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Q61576

- FKB10_MOUSE

UniProt

Q61576 - FKB10_MOUSE

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Protein
Peptidyl-prolyl cis-trans isomerase FKBP10
Gene
Fkbp10, Fkbp-rs, Fkbp1-rs, Fkbp6, Fkbp65, Fkbprp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin, but not by cyclosporin A.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi509 – 520121 Reviewed prediction
Add
BLAST
Calcium bindingi554 – 565122 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. FK506 binding Source: RefGenome
  2. calcium ion binding Source: InterPro
  3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome
  4. protein binding Source: MGI

GO - Biological processi

  1. peptidyl-proline modification Source: RefGenome
  2. protein folding Source: UniProtKB-KW
  3. protein peptidyl-prolyl isomerization Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP10 (EC:5.2.1.8)
Short name:
PPIase FKBP10
Alternative name(s):
65 kDa FK506-binding protein
Short name:
65 kDa FKBP
Short name:
FKBP-65
FK506-binding protein 10
Short name:
FKBP-10
Immunophilin FKBP65
Rotamase
Gene namesi
Name:Fkbp10
Synonyms:Fkbp-rs, Fkbp1-rs, Fkbp6, Fkbp65, Fkbprp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:104769. Fkbp10.

Subcellular locationi

Endoplasmic reticulum lumen 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  2. membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed prediction
Add
BLAST
Chaini34 – 581548Peptidyl-prolyl cis-trans isomerase FKBP10
PRO_0000025518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi181 – 1811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi351 – 3511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi392 – 3921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi406 – 4061N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Glycosylated and phosphorylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61576.
PaxDbiQ61576.
PRIDEiQ61576.

PTM databases

PhosphoSiteiQ61576.

Expressioni

Tissue specificityi

Expressed in aorta, brain, kidney, and lung.1 Publication

Developmental stagei

Expressed in 12-day-old mouse; no or barely detectable expression is found in adult tissues.1 Publication

Gene expression databases

ArrayExpressiQ61576.
BgeeiQ61576.
CleanExiMM_FKBP10.
MM_FKBP6.
GenevestigatoriQ61576.

Interactioni

Protein-protein interaction databases

BioGridi199687. 1 interaction.
DIPiDIP-448N.
IntActiQ61576. 1 interaction.
MINTiMINT-4095079.

Structurei

3D structure databases

ProteinModelPortaliQ61576.
SMRiQ61576. Positions 17-572.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 14989PPIase FKBP-type 1
Add
BLAST
Domaini173 – 26189PPIase FKBP-type 2
Add
BLAST
Domaini285 – 37389PPIase FKBP-type 3
Add
BLAST
Domaini398 – 48588PPIase FKBP-type 4
Add
BLAST
Domaini496 – 53136EF-hand 1
Add
BLAST
Domaini541 – 57636EF-hand 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi578 – 5814Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Contains 2 EF-hand domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG0545.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000230960.
HOVERGENiHBG051620.
InParanoidiA2A4I0.
KOiK09575.
OMAiPGYLFVW.
OrthoDBiEOG7T1R9S.
TreeFamiTF105296.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13202. EF-hand_5. 2 hits.
PF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61576-1 [UniParc]FASTAAdd to Basket

