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Protein

Peptidyl-prolyl cis-trans isomerase FKBP10

Gene

Fkbp10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin, but not by cyclosporin A.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi509 – 5201PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi554 – 5652PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP10 (EC:5.2.1.8)
Short name:
PPIase FKBP10
Alternative name(s):
65 kDa FK506-binding protein
Short name:
65 kDa FKBP
Short name:
FKBP-65
FK506-binding protein 10
Short name:
FKBP-10
Immunophilin FKBP65
Rotamase
Gene namesi
Name:Fkbp10
Synonyms:Fkbp-rs, Fkbp1-rs, Fkbp6, Fkbp65, Fkbprp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104769. Fkbp10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000002551834 – 581Peptidyl-prolyl cis-trans isomerase FKBP10Add BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Glycosylationi181N-linked (GlcNAc...)Sequence analysis1
Glycosylationi293N-linked (GlcNAc...)Sequence analysis1
Glycosylationi309N-linked (GlcNAc...)Sequence analysis1
Glycosylationi351N-linked (GlcNAc...)Sequence analysis1
Glycosylationi392N-linked (GlcNAc...)Sequence analysis1
Glycosylationi406N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated and phosphorylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61576.
PaxDbiQ61576.
PeptideAtlasiQ61576.
PRIDEiQ61576.

PTM databases

PhosphoSitePlusiQ61576.

Expressioni

Tissue specificityi

Expressed in aorta, brain, kidney, and lung.1 Publication

Developmental stagei

Expressed in 12-day-old mouse; no or barely detectable expression is found in adult tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000001555.
CleanExiMM_FKBP10.
MM_FKBP6.
ExpressionAtlasiQ61576. baseline and differential.
GenevisibleiQ61576. MM.

Interactioni

Protein-protein interaction databases

BioGridi199687. 1 interactor.
DIPiDIP-448N.
IntActiQ61576. 1 interactor.
MINTiMINT-4095079.
STRINGi10090.ENSMUSP00000001595.

Structurei

3D structure databases

ProteinModelPortaliQ61576.
SMRiQ61576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 149PPIase FKBP-type 1PROSITE-ProRule annotationAdd BLAST89
Domaini173 – 261PPIase FKBP-type 2PROSITE-ProRule annotationAdd BLAST89
Domaini285 – 373PPIase FKBP-type 3PROSITE-ProRule annotationAdd BLAST89
Domaini398 – 485PPIase FKBP-type 4PROSITE-ProRule annotationAdd BLAST88
Domaini496 – 531EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini541 – 576EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi578 – 581Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 4 PPIase FKBP-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000230960.
HOVERGENiHBG051620.
InParanoidiQ61576.
KOiK09575.
OMAiPGYLFVW.
OrthoDBiEOG091G02W1.
TreeFamiTF105296.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF13202. EF-hand_5. 2 hits.
PF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLVGSSSHT LHRLRILPLL LLLQTLERGL GRASPAGAPL EDVVIERYHI
60 70 80 90 100
PRACPREVQM GDFVRYHYNG TFEDGKKFDS SYDRSTLVAI VVGVGRLITG
110 120 130 140 150
MDRGLMGMCV NERRRLIVPP HLGYGSIGVA GLIPPDATLY FDVVLLDVWN
160 170 180 190 200
KADTVQSTIL LRPPYCPRMV QNSDFVRYHY NGTLLDGTAF DNSYSRGGTY
210 220 230 240 250
DTYIGSGWLI KGMDQGLLGM CPGEKRKIII PPFLAYGEKG YGTVIPPQAS
260 270 280 290 300
LVFYVLLLDV HNPKDTVQLE TLELPQGCVR RAVAGDFMRY HYNGSLMDGT
310 320 330 340 350
LFDSSYSRNH TYNTYVGQGY IIPGMDQGLQ GACIGERRRI TVPPHLAYGE
360 370 380 390 400
NGTGDKIPGS AVLIFDVHVI DFHNPSDPVE IKTLSRPPEN CNETSKIGDF
410 420 430 440 450
IRYHYNCSLL DGTRLFSSHD YEAPQEITLG ANKVIEGLDR GLQGMCVGER
460 470 480 490 500
RQLIVPPHLA HGENGARGVP GSAVLLFEVE LVSREDGLPT GYLFVWYQDP
510 520 530 540 550
STSLFEDMDL NKDGEVPPEE FSSFIKAQVN EGKGRLMPGQ DPDKTISDMF
560 570 580
QNQDRNQDGK ITAEELKLKS DEDQERVHEE L
Length:581
Mass (Da):64,697
Last modified:July 27, 2011 - v2
Checksum:iFD6F777940AD91E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14L → V in AAC37678 (PubMed:7493967).Curated1
Sequence conflicti189A → G in AAC37678 (PubMed:7493967).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07063 mRNA. Translation: AAC37678.1.
AF456413, AF456412 Genomic DNA. Translation: AAL57621.1.
AL590968 Genomic DNA. Translation: CAM23033.1.
CH466662 Genomic DNA. Translation: EDL02562.1.
BC029546 mRNA. Translation: AAH29546.1.
CCDSiCCDS25422.1.
PIRiI49669.
RefSeqiNP_034351.2. NM_010221.2.
UniGeneiMm.3894.

Genome annotation databases

EnsembliENSMUST00000001595; ENSMUSP00000001595; ENSMUSG00000001555.
GeneIDi14230.
KEGGimmu:14230.
UCSCiuc007llb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07063 mRNA. Translation: AAC37678.1.
AF456413, AF456412 Genomic DNA. Translation: AAL57621.1.
AL590968 Genomic DNA. Translation: CAM23033.1.
CH466662 Genomic DNA. Translation: EDL02562.1.
BC029546 mRNA. Translation: AAH29546.1.
CCDSiCCDS25422.1.
PIRiI49669.
RefSeqiNP_034351.2. NM_010221.2.
UniGeneiMm.3894.

3D structure databases

ProteinModelPortaliQ61576.
SMRiQ61576.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199687. 1 interactor.
DIPiDIP-448N.
IntActiQ61576. 1 interactor.
MINTiMINT-4095079.
STRINGi10090.ENSMUSP00000001595.

PTM databases

PhosphoSitePlusiQ61576.

Proteomic databases

MaxQBiQ61576.
PaxDbiQ61576.
PeptideAtlasiQ61576.
PRIDEiQ61576.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001595; ENSMUSP00000001595; ENSMUSG00000001555.
GeneIDi14230.
KEGGimmu:14230.
UCSCiuc007llb.2. mouse.

Organism-specific databases

CTDi60681.
MGIiMGI:104769. Fkbp10.

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000230960.
HOVERGENiHBG051620.
InParanoidiQ61576.
KOiK09575.
OMAiPGYLFVW.
OrthoDBiEOG091G02W1.
TreeFamiTF105296.

Miscellaneous databases

ChiTaRSiFkbp10. mouse.
PROiQ61576.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001555.
CleanExiMM_FKBP10.
MM_FKBP6.
ExpressionAtlasiQ61576. baseline and differential.
GenevisibleiQ61576. MM.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF13202. EF-hand_5. 2 hits.
PF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKB10_MOUSE
AccessioniPrimary (citable) accession number: Q61576
Secondary accession number(s): A2A4I0, Q8VHI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.