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Q61572

- FOXC1_MOUSE

UniProt

Q61572 - FOXC1_MOUSE

Protein

Forkhead box protein C1

Gene

Foxc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Transcriptional regulator. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi77 – 16892Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. DNA binding, bending Source: UniProtKB
    3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
    4. sequence-specific DNA binding Source: UniProtKB
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    6. transcription factor binding Source: UniProtKB
    7. transcription regulatory region DNA binding Source: BHF-UCL

    GO - Biological processi

    1. artery morphogenesis Source: MGI
    2. blood vessel development Source: MGI
    3. blood vessel remodeling Source: MGI
    4. brain development Source: MGI
    5. camera-type eye development Source: MGI
    6. cardiac muscle cell proliferation Source: MGI
    7. collagen fibril organization Source: MGI
    8. embryonic heart tube development Source: MGI
    9. eye development Source: MGI
    10. germ cell migration Source: MGI
    11. glycosaminoglycan metabolic process Source: MGI
    12. heart development Source: MGI
    13. heart morphogenesis Source: MGI
    14. in utero embryonic development Source: MGI
    15. kidney development Source: MGI
    16. lacrimal gland development Source: MGI
    17. lymph vessel development Source: MGI
    18. mesenchymal cell differentiation Source: MGI
    19. negative regulation of apoptotic process involved in outflow tract morphogenesis Source: MGI
    20. negative regulation of mitotic cell cycle Source: UniProtKB
    21. neural crest cell development Source: MGI
    22. Notch signaling pathway Source: MGI
    23. odontogenesis of dentin-containing tooth Source: UniProtKB
    24. ossification Source: MGI
    25. ovarian follicle development Source: MGI
    26. paraxial mesoderm formation Source: MGI
    27. positive regulation of transcription, DNA-templated Source: UniProtKB
    28. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    29. regulation of blood vessel size Source: MGI
    30. regulation of organ growth Source: MGI
    31. regulation of transcription, DNA-templated Source: UniProtKB
    32. skeletal system development Source: MGI
    33. somitogenesis Source: UniProtKB
    34. transcription from RNA polymerase II promoter Source: GOC
    35. ureteric bud development Source: MGI
    36. vascular endothelial growth factor receptor signaling pathway Source: MGI
    37. ventricular cardiac muscle tissue morphogenesis Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein C1
    Alternative name(s):
    Forkhead-related protein FKHL7
    Forkhead-related transcription factor 3
    Short name:
    FREAC-3
    Mesoderm/mesenchyme forkhead 1
    Short name:
    MF-1
    Transcription factor FKH-1
    Gene namesi
    Name:Foxc1
    Synonyms:Fkh1, Fkhl7, Freac3, Mf1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1347466. Foxc1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nuclear heterochromatin Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Forkhead box protein C1PRO_0000091807Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei237 – 2371PhosphoserineBy similarity
    Modified residuei243 – 2431PhosphoserineBy similarity
    Modified residuei320 – 3201PhosphoserineBy similarity
    Modified residuei521 – 5211PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ61572.
    PRIDEiQ61572.

    PTM databases

    PhosphoSiteiQ61572.

    Expressioni

    Tissue specificityi

    Expressed in many embryonic tissues, including prechondrogenic mesenchyme, periocular mesenchyme, meninges, endothelial cells, and kidney. Detected in adult brain, heart, kidney, adrenal gland, lung and testis, with lower levels in stomach, spleen and thymus.1 Publication

    Developmental stagei

    Expressed during embryogenesis.

    Gene expression databases

    BgeeiQ61572.
    CleanExiMM_FOXC1.
    GenevestigatoriQ61572.

    Interactioni

    Subunit structurei

    Interacts with C1QBP.By similarity

    Protein-protein interaction databases

    IntActiQ61572. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61572.
    SMRiQ61572. Positions 76-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi28 – 336Poly-Ala
    Compositional biasi169 – 1735Poly-Arg
    Compositional biasi194 – 1974Poly-Pro
    Compositional biasi264 – 27411Poly-SerAdd
    BLAST
    Compositional biasi375 – 38612Poly-GlyAdd
    BLAST
    Compositional biasi444 – 4518Poly-Ser
    Compositional biasi453 – 4564Poly-Gly
    Compositional biasi486 – 49611Poly-AlaAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00740000114928.
    HOGENOMiHOG000007939.
    HOVERGENiHBG051640.
    InParanoidiQ9QWR9.
    KOiK09396.
    OMAiYSSPCSQ.
    OrthoDBiEOG7C8GHD.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61572-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQARYSVSSP NSLGVVPYLG GEQSYYRAAA AAAGGGYTAM PAPMSVYSHP    50
    AHAEQYPGSM ARAYGPYTPQ PQPKDMVKPP YSYIALITMA IQNAPDKKIT 100
    LNGIYQFIMD RFPFYRDNKQ GWQNSIRHNL SLNECFVKVP RDDKKPGKGS 150
    YWTLDPDSYN MFENGSFLRR RRRFKKKDAV KDKEEKGRLH LQEPPPPQAG 200
    RQPAPAPPEQ AEGSAPGPQP PPVRIQDIKT ENGTCPSPPQ PLSPAAALGS 250
    GSAATVPKIE SPDSSSSSLS SGSSPPGSLP SARPLSLDAA EPAPPPQPAP 300
    PPHHSQGFSV DNIMTSLRGS PQGSAAELGS GLLASAAASS RAGIAPPLAL 350
    GAYSPGQSSL YSSPCSQSSS AGSSGGGGGG GGGGGGSSSA AGTGGAATYH 400
    CNLQAMSLYA AGERGGHLQG PAGGAGSAAV DDPLPDYSLP PATSSSSSSL 450
    SHGGGGQEAS HHPASHQGRL TSWYLNQAGG DLGHLASAAA AAAAAGYPGQ 500
    QQNFHSVREM FESQRIGLNN SPVNGNSSCQ MAFPASQSLY RTSGAFVYDC 550
    SKF 553
    Length:553
    Mass (Da):56,940
    Last modified:July 27, 2011 - v3
    Checksum:i3CDB14F69AA2F217
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti180 – 1867VKDKEEK → KKEITFI in AAA03159. (PubMed:8375339)Curated
    Sequence conflicti496 – 4961G → A in AAC24209. (PubMed:9635428)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045017 mRNA. Translation: AAC24209.1.
    AJ223298 Genomic DNA. Translation: CAA11239.1.
    AK144420 mRNA. Translation: BAE25882.1.
    BC052011 mRNA. Translation: AAH52011.1.
    X71939 Genomic DNA. Translation: CAA50741.1.
    L10406 mRNA. Translation: AAA03159.1.
    CCDSiCCDS26425.1.
    PIRiI49674.
    RefSeqiNP_032618.2. NM_008592.2.
    UniGeneiMm.12949.

    Genome annotation databases

    EnsembliENSMUST00000062292; ENSMUSP00000052196; ENSMUSG00000050295.
    GeneIDi17300.
    KEGGimmu:17300.
    UCSCiuc007pzp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045017 mRNA. Translation: AAC24209.1 .
    AJ223298 Genomic DNA. Translation: CAA11239.1 .
    AK144420 mRNA. Translation: BAE25882.1 .
    BC052011 mRNA. Translation: AAH52011.1 .
    X71939 Genomic DNA. Translation: CAA50741.1 .
    L10406 mRNA. Translation: AAA03159.1 .
    CCDSi CCDS26425.1.
    PIRi I49674.
    RefSeqi NP_032618.2. NM_008592.2.
    UniGenei Mm.12949.

    3D structure databases

    ProteinModelPortali Q61572.
    SMRi Q61572. Positions 76-168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61572. 2 interactions.

    PTM databases

    PhosphoSitei Q61572.

    Proteomic databases

    PaxDbi Q61572.
    PRIDEi Q61572.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000062292 ; ENSMUSP00000052196 ; ENSMUSG00000050295 .
    GeneIDi 17300.
    KEGGi mmu:17300.
    UCSCi uc007pzp.1. mouse.

    Organism-specific databases

    CTDi 2296.
    MGIi MGI:1347466. Foxc1.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00740000114928.
    HOGENOMi HOG000007939.
    HOVERGENi HBG051640.
    InParanoidi Q9QWR9.
    KOi K09396.
    OMAi YSSPCSQ.
    OrthoDBi EOG7C8GHD.
    TreeFami TF316127.

    Miscellaneous databases

    NextBioi 291834.
    PROi Q61572.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61572.
    CleanExi MM_FOXC1.
    Genevestigatori Q61572.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus."
      Kume T., Deng K.Y., Winfrey V., Gould D.B., Walter M.A., Hogan B.L.M.
      Cell 93:985-996(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The mouse Fkh1/Mf1 gene: cDNA sequence, chromosomal localization and expression in adult tissues."
      Hiemisch H., Schutz G., Kaestner K.H.
      Gene 220:77-82(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Embryo.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Diencephalon.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Embryonic brain.
    5. "Six members of the mouse forkhead gene family are developmentally regulated."
      Kaestner K.H., Lee K.H., Schloendorff J., Hiemisch H., Monaghan A.P., Schuetz G.
      Proc. Natl. Acad. Sci. U.S.A. 90:7628-7631(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-179.
      Strain: 129.
    6. "Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo."
      Sasaki H., Hogan B.L.
      Development 118:47-59(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-187.

    Entry informationi

    Entry nameiFOXC1_MOUSE
    AccessioniPrimary (citable) accession number: Q61572
    Secondary accession number(s): O88409, Q61582, Q9QWR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3