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MFLVGSSSHT LHRLRILPLL LLLQTLERGL GRASPAGAPL EDVVIERYHI    50
PRACPREVQM GDFVRYHYNG TFEDGKKFDS SYDRSTLVAI VVGVGRLITG 100
MDRGLMGMCV NERRRLIVPP HLGYGSIGVA GLIPPDATLY FDVVLLDVWN 150
KADTVQSTIL LRPPYCPRMV QNSDFVRYHY NGTLLDGTAF DNSYSRGGTY 200
DTYIGSGWLI KGMDQGLLGM CPGEKRKIII PPFLAYGEKG YGTVIPPQAS 250
LVFYVLLLDV HNPKDTVQLE TLELPQGCVR RAVAGDFMRY HYNGSLMDGT 300
LFDSSYSRNH TYNTYVGQGY IIPGMDQGLQ GACIGERRRI TVPPHLAYGE 350
NGTGDKIPGS AVLIFDVHVI DFHNPSDPVE IKTLSRPPEN CNETSKIGDF 400
IRYHYNCSLL DGTRLFSSHD YEAPQEITLG ANKVIEGLDR GLQGMCVGER 450
RQLIVPPHLA HGENGARGVP GSAVLLFEVE LVSREDGLPT GYLFVWYQDP 500
STSLFEDMDL NKDGEVPPEE FSSFIKAQVN EGKGRLMPGQ DPDKTISDMF 550
QNQDRNQDGK ITAEELKLKS DEDQERVHEE L 581
Length:581
Mass (Da):64,697
Last modified:July 27, 2011 - v2
Checksum:iFD6F777940AD91E9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141L → V in AAC37678. 1 Publication
Sequence conflicti189 – 1891A → G in AAC37678. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07063 mRNA. Translation: AAC37678.1.
AF456413, AF456412 Genomic DNA. Translation: AAL57621.1.
AL590968 Genomic DNA. Translation: CAM23033.1.
CH466662 Genomic DNA. Translation: EDL02562.1.
BC029546 mRNA. Translation: AAH29546.1.
CCDSiCCDS25422.1.
PIRiI49669.
RefSeqiNP_034351.2. NM_010221.2.
UniGeneiMm.3894.

Genome annotation databases

EnsembliENSMUST00000001595; ENSMUSP00000001595; ENSMUSG00000001555.
GeneIDi14230.
KEGGimmu:14230.
UCSCiuc007llb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07063 mRNA. Translation: AAC37678.1 .
AF456413 , AF456412 Genomic DNA. Translation: AAL57621.1 .
AL590968 Genomic DNA. Translation: CAM23033.1 .
CH466662 Genomic DNA. Translation: EDL02562.1 .
BC029546 mRNA. Translation: AAH29546.1 .
CCDSi CCDS25422.1.
PIRi I49669.
RefSeqi NP_034351.2. NM_010221.2.
UniGenei Mm.3894.

3D structure databases

ProteinModelPortali Q61576.
SMRi Q61576. Positions 17-572.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199687. 1 interaction.
DIPi DIP-448N.
IntActi Q61576. 1 interaction.
MINTi MINT-4095079.

PTM databases

PhosphoSitei Q61576.

Proteomic databases

MaxQBi Q61576.
PaxDbi Q61576.
PRIDEi Q61576.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001595 ; ENSMUSP00000001595 ; ENSMUSG00000001555 .
GeneIDi 14230.
KEGGi mmu:14230.
UCSCi uc007llb.2. mouse.

Organism-specific databases

CTDi 60681.
MGIi MGI:104769. Fkbp10.

Phylogenomic databases

eggNOGi COG0545.
GeneTreei ENSGT00530000062784.
HOGENOMi HOG000230960.
HOVERGENi HBG051620.
InParanoidi A2A4I0.
KOi K09575.
OMAi PGYLFVW.
OrthoDBi EOG7T1R9S.
TreeFami TF105296.

Miscellaneous databases

NextBioi 285499.
PROi Q61576.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61576.
Bgeei Q61576.
CleanExi MM_FKBP10.
MM_FKBP6.
Genevestigatori Q61576.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF13202. EF-hand_5. 2 hits.
PF00254. FKBP_C. 4 hits.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and localization of a novel FK506-binding protein to mouse chromosome 11."
    Simek S.L., Kozak C.A., Winterstein D., Hegamyer G., Colburn N.H.
    Genomics 18:407-409(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JB6.
    Tissue: Epidermis.
  2. "Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65)."
    Coss M.C., Winterstein D., Sowder R.C. II, Simek S.L.
    J. Biol. Chem. 270:29336-29341(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  3. "Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family."
    Patterson C.E., Gao J., Rooney A.P., Davis E.C.
    Genomics 79:881-889(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  7. "Developmental regulation of FKBP65: an ER localized extracellular matrix-binding protein."
    Patterson C.E., Schaub T., Coleman E.J., Davis E.C.
    Mol. Biol. Cell 11:3925-3935(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFKB10_MOUSE
AccessioniPrimary (citable) accession number: Q61576
Secondary accession number(s): A2A4I0, Q8VHI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi