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Q61572

- FOXC1_MOUSE

UniProt

Q61572 - FOXC1_MOUSE

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Protein

Forkhead box protein C1

Gene
Foxc1, Fkh1, Fkhl7, Freac3, Mf1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi77 – 16892Fork-headAdd
BLAST

GO - Molecular functioni

  1. chromatin DNA binding Source: RefGenome
  2. DNA binding Source: UniProtKB
  3. DNA binding, bending Source: UniProtKB
  4. double-stranded DNA binding Source: RefGenome
  5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  6. sequence-specific DNA binding Source: UniProtKB
  7. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. transcription factor binding Source: UniProtKB
  9. transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  1. artery morphogenesis Source: MGI
  2. blood vessel development Source: MGI
  3. blood vessel remodeling Source: MGI
  4. brain development Source: MGI
  5. camera-type eye development Source: MGI
  6. cardiac muscle cell proliferation Source: MGI
  7. collagen fibril organization Source: MGI
  8. embryonic heart tube development Source: MGI
  9. eye development Source: MGI
  10. germ cell migration Source: MGI
  11. glycosaminoglycan metabolic process Source: MGI
  12. heart development Source: MGI
  13. heart morphogenesis Source: MGI
  14. in utero embryonic development Source: MGI
  15. kidney development Source: MGI
  16. lacrimal gland development Source: MGI
  17. lymph vessel development Source: MGI
  18. mesenchymal cell differentiation Source: MGI
  19. negative regulation of apoptotic process involved in outflow tract morphogenesis Source: MGI
  20. negative regulation of mitotic cell cycle Source: UniProtKB
  21. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  22. neural crest cell development Source: MGI
  23. Notch signaling pathway Source: MGI
  24. odontogenesis of dentin-containing tooth Source: UniProtKB
  25. ossification Source: MGI
  26. ovarian follicle development Source: MGI
  27. paraxial mesoderm formation Source: MGI
  28. positive regulation of transcription, DNA-templated Source: UniProtKB
  29. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  30. regulation of blood vessel size Source: MGI
  31. regulation of organ growth Source: MGI
  32. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  33. regulation of transcription, DNA-templated Source: UniProtKB
  34. skeletal system development Source: MGI
  35. somitogenesis Source: UniProtKB
  36. transcription from RNA polymerase II promoter Source: GOC
  37. ureteric bud development Source: MGI
  38. vascular endothelial growth factor receptor signaling pathway Source: MGI
  39. ventricular cardiac muscle tissue morphogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein C1
Alternative name(s):
Forkhead-related protein FKHL7
Forkhead-related transcription factor 3
Short name:
FREAC-3
Mesoderm/mesenchyme forkhead 1
Short name:
MF-1
Transcription factor FKH-1
Gene namesi
Name:Foxc1
Synonyms:Fkh1, Fkhl7, Freac3, Mf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1347466. Foxc1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nuclear heterochromatin Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Forkhead box protein C1PRO_0000091807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei237 – 2371Phosphoserine By similarity
Modified residuei243 – 2431Phosphoserine By similarity
Modified residuei320 – 3201Phosphoserine By similarity
Modified residuei521 – 5211Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ61572.
PRIDEiQ61572.

PTM databases

PhosphoSiteiQ61572.

Expressioni

Tissue specificityi

Expressed in many embryonic tissues, including prechondrogenic mesenchyme, periocular mesenchyme, meninges, endothelial cells, and kidney. Detected in adult brain, heart, kidney, adrenal gland, lung and testis, with lower levels in stomach, spleen and thymus.1 Publication

Developmental stagei

Expressed during embryogenesis.

Gene expression databases

BgeeiQ61572.
CleanExiMM_FOXC1.
GenevestigatoriQ61572.

Interactioni

Subunit structurei

Interacts with C1QBP By similarity.

Protein-protein interaction databases

IntActiQ61572. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ61572.
SMRiQ61572. Positions 76-168.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 336Poly-Ala
Compositional biasi169 – 1735Poly-Arg
Compositional biasi194 – 1974Poly-Pro
Compositional biasi264 – 27411Poly-SerAdd
BLAST
Compositional biasi375 – 38612Poly-GlyAdd
BLAST
Compositional biasi444 – 4518Poly-Ser
Compositional biasi453 – 4564Poly-Gly
Compositional biasi486 – 49611Poly-AlaAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00740000114928.
HOGENOMiHOG000007939.
HOVERGENiHBG051640.
InParanoidiQ9QWR9.
KOiK09396.
OMAiYSSPCSQ.
OrthoDBiEOG7C8GHD.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61572-1 [UniParc]FASTAAdd to Basket

« Hide

MQARYSVSSP NSLGVVPYLG GEQSYYRAAA AAAGGGYTAM PAPMSVYSHP    50
AHAEQYPGSM ARAYGPYTPQ PQPKDMVKPP YSYIALITMA IQNAPDKKIT 100
LNGIYQFIMD RFPFYRDNKQ GWQNSIRHNL SLNECFVKVP RDDKKPGKGS 150
YWTLDPDSYN MFENGSFLRR RRRFKKKDAV KDKEEKGRLH LQEPPPPQAG 200
RQPAPAPPEQ AEGSAPGPQP PPVRIQDIKT ENGTCPSPPQ PLSPAAALGS 250
GSAATVPKIE SPDSSSSSLS SGSSPPGSLP SARPLSLDAA EPAPPPQPAP 300
PPHHSQGFSV DNIMTSLRGS PQGSAAELGS GLLASAAASS RAGIAPPLAL 350
GAYSPGQSSL YSSPCSQSSS AGSSGGGGGG GGGGGGSSSA AGTGGAATYH 400
CNLQAMSLYA AGERGGHLQG PAGGAGSAAV DDPLPDYSLP PATSSSSSSL 450
SHGGGGQEAS HHPASHQGRL TSWYLNQAGG DLGHLASAAA AAAAAGYPGQ 500
QQNFHSVREM FESQRIGLNN SPVNGNSSCQ MAFPASQSLY RTSGAFVYDC 550
SKF 553
Length:553
Mass (Da):56,940
Last modified:July 27, 2011 - v3
Checksum:i3CDB14F69AA2F217
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1867VKDKEEK → KKEITFI in AAA03159. 1 Publication
Sequence conflicti496 – 4961G → A in AAC24209. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF045017 mRNA. Translation: AAC24209.1.
AJ223298 Genomic DNA. Translation: CAA11239.1.
AK144420 mRNA. Translation: BAE25882.1.
BC052011 mRNA. Translation: AAH52011.1.
X71939 Genomic DNA. Translation: CAA50741.1.
L10406 mRNA. Translation: AAA03159.1.
CCDSiCCDS26425.1.
PIRiI49674.
RefSeqiNP_032618.2. NM_008592.2.
UniGeneiMm.12949.

Genome annotation databases

EnsembliENSMUST00000062292; ENSMUSP00000052196; ENSMUSG00000050295.
GeneIDi17300.
KEGGimmu:17300.
UCSCiuc007pzp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF045017 mRNA. Translation: AAC24209.1 .
AJ223298 Genomic DNA. Translation: CAA11239.1 .
AK144420 mRNA. Translation: BAE25882.1 .
BC052011 mRNA. Translation: AAH52011.1 .
X71939 Genomic DNA. Translation: CAA50741.1 .
L10406 mRNA. Translation: AAA03159.1 .
CCDSi CCDS26425.1.
PIRi I49674.
RefSeqi NP_032618.2. NM_008592.2.
UniGenei Mm.12949.

3D structure databases

ProteinModelPortali Q61572.
SMRi Q61572. Positions 76-168.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61572. 2 interactions.

PTM databases

PhosphoSitei Q61572.

Proteomic databases

PaxDbi Q61572.
PRIDEi Q61572.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062292 ; ENSMUSP00000052196 ; ENSMUSG00000050295 .
GeneIDi 17300.
KEGGi mmu:17300.
UCSCi uc007pzp.1. mouse.

Organism-specific databases

CTDi 2296.
MGIi MGI:1347466. Foxc1.

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00740000114928.
HOGENOMi HOG000007939.
HOVERGENi HBG051640.
InParanoidi Q9QWR9.
KOi K09396.
OMAi YSSPCSQ.
OrthoDBi EOG7C8GHD.
TreeFami TF316127.

Miscellaneous databases

NextBioi 291834.
PROi Q61572.
SOURCEi Search...

Gene expression databases

Bgeei Q61572.
CleanExi MM_FOXC1.
Genevestigatori Q61572.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus."
    Kume T., Deng K.Y., Winfrey V., Gould D.B., Walter M.A., Hogan B.L.M.
    Cell 93:985-996(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The mouse Fkh1/Mf1 gene: cDNA sequence, chromosomal localization and expression in adult tissues."
    Hiemisch H., Schutz G., Kaestner K.H.
    Gene 220:77-82(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryo.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Embryonic brain.
  5. "Six members of the mouse forkhead gene family are developmentally regulated."
    Kaestner K.H., Lee K.H., Schloendorff J., Hiemisch H., Monaghan A.P., Schuetz G.
    Proc. Natl. Acad. Sci. U.S.A. 90:7628-7631(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-179.
    Strain: 129.
  6. "Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo."
    Sasaki H., Hogan B.L.
    Development 118:47-59(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-187.

Entry informationi

Entry nameiFOXC1_MOUSE
AccessioniPrimary (citable) accession number: Q61572
Secondary accession number(s): O88409, Q61582, Q9QWR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi