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Q61576 (FKB10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase FKBP10

Short name=PPIase FKBP10
EC=5.2.1.8
Alternative name(s):
65 kDa FK506-binding protein
Short name=65 kDa FKBP
Short name=FKBP-65
FK506-binding protein 10
Short name=FKBP-10
Immunophilin FKBP65
Rotamase
Gene names
Name:Fkbp10
Synonyms:Fkbp-rs, Fkbp1-rs, Fkbp6, Fkbp65, Fkbprp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length581 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by both FK506 and rapamycin, but not by cyclosporin A.

Subcellular location

Endoplasmic reticulum lumen Ref.7.

Tissue specificity

Expressed in aorta, brain, kidney, and lung. Ref.7

Developmental stage

Expressed in 12-day-old mouse; no or barely detectable expression is found in adult tissues. Ref.7

Post-translational modification

Glycosylated and phosphorylated.

Sequence similarities

Contains 2 EF-hand domains.

Contains 4 PPIase FKBP-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 581548Peptidyl-prolyl cis-trans isomerase FKBP10
PRO_0000025518

Regions

Domain61 – 14989PPIase FKBP-type 1
Domain173 – 26189PPIase FKBP-type 2
Domain285 – 37389PPIase FKBP-type 3
Domain398 – 48588PPIase FKBP-type 4
Domain496 – 53136EF-hand 1
Domain541 – 57636EF-hand 2
Calcium binding509 – 520121 Potential
Calcium binding554 – 565122 Potential
Motif578 – 5814Prevents secretion from ER Potential

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation3091N-linked (GlcNAc...) Potential
Glycosylation3511N-linked (GlcNAc...) Potential
Glycosylation3921N-linked (GlcNAc...) Potential
Glycosylation4061N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict141L → V in AAC37678. Ref.2
Sequence conflict1891A → G in AAC37678. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q61576 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: FD6F777940AD91E9

FASTA58164,697
        10         20         30         40         50         60 
MFLVGSSSHT LHRLRILPLL LLLQTLERGL GRASPAGAPL EDVVIERYHI PRACPREVQM 

        70         80         90        100        110        120 
GDFVRYHYNG TFEDGKKFDS SYDRSTLVAI VVGVGRLITG MDRGLMGMCV NERRRLIVPP 

       130        140        150        160        170        180 
HLGYGSIGVA GLIPPDATLY FDVVLLDVWN KADTVQSTIL LRPPYCPRMV QNSDFVRYHY 

       190        200        210        220        230        240 
NGTLLDGTAF DNSYSRGGTY DTYIGSGWLI KGMDQGLLGM CPGEKRKIII PPFLAYGEKG 

       250        260        270        280        290        300 
YGTVIPPQAS LVFYVLLLDV HNPKDTVQLE TLELPQGCVR RAVAGDFMRY HYNGSLMDGT 

       310        320        330        340        350        360 
LFDSSYSRNH TYNTYVGQGY IIPGMDQGLQ GACIGERRRI TVPPHLAYGE NGTGDKIPGS 

       370        380        390        400        410        420 
AVLIFDVHVI DFHNPSDPVE IKTLSRPPEN CNETSKIGDF IRYHYNCSLL DGTRLFSSHD 

       430        440        450        460        470        480 
YEAPQEITLG ANKVIEGLDR GLQGMCVGER RQLIVPPHLA HGENGARGVP GSAVLLFEVE 

       490        500        510        520        530        540 
LVSREDGLPT GYLFVWYQDP STSLFEDMDL NKDGEVPPEE FSSFIKAQVN EGKGRLMPGQ 

       550        560        570        580 
DPDKTISDMF QNQDRNQDGK ITAEELKLKS DEDQERVHEE L 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and localization of a novel FK506-binding protein to mouse chromosome 11."
Simek S.L., Kozak C.A., Winterstein D., Hegamyer G., Colburn N.H.
Genomics 18:407-409(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: JB6.
Tissue: Epidermis.
[2]"Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65)."
Coss M.C., Winterstein D., Sowder R.C. II, Simek S.L.
J. Biol. Chem. 270:29336-29341(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[3]"Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family."
Patterson C.E., Gao J., Rooney A.P., Davis E.C.
Genomics 79:881-889(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3.
Tissue: Mammary tumor.
[7]"Developmental regulation of FKBP65: an ER localized extracellular matrix-binding protein."
Patterson C.E., Schaub T., Coleman E.J., Davis E.C.
Mol. Biol. Cell 11:3925-3935(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L07063 mRNA. Translation: AAC37678.1.
AF456413, AF456412 Genomic DNA. Translation: AAL57621.1.
AL590968 Genomic DNA. Translation: CAM23033.1.
CH466662 Genomic DNA. Translation: EDL02562.1.
BC029546 mRNA. Translation: AAH29546.1.
PIRI49669.
RefSeqNP_034351.2. NM_010221.2.
UniGeneMm.3894.

3D structure databases

ProteinModelPortalQ61576.
SMRQ61576. Positions 17-486, 501-567.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-448N.
IntActQ61576. 1 interaction.
MINTMINT-4095079.

PTM databases

PhosphoSiteQ61576.

Proteomic databases

PaxDbQ61576.
PRIDEQ61576.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001595; ENSMUSP00000001595; ENSMUSG00000001555.
GeneID14230.
KEGGmmu:14230.
UCSCuc007llb.2. mouse.

Organism-specific databases

CTD60681.
MGIMGI:104769. Fkbp10.

Phylogenomic databases

eggNOGCOG0545.
GeneTreeENSGT00530000062784.
HOGENOMHOG000230960.
HOVERGENHBG051620.
InParanoidA2A4I0.
KOK09575.
OMAPGYLFVW.
OrthoDBEOG7T1R9S.
TreeFamTF105296.

Gene expression databases

ArrayExpressQ61576.
BgeeQ61576.
CleanExMM_FKBP10.
MM_FKBP6.
GenevestigatorQ61576.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF13202. EF-hand_5. 2 hits.
PF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio285499.
PROQ61576.
SOURCESearch...

Entry information

Entry nameFKB10_MOUSE
AccessionPrimary (citable) accession number: Q61576
Secondary accession number(s): A2A4I0, Q8VHI1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot