UniProtKB - Q61581 (IBP7_MOUSE)
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Protein
Insulin-like growth factor-binding protein 7
Gene
Igfbp7
Organism
Mus musculus (Mouse)
Status
Functioni
Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion (By similarity).By similarity
GO - Molecular functioni
- insulin-like growth factor binding Source: InterPro
GO - Biological processi
- cell adhesion Source: UniProtKB
- inner ear development Source: MGI
- regulation of cell growth Source: InterPro
Keywordsi
Molecular function | Growth factor binding |
Biological process | Cell adhesion |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 7Short name: IBP-7 Short name: IGF-binding protein 7 Short name: IGFBP-7 Alternative name(s): MAC25 protein |
Gene namesi | Name:Igfbp7 Synonyms:Mac25 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1352480. Igfbp7. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000014393 | 26 – 281 | Insulin-like growth factor-binding protein 7Add BLAST | 256 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 170 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 180 ↔ 247 | PROSITE-ProRule annotation | ||
Modified residuei | 238 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q61581. |
PeptideAtlasi | Q61581. |
PRIDEi | Q61581. |
PTM databases
PhosphoSitePlusi | Q61581. |
Expressioni
Tissue specificityi
Expressed at high levels in lung, kidney, small intestine, testis and uterus and at moderate levels in liver.1 Publication
Inductioni
By retinoic acid.
Gene expression databases
CleanExi | MM_IGFBP7. |
Interactioni
GO - Molecular functioni
- insulin-like growth factor binding Source: InterPro
Protein-protein interaction databases
BioGridi | 205897. 6 interactors. |
IntActi | Q61581. 1 interactor. |
MINTi | Q61581. |
Structurei
3D structure databases
ProteinModelPortali | Q61581. |
SMRi | Q61581. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 103 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 77 | |
Domaini | 98 – 157 | Kazal-likePROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 159 – 263 | Ig-like C2-typeAdd BLAST | 105 |
Keywords - Domaini
Immunoglobulin domain, SignalPhylogenomic databases
HOVERGENi | HBG031621. |
InParanoidi | Q61581. |
PhylomeDBi | Q61581. |
Family and domain databases
Gene3Di | 2.60.40.10. 1 hit. |
InterProi | View protein in InterPro IPR009030. Growth_fac_rcpt_cys_sf. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR000867. IGFBP-like. IPR011390. IGFBP_rP_mac25. IPR002350. Kazal_dom. IPR036058. Kazal_dom_sf. |
PANTHERi | PTHR14186. PTHR14186. 1 hit. |
Pfami | View protein in Pfam PF00219. IGFBP. 1 hit. PF07648. Kazal_2. 1 hit. |
PIRSFi | PIRSF018239. IGFBP_rP_mac25. 1 hit. |
SMARTi | View protein in SMART SM00121. IB. 1 hit. SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. SM00280. KAZAL. 1 hit. |
SUPFAMi | SSF100895. SSF100895. 1 hit. SSF48726. SSF48726. 1 hit. SSF57184. SSF57184. 1 hit. |
PROSITEi | View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS51323. IGFBP_N_2. 1 hit. PS51465. KAZAL_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q61581-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERPPRALLL GAAGLLLLLL PLSSSSSSDA CGPCVPASCP ALPRLGCPLG
60 70 80 90 100
ETRDACGCCP VCARGEGEPC GGGAAGRGHC APGMECVKSR KRRKGKAGAA
110 120 130 140 150
AGGPATLAVC VCKSRYPVCG SNGITYPSGC QLRAASLRAE SRGEKAITQV
160 170 180 190 200
SKGTCEQGPS IVTPPKDIWN VTGAKVFLSC EVIGIPTPVL IWNKVKRDHS
210 220 230 240 250
GVQRTELLPG DRENLAIQTR GGPEKHEVTG WVLVSPLSKE DAGEYECHAS
260 270 280
NSQGQASAAA KITVVDALHE IPLKKGEGAQ L
Sequence cautioni
The sequence BAB17228 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 146 | A → P in AAC37696 (PubMed:8649839).Curated | 1 |
RNA editingi
Edited at positions 77 and 94.1 Publication
Partially edited. Position 77 seems to be edited at about 56% and position 94 at about 58%.
Partially edited. Position 77 seems to be edited at about 56% and position 94 at about 58%.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 77 | R → G in RNA edited version. | 1 | |
Natural varianti | 94 | K → R in RNA edited version. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L75822 mRNA. Translation: AAC37696.2. AB012886 mRNA. Translation: BAA33569.1. AB042198 Genomic DNA. Translation: BAB17228.1. Different initiation. |
RefSeqi | NP_032074.3. NM_008048.3. |
UniGenei | Mm.233470. |
Genome annotation databases
GeneIDi | 29817. |
KEGGi | mmu:29817. |
Keywords - Coding sequence diversityi
RNA editingSimilar proteinsi
Entry informationi
Entry namei | IBP7_MOUSE | |
Accessioni | Q61581Primary (citable) accession number: Q61581 Secondary accession number(s): O88812, Q9EQW0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | September 19, 2002 | |
Last modified: | February 28, 2018 | |
This is version 145 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |