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Q61549 (EMR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
EGF-like module-containing mucin-like hormone receptor-like 1
Alternative name(s):
Cell surface glycoprotein F4/80
EGF-like module receptor 1
EMR1 hormone receptor
Gene names
Name:Emr1
Synonyms:Gpf480
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length931 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Could be involved in cell-cell interactions.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

In macrophages; but absent from those which are localized within T-cell areas of lymph nodes and spleen. Low level of expression on blood monocytes.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 7 EGF-like domains.

Contains 1 GPS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 931904EGF-like module-containing mucin-like hormone receptor-like 1
PRO_0000012874

Regions

Topological domain28 – 644617Extracellular Potential
Transmembrane645 – 67228Helical; Name=1; Potential
Topological domain673 – 6797Cytoplasmic Potential
Transmembrane680 – 70122Helical; Name=2; Potential
Topological domain702 – 71110Extracellular Potential
Transmembrane712 – 73524Helical; Name=3; Potential
Topological domain736 – 75419Cytoplasmic Potential
Transmembrane755 – 77622Helical; Name=4; Potential
Topological domain777 – 79216Extracellular Potential
Transmembrane793 – 82129Helical; Name=5; Potential
Topological domain822 – 83918Cytoplasmic Potential
Transmembrane840 – 85920Helical; Name=6; Potential
Topological domain860 – 87415Extracellular Potential
Transmembrane875 – 89723Helical; Name=7; Potential
Topological domain898 – 93134Cytoplasmic Potential
Domain32 – 8049EGF-like 1
Domain81 – 13252EGF-like 2
Domain133 – 17240EGF-like 3; calcium-binding Potential
Domain173 – 22149EGF-like 4; calcium-binding Potential
Domain222 – 27150EGF-like 5; calcium-binding Potential
Domain272 – 31847EGF-like 6; calcium-binding Potential
Domain319 – 36749EGF-like 7; calcium-binding Potential
Domain592 – 64150GPS
Motif506 – 5083Cell attachment site Potential

Amino acid modifications

Glycosylation1481N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation2831N-linked (GlcNAc...) Potential
Glycosylation4051N-linked (GlcNAc...) Potential
Glycosylation4171N-linked (GlcNAc...) Potential
Glycosylation4741N-linked (GlcNAc...) Potential
Glycosylation4981N-linked (GlcNAc...) Potential
Glycosylation7061N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 48 By similarity
Disulfide bond42 ↔ 57 By similarity
Disulfide bond59 ↔ 79 By similarity
Disulfide bond85 ↔ 98 By similarity
Disulfide bond92 ↔ 107 By similarity
Disulfide bond109 ↔ 131 By similarity
Disulfide bond137 ↔ 149 By similarity
Disulfide bond143 ↔ 158 By similarity
Disulfide bond160 ↔ 171 By similarity
Disulfide bond177 ↔ 189 By similarity
Disulfide bond183 ↔ 198 By similarity
Disulfide bond200 ↔ 220 By similarity
Disulfide bond226 ↔ 239 By similarity
Disulfide bond233 ↔ 248 By similarity
Disulfide bond250 ↔ 270 By similarity
Disulfide bond276 ↔ 286 By similarity
Disulfide bond280 ↔ 295 By similarity
Disulfide bond297 ↔ 317 By similarity
Disulfide bond323 ↔ 336 By similarity
Disulfide bond330 ↔ 345 By similarity
Disulfide bond347 ↔ 366 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q61549 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 52963A667E8B76B5

FASTA931102,130
        10         20         30         40         50         60 
MWGFWLLLFW GFSGMYRWGM TTLPTLGQTL GGVNECQDTT TCPAYATCTD TTDSYYCTCK 

        70         80         90        100        110        120 
RGFLSSNGQT NFQGPGVECQ DVNECLQSDS PCGPNSVCTN ILGRAKCSCL RGFSSSTGKD 

       130        140        150        160        170        180 
WILGSLDNFL CADVDECLTI GICPKYSNCS NSVGSYSCTC QPGFVLNGSI CEDEDECVTR 

       190        200        210        220        230        240 
DVCPEHATCH NTLGSYYCTC NSGLESSGGG PMFQGLDESC EDVDECSRNS TLCGPTFICI 

       250        260        270        280        290        300 
NTLGSYSCSC PAGFSLPTFQ ILGHPADGNC TDIDECDDTC PLNSSCTNTI GSYFCTCHPG 

       310        320        330        340        350        360 
FASSNGQLNF KDLEVTCEDI DECTQDPLQC GLNSVCTNVP GSYICGCLPD FQMDPEGSQG 

       370        380        390        400        410        420 
YGNFNCKRIL FKCKEDLILQ SEQIQQCQAV QGRDLGYASF CTLVNATFTI LDNTCENKSA 

       430        440        450        460        470        480 
PVSLQSAATS VSLVLEQATT WFELSKEETS TLGTILLETV ESTMLAALLI PSGNASQMIQ 

       490        500        510        520        530        540 
TEYLDIESKV INEECKENES INLAARGDKM NVGCFIIKES VSTGAPGVAF VSFAHMESVL 

       550        560        570        580        590        600 
NERFFEDGQS FRKLRMNSRV VGGTVTGEKK EDFSKPIIYT LQHIQPKQKS ERPICVSWNT 

       610        620        630        640        650        660 
DVEDGRWTPS GCEIVEASET HTVCSCNRMA NLAIIMASGE LTMEFSLYII SHVGTVISLV 

       670        680        690        700        710        720 
CLALAIATFL LCRAVQNHNT YMHLHLCVCL FLAKILFLTG IDKTDNQTAC AIIAGFLHYL 

       730        740        750        760        770        780 
FLACFFWMLV EAVMLFLMVR NLKVVNYFSS RNIKMLHLCA FGYGLPVLVV IISASVQPRG 

       790        800        810        820        830        840 
YGMHNRCWLN TETGFIWSFL GPVCMIITIN SVLLAWTLWV LRQKLCSVSS EVSKLKDTRL 

       850        860        870        880        890        900 
LTFKAIAQIF ILGCSWVLGI FQIGPLASIM AYLFTIINSL QGAFIFLIHC LLNRQVRDEY 

       910        920        930 
KKLLTRKTDL SSHSQTSGIL LSSMPSTSKM G 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family."
McKnight A.J., Macfarlane A.J., Dri P., Turley L., Willis A.C., Gordon S.
J. Biol. Chem. 271:486-489(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Peritoneal cavity.
[2]"Identification and characterization of a seven transmembrane hormone receptor using differential display."
Lin H.H., Stubbs L.J., Mucenski M.L.
Genomics 41:301-308(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X93328 mRNA. Translation: CAA63720.1.
U66888 mRNA. Translation: AAC53184.1.
BC075688 mRNA. Translation: AAH75688.1.
RefSeqNP_034260.1. NM_010130.4.
XP_006523664.1. XM_006523601.1.
UniGeneMm.2254.

3D structure databases

ProteinModelPortalQ61549.
SMRQ61549. Positions 11-355, 436-629, 649-893.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS63.951.
GPCRDBSearch...

PTM databases

PhosphoSiteQ61549.

Proteomic databases

PaxDbQ61549.
PRIDEQ61549.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000004850; ENSMUSP00000004850; ENSMUSG00000004730.
ENSMUST00000086763; ENSMUSP00000083971; ENSMUSG00000004730.
GeneID13733.
KEGGmmu:13733.
UCSCuc008det.2. mouse.

Organism-specific databases

CTD2015.
MGIMGI:106912. Emr1.

Phylogenomic databases

eggNOGNOG239437.
GeneTreeENSGT00710000106562.
HOGENOMHOG000294115.
HOVERGENHBG048917.
InParanoidQ61549.
KOK04591.
OMARNHNTYL.
OrthoDBEOG7WHH8Q.
PhylomeDBQ61549.
TreeFamTF316380.

Gene expression databases

ArrayExpressQ61549.
BgeeQ61549.
GenevestigatorQ61549.

Family and domain databases

InterProIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR001740. GPCR_2_EMR1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSPR01128. EMR1HORMONER.
PR00249. GPCRSECRETIN.
SMARTSM00181. EGF. 1 hit.
SM00179. EGF_CA. 6 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 2 hits.
PROSITEPS00010. ASX_HYDROXYL. 6 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 5 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284538.
PROQ61549.
SOURCESearch...

Entry information

Entry nameEMR1_MOUSE
AccessionPrimary (citable) accession number: Q61549
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries