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Protein

Insulin-like growth factor-binding protein 7

Gene

Igfbp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 7
Short name:
IBP-7
Short name:
IGF-binding protein 7
Short name:
IGFBP-7
Alternative name(s):
MAC25 protein
Gene namesi
Name:Igfbp7
Synonyms:Mac25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1352480 Igfbp7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001439326 – 281Insulin-like growth factor-binding protein 7Add BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi110 ↔ 130PROSITE-ProRule annotation
Disulfide bondi119 ↔ 155PROSITE-ProRule annotation
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi180 ↔ 247PROSITE-ProRule annotation
Modified residuei238PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61581
PeptideAtlasiQ61581
PRIDEiQ61581

PTM databases

PhosphoSitePlusiQ61581

Expressioni

Tissue specificityi

Expressed at high levels in lung, kidney, small intestine, testis and uterus and at moderate levels in liver.1 Publication

Inductioni

By retinoic acid.

Gene expression databases

CleanExiMM_IGFBP7

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205897, 6 interactors
IntActiQ61581, 1 interactor
MINTiQ61581

Structurei

3D structure databases

ProteinModelPortaliQ61581
SMRiQ61581
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 103IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST77
Domaini98 – 157Kazal-likePROSITE-ProRule annotationAdd BLAST60
Domaini159 – 263Ig-like C2-typeAdd BLAST105

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

HOVERGENiHBG031621
InParanoidiQ61581
PhylomeDBiQ61581

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR000867 IGFBP-like
IPR011390 IGFBP_rP_mac25
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PANTHERiPTHR14186 PTHR14186, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF07648 Kazal_2, 1 hit
PIRSFiPIRSF018239 IGFBP_rP_mac25, 1 hit
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF48726 SSF48726, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS51465 KAZAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPPRALLL GAAGLLLLLL PLSSSSSSDA CGPCVPASCP ALPRLGCPLG
60 70 80 90 100
ETRDACGCCP VCARGEGEPC GGGAAGRGHC APGMECVKSR KRRKGKAGAA
110 120 130 140 150
AGGPATLAVC VCKSRYPVCG SNGITYPSGC QLRAASLRAE SRGEKAITQV
160 170 180 190 200
SKGTCEQGPS IVTPPKDIWN VTGAKVFLSC EVIGIPTPVL IWNKVKRDHS
210 220 230 240 250
GVQRTELLPG DRENLAIQTR GGPEKHEVTG WVLVSPLSKE DAGEYECHAS
260 270 280
NSQGQASAAA KITVVDALHE IPLKKGEGAQ L
Length:281
Mass (Da):28,969
Last modified:September 19, 2002 - v3
Checksum:iA70AE6B7D2D4AB58
GO

Sequence cautioni

The sequence BAB17228 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146A → P in AAC37696 (PubMed:8649839).Curated1

RNA editingi

Edited at positions 77 and 94.1 Publication
Partially edited. Position 77 seems to be edited at about 56% and position 94 at about 58%.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti77R → G in RNA edited version. 1
Natural varianti94K → R in RNA edited version. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L75822 mRNA Translation: AAC37696.2
AB012886 mRNA Translation: BAA33569.1
AB042198 Genomic DNA Translation: BAB17228.1 Different initiation.
RefSeqiNP_032074.3, NM_008048.3
UniGeneiMm.233470

Genome annotation databases

GeneIDi29817
KEGGimmu:29817

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiIBP7_MOUSE
AccessioniPrimary (citable) accession number: Q61581
Secondary accession number(s): O88812, Q9EQW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: June 20, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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