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Protein

Insulin-like growth factor-binding protein 7

Gene

Igfbp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB
  • inner ear development Source: MGI
  • regulation of cell growth Source: InterPro

Keywordsi

Molecular functionGrowth factor binding
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 7
Short name:
IBP-7
Short name:
IGF-binding protein 7
Short name:
IGFBP-7
Alternative name(s):
MAC25 protein
Gene namesi
Name:Igfbp7
Synonyms:Mac25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1352480. Igfbp7.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular space Source: BHF-UCL

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001439326 – 281Insulin-like growth factor-binding protein 7Add BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi180 ↔ 247PROSITE-ProRule annotation
Modified residuei238PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61581.
PeptideAtlasiQ61581.
PRIDEiQ61581.

PTM databases

PhosphoSitePlusiQ61581.

Expressioni

Tissue specificityi

Expressed at high levels in lung, kidney, small intestine, testis and uterus and at moderate levels in liver.1 Publication

Inductioni

By retinoic acid.

Gene expression databases

BgeeiENSMUSG00000036256.
CleanExiMM_IGFBP7.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205897. 6 interactors.
IntActiQ61581. 1 interactor.
MINTiMINT-4098305.

Structurei

3D structure databases

ProteinModelPortaliQ61581.
SMRiQ61581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 103IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST77
Domaini98 – 157Kazal-likePROSITE-ProRule annotationAdd BLAST60
Domaini159 – 263Ig-like C2-typeAdd BLAST105

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

HOVERGENiHBG031621.
InParanoidiQ61581.
PhylomeDBiQ61581.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000867. IGFBP-like.
IPR011390. IGFBP_rP_mac25.
IPR002350. Kazal_dom.
PANTHERiPTHR14186. PTHR14186. 1 hit.
PfamiView protein in Pfam
PF00219. IGFBP. 1 hit.
PF07648. Kazal_2. 1 hit.
PIRSFiPIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTiView protein in SMART
SM00121. IB. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00280. KAZAL. 1 hit.
SUPFAMiSSF100895. SSF100895. 1 hit.
SSF48726. SSF48726. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPPRALLL GAAGLLLLLL PLSSSSSSDA CGPCVPASCP ALPRLGCPLG
60 70 80 90 100
ETRDACGCCP VCARGEGEPC GGGAAGRGHC APGMECVKSR KRRKGKAGAA
110 120 130 140 150
AGGPATLAVC VCKSRYPVCG SNGITYPSGC QLRAASLRAE SRGEKAITQV
160 170 180 190 200
SKGTCEQGPS IVTPPKDIWN VTGAKVFLSC EVIGIPTPVL IWNKVKRDHS
210 220 230 240 250
GVQRTELLPG DRENLAIQTR GGPEKHEVTG WVLVSPLSKE DAGEYECHAS
260 270 280
NSQGQASAAA KITVVDALHE IPLKKGEGAQ L
Length:281
Mass (Da):28,969
Last modified:September 19, 2002 - v3
Checksum:iA70AE6B7D2D4AB58
GO

Sequence cautioni

The sequence BAB17228 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146A → P in AAC37696 (PubMed:8649839).Curated1

RNA editingi

Edited at positions 77 and 94.1 Publication
Partially edited. Position 77 seems to be edited at about 56% and position 94 at about 58%.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti77R → G in RNA edited version. 1
Natural varianti94K → R in RNA edited version. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L75822 mRNA. Translation: AAC37696.2.
AB012886 mRNA. Translation: BAA33569.1.
AB042198 Genomic DNA. Translation: BAB17228.1. Different initiation.
RefSeqiNP_032074.3. NM_008048.3.
UniGeneiMm.233470.

Genome annotation databases

GeneIDi29817.
KEGGimmu:29817.

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIBP7_MOUSE
AccessioniPrimary (citable) accession number: Q61581
Secondary accession number(s): O88812, Q9EQW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: May 10, 2017
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot