Igfbp7

Functionⁱ

Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion (By similarity).By similarity

GO - Molecular functionⁱ

insulin-like growth factor binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion Source: UniProtKB
inner ear development
Source: MGI
Inferred from direct assayⁱ
- 21795542
regulation of cell growth Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding
Biological process	Cell adhesion

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 7 Short name: IBP-7 Short name: IGF-binding protein 7 Short name: IGFBP-7 Alternative name(s): MAC25 protein
Gene namesⁱ	Name:Igfbp7 Synonyms:Mac25
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:1352480. Igfbp7.

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_0000014393	26 – 281	Insulin-like growth factor-binding protein 7Add BLAST		256

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	170	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	180 ↔ 247	PROSITE-ProRule annotation
Modified residueⁱ	238	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q61581.
PeptideAtlas More...PeptideAtlasⁱ	Q61581.
PRIDEⁱ	Q61581.

PTM databases

PhosphoSitePlusⁱ	Q61581.

PhosphoSitePlusⁱ

Q61581.

Expressionⁱ

Tissue specificityⁱ

Expressed at high levels in lung, kidney, small intestine, testis and uterus and at moderate levels in liver.1 Publication

Inductionⁱ

By retinoic acid.

Gene expression databases

CleanExⁱ	MM_IGFBP7.

CleanExⁱ

MM_IGFBP7.

Interactionⁱ

GO - Molecular functionⁱ

insulin-like growth factor binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	205897. 6 interactors.
IntActⁱ	Q61581. 1 interactor.
Molecular INTeraction database More...MINTⁱ	Q61581.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q61581.
SMRⁱ	Q61581.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	27 – 103	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST	77
Domainⁱ	98 – 157	Kazal-likePROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	159 – 263	Ig-like C2-typeAdd BLAST	105

Keywords - Domainⁱ

Immunoglobulin domain, Signal

Phylogenomic databases

HOVERGENⁱ	HBG031621.
InParanoidⁱ	Q61581.
PhylomeDBⁱ	Q61581.

Family and domain databases

Gene3Dⁱ	2.60.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR009030. Growth_fac_rcpt_cys_sf. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR000867. IGFBP-like. IPR011390. IGFBP_rP_mac25. IPR002350. Kazal_dom. IPR036058. Kazal_dom_sf.
PANTHERⁱ	PTHR14186. PTHR14186. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219. IGFBP. 1 hit. PF07648. Kazal_2. 1 hit.
PIRSFⁱ	PIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTⁱ	View protein in SMART SM00121. IB. 1 hit. SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. SM00280. KAZAL. 1 hit.
SUPFAMⁱ	SSF100895. SSF100895. 1 hit. SSF48726. SSF48726. 1 hit. SSF57184. SSF57184. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS51323. IGFBP_N_2. 1 hit. PS51465. KAZAL_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q61581-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MERPPRALLL GAAGLLLLLL PLSSSSSSDA CGPCVPASCP ALPRLGCPLG 
        60         70         80         90        100
ETRDACGCCP VCARGEGEPC GGGAAGRGHC APGMECVKSR KRRKGKAGAA 
       110        120        130        140        150
AGGPATLAVC VCKSRYPVCG SNGITYPSGC QLRAASLRAE SRGEKAITQV 
       160        170        180        190        200
SKGTCEQGPS IVTPPKDIWN VTGAKVFLSC EVIGIPTPVL IWNKVKRDHS 
       210        220        230        240        250
GVQRTELLPG DRENLAIQTR GGPEKHEVTG WVLVSPLSKE DAGEYECHAS 
       260        270        280 
NSQGQASAAA KITVVDALHE IPLKKGEGAQ L

Length:281

Mass (Da):28,969

Last modified:September 19, 2002 - v3

Checksum:ⁱA70AE6B7D2D4AB58

GO

Sequence cautionⁱ

The sequence BAB17228 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	146	A → P in AAC37696 (PubMed:8649839).Curated		1

RNA editingⁱ

Edited at positions 77 and 94.1 Publication
Partially edited. Position 77 seems to be edited at about 56% and position 94 at about 58%.

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱ	77	R → G in RNA edited version.		1
Natural variantⁱ	94	K → R in RNA edited version.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L75822 mRNA. Translation: AAC37696.2. AB012886 mRNA. Translation: BAA33569.1. AB042198 Genomic DNA. Translation: BAB17228.1. Different initiation.
NCBI Reference Sequences More...RefSeqⁱ	NP_032074.3. NM_008048.3.
UniGeneⁱ	Mm.233470.

Genome annotation databases

GeneIDⁱ	29817.
KEGGⁱ	mmu:29817.

Keywords - Coding sequence diversityⁱ

RNA editing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q61581	F8WH23	Mus musculus (Mouse)	281	UniRef100_Q61581	Cluster: Insulin-like growth factor-binding protein 7	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q61581	F8WH23 Q3UFA6 UPI00067B9797 A0A5E1 Q5RJM3 UPI00038C6518 UPI0004ED22E6 Q811C8	Mus musculus (Mouse) Microtus ochrogaster (Prairie vole) Rattus norvegicus (Rat) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili)	281	UniRef90_Q61581	Cluster: Insulin-like growth factor-binding protein 7	9

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q61581	F8WH23 UPI00067B9797 Q3UFA6 Q5RJM3 A0A5E1 UPI00038C6518 UPI0004ED22E6 Q811C8 A0A2K6FFK1 A0A286XBR6 +53	Mus musculus (Mouse) Microtus ochrogaster (Prairie vole) Rattus norvegicus (Rat) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) Cavia porcellus (Guinea pig) Heterocephalus glaber (Naked mole rat) Chrysochloris asiatica (Cape golden mole) Loxodonta africana (African elephant) Canis lupus familiaris (Dog) (Canis familiaris) And more	281	UniRef50_Q61581	Cluster: Insulin-like growth factor-binding protein 7	64

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L75822 mRNA. Translation: AAC37696.2. AB012886 mRNA. Translation: BAA33569.1. AB042198 Genomic DNA. Translation: BAB17228.1. Different initiation.
NCBI Reference Sequences More...RefSeqⁱ	NP_032074.3. NM_008048.3.
UniGeneⁱ	Mm.233470.

3D structure databases

ProteinModelPortalⁱ	Q61581.
SMRⁱ	Q61581.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	205897. 6 interactors.
IntActⁱ	Q61581. 1 interactor.
Molecular INTeraction database More...MINTⁱ	Q61581.

PTM databases

PhosphoSitePlusⁱ	Q61581.

PhosphoSitePlusⁱ

Q61581.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q61581.
PeptideAtlas More...PeptideAtlasⁱ	Q61581.
PRIDEⁱ	Q61581.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	29817.
KEGGⁱ	mmu:29817.

Organism-specific databases

CTDⁱ	3490.
MGIⁱ	MGI:1352480. Igfbp7.

Phylogenomic databases

HOVERGENⁱ	HBG031621.
InParanoidⁱ	Q61581.
PhylomeDBⁱ	Q61581.

Miscellaneous databases

ChiTaRSⁱ	Igfbp7. mouse.
Protein Ontology More...PROⁱ	PR:Q61581.
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_IGFBP7.

CleanExⁱ

MM_IGFBP7.

Family and domain databases

Gene3Dⁱ	2.60.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR009030. Growth_fac_rcpt_cys_sf. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR000867. IGFBP-like. IPR011390. IGFBP_rP_mac25. IPR002350. Kazal_dom. IPR036058. Kazal_dom_sf.
PANTHERⁱ	PTHR14186. PTHR14186. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219. IGFBP. 1 hit. PF07648. Kazal_2. 1 hit.
PIRSFⁱ	PIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTⁱ	View protein in SMART SM00121. IB. 1 hit. SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. SM00280. KAZAL. 1 hit.
SUPFAMⁱ	SSF100895. SSF100895. 1 hit. SSF48726. SSF48726. 1 hit. SSF57184. SSF57184. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS51323. IGFBP_N_2. 1 hit. PS51465. KAZAL_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IBP7_MOUSE
Accessionⁱ	Q61581Primary (citable) accession number: Q61581 Secondary accession number(s): O88812, Q9EQW0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	September 19, 2002
	Last modified:	February 28, 2018
	This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q61581 (IBP7_MOUSE)

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Insulin-like growth factor-binding protein 7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