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Q61549

- EMR1_MOUSE

UniProt

Q61549 - EMR1_MOUSE

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Protein

EGF-like module-containing mucin-like hormone receptor-like 1

Gene

Emr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Could be involved in cell-cell interactions.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Protein family/group databases

MEROPSiS63.951.

Names & Taxonomyi

Protein namesi
Recommended name:
EGF-like module-containing mucin-like hormone receptor-like 1
Alternative name(s):
Cell surface glycoprotein F4/80
EGF-like module receptor 1
EMR1 hormone receptor
Gene namesi
Name:Emr1
Synonyms:Gpf480
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:106912. Emr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 644617ExtracellularSequence AnalysisAdd
BLAST
Transmembranei645 – 67228Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini673 – 6797CytoplasmicSequence Analysis
Transmembranei680 – 70122Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini702 – 71110ExtracellularSequence Analysis
Transmembranei712 – 73524Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini736 – 75419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei755 – 77622Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini777 – 79216ExtracellularSequence AnalysisAdd
BLAST
Transmembranei793 – 82129Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini822 – 83918CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei840 – 85920Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini860 – 87415ExtracellularSequence AnalysisAdd
BLAST
Transmembranei875 – 89723Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini898 – 93134CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell periphery Source: MGI
  2. external side of plasma membrane Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 931904EGF-like module-containing mucin-like hormone receptor-like 1PRO_0000012874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 48PROSITE-ProRule annotation
Disulfide bondi42 ↔ 57PROSITE-ProRule annotation
Disulfide bondi59 ↔ 79PROSITE-ProRule annotation
Disulfide bondi85 ↔ 98PROSITE-ProRule annotation
Disulfide bondi92 ↔ 107PROSITE-ProRule annotation
Disulfide bondi109 ↔ 131PROSITE-ProRule annotation
Disulfide bondi137 ↔ 149PROSITE-ProRule annotation
Disulfide bondi143 ↔ 158PROSITE-ProRule annotation
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi160 ↔ 171PROSITE-ProRule annotation
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi177 ↔ 189PROSITE-ProRule annotation
Disulfide bondi183 ↔ 198PROSITE-ProRule annotation
Disulfide bondi200 ↔ 220PROSITE-ProRule annotation
Disulfide bondi226 ↔ 239PROSITE-ProRule annotation
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi233 ↔ 248PROSITE-ProRule annotation
Disulfide bondi250 ↔ 270PROSITE-ProRule annotation
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi276 ↔ 286PROSITE-ProRule annotation
Disulfide bondi280 ↔ 295PROSITE-ProRule annotation
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi297 ↔ 317PROSITE-ProRule annotation
Disulfide bondi323 ↔ 336PROSITE-ProRule annotation
Disulfide bondi330 ↔ 345PROSITE-ProRule annotation
Disulfide bondi347 ↔ 366PROSITE-ProRule annotation
Glycosylationi405 – 4051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi706 – 7061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61549.
PaxDbiQ61549.
PRIDEiQ61549.

PTM databases

PhosphoSiteiQ61549.

Expressioni

Tissue specificityi

In macrophages; but absent from those which are localized within T-cell areas of lymph nodes and spleen. Low level of expression on blood monocytes.

Gene expression databases

BgeeiQ61549.
ExpressionAtlasiQ61549. baseline and differential.
GenevestigatoriQ61549.

Structurei

3D structure databases

ProteinModelPortaliQ61549.
SMRiQ61549. Positions 42-355, 436-629, 649-893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 8049EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini81 – 13252EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini133 – 17240EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini173 – 22149EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini222 – 27150EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini272 – 31847EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini319 – 36749EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini592 – 64150GPSPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi506 – 5083Cell attachment siteSequence Analysis

Sequence similaritiesi

Contains 7 EGF-like domains.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239437.
GeneTreeiENSGT00760000118787.
HOGENOMiHOG000294115.
HOVERGENiHBG048917.
InParanoidiQ61549.
KOiK04591.
OMAiRNHNTYL.
OrthoDBiEOG7WHH8Q.
PhylomeDBiQ61549.
TreeFamiTF316380.

Family and domain databases

InterProiIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 6 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 5 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61549-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWGFWLLLFW GFSGMYRWGM TTLPTLGQTL GGVNECQDTT TCPAYATCTD
60 70 80 90 100
TTDSYYCTCK RGFLSSNGQT NFQGPGVECQ DVNECLQSDS PCGPNSVCTN
110 120 130 140 150
ILGRAKCSCL RGFSSSTGKD WILGSLDNFL CADVDECLTI GICPKYSNCS
160 170 180 190 200
NSVGSYSCTC QPGFVLNGSI CEDEDECVTR DVCPEHATCH NTLGSYYCTC
210 220 230 240 250
NSGLESSGGG PMFQGLDESC EDVDECSRNS TLCGPTFICI NTLGSYSCSC
260 270 280 290 300
PAGFSLPTFQ ILGHPADGNC TDIDECDDTC PLNSSCTNTI GSYFCTCHPG
310 320 330 340 350
FASSNGQLNF KDLEVTCEDI DECTQDPLQC GLNSVCTNVP GSYICGCLPD
360 370 380 390 400
FQMDPEGSQG YGNFNCKRIL FKCKEDLILQ SEQIQQCQAV QGRDLGYASF
410 420 430 440 450
CTLVNATFTI LDNTCENKSA PVSLQSAATS VSLVLEQATT WFELSKEETS
460 470 480 490 500
TLGTILLETV ESTMLAALLI PSGNASQMIQ TEYLDIESKV INEECKENES
510 520 530 540 550
INLAARGDKM NVGCFIIKES VSTGAPGVAF VSFAHMESVL NERFFEDGQS
560 570 580 590 600
FRKLRMNSRV VGGTVTGEKK EDFSKPIIYT LQHIQPKQKS ERPICVSWNT
610 620 630 640 650
DVEDGRWTPS GCEIVEASET HTVCSCNRMA NLAIIMASGE LTMEFSLYII
660 670 680 690 700
SHVGTVISLV CLALAIATFL LCRAVQNHNT YMHLHLCVCL FLAKILFLTG
710 720 730 740 750
IDKTDNQTAC AIIAGFLHYL FLACFFWMLV EAVMLFLMVR NLKVVNYFSS
760 770 780 790 800
RNIKMLHLCA FGYGLPVLVV IISASVQPRG YGMHNRCWLN TETGFIWSFL
810 820 830 840 850
GPVCMIITIN SVLLAWTLWV LRQKLCSVSS EVSKLKDTRL LTFKAIAQIF
860 870 880 890 900
ILGCSWVLGI FQIGPLASIM AYLFTIINSL QGAFIFLIHC LLNRQVRDEY
910 920 930
KKLLTRKTDL SSHSQTSGIL LSSMPSTSKM G
Length:931
Mass (Da):102,130
Last modified:November 1, 1997 - v1
Checksum:i52963A667E8B76B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93328 mRNA. Translation: CAA63720.1.
U66888 mRNA. Translation: AAC53184.1.
BC075688 mRNA. Translation: AAH75688.1.
CCDSiCCDS50160.1.
RefSeqiNP_034260.1. NM_010130.4.
XP_006523664.1. XM_006523601.1.
UniGeneiMm.2254.

Genome annotation databases

EnsembliENSMUST00000004850; ENSMUSP00000004850; ENSMUSG00000004730.
ENSMUST00000086763; ENSMUSP00000083971; ENSMUSG00000004730.
GeneIDi13733.
KEGGimmu:13733.
UCSCiuc008det.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93328 mRNA. Translation: CAA63720.1 .
U66888 mRNA. Translation: AAC53184.1 .
BC075688 mRNA. Translation: AAH75688.1 .
CCDSi CCDS50160.1.
RefSeqi NP_034260.1. NM_010130.4.
XP_006523664.1. XM_006523601.1.
UniGenei Mm.2254.

3D structure databases

ProteinModelPortali Q61549.
SMRi Q61549. Positions 42-355, 436-629, 649-893.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S63.951.
GPCRDBi Search...

PTM databases

PhosphoSitei Q61549.

Proteomic databases

MaxQBi Q61549.
PaxDbi Q61549.
PRIDEi Q61549.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004850 ; ENSMUSP00000004850 ; ENSMUSG00000004730 .
ENSMUST00000086763 ; ENSMUSP00000083971 ; ENSMUSG00000004730 .
GeneIDi 13733.
KEGGi mmu:13733.
UCSCi uc008det.2. mouse.

Organism-specific databases

CTDi 2015.
MGIi MGI:106912. Emr1.

Phylogenomic databases

eggNOGi NOG239437.
GeneTreei ENSGT00760000118787.
HOGENOMi HOG000294115.
HOVERGENi HBG048917.
InParanoidi Q61549.
KOi K04591.
OMAi RNHNTYL.
OrthoDBi EOG7WHH8Q.
PhylomeDBi Q61549.
TreeFami TF316380.

Miscellaneous databases

NextBioi 284538.
PROi Q61549.
SOURCEi Search...

Gene expression databases

Bgeei Q61549.
ExpressionAtlasi Q61549. baseline and differential.
Genevestigatori Q61549.

Family and domain databases

InterProi IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 6 hits.
SM00303. GPS. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 6 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 5 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family."
    McKnight A.J., Macfarlane A.J., Dri P., Turley L., Willis A.C., Gordon S.
    J. Biol. Chem. 271:486-489(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Peritoneal cavity.
  2. "Identification and characterization of a seven transmembrane hormone receptor using differential display."
    Lin H.H., Stubbs L.J., Mucenski M.L.
    Genomics 41:301-308(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiEMR1_MOUSE
AccessioniPrimary (citable) accession number: Q61549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3