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Q61578

- ADRO_MOUSE

UniProt

Q61578 - ADRO_MOUSE

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Protein
NADPH:adrenodoxin oxidoreductase, mitochondrial
Gene
Fdxr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

Catalytic activityi

2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH.

Cofactori

FAD.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511FAD; via amide nitrogen By similarity
Binding sitei72 – 721FAD By similarity
Binding sitei80 – 801FAD; via amide nitrogen By similarity
Binding sitei116 – 1161FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei243 – 2431NADP By similarity
Binding sitei401 – 4011FAD; via amide nitrogen By similarity
Binding sitei408 – 4081NADP; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi187 – 1904NADP By similarity
Nucleotide bindingi231 – 2322NADP By similarity
Nucleotide bindingi408 – 4103FAD By similarity

GO - Molecular functioni

  1. NADPH binding Source: Ensembl
  2. NADPH-adrenodoxin reductase activity Source: Ensembl

GO - Biological processi

  1. NADPH oxidation Source: Ensembl
  2. cholesterol metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cholesterol metabolism, Electron transport, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transport

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

ReactomeiREACT_196619. Electron transport from NADPH to Ferredoxin.
UniPathwayiUPA00296.

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH:adrenodoxin oxidoreductase, mitochondrial (EC:1.18.1.6)
Short name:
AR
Short name:
Adrenodoxin reductase
Alternative name(s):
Ferredoxin--NADP(+) reductase
Short name:
Ferredoxin reductase
Gene namesi
Name:Fdxr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:104724. Fdxr.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: MGI
  2. mitochondrial matrix Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434Mitochondrion Reviewed prediction
Add
BLAST
Chaini35 – 494460NADPH:adrenodoxin oxidoreductase, mitochondrial
PRO_0000019421Add
BLAST

Proteomic databases

MaxQBiQ61578.
PaxDbiQ61578.
PRIDEiQ61578.

2D gel databases

REPRODUCTION-2DPAGEQ61578.

PTM databases

PhosphoSiteiQ61578.

Expressioni

Tissue specificityi

Expressed in the adrenal, testis and ovary and to a lesser extent in the liver and kidney.

Gene expression databases

BgeeiQ61578.
CleanExiMM_FDXR.
GenevestigatoriQ61578.

Interactioni

Subunit structurei

Monomer. Interacts directly with FDX1 By similarity.

Protein-protein interaction databases

IntActiQ61578. 1 interaction.
MINTiMINT-151907.

Structurei

3D structure databases

ProteinModelPortaliQ61578.
SMRiQ61578. Positions 40-494.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0493.
GeneTreeiENSGT00390000013574.
HOVERGENiHBG002132.
InParanoidiQ61578.
KOiK00528.
OMAiVGYKSRP.
OrthoDBiEOG7H1JJX.
TreeFamiTF314193.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR021163. Adrenodoxin_Rdtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFiPIRSF000362. FNR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61578-1 [UniParc]FASTAAdd to Basket

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MAPRCWHWWR WSAWSGLRPS PSRSTPTPGF CQKFSTQEKT PQICVVGSGP    50
AGFYTAQHLL KHHTHAHVDI YEKQLVPFGL VRFGVAPDHP EVKNVINTFT 100
QTARSDRCAF QGNVVVGRDV SVPELREAYH AVVLSYGAED HQPLGIPGEE 150
LPGVVSARAF VGWYNGLPEN QELAPDLSCD TAVILGQGNV ALDVARILLT 200
PPEHLEKTDI TEAALGALRQ SRVKTVWIVG RRGPLQVAFT IKELREMIQL 250
PGTRPILDPS DFLGLQDRIK DVPRPRRRLT ELLLRTATEK PGVEEAARQA 300
LASRAWGLRF FRSPQQVLPT PDGQRVAGIR LAVTSLEGVG ESTRAVPTGD 350
VEDLPCGLLL SSVGYKSRPI DPSVPFDPKL GVIPNTEGRV VNVPGLYCSG 400
WVKRGPTGVI TTTMTDSFLT SQALLEDLKA GLLPSGPRPG YVAIQALLSN 450
RGVRPVSFSD WEKLDAEEVS RGQGTGKPRE KLVDRREMLR LLGH 494
Length:494
Mass (Da):54,202
Last modified:November 1, 1996 - v1
Checksum:i4BD279DFC606A5C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49920 mRNA. Translation: BAA08659.1.
CCDSiCCDS25625.1.
PIRiS60028.
RefSeqiNP_032023.1. NM_007997.1.
UniGeneiMm.4719.

Genome annotation databases

EnsembliENSMUST00000021078; ENSMUSP00000021078; ENSMUSG00000018861.
GeneIDi14149.
KEGGimmu:14149.
UCSCiuc007mgy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49920 mRNA. Translation: BAA08659.1 .
CCDSi CCDS25625.1.
PIRi S60028.
RefSeqi NP_032023.1. NM_007997.1.
UniGenei Mm.4719.

3D structure databases

ProteinModelPortali Q61578.
SMRi Q61578. Positions 40-494.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61578. 1 interaction.
MINTi MINT-151907.

PTM databases

PhosphoSitei Q61578.

2D gel databases

REPRODUCTION-2DPAGE Q61578.

Proteomic databases

MaxQBi Q61578.
PaxDbi Q61578.
PRIDEi Q61578.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021078 ; ENSMUSP00000021078 ; ENSMUSG00000018861 .
GeneIDi 14149.
KEGGi mmu:14149.
UCSCi uc007mgy.1. mouse.

Organism-specific databases

CTDi 2232.
MGIi MGI:104724. Fdxr.

Phylogenomic databases

eggNOGi COG0493.
GeneTreei ENSGT00390000013574.
HOVERGENi HBG002132.
InParanoidi Q61578.
KOi K00528.
OMAi VGYKSRP.
OrthoDBi EOG7H1JJX.
TreeFami TF314193.

Enzyme and pathway databases

UniPathwayi UPA00296 .
Reactomei REACT_196619. Electron transport from NADPH to Ferredoxin.

Miscellaneous databases

NextBioi 285258.
PROi Q61578.
SOURCEi Search...

Gene expression databases

Bgeei Q61578.
CleanExi MM_FDXR.
Genevestigatori Q61578.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR021163. Adrenodoxin_Rdtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PIRSFi PIRSF000362. FNR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of mouse ferredoxin reductase from kidney."
    Itoh S., Iemura O., Yamada E., Yoshimura T., Tsujikawa K., Kohama Y., Mimura T.
    Biochim. Biophys. Acta 1264:159-162(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Kidney.

Entry informationi

Entry nameiADRO_MOUSE
AccessioniPrimary (citable) accession number: Q61578
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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