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Q61581

- IBP7_MOUSE

UniProt

Q61581 - IBP7_MOUSE

Protein

Insulin-like growth factor-binding protein 7

Gene

Igfbp7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (19 Sep 2002)
      Previous versions | rss
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    Functioni

    Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion By similarity.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB
    2. inner ear development Source: MGI
    3. regulation of cell growth Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Growth factor binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 7
    Short name:
    IBP-7
    Short name:
    IGF-binding protein 7
    Short name:
    IGFBP-7
    Alternative name(s):
    MAC25 protein
    Gene namesi
    Name:Igfbp7
    Synonyms:Mac25
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1352480. Igfbp7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 281256Insulin-like growth factor-binding protein 7PRO_0000014393Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi180 ↔ 247PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ61581.
    PaxDbiQ61581.
    PRIDEiQ61581.

    PTM databases

    PhosphoSiteiQ61581.

    Expressioni

    Tissue specificityi

    Expressed at high levels in lung, kidney, small intestine, testis and uterus and at moderate levels in liver.1 Publication

    Inductioni

    By retinoic acid.

    Gene expression databases

    ArrayExpressiQ61581.
    BgeeiQ61581.
    CleanExiMM_IGFBP7.
    GenevestigatoriQ61581.

    Interactioni

    Protein-protein interaction databases

    BioGridi205897. 6 interactions.
    IntActiQ61581. 1 interaction.
    MINTiMINT-4098305.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61581.
    SMRiQ61581. Positions 34-264.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 10377IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini98 – 15760Kazal-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini159 – 263105Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG40288.
    HOVERGENiHBG031621.
    InParanoidiQ61581.
    PhylomeDBiQ61581.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR000867. IGFBP-like.
    IPR011390. IGFBP_rP_mac25.
    IPR002350. Kazal_dom.
    [Graphical view]
    PANTHERiPTHR14186. PTHR14186. 1 hit.
    PfamiPF07679. I-set. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018239. IGFBP_rP_mac25. 1 hit.
    SMARTiSM00121. IB. 1 hit.
    SM00409. IG. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61581-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERPPRALLL GAAGLLLLLL PLSSSSSSDA CGPCVPASCP ALPRLGCPLG    50
    ETRDACGCCP VCARGEGEPC GGGAAGRGHC APGMECVKSR KRRKGKAGAA 100
    AGGPATLAVC VCKSRYPVCG SNGITYPSGC QLRAASLRAE SRGEKAITQV 150
    SKGTCEQGPS IVTPPKDIWN VTGAKVFLSC EVIGIPTPVL IWNKVKRDHS 200
    GVQRTELLPG DRENLAIQTR GGPEKHEVTG WVLVSPLSKE DAGEYECHAS 250
    NSQGQASAAA KITVVDALHE IPLKKGEGAQ L 281
    Length:281
    Mass (Da):28,969
    Last modified:September 19, 2002 - v3
    Checksum:iA70AE6B7D2D4AB58
    GO

    Sequence cautioni

    The sequence BAB17228.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1461A → P in AAC37696. (PubMed:8649839)Curated

    RNA editingi

    Partially edited. Position 77 seems to be edited at about 56% and position 94 at about 58%.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771R → G in RNA edited version.
    Natural varianti94 – 941K → R in RNA edited version.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L75822 mRNA. Translation: AAC37696.2.
    AB012886 mRNA. Translation: BAA33569.1.
    AB042198 Genomic DNA. Translation: BAB17228.1. Different initiation.
    RefSeqiNP_032074.3. NM_008048.3.
    UniGeneiMm.233470.

    Genome annotation databases

    GeneIDi29817.
    KEGGimmu:29817.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L75822 mRNA. Translation: AAC37696.2 .
    AB012886 mRNA. Translation: BAA33569.1 .
    AB042198 Genomic DNA. Translation: BAB17228.1 . Different initiation.
    RefSeqi NP_032074.3. NM_008048.3.
    UniGenei Mm.233470.

    3D structure databases

    ProteinModelPortali Q61581.
    SMRi Q61581. Positions 34-264.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205897. 6 interactions.
    IntActi Q61581. 1 interaction.
    MINTi MINT-4098305.

    PTM databases

    PhosphoSitei Q61581.

    Proteomic databases

    MaxQBi Q61581.
    PaxDbi Q61581.
    PRIDEi Q61581.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29817.
    KEGGi mmu:29817.

    Organism-specific databases

    CTDi 3490.
    MGIi MGI:1352480. Igfbp7.

    Phylogenomic databases

    eggNOGi NOG40288.
    HOVERGENi HBG031621.
    InParanoidi Q61581.
    PhylomeDBi Q61581.

    Miscellaneous databases

    ChiTaRSi IGFBP7. mouse.
    NextBioi 306982.
    PROi Q61581.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61581.
    Bgeei Q61581.
    CleanExi MM_IGFBP7.
    Genevestigatori Q61581.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR000867. IGFBP-like.
    IPR011390. IGFBP_rP_mac25.
    IPR002350. Kazal_dom.
    [Graphical view ]
    PANTHERi PTHR14186. PTHR14186. 1 hit.
    Pfami PF07679. I-set. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018239. IGFBP_rP_mac25. 1 hit.
    SMARTi SM00121. IB. 1 hit.
    SM00409. IG. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A follistatin-like gene, mac25, may act as a growth suppressor of osteosarcoma cells."
      Kato M.V., Sato H., Tsukada T., Ikawa Y., Aizawa S., Nagayoshi M.
      Oncogene 12:1361-1364(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], RNA EDITING OF POSITION 94.
      Tissue: Spleen.
    2. "A secreted tumor-suppressor, mac25, with activin-binding activity."
      Kato M.V.
      Mol. Med. 6:126-135(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "Methylation and downregulated expression of mac25/insulin-like growth factor binding protein-7 is associated with liver tumorigenesis in SV40T/t antigen transgenic mice, screened by restriction landmark genomic scanning for methylation (RLGS-M)."
      Komatsu S., Okazaki Y., Tateno M., Kawai J., Konno H., Kusakabe M., Yoshiki A., Muramatsu M., Held W.A., Hayashizaki Y.
      Biochem. Biophys. Res. Commun. 267:109-117(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: C57BL/6.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-157.
    5. "Screening of human SNP database identifies recoding sites of A-to-I RNA editing."
      Gommans W.M., Tatalias N.E., Sie C.P., Dupuis D., Vendetti N., Smith L., Kaushal R., Maas S.
      RNA 14:2074-2085(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: RNA EDITING OF POSITIONS 77 AND 94.

    Entry informationi

    Entry nameiIBP7_MOUSE
    AccessioniPrimary (citable) accession number: Q61581
    Secondary accession number(s): O88812, Q9EQW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3