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Protein

Adhesion G protein-coupled receptor E1

Gene

Adgre1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Adaptive immunity, Immunity

Keywords - Ligandi

Calcium

Protein family/group databases

MEROPSiP02.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor E1
Alternative name(s):
Cell surface glycoprotein F4/80
EGF-like module receptor 1
EGF-like module-containing mucin-like hormone receptor-like 1
EMR1 hormone receptor
Gene namesi
Name:Adgre1
Synonyms:Emr1, Gpf480
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:106912. Adgre1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 644ExtracellularCuratedAdd BLAST617
Transmembranei645 – 672Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini673 – 679CytoplasmicCurated7
Transmembranei680 – 701Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini702 – 711ExtracellularCurated10
Transmembranei712 – 735Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini736 – 754CytoplasmicCuratedAdd BLAST19
Transmembranei755 – 776Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini777 – 792ExtracellularCuratedAdd BLAST16
Transmembranei793 – 821Helical; Name=5Sequence analysisAdd BLAST29
Topological domaini822 – 839CytoplasmicCuratedAdd BLAST18
Transmembranei840 – 859Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini860 – 874ExtracellularCuratedAdd BLAST15
Transmembranei875 – 897Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini898 – 931CytoplasmicCuratedAdd BLAST34

GO - Cellular componenti

  • cell periphery Source: MGI
  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Deficient mice fail to develop peripheral tolerance after inoculation with antigen because of a lack of efferent regulatory T-cell development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001287428 – 931Adhesion G protein-coupled receptor E1Add BLAST904

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 48PROSITE-ProRule annotation
Disulfide bondi42 ↔ 57PROSITE-ProRule annotation
Disulfide bondi59 ↔ 79PROSITE-ProRule annotation
Disulfide bondi85 ↔ 98PROSITE-ProRule annotation
Disulfide bondi92 ↔ 107PROSITE-ProRule annotation
Disulfide bondi109 ↔ 131PROSITE-ProRule annotation
Disulfide bondi137 ↔ 149PROSITE-ProRule annotation
Disulfide bondi143 ↔ 158PROSITE-ProRule annotation
Glycosylationi148N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi160 ↔ 171PROSITE-ProRule annotation
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi177 ↔ 189PROSITE-ProRule annotation
Disulfide bondi183 ↔ 198PROSITE-ProRule annotation
Disulfide bondi200 ↔ 220PROSITE-ProRule annotation
Disulfide bondi226 ↔ 239PROSITE-ProRule annotation
Glycosylationi229N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi233 ↔ 248PROSITE-ProRule annotation
Disulfide bondi250 ↔ 270PROSITE-ProRule annotation
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi276 ↔ 286PROSITE-ProRule annotation
Disulfide bondi280 ↔ 295PROSITE-ProRule annotation
Glycosylationi283N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi297 ↔ 317PROSITE-ProRule annotation
Disulfide bondi323 ↔ 336PROSITE-ProRule annotation
Disulfide bondi330 ↔ 345PROSITE-ProRule annotation
Disulfide bondi347 ↔ 366PROSITE-ProRule annotation
Glycosylationi405N-linked (GlcNAc...)Sequence analysis1
Glycosylationi417N-linked (GlcNAc...)Sequence analysis1
Glycosylationi474N-linked (GlcNAc...)Sequence analysis1
Glycosylationi498N-linked (GlcNAc...)Sequence analysis1
Glycosylationi706N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61549.
PaxDbiQ61549.
PRIDEiQ61549.

PTM databases

iPTMnetiQ61549.
PhosphoSitePlusiQ61549.

Expressioni

Tissue specificityi

In macrophages; but absent from those which are localized within T-cell areas of lymph nodes and spleen. Low level of expression on blood monocytes.

Gene expression databases

BgeeiENSMUSG00000004730.
ExpressionAtlasiQ61549. baseline and differential.
GenevisibleiQ61549. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004850.

Structurei

3D structure databases

ProteinModelPortaliQ61549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 80EGF-like 1PROSITE-ProRule annotationAdd BLAST49
Domaini81 – 132EGF-like 2PROSITE-ProRule annotationAdd BLAST52
Domaini133 – 172EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini173 – 221EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST49
Domaini222 – 271EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST50
Domaini272 – 318EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST47
Domaini319 – 367EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST49
Domaini592 – 641GPSPROSITE-ProRule annotationAdd BLAST50

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi506 – 508Cell attachment siteSequence analysis3

Sequence similaritiesi

Contains 7 EGF-like domains.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000294115.
HOVERGENiHBG048917.
InParanoidiQ61549.
KOiK04591.
OMAiCENKTTV.
OrthoDBiEOG091G00GJ.
PhylomeDBiQ61549.
TreeFamiTF316380.

Family and domain databases

InterProiIPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1-like_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 5 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 7 hits.
SM00179. EGF_CA. 7 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 5 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGFWLLLFW GFSGMYRWGM TTLPTLGQTL GGVNECQDTT TCPAYATCTD
60 70 80 90 100
TTDSYYCTCK RGFLSSNGQT NFQGPGVECQ DVNECLQSDS PCGPNSVCTN
110 120 130 140 150
ILGRAKCSCL RGFSSSTGKD WILGSLDNFL CADVDECLTI GICPKYSNCS
160 170 180 190 200
NSVGSYSCTC QPGFVLNGSI CEDEDECVTR DVCPEHATCH NTLGSYYCTC
210 220 230 240 250
NSGLESSGGG PMFQGLDESC EDVDECSRNS TLCGPTFICI NTLGSYSCSC
260 270 280 290 300
PAGFSLPTFQ ILGHPADGNC TDIDECDDTC PLNSSCTNTI GSYFCTCHPG
310 320 330 340 350
FASSNGQLNF KDLEVTCEDI DECTQDPLQC GLNSVCTNVP GSYICGCLPD
360 370 380 390 400
FQMDPEGSQG YGNFNCKRIL FKCKEDLILQ SEQIQQCQAV QGRDLGYASF
410 420 430 440 450
CTLVNATFTI LDNTCENKSA PVSLQSAATS VSLVLEQATT WFELSKEETS
460 470 480 490 500
TLGTILLETV ESTMLAALLI PSGNASQMIQ TEYLDIESKV INEECKENES
510 520 530 540 550
INLAARGDKM NVGCFIIKES VSTGAPGVAF VSFAHMESVL NERFFEDGQS
560 570 580 590 600
FRKLRMNSRV VGGTVTGEKK EDFSKPIIYT LQHIQPKQKS ERPICVSWNT
610 620 630 640 650
DVEDGRWTPS GCEIVEASET HTVCSCNRMA NLAIIMASGE LTMEFSLYII
660 670 680 690 700
SHVGTVISLV CLALAIATFL LCRAVQNHNT YMHLHLCVCL FLAKILFLTG
710 720 730 740 750
IDKTDNQTAC AIIAGFLHYL FLACFFWMLV EAVMLFLMVR NLKVVNYFSS
760 770 780 790 800
RNIKMLHLCA FGYGLPVLVV IISASVQPRG YGMHNRCWLN TETGFIWSFL
810 820 830 840 850
GPVCMIITIN SVLLAWTLWV LRQKLCSVSS EVSKLKDTRL LTFKAIAQIF
860 870 880 890 900
ILGCSWVLGI FQIGPLASIM AYLFTIINSL QGAFIFLIHC LLNRQVRDEY
910 920 930
KKLLTRKTDL SSHSQTSGIL LSSMPSTSKM G
Length:931
Mass (Da):102,130
Last modified:November 1, 1997 - v1
Checksum:i52963A667E8B76B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93328 mRNA. Translation: CAA63720.1.
U66888 mRNA. Translation: AAC53184.1.
BC075688 mRNA. Translation: AAH75688.1.
CCDSiCCDS50160.1.
RefSeqiNP_034260.1. NM_010130.4.
XP_006523664.1. XM_006523601.1.
UniGeneiMm.2254.

Genome annotation databases

EnsembliENSMUST00000004850; ENSMUSP00000004850; ENSMUSG00000004730.
ENSMUST00000086763; ENSMUSP00000083971; ENSMUSG00000004730.
GeneIDi13733.
KEGGimmu:13733.
UCSCiuc008det.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93328 mRNA. Translation: CAA63720.1.
U66888 mRNA. Translation: AAC53184.1.
BC075688 mRNA. Translation: AAH75688.1.
CCDSiCCDS50160.1.
RefSeqiNP_034260.1. NM_010130.4.
XP_006523664.1. XM_006523601.1.
UniGeneiMm.2254.

3D structure databases

ProteinModelPortaliQ61549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004850.

Protein family/group databases

MEROPSiP02.951.
GPCRDBiSearch...

PTM databases

iPTMnetiQ61549.
PhosphoSitePlusiQ61549.

Proteomic databases

MaxQBiQ61549.
PaxDbiQ61549.
PRIDEiQ61549.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004850; ENSMUSP00000004850; ENSMUSG00000004730.
ENSMUST00000086763; ENSMUSP00000083971; ENSMUSG00000004730.
GeneIDi13733.
KEGGimmu:13733.
UCSCiuc008det.2. mouse.

Organism-specific databases

CTDi2015.
MGIiMGI:106912. Adgre1.

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000294115.
HOVERGENiHBG048917.
InParanoidiQ61549.
KOiK04591.
OMAiCENKTTV.
OrthoDBiEOG091G00GJ.
PhylomeDBiQ61549.
TreeFamiTF316380.

Miscellaneous databases

PROiQ61549.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004730.
ExpressionAtlasiQ61549. baseline and differential.
GenevisibleiQ61549. MM.

Family and domain databases

InterProiIPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1-like_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 5 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 7 hits.
SM00179. EGF_CA. 7 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 5 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRE1_MOUSE
AccessioniPrimary (citable) accession number: Q61549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.