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Protein

Insulin-like growth factor-binding protein 7

Gene

Igfbp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion (By similarity).By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB
  2. inner ear development Source: MGI
  3. regulation of cell growth Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Growth factor binding

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 7
Short name:
IBP-7
Short name:
IGF-binding protein 7
Short name:
IGFBP-7
Alternative name(s):
MAC25 protein
Gene namesi
Name:Igfbp7
Synonyms:Mac25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1352480. Igfbp7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 281256Insulin-like growth factor-binding protein 7PRO_0000014393Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi180 ↔ 247PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61581.
PaxDbiQ61581.
PRIDEiQ61581.

PTM databases

PhosphoSiteiQ61581.

Expressioni

Tissue specificityi

Expressed at high levels in lung, kidney, small intestine, testis and uterus and at moderate levels in liver.1 Publication

Inductioni

By retinoic acid.

Gene expression databases

BgeeiQ61581.
CleanExiMM_IGFBP7.
ExpressionAtlasiQ61581. baseline and differential.
GenevestigatoriQ61581.

Interactioni

Protein-protein interaction databases

BioGridi205897. 6 interactions.
IntActiQ61581. 1 interaction.
MINTiMINT-4098305.

Structurei

3D structure databases

ProteinModelPortaliQ61581.
SMRiQ61581. Positions 34-153, 157-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 10377IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini98 – 15760Kazal-likePROSITE-ProRule annotationAdd
BLAST
Domaini159 – 263105Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG40288.
HOVERGENiHBG031621.
InParanoidiQ61581.
PhylomeDBiQ61581.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR000867. IGFBP-like.
IPR011390. IGFBP_rP_mac25.
IPR002350. Kazal_dom.
[Graphical view]
PANTHERiPTHR14186. PTHR14186. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF00219. IGFBP. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
PIRSFiPIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTiSM00121. IB. 1 hit.
SM00409. IG. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPPRALLL GAAGLLLLLL PLSSSSSSDA CGPCVPASCP ALPRLGCPLG
60 70 80 90 100
ETRDACGCCP VCARGEGEPC GGGAAGRGHC APGMECVKSR KRRKGKAGAA
110 120 130 140 150
AGGPATLAVC VCKSRYPVCG SNGITYPSGC QLRAASLRAE SRGEKAITQV
160 170 180 190 200
SKGTCEQGPS IVTPPKDIWN VTGAKVFLSC EVIGIPTPVL IWNKVKRDHS
210 220 230 240 250
GVQRTELLPG DRENLAIQTR GGPEKHEVTG WVLVSPLSKE DAGEYECHAS
260 270 280
NSQGQASAAA KITVVDALHE IPLKKGEGAQ L
Length:281
Mass (Da):28,969
Last modified:September 19, 2002 - v3
Checksum:iA70AE6B7D2D4AB58
GO

Sequence cautioni

The sequence BAB17228.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461A → P in AAC37696 (PubMed:8649839).Curated

RNA editingi

Edited at positions 77 and 94.1 Publication
Partially edited. Position 77 seems to be edited at about 56% and position 94 at about 58%.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771R → G in RNA edited version.
Natural varianti94 – 941K → R in RNA edited version.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L75822 mRNA. Translation: AAC37696.2.
AB012886 mRNA. Translation: BAA33569.1.
AB042198 Genomic DNA. Translation: BAB17228.1. Different initiation.
RefSeqiNP_032074.3. NM_008048.3.
UniGeneiMm.233470.

Genome annotation databases

GeneIDi29817.
KEGGimmu:29817.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L75822 mRNA. Translation: AAC37696.2.
AB012886 mRNA. Translation: BAA33569.1.
AB042198 Genomic DNA. Translation: BAB17228.1. Different initiation.
RefSeqiNP_032074.3. NM_008048.3.
UniGeneiMm.233470.

3D structure databases

ProteinModelPortaliQ61581.
SMRiQ61581. Positions 34-153, 157-264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205897. 6 interactions.
IntActiQ61581. 1 interaction.
MINTiMINT-4098305.

PTM databases

PhosphoSiteiQ61581.

Proteomic databases

MaxQBiQ61581.
PaxDbiQ61581.
PRIDEiQ61581.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29817.
KEGGimmu:29817.

Organism-specific databases

CTDi3490.
MGIiMGI:1352480. Igfbp7.

Phylogenomic databases

eggNOGiNOG40288.
HOVERGENiHBG031621.
InParanoidiQ61581.
PhylomeDBiQ61581.

Miscellaneous databases

NextBioi306982.
PROiQ61581.
SOURCEiSearch...

Gene expression databases

BgeeiQ61581.
CleanExiMM_IGFBP7.
ExpressionAtlasiQ61581. baseline and differential.
GenevestigatoriQ61581.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR000867. IGFBP-like.
IPR011390. IGFBP_rP_mac25.
IPR002350. Kazal_dom.
[Graphical view]
PANTHERiPTHR14186. PTHR14186. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF00219. IGFBP. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
PIRSFiPIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTiSM00121. IB. 1 hit.
SM00409. IG. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A follistatin-like gene, mac25, may act as a growth suppressor of osteosarcoma cells."
    Kato M.V., Sato H., Tsukada T., Ikawa Y., Aizawa S., Nagayoshi M.
    Oncogene 12:1361-1364(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], RNA EDITING OF POSITION 94.
    Tissue: Spleen.
  2. "A secreted tumor-suppressor, mac25, with activin-binding activity."
    Kato M.V.
    Mol. Med. 6:126-135(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Methylation and downregulated expression of mac25/insulin-like growth factor binding protein-7 is associated with liver tumorigenesis in SV40T/t antigen transgenic mice, screened by restriction landmark genomic scanning for methylation (RLGS-M)."
    Komatsu S., Okazaki Y., Tateno M., Kawai J., Konno H., Kusakabe M., Yoshiki A., Muramatsu M., Held W.A., Hayashizaki Y.
    Biochem. Biophys. Res. Commun. 267:109-117(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-157.
  5. "Screening of human SNP database identifies recoding sites of A-to-I RNA editing."
    Gommans W.M., Tatalias N.E., Sie C.P., Dupuis D., Vendetti N., Smith L., Kaushal R., Maas S.
    RNA 14:2074-2085(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING OF POSITIONS 77 AND 94.

Entry informationi

Entry nameiIBP7_MOUSE
AccessioniPrimary (citable) accession number: Q61581
Secondary accession number(s): O88812, Q9EQW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: February 4, 2015
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.