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Protein

Forkhead box protein C1

Gene

Foxc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi77 – 16892Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • artery morphogenesis Source: MGI
  • blood vessel development Source: MGI
  • blood vessel remodeling Source: MGI
  • brain development Source: MGI
  • camera-type eye development Source: MGI
  • cardiac muscle cell proliferation Source: MGI
  • cell migration Source: MGI
  • cell proliferation Source: MGI
  • collagen fibril organization Source: MGI
  • embryonic heart tube development Source: MGI
  • eye development Source: MGI
  • germ cell migration Source: MGI
  • glycosaminoglycan metabolic process Source: MGI
  • heart development Source: MGI
  • heart morphogenesis Source: MGI
  • in utero embryonic development Source: MGI
  • kidney development Source: MGI
  • lacrimal gland development Source: MGI
  • lymph vessel development Source: MGI
  • maintenance of lens transparency Source: UniProtKB
  • mesenchymal cell development Source: UniProtKB
  • mesenchymal cell differentiation Source: MGI
  • negative regulation of angiogenesis Source: UniProtKB
  • negative regulation of apoptotic process involved in outflow tract morphogenesis Source: MGI
  • negative regulation of lymphangiogenesis Source: UniProtKB
  • negative regulation of mitotic cell cycle Source: UniProtKB
  • neural crest cell development Source: MGI
  • Notch signaling pathway Source: MGI
  • odontogenesis of dentin-containing tooth Source: UniProtKB
  • ossification Source: MGI
  • ovarian follicle development Source: MGI
  • paraxial mesoderm formation Source: MGI
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of hematopoietic progenitor cell differentiation Source: UniProtKB
  • positive regulation of hematopoietic stem cell differentiation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • regulation of blood vessel size Source: MGI
  • regulation of organ growth Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB
  • skeletal system development Source: MGI
  • somitogenesis Source: UniProtKB
  • transcription from RNA polymerase II promoter Source: GOC
  • ureteric bud development Source: MGI
  • vascular endothelial growth factor receptor signaling pathway Source: MGI
  • vascular endothelial growth factor signaling pathway Source: UniProtKB
  • ventricular cardiac muscle tissue morphogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein C1
Alternative name(s):
Forkhead-related protein FKHL7
Forkhead-related transcription factor 3
Short name:
FREAC-3
Mesoderm/mesenchyme forkhead 1
Short name:
MF-1
Transcription factor FKH-1
Gene namesi
Name:Foxc1
Synonyms:Fkh1, Fkhl7, Freac3, Mf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1347466. Foxc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Forkhead box protein C1PRO_0000091807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei237 – 2371PhosphoserineBy similarity
Modified residuei243 – 2431PhosphoserineBy similarity
Modified residuei320 – 3201PhosphoserineBy similarity
Modified residuei521 – 5211PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ61572.
PRIDEiQ61572.

PTM databases

PhosphoSiteiQ61572.

Expressioni

Tissue specificityi

Expressed in many embryonic tissues, including prechondrogenic mesenchyme, periocular mesenchyme, meninges, endothelial cells, and kidney. Detected in adult brain, heart, kidney, adrenal gland, lung and testis, with lower levels in stomach, spleen and thymus.1 Publication

Developmental stagei

Expressed during embryogenesis.

Gene expression databases

BgeeiQ61572.
CleanExiMM_FOXC1.
GenevisibleiQ61572. MM.

Interactioni

Subunit structurei

Interacts with C1QBP.By similarity

Protein-protein interaction databases

IntActiQ61572. 2 interactions.
STRINGi10090.ENSMUSP00000052196.

