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Q61575

- FOXN1_MOUSE

UniProt

Q61575 - FOXN1_MOUSE

Protein

Forkhead box protein N1

Gene

Foxn1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcriptional regulator involved in development.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi271 – 36797Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. epidermis development Source: MGI
    3. epithelial cell proliferation Source: UniProtKB
    4. hair follicle development Source: MGI
    5. keratinocyte differentiation Source: MGI
    6. lymphocyte homeostasis Source: MGI
    7. nail development Source: MGI
    8. regulation of T cell differentiation in thymus Source: MGI
    9. thymus development Source: MGI
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein N1
    Alternative name(s):
    Hepatocyte nuclear factor 3 forkhead homolog 11
    Short name:
    HFH-11
    Short name:
    HNF-3/forkhead homolog 11
    Winged-helix transcription factor nude
    Gene namesi
    Name:Foxn1
    Synonyms:Fkh19, Hfh11, Whn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:102949. Foxn1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 648648Forkhead box protein N1PRO_0000091867Add
    BLAST

    Proteomic databases

    PRIDEiQ61575.

    PTM databases

    PhosphoSiteiQ61575.

    Expressioni

    Tissue specificityi

    Expressed in thymus and skin.

    Gene expression databases

    BgeeiQ61575.
    CleanExiMM_FOXN1.
    GenevestigatoriQ61575.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61575.
    SMRiQ61575. Positions 271-351.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi573 – 5764Poly-Pro

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00750000117242.
    HOGENOMiHOG000059593.
    HOVERGENiHBG051653.
    InParanoidiQ61575.
    KOiK09407.
    OMAiGHSFKTP.
    OrthoDBiEOG75F4D8.
    PhylomeDBiQ61575.
    TreeFamiTF329867.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61575-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSLLPPQSD VTLPGSTRLE GEPQGDLMQA PGLPDSPAPQ NKHANFSCSS    50
    FVPDGPPERT PSLPPHSPSI ASPDPEQIQG HCTAGPGPGS FRLSPSEKYP 100
    GFGFEEGPAG SPGRFLKGNH MPFHPYKRHF HEDIFSEAQT AMALDGHSFK 150
    TQGALEAFEE IPVDMGDAEA FLPSFPAEAW CNKLPYPSQE HNQILQGSEV 200
    KVKPQALDSG PGMYCYQPPL QHMYCSSQPA FHQYSPGGGS YPVPYLGSPH 250
    YPYQRIAPQA NAEGHQPLFP KPIYSYSILI FMALKNSKTG SLPVSEIYNF 300
    MTEHFPYFKT APDGWKNSVR HNLSLNKCFE KVENKSGSSS RKGCLWALNP 350
    SKIDKMQEEL QKWKRKDPIA VRKSMAKPEE LDSLIGDKRE KLGSPLLGCP 400
    PPGLAGPGPI RPMAPSAGLS QPLHPMHPAP GPMPGKNPLQ DLLGGHAPSC 450
    YGQTYPHLSP SLAPSGHQQP LFPQPDGHLE LQAQPGTPQD SPLPAHTPPS 500
    HGAKLMAEPS SARTMHDTLL PDGDLGTDLD AINPSLTDFD FQGNLWEQLK 550
    DDSLALDPLV LVTSSPTSSS MLPPPPAAHC FPPGPCLAET GNEAGELAPP 600
    GSGGSGALGD MHLSTLYSAF VELESTPSSA AAGPAVYLSP GSKPLALA 648
    Length:648
    Mass (Da):69,245
    Last modified:November 1, 1996 - v1
    Checksum:i7A75411BDE2B23E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81593 mRNA. Translation: CAA57279.1.
    CCDSiCCDS25102.1.
    RefSeqiNP_032264.1. NM_008238.2.
    XP_006532329.1. XM_006532266.1.
    UniGeneiMm.392151.
    Mm.4496.

    Genome annotation databases

    EnsembliENSMUST00000108294; ENSMUSP00000103929; ENSMUSG00000002057.
    GeneIDi15218.
    KEGGimmu:15218.
    UCSCiuc007kjd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81593 mRNA. Translation: CAA57279.1 .
    CCDSi CCDS25102.1.
    RefSeqi NP_032264.1. NM_008238.2.
    XP_006532329.1. XM_006532266.1.
    UniGenei Mm.392151.
    Mm.4496.

    3D structure databases

    ProteinModelPortali Q61575.
    SMRi Q61575. Positions 271-351.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q61575.

    Proteomic databases

    PRIDEi Q61575.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000108294 ; ENSMUSP00000103929 ; ENSMUSG00000002057 .
    GeneIDi 15218.
    KEGGi mmu:15218.
    UCSCi uc007kjd.1. mouse.

    Organism-specific databases

    CTDi 8456.
    MGIi MGI:102949. Foxn1.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00750000117242.
    HOGENOMi HOG000059593.
    HOVERGENi HBG051653.
    InParanoidi Q61575.
    KOi K09407.
    OMAi GHSFKTP.
    OrthoDBi EOG75F4D8.
    PhylomeDBi Q61575.
    TreeFami TF329867.

    Miscellaneous databases

    NextBioi 287799.
    PROi Q61575.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61575.
    CleanExi MM_FOXN1.
    Genevestigatori Q61575.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "New member of the winged-helix protein family disrupted in mouse and rat nude mutations."
      Nehls M., Pfeifer D., Schorpp M., Hedrich H., Boehm T.
      Nature 372:103-107(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Skin.
    2. "Characterization of mouse and human nude genes."
      Schorpp M., Hofmann M., Dear T.N., Boehm T.
      Immunogenetics 46:509-515(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Skin and Thymus.

    Entry informationi

    Entry nameiFOXN1_MOUSE
    AccessioniPrimary (citable) accession number: Q61575
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3