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Q61575

- FOXN1_MOUSE

UniProt

Q61575 - FOXN1_MOUSE

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Protein
Forkhead box protein N1
Gene
Foxn1, Fkh19, Hfh11, Whn
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional regulator involved in development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi271 – 36797Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  3. double-stranded DNA binding Source: RefGenome
  4. sequence-specific DNA binding Source: InterPro
  5. transcription factor binding Source: RefGenome

GO - Biological processi

  1. cell proliferation Source: UniProtKB
  2. epidermis development Source: MGI
  3. epithelial cell proliferation Source: UniProtKB
  4. hair follicle development Source: MGI
  5. keratinocyte differentiation Source: MGI
  6. lymphocyte homeostasis Source: MGI
  7. nail development Source: MGI
  8. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  9. pattern specification process Source: RefGenome
  10. regulation of T cell differentiation in thymus Source: MGI
  11. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  12. thymus development Source: MGI
  13. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein N1
Alternative name(s):
Hepatocyte nuclear factor 3 forkhead homolog 11
Short name:
HFH-11
Short name:
HNF-3/forkhead homolog 11
Winged-helix transcription factor nude
Gene namesi
Name:Foxn1
Synonyms:Fkh19, Hfh11, Whn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:102949. Foxn1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Forkhead box protein N1
PRO_0000091867Add
BLAST

Proteomic databases

PRIDEiQ61575.

PTM databases

PhosphoSiteiQ61575.

Expressioni

Tissue specificityi

Expressed in thymus and skin.

Gene expression databases

BgeeiQ61575.
CleanExiMM_FOXN1.
GenevestigatoriQ61575.

Structurei

3D structure databases

ProteinModelPortaliQ61575.
SMRiQ61575. Positions 271-351.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi573 – 5764Poly-Pro

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00750000117242.
HOGENOMiHOG000059593.
HOVERGENiHBG051653.
InParanoidiQ61575.
KOiK09407.
OMAiGHSFKTP.
OrthoDBiEOG75F4D8.
PhylomeDBiQ61575.
TreeFamiTF329867.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61575-1 [UniParc]FASTAAdd to Basket

« Hide

MVSLLPPQSD VTLPGSTRLE GEPQGDLMQA PGLPDSPAPQ NKHANFSCSS    50
FVPDGPPERT PSLPPHSPSI ASPDPEQIQG HCTAGPGPGS FRLSPSEKYP 100
GFGFEEGPAG SPGRFLKGNH MPFHPYKRHF HEDIFSEAQT AMALDGHSFK 150
TQGALEAFEE IPVDMGDAEA FLPSFPAEAW CNKLPYPSQE HNQILQGSEV 200
KVKPQALDSG PGMYCYQPPL QHMYCSSQPA FHQYSPGGGS YPVPYLGSPH 250
YPYQRIAPQA NAEGHQPLFP KPIYSYSILI FMALKNSKTG SLPVSEIYNF 300
MTEHFPYFKT APDGWKNSVR HNLSLNKCFE KVENKSGSSS RKGCLWALNP 350
SKIDKMQEEL QKWKRKDPIA VRKSMAKPEE LDSLIGDKRE KLGSPLLGCP 400
PPGLAGPGPI RPMAPSAGLS QPLHPMHPAP GPMPGKNPLQ DLLGGHAPSC 450
YGQTYPHLSP SLAPSGHQQP LFPQPDGHLE LQAQPGTPQD SPLPAHTPPS 500
HGAKLMAEPS SARTMHDTLL PDGDLGTDLD AINPSLTDFD FQGNLWEQLK 550
DDSLALDPLV LVTSSPTSSS MLPPPPAAHC FPPGPCLAET GNEAGELAPP 600
GSGGSGALGD MHLSTLYSAF VELESTPSSA AAGPAVYLSP GSKPLALA 648
Length:648
Mass (Da):69,245
Last modified:November 1, 1996 - v1
Checksum:i7A75411BDE2B23E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81593 mRNA. Translation: CAA57279.1.
CCDSiCCDS25102.1.
RefSeqiNP_032264.1. NM_008238.2.
XP_006532329.1. XM_006532266.1.
UniGeneiMm.392151.
Mm.4496.

Genome annotation databases

EnsembliENSMUST00000108294; ENSMUSP00000103929; ENSMUSG00000002057.
GeneIDi15218.
KEGGimmu:15218.
UCSCiuc007kjd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81593 mRNA. Translation: CAA57279.1 .
CCDSi CCDS25102.1.
RefSeqi NP_032264.1. NM_008238.2.
XP_006532329.1. XM_006532266.1.
UniGenei Mm.392151.
Mm.4496.

3D structure databases

ProteinModelPortali Q61575.
SMRi Q61575. Positions 271-351.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q61575.

Proteomic databases

PRIDEi Q61575.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000108294 ; ENSMUSP00000103929 ; ENSMUSG00000002057 .
GeneIDi 15218.
KEGGi mmu:15218.
UCSCi uc007kjd.1. mouse.

Organism-specific databases

CTDi 8456.
MGIi MGI:102949. Foxn1.

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00750000117242.
HOGENOMi HOG000059593.
HOVERGENi HBG051653.
InParanoidi Q61575.
KOi K09407.
OMAi GHSFKTP.
OrthoDBi EOG75F4D8.
PhylomeDBi Q61575.
TreeFami TF329867.

Miscellaneous databases

NextBioi 287799.
PROi Q61575.
SOURCEi Search...

Gene expression databases

Bgeei Q61575.
CleanExi MM_FOXN1.
Genevestigatori Q61575.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "New member of the winged-helix protein family disrupted in mouse and rat nude mutations."
    Nehls M., Pfeifer D., Schorpp M., Hedrich H., Boehm T.
    Nature 372:103-107(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Skin.
  2. "Characterization of mouse and human nude genes."
    Schorpp M., Hofmann M., Dear T.N., Boehm T.
    Immunogenetics 46:509-515(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Skin and Thymus.

Entry informationi

Entry nameiFOXN1_MOUSE
AccessioniPrimary (citable) accession number: Q61575
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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