Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q61575 (FOXN1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein N1
Alternative name(s):
Hepatocyte nuclear factor 3 forkhead homolog 11
Short name=HFH-11
Short name=HNF-3/forkhead homolog 11
Winged-helix transcription factor nude
Gene names
Name:Foxn1
Synonyms:Fkh19, Hfh11, Whn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length648 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional regulator involved in development.

Subcellular location

Nucleus.

Tissue specificity

Expressed in thymus and skin.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell proliferation

Inferred from direct assay PubMed 9032290. Source: UniProtKB

embryo development

Inferred from Biological aspect of Ancestor. Source: RefGenome

epidermis development

Inferred from mutant phenotype PubMed 22072979. Source: MGI

epithelial cell proliferation

Inferred from direct assay PubMed 9032290. Source: UniProtKB

hair follicle development

Inferred from mutant phenotype PubMed 21191399. Source: MGI

keratinocyte differentiation

Inferred from direct assay PubMed 11841548. Source: MGI

lymphocyte homeostasis

Inferred from mutant phenotype PubMed 22072979. Source: MGI

nail development

Inferred from mutant phenotype PubMed 21191399. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

pattern specification process

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of T cell differentiation in thymus

Inferred from mutant phenotype PubMed 22072979. Source: MGI

regulation of sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

thymus development

Inferred from mutant phenotype PubMed 22072979. Source: MGI

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 648648Forkhead box protein N1
PRO_0000091867

Regions

DNA binding271 – 36797Fork-head
Compositional bias573 – 5764Poly-Pro

Sequences

Sequence LengthMass (Da)Tools
Q61575 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7A75411BDE2B23E5

FASTA64869,245
        10         20         30         40         50         60 
MVSLLPPQSD VTLPGSTRLE GEPQGDLMQA PGLPDSPAPQ NKHANFSCSS FVPDGPPERT 

        70         80         90        100        110        120 
PSLPPHSPSI ASPDPEQIQG HCTAGPGPGS FRLSPSEKYP GFGFEEGPAG SPGRFLKGNH 

       130        140        150        160        170        180 
MPFHPYKRHF HEDIFSEAQT AMALDGHSFK TQGALEAFEE IPVDMGDAEA FLPSFPAEAW 

       190        200        210        220        230        240 
CNKLPYPSQE HNQILQGSEV KVKPQALDSG PGMYCYQPPL QHMYCSSQPA FHQYSPGGGS 

       250        260        270        280        290        300 
YPVPYLGSPH YPYQRIAPQA NAEGHQPLFP KPIYSYSILI FMALKNSKTG SLPVSEIYNF 

       310        320        330        340        350        360 
MTEHFPYFKT APDGWKNSVR HNLSLNKCFE KVENKSGSSS RKGCLWALNP SKIDKMQEEL 

       370        380        390        400        410        420 
QKWKRKDPIA VRKSMAKPEE LDSLIGDKRE KLGSPLLGCP PPGLAGPGPI RPMAPSAGLS 

       430        440        450        460        470        480 
QPLHPMHPAP GPMPGKNPLQ DLLGGHAPSC YGQTYPHLSP SLAPSGHQQP LFPQPDGHLE 

       490        500        510        520        530        540 
LQAQPGTPQD SPLPAHTPPS HGAKLMAEPS SARTMHDTLL PDGDLGTDLD AINPSLTDFD 

       550        560        570        580        590        600 
FQGNLWEQLK DDSLALDPLV LVTSSPTSSS MLPPPPAAHC FPPGPCLAET GNEAGELAPP 

       610        620        630        640 
GSGGSGALGD MHLSTLYSAF VELESTPSSA AAGPAVYLSP GSKPLALA 

« Hide

References

[1]"New member of the winged-helix protein family disrupted in mouse and rat nude mutations."
Nehls M., Pfeifer D., Schorpp M., Hedrich H., Boehm T.
Nature 372:103-107(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Skin.
[2]"Characterization of mouse and human nude genes."
Schorpp M., Hofmann M., Dear T.N., Boehm T.
Immunogenetics 46:509-515(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Skin and Thymus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X81593 mRNA. Translation: CAA57279.1.
RefSeqNP_032264.1. NM_008238.2.
XP_006532329.1. XM_006532266.1.
UniGeneMm.392151.
Mm.4496.

3D structure databases

ProteinModelPortalQ61575.
SMRQ61575. Positions 271-351.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ61575.

Proteomic databases

PRIDEQ61575.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000108294; ENSMUSP00000103929; ENSMUSG00000002057.
GeneID15218.
KEGGmmu:15218.
UCSCuc007kjd.1. mouse.

Organism-specific databases

CTD8456.
MGIMGI:102949. Foxn1.

Phylogenomic databases

eggNOGCOG5025.
GeneTreeENSGT00750000117242.
HOGENOMHOG000059593.
HOVERGENHBG051653.
InParanoidQ61575.
KOK09407.
OMAGHSFKTP.
OrthoDBEOG75F4D8.
PhylomeDBQ61575.
TreeFamTF329867.

Gene expression databases

BgeeQ61575.
CleanExMM_FOXN1.
GenevestigatorQ61575.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio287799.
PROQ61575.
SOURCESearch...

Entry information

Entry nameFOXN1_MOUSE
AccessionPrimary (citable) accession number: Q61575
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot