDAVLMDGL TESDTASVNE NGLVTVADYI SRAESQSRQR NLPRETLAKN KKEMAKDVIE 610 620 630 640 650 EHGPSEKAIN GPTSASGDEI PKLPRTLGEE KTKTLKEDST QEAAVLNGVS « Hide
Isoform D [UniParc]. Checksum: 92C675950981B238 Show »	FASTA	621	69,715
10 20 30 40 50 60 MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS 70 80 90 100 110 120 EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT 130 140 150 160 170 180 VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR 190 200 210 220 230 240 VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN 250 260 270 280 290 300 IQQARKVPGV TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN 310 320 330 340 350 360 GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE 370 380 390 400 410 420 VEQLRMERLQ IDEQLRQIGS RSYSGRGRGR RGPNYTSGYG TNSELSNPSE TESERKDELS 430 440 450 460 470 480 DWSLAGEDDR ETRHQRDSRR RPGGRGRSVS GGRGRGGPRG GKSSISSVLK DPDSNPYSLL 490 500 510 520 530 540 DNTESDQTAD TDASESHHST NRRRRSRRRR TDEDAVLMDG LTESDTASVN ENGLVTVADY 550 560 570 580 590 600 ISRAESQSRQ RNLPRETLAK NKKEMAKDVI EEHGPSEKAI NGPTSASGDE IPKLPRTLGE 610 620 EKTKTLKEDS TQEAAVLNGV S « Hide
Isoform F [UniParc]. Checksum: EF2F32D4150CF24E Show »	FASTA	648	73,123
10 20 30 40 50 60 MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS 70 80 90 100 110 120 EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT 130 140 150 160 170 180 VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR 190 200 210 220 230 240 VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN 250 260 270 280 290 300 IQQARKVPGV TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN 310 320 330 340 350 360 GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE 370 380 390 400 410 420 VEQLRMERLQ IDEQLRQIGS RSYSGRGRGR RGPNYTSGYG TNSELSNPSE TESERKDELS 430 440 450 460 470 480 DWSLAGEDDR ETRHQRDSRR RPGGRGRSVS GGRGRGGPRG GKSSISSVLK DPDSNPYSLL 490 500 510 520 530 540 DNTESDQTAD TDASESHHST NRRRRSRRRR TDEDAVLMDG LTESDTASVN ENGLDDSEKK 550 560 570 580 590 600 PQRRNRSRRR RFRGQAEDRQ PVTVADYISR AESQSRQRNL PRETLAKNKK EMAKDVIEEH 610 620 630 640 GPSEKAINGP TSASGDEIPK LPRTLGEEKT KTLKEDSTQE AAVLNGVS « Hide
Isoform G [UniParc]. Checksum: 9E24A06DDB03FA63 Show »	FASTA	651	73,358
10 20 30 40 50 60 MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS 70 80 90 100 110 120 EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT 130 140 150 160 170 180 VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR 190 200 210 220 230 240 VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN 250 260 270 280 290 300 IQQARKVPGV TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN 310 320 330 340 350 360 GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE 370 380 390 400 410 420 VEQLRMERLQ IDEQLRQIGM GFRPSSTRGP EREKGYATDE STVSSVQGSR SYSGRGRGRR 430 440 450 460 470 480 GPNYTSGYGE DDRETRHQRD SRRRPGGRGR SVSGGRGRGG PRGGKSSISS VLKDPDSNPY 490 500 510 520 530 540 SLLDNTESDQ TADTDASESH HSTNRRRRSR RRRTDEDAVL MDGLTESDTA SVNENGLDDS 550 560 570 580 590 600 EKKPQRRNRS RRRRFRGQAE DRQPVTVADY ISRAESQSRQ RNLPRETLAK NKKEMAKDVI 610 620 630 640 650 EEHGPSEKAI NGPTSASGDE IPKLPRTLGE EKTKTLKEDS TQEAAVLNGV S « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Highly conserved 3' UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1." Coy J.F., Sedlacek Z., Baechner D., Hameister H., Joos S., Lichter P., Delius H., Poustka A. Hum. Mol. Genet. 4:2209-2218(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). Tissue: Fetal brain.
[2]	"Alternative splicing in the murine and human FXR1 genes." Kirkpatrick L.L., McIlwain K.A., Nelson D.L. Genomics 59:193-202(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A; B; C; D; E; F AND G), TISSUE SPECIFICITY.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: Kidney.
[4]	"A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P." Schenck A., Bardoni B., Moro A., Bagni C., Mandel J.-L. Proc. Natl. Acad. Sci. U.S.A. 98:8844-8849(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CYFIP2.
[5]	"Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo." Mientjes E.J., Willemsen R., Kirkpatrick L.L., Nieuwenhuizen I.M., Hoogeveen-Westerveld M., Verweij M., Reis S., Bardoni B., Hoogeveen A.T., Oostra B.A., Nelson D.L. Hum. Mol. Genet. 13:1291-1302(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[6]	"The RNA-binding protein Fragile X-related 1 regulates somite formation in Xenopus laevis." Huot M.-E., Bisson N., Davidovic L., Mazroui R., Labelle Y., Moss T., Khandjian E.W. Mol. Biol. Cell 16:4350-4361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling." Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R. J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-68, MASS SPECTROMETRY. Tissue: Mast cell.
[8]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435, MASS SPECTROMETRY. Tissue: Liver.
[9]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-641, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X90875 mRNA. Translation: CAA62383.1. AF124385 mRNA. Translation: AAD30211.1. AF124394 AF124393 Genomic DNA. Translation: AAD30212.1. AF124394 AF124393 Genomic DNA. Translation: AAD30213.1. AF124394 AF124393 Genomic DNA. Translation: AAD30214.1. AF124394 AF124393 Genomic DNA. Translation: AAD30215.1. AF124394 AF124393 Genomic DNA. Translation: AAD30216.1. AF124394 AF124393 Genomic DNA. Translation: AAD30217.1. AF124394 AF124393 Genomic DNA. Translation: AAD30218.1. BC019139 mRNA. Translation: AAH19139.1.
IPI	IPI00122521. IPI00230597. IPI00230598. IPI00230599. IPI00230600. IPI00230601. IPI00230602.
RefSeq	NP_001106659.1. NM_001113188.1. NP_001106660.1. NM_001113189.1. NP_032079.1. NM_008053.2.
UniGene	Mm.259021.
3D structure databases
ProteinModelPortal	Q61584.
SMR	Q61584. Positions 3-121, 212-359.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-257148.
PTM databases
PhosphoSite	Q61584.
Proteomic databases
PaxDb	Q61584.
PRIDE	Q61584.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000001620; ENSMUSP00000001620; ENSMUSG00000027680. ENSMUST00000167354; ENSMUSP00000130216; ENSMUSG00000027680.
GeneID	14359.
KEGG	mmu:14359.
UCSC	uc008oxk.2. mouse. uc008oxl.2. mouse. uc008oxn.2. mouse.
Organism-specific databases
CTD	8087.
MGI	MGI:104860. Fxr1.
Phylogenomic databases
eggNOG	NOG75351.
GeneTree	ENSGT00390000017033.
HOVERGEN	HBG005739.
InParanoid	Q61584.
KO	K15516.
OMA	GMVPFTF.
OrthoDB	EOG49KFQB.
Gene expression databases
ArrayExpress	Q61584.
Bgee	Q61584.
Genevestigator	Q61584.
GermOnline	ENSMUSG00000027680. Mus musculus.
Family and domain databases
InterPro	IPR008395. Agenet-like_dom. IPR022034. Frag_X_MRP_fam. IPR004087. KH_dom. IPR004088. KH_dom_type_1. [Graphical view]
Pfam	PF05641. Agenet. 1 hit. PF12235. FXR1P_C. 1 hit. PF00013. KH_1. 2 hits. [Graphical view]
SMART	SM00322. KH. 2 hits. [Graphical view]
PROSITE	PS51641. AGENET_LIKE. 2 hits. PS50084. KH_TYPE_1. 2 hits. PS50304. TUDOR. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	285817.
SOURCE	Search...

Entry information

Entry name

FXR1_MOUSE

Accession

Primary (citable) accession number: Q61584
Secondary accession number(s): Q8VCU4

Q9WUA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 123 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents