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Q61578

- ADRO_MOUSE

UniProt

Q61578 - ADRO_MOUSE

Protein

NADPH:adrenodoxin oxidoreductase, mitochondrial

Gene

Fdxr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

    Catalytic activityi

    2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH.

    Cofactori

    FAD.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511FAD; via amide nitrogenBy similarity
    Binding sitei72 – 721FADBy similarity
    Binding sitei80 – 801FAD; via amide nitrogenBy similarity
    Binding sitei116 – 1161FAD; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei243 – 2431NADPBy similarity
    Binding sitei401 – 4011FAD; via amide nitrogenBy similarity
    Binding sitei408 – 4081NADP; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi187 – 1904NADPBy similarity
    Nucleotide bindingi231 – 2322NADPBy similarity
    Nucleotide bindingi408 – 4103FADBy similarity

    GO - Molecular functioni

    1. NADPH-adrenodoxin reductase activity Source: Ensembl
    2. NADPH binding Source: Ensembl

    GO - Biological processi

    1. cholesterol metabolic process Source: UniProtKB-UniPathway
    2. NADPH oxidation Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Cholesterol metabolism, Electron transport, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transport

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    ReactomeiREACT_196619. Electron transport from NADPH to Ferredoxin.
    UniPathwayiUPA00296.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADPH:adrenodoxin oxidoreductase, mitochondrial (EC:1.18.1.6)
    Short name:
    AR
    Short name:
    Adrenodoxin reductase
    Alternative name(s):
    Ferredoxin--NADP(+) reductase
    Short name:
    Ferredoxin reductase
    Gene namesi
    Name:Fdxr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:104724. Fdxr.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: MGI
    2. mitochondrial matrix Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3434MitochondrionSequence AnalysisAdd
    BLAST
    Chaini35 – 494460NADPH:adrenodoxin oxidoreductase, mitochondrialPRO_0000019421Add
    BLAST

    Proteomic databases

    MaxQBiQ61578.
    PaxDbiQ61578.
    PRIDEiQ61578.

    2D gel databases

    REPRODUCTION-2DPAGEQ61578.

    PTM databases

    PhosphoSiteiQ61578.

    Expressioni

    Tissue specificityi

    Expressed in the adrenal, testis and ovary and to a lesser extent in the liver and kidney.

    Gene expression databases

    BgeeiQ61578.
    CleanExiMM_FDXR.
    GenevestigatoriQ61578.

    Interactioni

    Subunit structurei

    Monomer. Interacts directly with FDX1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ61578. 1 interaction.
    MINTiMINT-151907.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61578.
    SMRiQ61578. Positions 40-494.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0493.
    GeneTreeiENSGT00390000013574.
    HOVERGENiHBG002132.
    InParanoidiQ61578.
    KOiK00528.
    OMAiVGYKSRP.
    OrthoDBiEOG7H1JJX.
    TreeFamiTF314193.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR021163. Adrenodoxin_Rdtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PIRSFiPIRSF000362. FNR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61578-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPRCWHWWR WSAWSGLRPS PSRSTPTPGF CQKFSTQEKT PQICVVGSGP    50
    AGFYTAQHLL KHHTHAHVDI YEKQLVPFGL VRFGVAPDHP EVKNVINTFT 100
    QTARSDRCAF QGNVVVGRDV SVPELREAYH AVVLSYGAED HQPLGIPGEE 150
    LPGVVSARAF VGWYNGLPEN QELAPDLSCD TAVILGQGNV ALDVARILLT 200
    PPEHLEKTDI TEAALGALRQ SRVKTVWIVG RRGPLQVAFT IKELREMIQL 250
    PGTRPILDPS DFLGLQDRIK DVPRPRRRLT ELLLRTATEK PGVEEAARQA 300
    LASRAWGLRF FRSPQQVLPT PDGQRVAGIR LAVTSLEGVG ESTRAVPTGD 350
    VEDLPCGLLL SSVGYKSRPI DPSVPFDPKL GVIPNTEGRV VNVPGLYCSG 400
    WVKRGPTGVI TTTMTDSFLT SQALLEDLKA GLLPSGPRPG YVAIQALLSN 450
    RGVRPVSFSD WEKLDAEEVS RGQGTGKPRE KLVDRREMLR LLGH 494
    Length:494
    Mass (Da):54,202
    Last modified:November 1, 1996 - v1
    Checksum:i4BD279DFC606A5C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49920 mRNA. Translation: BAA08659.1.
    CCDSiCCDS25625.1.
    PIRiS60028.
    RefSeqiNP_032023.1. NM_007997.1.
    UniGeneiMm.4719.

    Genome annotation databases

    EnsembliENSMUST00000021078; ENSMUSP00000021078; ENSMUSG00000018861.
    GeneIDi14149.
    KEGGimmu:14149.
    UCSCiuc007mgy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49920 mRNA. Translation: BAA08659.1 .
    CCDSi CCDS25625.1.
    PIRi S60028.
    RefSeqi NP_032023.1. NM_007997.1.
    UniGenei Mm.4719.

    3D structure databases

    ProteinModelPortali Q61578.
    SMRi Q61578. Positions 40-494.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61578. 1 interaction.
    MINTi MINT-151907.

    PTM databases

    PhosphoSitei Q61578.

    2D gel databases

    REPRODUCTION-2DPAGE Q61578.

    Proteomic databases

    MaxQBi Q61578.
    PaxDbi Q61578.
    PRIDEi Q61578.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021078 ; ENSMUSP00000021078 ; ENSMUSG00000018861 .
    GeneIDi 14149.
    KEGGi mmu:14149.
    UCSCi uc007mgy.1. mouse.

    Organism-specific databases

    CTDi 2232.
    MGIi MGI:104724. Fdxr.

    Phylogenomic databases

    eggNOGi COG0493.
    GeneTreei ENSGT00390000013574.
    HOVERGENi HBG002132.
    InParanoidi Q61578.
    KOi K00528.
    OMAi VGYKSRP.
    OrthoDBi EOG7H1JJX.
    TreeFami TF314193.

    Enzyme and pathway databases

    UniPathwayi UPA00296 .
    Reactomei REACT_196619. Electron transport from NADPH to Ferredoxin.

    Miscellaneous databases

    NextBioi 285258.
    PROi Q61578.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61578.
    CleanExi MM_FDXR.
    Genevestigatori Q61578.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR021163. Adrenodoxin_Rdtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PIRSFi PIRSF000362. FNR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of mouse ferredoxin reductase from kidney."
      Itoh S., Iemura O., Yamada E., Yoshimura T., Tsujikawa K., Kohama Y., Mimura T.
      Biochim. Biophys. Acta 1264:159-162(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Kidney.

    Entry informationi

    Entry nameiADRO_MOUSE
    AccessioniPrimary (citable) accession number: Q61578
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3