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Reviewed, UniProtKB/Swiss-Prot Q61576 (FKB10_MOUSE)

Last modified February 9, 2010. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    FK506-binding protein 10
    EC=5.2.1.8
Alternative name(s):
    Peptidyl-prolyl cis-trans isomerase
      Short name=PPIase
      Short name=Rotamase
    Immunophilin FKBP65
    65 kDa FK506-binding protein
    FKBP65
Gene names
Name: Fkbp10
Synonyms: Fkbp-rs, Fkbp1-rs, Fkbp6, Fkbprp
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length581 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by both FK506 and rapamycin, but not by cyclosporin A.

Subcellular location

Endoplasmic reticulum lumen Ref.5.

Tissue specificity

Expressed in aorta, brain, kidney, and lung. Ref.5

Developmental stage

Expressed in 12-day-old mouse; no or barely detectable expression is found in adult tissues. Ref.5

Post-translational modification

Glycosylated and phosphorylated.

Sequence similarities

Contains 2 EF-hand domains.

Contains 4 PPIase FKBP-type domains.

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Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainRepeat
Signal
   LigandCalcium
   Molecular functionIsomerase
Rotamase
   PTMGlycoprotein
Phosphoprotein
Gene Ontology (GO)
   Biological processprotein folding

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

peptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction. Source: MGI

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 581548FK506-binding protein 10
PRO_0000025518

Regions

Domain61 – 14989PPIase FKBP-type 1
Domain173 – 26189PPIase FKBP-type 2
Domain285 – 37389PPIase FKBP-type 3
Domain398 – 48588PPIase FKBP-type 4
Domain496 – 53136EF-hand 1
Domain541 – 57636EF-hand 2
Calcium binding509 – 520121 Potential
Calcium binding554 – 565122 Potential
Motif578 – 5814Prevents secretion from ER Potential

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation3091N-linked (GlcNAc...) Potential
Glycosylation3511N-linked (GlcNAc...) Potential
Glycosylation3921N-linked (GlcNAc...) Potential
Glycosylation4061N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict141V → L in AAL57621. Ref.3
Sequence conflict141V → L in AAH29546. Ref.3
Sequence conflict1891G → A in AAL57621. Ref.3
Sequence conflict1891G → A in AAH29546. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
Q61576-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 1B51B3032089F555

FASTA58164,669
        10         20         30         40         50         60 
MFLVGSSSHT LHRVRILPLL LLLQTLERGL GRASPAGAPL EDVVIERYHI PRACPREVQM 

        70         80         90        100        110        120 
GDFVRYHYNG TFEDGKKFDS SYDRSTLVAI VVGVGRLITG MDRGLMGMCV NERRRLIVPP 

       130        140        150        160        170        180 
HLGYGSIGVA GLIPPDATLY FDVVLLDVWN KADTVQSTIL LRPPYCPRMV QNSDFVRYHY 

       190        200        210        220        230        240 
NGTLLDGTGF DNSYSRGGTY DTYIGSGWLI KGMDQGLLGM CPGEKRKIII PPFLAYGEKG 

       250        260        270        280        290        300 
YGTVIPPQAS LVFYVLLLDV HNPKDTVQLE TLELPQGCVR RAVAGDFMRY HYNGSLMDGT 

       310        320        330        340        350        360 
LFDSSYSRNH TYNTYVGQGY IIPGMDQGLQ GACIGERRRI TVPPHLAYGE NGTGDKIPGS 

       370        380        390        400        410        420 
AVLIFDVHVI DFHNPSDPVE IKTLSRPPEN CNETSKIGDF IRYHYNCSLL DGTRLFSSHD 

       430        440        450        460        470        480 
YEAPQEITLG ANKVIEGLDR GLQGMCVGER RQLIVPPHLA HGENGARGVP GSAVLLFEVE 

       490        500        510        520        530        540 
LVSREDGLPT GYLFVWYQDP STSLFEDMDL NKDGEVPPEE FSSFIKAQVN EGKGRLMPGQ 

       550        560        570        580 
DPDKTISDMF QNQDRNQDGK ITAEELKLKS DEDQERVHEE L

« Hide

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References

« Hide 'large scale' references
[1]"Sequence and localization of a novel FK506-binding protein to mouse chromosome 11."
Simek S.L., Kozak C.A., Winterstein D., Hegamyer G., Colburn N.H.
Genomics 18:407-409(1993) [PubMed: 7507077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: JB6.
Tissue: Epidermis.
[2]"Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65)."
Coss M.C., Winterstein D., Sowder R.C. II, Simek S.L.
J. Biol. Chem. 270:29336-29341(1995) [PubMed: 7493967] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[3]"Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family."
Patterson C.E., Gao J., Rooney A.P., Davis E.C.
Genomics 79:881-889(2002) [PubMed: 12036304] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3.
Tissue: Mammary tumor.
[5]"Developmental regulation of FKBP65: an ER localized extracellular matrix-binding protein."
Patterson C.E., Schaub T., Coleman E.J., Davis E.C.
Mol. Biol. Cell 11:3925-3935(2000) [PubMed: 11071917] [Abstract]
Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L07063 mRNA. Translation: AAC37678.1.
AF456413, AF456412 Genomic DNA. Translation: AAL57621.1.
BC029546 mRNA. Translation: AAH29546.1.
IPIIPI00122493.
PIRI49669.
RefSeqNP_034351.2.
UniGeneMm.3894

3D structure databases

SMRQ61576. Positions 172-426, 391-484.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-448N.
STRINGQ61576.

Proteomic databases

PRIDEQ61576.

Genome annotation databases

EnsemblENSMUST00000001595; ENSMUSP00000001595; ENSMUSG00000001555; Mus musculus. [Genome view]
GeneID14230.
UCSCuc007llb.1. mouse.

Organism-specific databases

CTD14230.
MGIMGI:104769. Fkbp10.

Phylogenomic databases

HOGENOMHBG444846.
HOVERGENQ61576.
InParanoidQ61576.
PhylomeDBQ61576.

Enzyme and pathway databases

BRENDA5.2.1.8. 244.

Gene expression databases

ArrayExpressQ61576.
BgeeQ61576.
CleanExMM_FKBP10.
MM_FKBP6.
GenevestigatorQ61576.
GermOnlineENSMUSG00000001555. Mus musculus.

Family and domain databases

InterProIPR018247. EF_Hand_1_Ca_BS.
IPR018249. EF_HAND_2.
IPR002048. EF_hand_Ca_bd.
IPR001179. PPIase_FKBP.
[Graphical view]
PANTHERPTHR10516. PPIase_FKBP. 1 hit.
PfamPF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio285499.
SOURCESearch...

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Entry information

Entry nameFKB10_MOUSE
AccessionPrimary (citable) accession number: Q61576
Secondary accession number(s): Q8VHI1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: February 9, 2010
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents