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Q61549

- EMR1_MOUSE

UniProt

Q61549 - EMR1_MOUSE

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Protein
EGF-like module-containing mucin-like hormone receptor-like 1
Gene
Emr1, Gpf480
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Could be involved in cell-cell interactions.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro

GO - Biological processi

  1. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Protein family/group databases

MEROPSiS63.951.

Names & Taxonomyi

Protein namesi
Recommended name:
EGF-like module-containing mucin-like hormone receptor-like 1
Alternative name(s):
Cell surface glycoprotein F4/80
EGF-like module receptor 1
EMR1 hormone receptor
Gene namesi
Name:Emr1
Synonyms:Gpf480
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:106912. Emr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 644617Extracellular Reviewed prediction
Add
BLAST
Transmembranei645 – 67228Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini673 – 6797Cytoplasmic Reviewed prediction
Transmembranei680 – 70122Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini702 – 71110Extracellular Reviewed prediction
Transmembranei712 – 73524Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini736 – 75419Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei755 – 77622Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini777 – 79216Extracellular Reviewed prediction
Add
BLAST
Transmembranei793 – 82129Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini822 – 83918Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei840 – 85920Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini860 – 87415Extracellular Reviewed prediction
Add
BLAST
Transmembranei875 – 89723Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini898 – 93134Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell periphery Source: MGI
  2. external side of plasma membrane Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 931904EGF-like module-containing mucin-like hormone receptor-like 1
PRO_0000012874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 48 By similarity
Disulfide bondi42 ↔ 57 By similarity
Disulfide bondi59 ↔ 79 By similarity
Disulfide bondi85 ↔ 98 By similarity
Disulfide bondi92 ↔ 107 By similarity
Disulfide bondi109 ↔ 131 By similarity
Disulfide bondi137 ↔ 149 By similarity
Disulfide bondi143 ↔ 158 By similarity
Glycosylationi148 – 1481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi160 ↔ 171 By similarity
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi177 ↔ 189 By similarity
Disulfide bondi183 ↔ 198 By similarity
Disulfide bondi200 ↔ 220 By similarity
Disulfide bondi226 ↔ 239 By similarity
Glycosylationi229 – 2291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi233 ↔ 248 By similarity
Disulfide bondi250 ↔ 270 By similarity
Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi276 ↔ 286 By similarity
Disulfide bondi280 ↔ 295 By similarity
Glycosylationi283 – 2831N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi297 ↔ 317 By similarity
Disulfide bondi323 ↔ 336 By similarity
Disulfide bondi330 ↔ 345 By similarity
Disulfide bondi347 ↔ 366 By similarity
Glycosylationi405 – 4051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi417 – 4171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi474 – 4741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi498 – 4981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi706 – 7061N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61549.
PaxDbiQ61549.
PRIDEiQ61549.

PTM databases

PhosphoSiteiQ61549.

Expressioni

Tissue specificityi

In macrophages; but absent from those which are localized within T-cell areas of lymph nodes and spleen. Low level of expression on blood monocytes.

Gene expression databases

ArrayExpressiQ61549.
BgeeiQ61549.
GenevestigatoriQ61549.

Structurei

3D structure databases

ProteinModelPortaliQ61549.
SMRiQ61549. Positions 42-355, 436-629, 649-893.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 8049EGF-like 1
Add
BLAST
Domaini81 – 13252EGF-like 2
Add
BLAST
Domaini133 – 17240EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini173 – 22149EGF-like 4; calcium-binding Reviewed prediction
Add
BLAST
Domaini222 – 27150EGF-like 5; calcium-binding Reviewed prediction
Add
BLAST
Domaini272 – 31847EGF-like 6; calcium-binding Reviewed prediction
Add
BLAST
Domaini319 – 36749EGF-like 7; calcium-binding Reviewed prediction
Add
BLAST
Domaini592 – 64150GPS
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi506 – 5083Cell attachment site Reviewed prediction

Sequence similaritiesi

Contains 7 EGF-like domains.
Contains 1 GPS domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239437.
GeneTreeiENSGT00710000106562.
HOGENOMiHOG000294115.
HOVERGENiHBG048917.
InParanoidiQ61549.
KOiK04591.
OMAiRNHNTYL.
OrthoDBiEOG7WHH8Q.
PhylomeDBiQ61549.
TreeFamiTF316380.

Family and domain databases

InterProiIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 6 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 5 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61549-1 [UniParc]FASTAAdd to Basket

« Hide

MWGFWLLLFW GFSGMYRWGM TTLPTLGQTL GGVNECQDTT TCPAYATCTD    50
TTDSYYCTCK RGFLSSNGQT NFQGPGVECQ DVNECLQSDS PCGPNSVCTN 100
ILGRAKCSCL RGFSSSTGKD WILGSLDNFL CADVDECLTI GICPKYSNCS 150
NSVGSYSCTC QPGFVLNGSI CEDEDECVTR DVCPEHATCH NTLGSYYCTC 200
NSGLESSGGG PMFQGLDESC EDVDECSRNS TLCGPTFICI NTLGSYSCSC 250
PAGFSLPTFQ ILGHPADGNC TDIDECDDTC PLNSSCTNTI GSYFCTCHPG 300
FASSNGQLNF KDLEVTCEDI DECTQDPLQC GLNSVCTNVP GSYICGCLPD 350
FQMDPEGSQG YGNFNCKRIL FKCKEDLILQ SEQIQQCQAV QGRDLGYASF 400
CTLVNATFTI LDNTCENKSA PVSLQSAATS VSLVLEQATT WFELSKEETS 450
TLGTILLETV ESTMLAALLI PSGNASQMIQ TEYLDIESKV INEECKENES 500
INLAARGDKM NVGCFIIKES VSTGAPGVAF VSFAHMESVL NERFFEDGQS 550
FRKLRMNSRV VGGTVTGEKK EDFSKPIIYT LQHIQPKQKS ERPICVSWNT 600
DVEDGRWTPS GCEIVEASET HTVCSCNRMA NLAIIMASGE LTMEFSLYII 650
SHVGTVISLV CLALAIATFL LCRAVQNHNT YMHLHLCVCL FLAKILFLTG 700
IDKTDNQTAC AIIAGFLHYL FLACFFWMLV EAVMLFLMVR NLKVVNYFSS 750
RNIKMLHLCA FGYGLPVLVV IISASVQPRG YGMHNRCWLN TETGFIWSFL 800
GPVCMIITIN SVLLAWTLWV LRQKLCSVSS EVSKLKDTRL LTFKAIAQIF 850
ILGCSWVLGI FQIGPLASIM AYLFTIINSL QGAFIFLIHC LLNRQVRDEY 900
KKLLTRKTDL SSHSQTSGIL LSSMPSTSKM G 931
Length:931
Mass (Da):102,130
Last modified:November 1, 1997 - v1
Checksum:i52963A667E8B76B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X93328 mRNA. Translation: CAA63720.1.
U66888 mRNA. Translation: AAC53184.1.
BC075688 mRNA. Translation: AAH75688.1.
CCDSiCCDS50160.1.
RefSeqiNP_034260.1. NM_010130.4.
XP_006523664.1. XM_006523601.1.
UniGeneiMm.2254.

Genome annotation databases

EnsembliENSMUST00000004850; ENSMUSP00000004850; ENSMUSG00000004730.
ENSMUST00000086763; ENSMUSP00000083971; ENSMUSG00000004730.
GeneIDi13733.
KEGGimmu:13733.
UCSCiuc008det.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X93328 mRNA. Translation: CAA63720.1 .
U66888 mRNA. Translation: AAC53184.1 .
BC075688 mRNA. Translation: AAH75688.1 .
CCDSi CCDS50160.1.
RefSeqi NP_034260.1. NM_010130.4.
XP_006523664.1. XM_006523601.1.
UniGenei Mm.2254.

3D structure databases

ProteinModelPortali Q61549.
SMRi Q61549. Positions 42-355, 436-629, 649-893.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S63.951.
GPCRDBi Search...

PTM databases

PhosphoSitei Q61549.

Proteomic databases

MaxQBi Q61549.
PaxDbi Q61549.
PRIDEi Q61549.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004850 ; ENSMUSP00000004850 ; ENSMUSG00000004730 .
ENSMUST00000086763 ; ENSMUSP00000083971 ; ENSMUSG00000004730 .
GeneIDi 13733.
KEGGi mmu:13733.
UCSCi uc008det.2. mouse.

Organism-specific databases

CTDi 2015.
MGIi MGI:106912. Emr1.

Phylogenomic databases

eggNOGi NOG239437.
GeneTreei ENSGT00710000106562.
HOGENOMi HOG000294115.
HOVERGENi HBG048917.
InParanoidi Q61549.
KOi K04591.
OMAi RNHNTYL.
OrthoDBi EOG7WHH8Q.
PhylomeDBi Q61549.
TreeFami TF316380.

Miscellaneous databases

NextBioi 284538.
PROi Q61549.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61549.
Bgeei Q61549.
Genevestigatori Q61549.

Family and domain databases

InterProi IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 6 hits.
SM00303. GPS. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 6 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 5 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family."
    McKnight A.J., Macfarlane A.J., Dri P., Turley L., Willis A.C., Gordon S.
    J. Biol. Chem. 271:486-489(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Peritoneal cavity.
  2. "Identification and characterization of a seven transmembrane hormone receptor using differential display."
    Lin H.H., Stubbs L.J., Mucenski M.L.
    Genomics 41:301-308(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiEMR1_MOUSE
AccessioniPrimary (citable) accession number: Q61549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi