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Q61549

- EMR1_MOUSE

UniProt

Q61549 - EMR1_MOUSE

Protein

EGF-like module-containing mucin-like hormone receptor-like 1

Gene

Emr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Could be involved in cell-cell interactions.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Calcium

    Protein family/group databases

    MEROPSiS63.951.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EGF-like module-containing mucin-like hormone receptor-like 1
    Alternative name(s):
    Cell surface glycoprotein F4/80
    EGF-like module receptor 1
    EMR1 hormone receptor
    Gene namesi
    Name:Emr1
    Synonyms:Gpf480
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:106912. Emr1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell periphery Source: MGI
    2. external side of plasma membrane Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 931904EGF-like module-containing mucin-like hormone receptor-like 1PRO_0000012874Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 48PROSITE-ProRule annotation
    Disulfide bondi42 ↔ 57PROSITE-ProRule annotation
    Disulfide bondi59 ↔ 79PROSITE-ProRule annotation
    Disulfide bondi85 ↔ 98PROSITE-ProRule annotation
    Disulfide bondi92 ↔ 107PROSITE-ProRule annotation
    Disulfide bondi109 ↔ 131PROSITE-ProRule annotation
    Disulfide bondi137 ↔ 149PROSITE-ProRule annotation
    Disulfide bondi143 ↔ 158PROSITE-ProRule annotation
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi160 ↔ 171PROSITE-ProRule annotation
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi177 ↔ 189PROSITE-ProRule annotation
    Disulfide bondi183 ↔ 198PROSITE-ProRule annotation
    Disulfide bondi200 ↔ 220PROSITE-ProRule annotation
    Disulfide bondi226 ↔ 239PROSITE-ProRule annotation
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi233 ↔ 248PROSITE-ProRule annotation
    Disulfide bondi250 ↔ 270PROSITE-ProRule annotation
    Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi276 ↔ 286PROSITE-ProRule annotation
    Disulfide bondi280 ↔ 295PROSITE-ProRule annotation
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi297 ↔ 317PROSITE-ProRule annotation
    Disulfide bondi323 ↔ 336PROSITE-ProRule annotation
    Disulfide bondi330 ↔ 345PROSITE-ProRule annotation
    Disulfide bondi347 ↔ 366PROSITE-ProRule annotation
    Glycosylationi405 – 4051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi706 – 7061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ61549.
    PaxDbiQ61549.
    PRIDEiQ61549.

    PTM databases

    PhosphoSiteiQ61549.

    Expressioni

    Tissue specificityi

    In macrophages; but absent from those which are localized within T-cell areas of lymph nodes and spleen. Low level of expression on blood monocytes.

    Gene expression databases

    ArrayExpressiQ61549.
    BgeeiQ61549.
    GenevestigatoriQ61549.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61549.
    SMRiQ61549. Positions 42-355, 436-629, 649-893.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 644617ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini673 – 6797CytoplasmicSequence Analysis
    Topological domaini702 – 71110ExtracellularSequence Analysis
    Topological domaini736 – 75419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini777 – 79216ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini822 – 83918CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini860 – 87415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini898 – 93134CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei645 – 67228Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei680 – 70122Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei712 – 73524Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei755 – 77622Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei793 – 82129Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei840 – 85920Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei875 – 89723Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 8049EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini81 – 13252EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini133 – 17240EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini173 – 22149EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini222 – 27150EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini272 – 31847EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini319 – 36749EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini592 – 64150GPSPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi506 – 5083Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Contains 7 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 GPS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG239437.
    GeneTreeiENSGT00710000106562.
    HOGENOMiHOG000294115.
    HOVERGENiHBG048917.
    InParanoidiQ61549.
    KOiK04591.
    OMAiRNHNTYL.
    OrthoDBiEOG7WHH8Q.
    PhylomeDBiQ61549.
    TreeFamiTF316380.

    Family and domain databases

    InterProiIPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR017981. GPCR_2-like.
    IPR001740. GPCR_2_EMR1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF12662. cEGF. 2 hits.
    PF07645. EGF_CA. 3 hits.
    PF01825. GPS. 1 hit.
    [Graphical view]
    PRINTSiPR01128. EMR1HORMONER.
    PR00249. GPCRSECRETIN.
    SMARTiSM00181. EGF. 1 hit.
    SM00179. EGF_CA. 6 hits.
    SM00303. GPS. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 2 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 7 hits.
    PS01187. EGF_CA. 5 hits.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61549-1 [UniParc]FASTAAdd to Basket

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    MWGFWLLLFW GFSGMYRWGM TTLPTLGQTL GGVNECQDTT TCPAYATCTD    50
    TTDSYYCTCK RGFLSSNGQT NFQGPGVECQ DVNECLQSDS PCGPNSVCTN 100
    ILGRAKCSCL RGFSSSTGKD WILGSLDNFL CADVDECLTI GICPKYSNCS 150
    NSVGSYSCTC QPGFVLNGSI CEDEDECVTR DVCPEHATCH NTLGSYYCTC 200
    NSGLESSGGG PMFQGLDESC EDVDECSRNS TLCGPTFICI NTLGSYSCSC 250
    PAGFSLPTFQ ILGHPADGNC TDIDECDDTC PLNSSCTNTI GSYFCTCHPG 300
    FASSNGQLNF KDLEVTCEDI DECTQDPLQC GLNSVCTNVP GSYICGCLPD 350
    FQMDPEGSQG YGNFNCKRIL FKCKEDLILQ SEQIQQCQAV QGRDLGYASF 400
    CTLVNATFTI LDNTCENKSA PVSLQSAATS VSLVLEQATT WFELSKEETS 450
    TLGTILLETV ESTMLAALLI PSGNASQMIQ TEYLDIESKV INEECKENES 500
    INLAARGDKM NVGCFIIKES VSTGAPGVAF VSFAHMESVL NERFFEDGQS 550
    FRKLRMNSRV VGGTVTGEKK EDFSKPIIYT LQHIQPKQKS ERPICVSWNT 600
    DVEDGRWTPS GCEIVEASET HTVCSCNRMA NLAIIMASGE LTMEFSLYII 650
    SHVGTVISLV CLALAIATFL LCRAVQNHNT YMHLHLCVCL FLAKILFLTG 700
    IDKTDNQTAC AIIAGFLHYL FLACFFWMLV EAVMLFLMVR NLKVVNYFSS 750
    RNIKMLHLCA FGYGLPVLVV IISASVQPRG YGMHNRCWLN TETGFIWSFL 800
    GPVCMIITIN SVLLAWTLWV LRQKLCSVSS EVSKLKDTRL LTFKAIAQIF 850
    ILGCSWVLGI FQIGPLASIM AYLFTIINSL QGAFIFLIHC LLNRQVRDEY 900
    KKLLTRKTDL SSHSQTSGIL LSSMPSTSKM G 931
    Length:931
    Mass (Da):102,130
    Last modified:November 1, 1997 - v1
    Checksum:i52963A667E8B76B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X93328 mRNA. Translation: CAA63720.1.
    U66888 mRNA. Translation: AAC53184.1.
    BC075688 mRNA. Translation: AAH75688.1.
    CCDSiCCDS50160.1.
    RefSeqiNP_034260.1. NM_010130.4.
    XP_006523664.1. XM_006523601.1.
    UniGeneiMm.2254.

    Genome annotation databases

    EnsembliENSMUST00000004850; ENSMUSP00000004850; ENSMUSG00000004730.
    ENSMUST00000086763; ENSMUSP00000083971; ENSMUSG00000004730.
    GeneIDi13733.
    KEGGimmu:13733.
    UCSCiuc008det.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X93328 mRNA. Translation: CAA63720.1 .
    U66888 mRNA. Translation: AAC53184.1 .
    BC075688 mRNA. Translation: AAH75688.1 .
    CCDSi CCDS50160.1.
    RefSeqi NP_034260.1. NM_010130.4.
    XP_006523664.1. XM_006523601.1.
    UniGenei Mm.2254.

    3D structure databases

    ProteinModelPortali Q61549.
    SMRi Q61549. Positions 42-355, 436-629, 649-893.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S63.951.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q61549.

    Proteomic databases

    MaxQBi Q61549.
    PaxDbi Q61549.
    PRIDEi Q61549.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004850 ; ENSMUSP00000004850 ; ENSMUSG00000004730 .
    ENSMUST00000086763 ; ENSMUSP00000083971 ; ENSMUSG00000004730 .
    GeneIDi 13733.
    KEGGi mmu:13733.
    UCSCi uc008det.2. mouse.

    Organism-specific databases

    CTDi 2015.
    MGIi MGI:106912. Emr1.

    Phylogenomic databases

    eggNOGi NOG239437.
    GeneTreei ENSGT00710000106562.
    HOGENOMi HOG000294115.
    HOVERGENi HBG048917.
    InParanoidi Q61549.
    KOi K04591.
    OMAi RNHNTYL.
    OrthoDBi EOG7WHH8Q.
    PhylomeDBi Q61549.
    TreeFami TF316380.

    Miscellaneous databases

    NextBioi 284538.
    PROi Q61549.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61549.
    Bgeei Q61549.
    Genevestigatori Q61549.

    Family and domain databases

    InterProi IPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR017981. GPCR_2-like.
    IPR001740. GPCR_2_EMR1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF12662. cEGF. 2 hits.
    PF07645. EGF_CA. 3 hits.
    PF01825. GPS. 1 hit.
    [Graphical view ]
    PRINTSi PR01128. EMR1HORMONER.
    PR00249. GPCRSECRETIN.
    SMARTi SM00181. EGF. 1 hit.
    SM00179. EGF_CA. 6 hits.
    SM00303. GPS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 2 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 6 hits.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 7 hits.
    PS01187. EGF_CA. 5 hits.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family."
      McKnight A.J., Macfarlane A.J., Dri P., Turley L., Willis A.C., Gordon S.
      J. Biol. Chem. 271:486-489(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Peritoneal cavity.
    2. "Identification and characterization of a seven transmembrane hormone receptor using differential display."
      Lin H.H., Stubbs L.J., Mucenski M.L.
      Genomics 41:301-308(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye.

    Entry informationi

    Entry nameiEMR1_MOUSE
    AccessioniPrimary (citable) accession number: Q61549
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 136 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3