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Q61581

- IBP7_MOUSE

UniProt

Q61581 - IBP7_MOUSE

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Protein

Insulin-like growth factor-binding protein 7

Gene
Igfbp7, Mac25
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB
  2. inner ear development Source: MGI
  3. regulation of cell growth Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Growth factor binding

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 7
Short name:
IBP-7
Short name:
IGF-binding protein 7
Short name:
IGFBP-7
Alternative name(s):
MAC25 protein
Gene namesi
Name:Igfbp7
Synonyms:Mac25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1352480. Igfbp7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 281256Insulin-like growth factor-binding protein 7PRO_0000014393Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi170 – 1701N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi180 ↔ 247 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61581.
PaxDbiQ61581.
PRIDEiQ61581.

PTM databases

PhosphoSiteiQ61581.

Expressioni

Tissue specificityi

Expressed at high levels in lung, kidney, small intestine, testis and uterus and at moderate levels in liver.1 Publication

Inductioni

By retinoic acid.

Gene expression databases

ArrayExpressiQ61581.
BgeeiQ61581.
CleanExiMM_IGFBP7.
GenevestigatoriQ61581.

Interactioni

Protein-protein interaction databases

BioGridi205897. 6 interactions.
IntActiQ61581. 1 interaction.
MINTiMINT-4098305.

Structurei

3D structure databases

ProteinModelPortaliQ61581.
SMRiQ61581. Positions 34-264.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 10377IGFBP N-terminalAdd
BLAST
Domaini98 – 15760Kazal-likeAdd
BLAST
Domaini159 – 263105Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG40288.
HOVERGENiHBG031621.
InParanoidiQ61581.
PhylomeDBiQ61581.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR000867. IGFBP-like.
IPR011390. IGFBP_rP_mac25.
IPR002350. Kazal_dom.
[Graphical view]
PANTHERiPTHR14186. PTHR14186. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF00219. IGFBP. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
PIRSFiPIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTiSM00121. IB. 1 hit.
SM00409. IG. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61581-1 [UniParc]FASTAAdd to Basket

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MERPPRALLL GAAGLLLLLL PLSSSSSSDA CGPCVPASCP ALPRLGCPLG    50
ETRDACGCCP VCARGEGEPC GGGAAGRGHC APGMECVKSR KRRKGKAGAA 100
AGGPATLAVC VCKSRYPVCG SNGITYPSGC QLRAASLRAE SRGEKAITQV 150
SKGTCEQGPS IVTPPKDIWN VTGAKVFLSC EVIGIPTPVL IWNKVKRDHS 200
GVQRTELLPG DRENLAIQTR GGPEKHEVTG WVLVSPLSKE DAGEYECHAS 250
NSQGQASAAA KITVVDALHE IPLKKGEGAQ L 281
Length:281
Mass (Da):28,969
Last modified:September 19, 2002 - v3
Checksum:iA70AE6B7D2D4AB58
GO

Sequence cautioni

The sequence BAB17228.1 differs from that shown. Reason: Erroneous initiation.

RNA editingi

Partially edited. Position 77 seems to be edited at about 56% and position 94 at about 58%.2 Publications

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771R → G in RNA edited version.
Natural varianti94 – 941K → R in RNA edited version.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461A → P in AAC37696. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L75822 mRNA. Translation: AAC37696.2.
AB012886 mRNA. Translation: BAA33569.1.
AB042198 Genomic DNA. Translation: BAB17228.1. Different initiation.
RefSeqiNP_032074.3. NM_008048.3.
UniGeneiMm.233470.

Genome annotation databases

GeneIDi29817.
KEGGimmu:29817.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L75822 mRNA. Translation: AAC37696.2 .
AB012886 mRNA. Translation: BAA33569.1 .
AB042198 Genomic DNA. Translation: BAB17228.1 . Different initiation.
RefSeqi NP_032074.3. NM_008048.3.
UniGenei Mm.233470.

3D structure databases

ProteinModelPortali Q61581.
SMRi Q61581. Positions 34-264.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 205897. 6 interactions.
IntActi Q61581. 1 interaction.
MINTi MINT-4098305.

PTM databases

PhosphoSitei Q61581.

Proteomic databases

MaxQBi Q61581.
PaxDbi Q61581.
PRIDEi Q61581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29817.
KEGGi mmu:29817.

Organism-specific databases

CTDi 3490.
MGIi MGI:1352480. Igfbp7.

Phylogenomic databases

eggNOGi NOG40288.
HOVERGENi HBG031621.
InParanoidi Q61581.
PhylomeDBi Q61581.

Miscellaneous databases

ChiTaRSi IGFBP7. mouse.
NextBioi 306982.
PROi Q61581.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61581.
Bgeei Q61581.
CleanExi MM_IGFBP7.
Genevestigatori Q61581.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR000867. IGFBP-like.
IPR011390. IGFBP_rP_mac25.
IPR002350. Kazal_dom.
[Graphical view ]
PANTHERi PTHR14186. PTHR14186. 1 hit.
Pfami PF07679. I-set. 1 hit.
PF00219. IGFBP. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTi SM00121. IB. 1 hit.
SM00409. IG. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A follistatin-like gene, mac25, may act as a growth suppressor of osteosarcoma cells."
    Kato M.V., Sato H., Tsukada T., Ikawa Y., Aizawa S., Nagayoshi M.
    Oncogene 12:1361-1364(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], RNA EDITING OF POSITION 94.
    Tissue: Spleen.
  2. "A secreted tumor-suppressor, mac25, with activin-binding activity."
    Kato M.V.
    Mol. Med. 6:126-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Methylation and downregulated expression of mac25/insulin-like growth factor binding protein-7 is associated with liver tumorigenesis in SV40T/t antigen transgenic mice, screened by restriction landmark genomic scanning for methylation (RLGS-M)."
    Komatsu S., Okazaki Y., Tateno M., Kawai J., Konno H., Kusakabe M., Yoshiki A., Muramatsu M., Held W.A., Hayashizaki Y.
    Biochem. Biophys. Res. Commun. 267:109-117(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-157.
  5. "Screening of human SNP database identifies recoding sites of A-to-I RNA editing."
    Gommans W.M., Tatalias N.E., Sie C.P., Dupuis D., Vendetti N., Smith L., Kaushal R., Maas S.
    RNA 14:2074-2085(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING OF POSITIONS 77 AND 94.

Entry informationi

Entry nameiIBP7_MOUSE
AccessioniPrimary (citable) accession number: Q61581
Secondary accession number(s): O88812, Q9EQW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: July 9, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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