Reviewed, UniProtKB/Swiss-Prot Q61575 (FOXN1_MOUSE)

Names and origin

Protein names

Recommended name:
    Forkhead box protein N1
Alternative name(s):
    Winged-helix transcription factor nude
    Hepatocyte nuclear factor 3 forkhead homolog 11
      Short name=HNF-3/forkhead homolog 11
      Short name=HFH-11

Gene names

Name:	Foxn1
Synonyms:	Fkh19, Hfh11, Whn

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	648 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Transcriptional regulator involved in development.
Subcellular location	Nucleus.
Tissue specificity	Expressed in thymus and skin.
Sequence similarities	Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	epithelial cell proliferation Inferred from direct assay. Source: UniProtKB keratinocyte differentiation Inferred from direct assay. Source: MGI multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 648	648	Forkhead box protein N1		PRO_0000091867
Regions
	DNA binding	271 – 367	97	Fork-head
	Compositional bias	573 – 576	4	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	Q61575-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7A75411BDE2B23E5	FASTA	648	69,245
	10 20 30 40 50 60 MVSLLPPQSD VTLPGSTRLE GEPQGDLMQA PGLPDSPAPQ NKHANFSCSS FVPDGPPERT 70 80 90 100 110 120 PSLPPHSPSI ASPDPEQIQG HCTAGPGPGS FRLSPSEKYP GFGFEEGPAG SPGRFLKGNH 130 140 150 160 170 180 MPFHPYKRHF HEDIFSEAQT AMALDGHSFK TQGALEAFEE IPVDMGDAEA FLPSFPAEAW 190 200 210 220 230 240 CNKLPYPSQE HNQILQGSEV KVKPQALDSG PGMYCYQPPL QHMYCSSQPA FHQYSPGGGS 250 260 270 280 290 300 YPVPYLGSPH YPYQRIAPQA NAEGHQPLFP KPIYSYSILI FMALKNSKTG SLPVSEIYNF 310 320 330 340 350 360 MTEHFPYFKT APDGWKNSVR HNLSLNKCFE KVENKSGSSS RKGCLWALNP SKIDKMQEEL 370 380 390 400 410 420 QKWKRKDPIA VRKSMAKPEE LDSLIGDKRE KLGSPLLGCP PPGLAGPGPI RPMAPSAGLS 430 440 450 460 470 480 QPLHPMHPAP GPMPGKNPLQ DLLGGHAPSC YGQTYPHLSP SLAPSGHQQP LFPQPDGHLE 490 500 510 520 530 540 LQAQPGTPQD SPLPAHTPPS HGAKLMAEPS SARTMHDTLL PDGDLGTDLD AINPSLTDFD 550 560 570 580 590 600 FQGNLWEQLK DDSLALDPLV LVTSSPTSSS MLPPPPAAHC FPPGPCLAET GNEAGELAPP 610 620 630 640 GSGGSGALGD MHLSTLYSAF VELESTPSSA AAGPAVYLSP GSKPLALA

References

[1]	"New member of the winged-helix protein family disrupted in mouse and rat nude mutations." Nehls M., Pfeifer D., Schorpp M., Hedrich H., Boehm T. Nature 372:103-107(1994) [PubMed: 7969402] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Skin.
[2]	"Characterization of mouse and human nude genes." Schorpp M., Hofmann M., Dear T.N., Boehm T. Immunogenetics 46:509-515(1997) [PubMed: 9321431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Skin and Thymus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X81593 mRNA. Translation: CAA57279.1.
IPI	IPI00122489.
RefSeq	NP_032264.1.
UniGene	Mm.4496
3D structure databases
HSSP	HSSP built from PDB template 1E17 based on UniProtKB P98177.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000002057. Mus musculus. [Contig view]
GeneID	15218.
KEGG	mmu:15218.
Organism-specific databases
MGI	MGI:102949. Foxn1.
Phylogenomic databases
HOGENOM	Q61575.
HOVERGEN	Q61575.
OMA	Q61575. TDLDAIN.
Gene expression databases
ArrayExpress	Q61575.
Bgee	Q61575.
CleanEx	MM_FOXN1.
GermOnline	ENSMUSG00000002057. Mus musculus.
Family and domain databases
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PANTHER	PTHR11829. Fork_box_protein. 1 hit.
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
ProDom	PD000425. TF_Fork_head. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. False negative. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	287799.
SOURCE	Search...

Entry information

Entry name

FOXN1_MOUSE

Accession

Primary (citable) accession number: Q61575

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)