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Q61576

- FKB10_MOUSE

UniProt

Q61576 - FKB10_MOUSE

Protein

Peptidyl-prolyl cis-trans isomerase FKBP10

Gene

Fkbp10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins during protein synthesis.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Inhibited by both FK506 and rapamycin, but not by cyclosporin A.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi509 – 520121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi554 – 565122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. FK506 binding Source: RefGenome
    3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome
    4. protein binding Source: MGI

    GO - Biological processi

    1. chaperone-mediated protein folding Source: RefGenome
    2. protein peptidyl-prolyl isomerization Source: RefGenome

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP10 (EC:5.2.1.8)
    Short name:
    PPIase FKBP10
    Alternative name(s):
    65 kDa FK506-binding protein
    Short name:
    65 kDa FKBP
    Short name:
    FKBP-65
    FK506-binding protein 10
    Short name:
    FKBP-10
    Immunophilin FKBP65
    Rotamase
    Gene namesi
    Name:Fkbp10
    Synonyms:Fkbp-rs, Fkbp1-rs, Fkbp6, Fkbp65, Fkbprp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:104769. Fkbp10.

    Subcellular locationi

    Endoplasmic reticulum lumen 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    2. endoplasmic reticulum membrane Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 581548Peptidyl-prolyl cis-trans isomerase FKBP10PRO_0000025518Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated and phosphorylated.

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ61576.
    PaxDbiQ61576.
    PRIDEiQ61576.

    PTM databases

    PhosphoSiteiQ61576.

    Expressioni

    Tissue specificityi

    Expressed in aorta, brain, kidney, and lung.1 Publication

    Developmental stagei

    Expressed in 12-day-old mouse; no or barely detectable expression is found in adult tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ61576.
    BgeeiQ61576.
    CleanExiMM_FKBP10.
    MM_FKBP6.
    GenevestigatoriQ61576.

    Interactioni

    Protein-protein interaction databases

    BioGridi199687. 1 interaction.
    DIPiDIP-448N.
    IntActiQ61576. 1 interaction.
    MINTiMINT-4095079.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61576.
    SMRiQ61576. Positions 17-572.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 14989PPIase FKBP-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini173 – 26189PPIase FKBP-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini285 – 37389PPIase FKBP-type 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini398 – 48588PPIase FKBP-type 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini496 – 53136EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini541 – 57636EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi578 – 5814Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 4 PPIase FKBP-type domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0545.
    GeneTreeiENSGT00530000062784.
    HOGENOMiHOG000230960.
    HOVERGENiHBG051620.
    InParanoidiA2A4I0.
    KOiK09575.
    OMAiPGYLFVW.
    OrthoDBiEOG7T1R9S.
    TreeFamiTF105296.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF13202. EF-hand_5. 2 hits.
    PF00254. FKBP_C. 4 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61576-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLVGSSSHT LHRLRILPLL LLLQTLERGL GRASPAGAPL EDVVIERYHI    50
    PRACPREVQM GDFVRYHYNG TFEDGKKFDS SYDRSTLVAI VVGVGRLITG 100
    MDRGLMGMCV NERRRLIVPP HLGYGSIGVA GLIPPDATLY FDVVLLDVWN 150
    KADTVQSTIL LRPPYCPRMV QNSDFVRYHY NGTLLDGTAF DNSYSRGGTY 200
    DTYIGSGWLI KGMDQGLLGM CPGEKRKIII PPFLAYGEKG YGTVIPPQAS 250
    LVFYVLLLDV HNPKDTVQLE TLELPQGCVR RAVAGDFMRY HYNGSLMDGT 300
    LFDSSYSRNH TYNTYVGQGY IIPGMDQGLQ GACIGERRRI TVPPHLAYGE 350
    NGTGDKIPGS AVLIFDVHVI DFHNPSDPVE IKTLSRPPEN CNETSKIGDF 400
    IRYHYNCSLL DGTRLFSSHD YEAPQEITLG ANKVIEGLDR GLQGMCVGER 450
    RQLIVPPHLA HGENGARGVP GSAVLLFEVE LVSREDGLPT GYLFVWYQDP 500
    STSLFEDMDL NKDGEVPPEE FSSFIKAQVN EGKGRLMPGQ DPDKTISDMF 550
    QNQDRNQDGK ITAEELKLKS DEDQERVHEE L 581
    Length:581
    Mass (Da):64,697
    Last modified:July 27, 2011 - v2
    Checksum:iFD6F777940AD91E9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141L → V in AAC37678. (PubMed:7493967)Curated
    Sequence conflicti189 – 1891A → G in AAC37678. (PubMed:7493967)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07063 mRNA. Translation: AAC37678.1.
    AF456413, AF456412 Genomic DNA. Translation: AAL57621.1.
    AL590968 Genomic DNA. Translation: CAM23033.1.
    CH466662 Genomic DNA. Translation: EDL02562.1.
    BC029546 mRNA. Translation: AAH29546.1.
    CCDSiCCDS25422.1.
    PIRiI49669.
    RefSeqiNP_034351.2. NM_010221.2.
    UniGeneiMm.3894.

    Genome annotation databases

    EnsembliENSMUST00000001595; ENSMUSP00000001595; ENSMUSG00000001555.
    GeneIDi14230.
    KEGGimmu:14230.
    UCSCiuc007llb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07063 mRNA. Translation: AAC37678.1 .
    AF456413 , AF456412 Genomic DNA. Translation: AAL57621.1 .
    AL590968 Genomic DNA. Translation: CAM23033.1 .
    CH466662 Genomic DNA. Translation: EDL02562.1 .
    BC029546 mRNA. Translation: AAH29546.1 .
    CCDSi CCDS25422.1.
    PIRi I49669.
    RefSeqi NP_034351.2. NM_010221.2.
    UniGenei Mm.3894.

    3D structure databases

    ProteinModelPortali Q61576.
    SMRi Q61576. Positions 17-572.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199687. 1 interaction.
    DIPi DIP-448N.
    IntActi Q61576. 1 interaction.
    MINTi MINT-4095079.

    PTM databases

    PhosphoSitei Q61576.

    Proteomic databases

    MaxQBi Q61576.
    PaxDbi Q61576.
    PRIDEi Q61576.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001595 ; ENSMUSP00000001595 ; ENSMUSG00000001555 .
    GeneIDi 14230.
    KEGGi mmu:14230.
    UCSCi uc007llb.2. mouse.

    Organism-specific databases

    CTDi 60681.
    MGIi MGI:104769. Fkbp10.

    Phylogenomic databases

    eggNOGi COG0545.
    GeneTreei ENSGT00530000062784.
    HOGENOMi HOG000230960.
    HOVERGENi HBG051620.
    InParanoidi A2A4I0.
    KOi K09575.
    OMAi PGYLFVW.
    OrthoDBi EOG7T1R9S.
    TreeFami TF105296.

    Miscellaneous databases

    NextBioi 285499.
    PROi Q61576.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61576.
    Bgeei Q61576.
    CleanExi MM_FKBP10.
    MM_FKBP6.
    Genevestigatori Q61576.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF13202. EF-hand_5. 2 hits.
    PF00254. FKBP_C. 4 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and localization of a novel FK506-binding protein to mouse chromosome 11."
      Simek S.L., Kozak C.A., Winterstein D., Hegamyer G., Colburn N.H.
      Genomics 18:407-409(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: JB6.
      Tissue: Epidermis.
    2. "Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65)."
      Coss M.C., Winterstein D., Sowder R.C. II, Simek S.L.
      J. Biol. Chem. 270:29336-29341(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    3. "Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family."
      Patterson C.E., Gao J., Rooney A.P., Davis E.C.
      Genomics 79:881-889(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3.
      Tissue: Mammary tumor.
    7. "Developmental regulation of FKBP65: an ER localized extracellular matrix-binding protein."
      Patterson C.E., Schaub T., Coleman E.J., Davis E.C.
      Mol. Biol. Cell 11:3925-3935(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFKB10_MOUSE
    AccessioniPrimary (citable) accession number: Q61576
    Secondary accession number(s): A2A4I0, Q8VHI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3