Structurei

3D structure databases

ProteinModelPortaliQ61572.
SMRiQ61572. Positions 76-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 336Poly-Ala
Compositional biasi169 – 1735Poly-Arg
Compositional biasi194 – 1974Poly-Pro
Compositional biasi264 – 27411Poly-SerAdd
BLAST
Compositional biasi375 – 38612Poly-GlyAdd
BLAST
Compositional biasi444 – 4518Poly-Ser
Compositional biasi453 – 4564Poly-Gly
Compositional biasi486 – 49611Poly-AlaAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007939.
HOVERGENiHBG051640.
InParanoidiQ61572.
KOiK09396.
OMAiYSSPCSQ.
OrthoDBiEOG7C8GHD.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQARYSVSSP NSLGVVPYLG GEQSYYRAAA AAAGGGYTAM PAPMSVYSHP
60 70 80 90 100
AHAEQYPGSM ARAYGPYTPQ PQPKDMVKPP YSYIALITMA IQNAPDKKIT
110 120 130 140 150
LNGIYQFIMD RFPFYRDNKQ GWQNSIRHNL SLNECFVKVP RDDKKPGKGS
160 170 180 190 200
YWTLDPDSYN MFENGSFLRR RRRFKKKDAV KDKEEKGRLH LQEPPPPQAG
210 220 230 240 250
RQPAPAPPEQ AEGSAPGPQP PPVRIQDIKT ENGTCPSPPQ PLSPAAALGS
260 270 280 290 300
GSAATVPKIE SPDSSSSSLS SGSSPPGSLP SARPLSLDAA EPAPPPQPAP
310 320 330 340 350
PPHHSQGFSV DNIMTSLRGS PQGSAAELGS GLLASAAASS RAGIAPPLAL
360 370 380 390 400
GAYSPGQSSL YSSPCSQSSS AGSSGGGGGG GGGGGGSSSA AGTGGAATYH
410 420 430 440 450
CNLQAMSLYA AGERGGHLQG PAGGAGSAAV DDPLPDYSLP PATSSSSSSL
460 470 480 490 500
SHGGGGQEAS HHPASHQGRL TSWYLNQAGG DLGHLASAAA AAAAAGYPGQ
510 520 530 540 550
QQNFHSVREM FESQRIGLNN SPVNGNSSCQ MAFPASQSLY RTSGAFVYDC

SKF
Length:553
Mass (Da):56,940
Last modified:July 27, 2011 - v3
Checksum:i3CDB14F69AA2F217
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1867VKDKEEK → KKEITFI in AAA03159 (PubMed:8375339).Curated
Sequence conflicti496 – 4961G → A in AAC24209 (PubMed:9635428).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045017 mRNA. Translation: AAC24209.1.
AJ223298 Genomic DNA. Translation: CAA11239.1.
AK144420 mRNA. Translation: BAE25882.1.
BC052011 mRNA. Translation: AAH52011.1.
X71939 Genomic DNA. Translation: CAA50741.1.
L10406 mRNA. Translation: AAA03159.1.
CCDSiCCDS26425.1.
PIRiI49674.
RefSeqiNP_032618.2. NM_008592.2.
UniGeneiMm.12949.

Genome annotation databases

EnsembliENSMUST00000062292; ENSMUSP00000052196; ENSMUSG00000050295.
GeneIDi17300.
KEGGimmu:17300.
UCSCiuc007pzp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045017 mRNA. Translation: AAC24209.1.
AJ223298 Genomic DNA. Translation: CAA11239.1.
AK144420 mRNA. Translation: BAE25882.1.
BC052011 mRNA. Translation: AAH52011.1.
X71939 Genomic DNA. Translation: CAA50741.1.
L10406 mRNA. Translation: AAA03159.1.
CCDSiCCDS26425.1.
PIRiI49674.
RefSeqiNP_032618.2. NM_008592.2.
UniGeneiMm.12949.

3D structure databases

ProteinModelPortaliQ61572.
SMRiQ61572. Positions 76-168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61572. 2 interactions.
STRINGi10090.ENSMUSP00000052196.

PTM databases

PhosphoSiteiQ61572.

Proteomic databases

PaxDbiQ61572.
PRIDEiQ61572.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062292; ENSMUSP00000052196; ENSMUSG00000050295.
GeneIDi17300.
KEGGimmu:17300.
UCSCiuc007pzp.1. mouse.

Organism-specific databases

CTDi2296.
MGIiMGI:1347466. Foxc1.

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000007939.
HOVERGENiHBG051640.
InParanoidiQ61572.
KOiK09396.
OMAiYSSPCSQ.
OrthoDBiEOG7C8GHD.
TreeFamiTF316127.

Miscellaneous databases

NextBioi291834.
PROiQ61572.
SOURCEiSearch...

Gene expression databases

BgeeiQ61572.
CleanExiMM_FOXC1.
GenevisibleiQ61572. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus."
    Kume T., Deng K.Y., Winfrey V., Gould D.B., Walter M.A., Hogan B.L.M.
    Cell 93:985-996(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The mouse Fkh1/Mf1 gene: cDNA sequence, chromosomal localization and expression in adult tissues."
    Hiemisch H., Schutz G., Kaestner K.H.
    Gene 220:77-82(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryo.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Embryonic brain.
  5. "Six members of the mouse forkhead gene family are developmentally regulated."
    Kaestner K.H., Lee K.H., Schloendorff J., Hiemisch H., Monaghan A.P., Schuetz G.
    Proc. Natl. Acad. Sci. U.S.A. 90:7628-7631(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-179.
    Strain: 129.
  6. "Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo."
    Sasaki H., Hogan B.L.
    Development 118:47-59(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-187.

Entry informationi

Entry nameiFOXC1_MOUSE
AccessioniPrimary (citable) accession number: Q61572
Secondary accession number(s): O88409, Q61582, Q9QWR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.