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Reviewed, UniProtKB/Swiss-Prot Q61543 (GSLG1_MOUSE)

Last modified June 16, 2009. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Golgi apparatus protein 1
Alternative name(s):
    Golgi sialoglycoprotein MG-160
    E-selectin ligand 1
      Short name=ESL-1
      Short name=Selel
Gene names
Name: Glg1
Synonyms: Esl1, Mg160, Selel
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length1175 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Binds fibroblast growth factor By similarity. Binds E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

Subcellular location

Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note: Golgi and microvilli on the cell surface. Ref.4

Tissue specificity

Widely expressed; found in myeloid cells, fibroblasts, colon carcinoma, endothelioma, teratocarcinoma, lymphoma, myeloma.

Post-translational modification

Fucosylation is essential for binding to E-selectin.

N-glycosylated. Contains sialic acid residues By similarity.

Sequence similarities

Contains 16 Cys-rich GLG1 repeats.

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Ontologies

Keywords
   Cellular componentCell membrane
Golgi apparatus
Membrane
   DomainRepeat
Signal
Transmembrane
   LigandSialic acid
   PTMGlycoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular componentGolgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 11751148Golgi apparatus protein 1
PRO_0000011121

Regions

Topological domain28 – 11411114Extracellular Potential
Transmembrane1142 – 116221 Potential
Topological domain1163 – 117513Cytoplasmic Potential
Repeat112 – 14534Cys-rich GLG1 1
Repeat146 – 20863Cys-rich GLG1 2
Repeat211 – 27464Cys-rich GLG1 3
Repeat282 – 34261Cys-rich GLG1 4
Repeat343 – 40967Cys-rich GLG1 5
Repeat410 – 46960Cys-rich GLG1 6
Repeat471 – 53363Cys-rich GLG1 7
Repeat534 – 60067Cys-rich GLG1 8
Repeat605 – 66460Cys-rich GLG1 9
Repeat666 – 72459Cys-rich GLG1 10
Repeat725 – 78460Cys-rich GLG1 11
Repeat792 – 85261Cys-rich GLG1 12
Repeat854 – 90754Cys-rich GLG1 13
Repeat908 – 97568Cys-rich GLG1 14
Repeat976 – 103156Cys-rich GLG1 15
Repeat1037 – 109761Cys-rich GLG1 16
Compositional bias46 – 516Poly-Gly
Compositional bias66 – 705Poly-Gln
Compositional bias74 – 829Poly-Gln

Amino acid modifications

Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation2061N-linked (GlcNAc...) Potential
Glycosylation5771N-linked (GlcNAc...) Potential
Glycosylation6731N-linked (GlcNAc...) Potential
Glycosylation7821N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q61543-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 105835DD38C7338B

FASTA1,175133,734
        10         20         30         40         50         60 
MAVCGRVRGM FRLSAALPLL LLAAAGAQNG HGQGQGPGTN FGPFPGQGGG GSPAGQQPPQ 

        70         80         90        100        110        120 
QPQLSQQQQQ PPPQQQQQQQ QQSLFAAGGL PARRGGAGPG GTGGGWKLAE EESCREDVTR 

       130        140        150        160        170        180 
VCPKHTWSNN LAVLECLQDV REPENEISSD CNHLLWNYKL NLTTDPKFES VAREVCKSTI 

       190        200        210        220        230        240 
SEIKECAEEP VGKGYMVSCL VDHRGNITEY QCHQYITKMT AIIFSDYRLI CGFMDDCKND 

       250        260        270        280        290        300 
INLLKCGSIR LGEKDAHSQG EVVSCLEKGL VKEAEEKEPK IQVSELCKKA ILRVAELSSD 

       310        320        330        340        350        360 
DFHLDRHLYF ACRDDRERFC ENTQAGEGRV YKCLFNHKFE ESMSEKCREA LTTRQKLIAQ 

       370        380        390        400        410        420 
DYKVSYSLAK SCKSDLKKYR CNVENLPRSR EARLSYLLMC LESAVHRGRQ VSSECQGEML 

       430        440        450        460        470        480 
DYRRMLMEDF SLSPEIILSC RGEIEHHCSG LHRKGRTLHC LMKVVRGEKG NLGMNCQQAL 

       490        500        510        520        530        540 
QTLIQETDPG ADYRIDRALN EACESVIQTA CKHIRSGDPM ILSCLMEHLY TEKMVEDCEH 

       550        560        570        580        590        600 
RLLELQYFIS RDWKLDPVLY RKCQGDASRL CHTHGWNETS ELMPPGAVFS CLYRHAYRTE 

       610        620        630        640        650        660 
EQGRRLSREC RAEVQRILHQ RAMDVKLDPA LQDKCLIDLG KWCSEKTETG QELECLQDHL 

       670        680        690        700        710        720 
DDLAVECRDI VGNLTELESE DIQIEALLMR ACEPIIQNFC HDVADNQIDS GDLMECLIQN 

       730        740        750        760        770        780 
KHQKDMNEKC AIGVTHFQLV QMKDFRFSYK FKMACKEDVL KLCPNIKKKV DVVICLSTTV 

       790        800        810        820        830        840 
RNDTLQEAKE HRVSLKCRKQ LRVEELEMTE DIRLEPDLYE ACKSDIKNYC STVQYGNAQI 

       850        860        870        880        890        900 
IECLKENKKQ LSTRCHQKVF KLQETEMMDP ELDYTLMRVC KQMIKRFCPE ADSKTMLQCL 

       910        920        930        940        950        960 
KQNKNSELMD PKCKQMITKR QITQNTDYRL NPVLRKACKA DIPKFCHGIL TKAKDDSELE 

       970        980        990       1000       1010       1020 
GQVISCLKLR YADQRLSSDC EDQIRIIIQE SALDYRLDPQ LQLHCSDEIA NLCAEEAAAQ 

      1030       1040       1050       1060       1070       1080 
EQTGQVEECL KVNLLKIKTE LCKKEVLNML KESKADIFVD PVLHTACALD IKHHCAAITP 

      1090       1100       1110       1120       1130       1140 
GRGRQMSCLM EALEDKRVRL QPECKKRLND RIEMWSYAAK VAPADGFSDL AMQVMTSPSK 

      1150       1160       1170 
NYILSVISGS ICILFLIGLM CGRITKRVTR ELKDR

« Hide

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References

« Hide 'large scale' references
[1]"The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor."
Steegmaier M., Levinovitz A., Isenmann S., Borges E., Lenter M., Kocher H.P., Kleuser B., Vestweber D.
Nature 373:615-620(1995) [PubMed: 7531823] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 255-266; 357-363; 636-641 AND 744-750.
Tissue: Neutrophil.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
[3]"Structure of the murine E-selectin ligand 1 (ESL-1) gene and assignment to chromosome 8."
Willmroth F., Beaudet A.L.
Mamm. Genome 10:1085-1088(1999) [PubMed: 10556428] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-138.
Strain: 129/Sv.
Tissue: Embryonic stem cell.
[4]"The E-selectin-ligand ESL-1 is located in the Golgi as well as on microvilli on the cell surface."
Steegmaier M., Borges E., Berger J., Schwarz H., Vestweber D.
J. Cell Sci. 110:687-694(1997) [PubMed: 9099943] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X84037 mRNA. Translation: CAA58855.1.
BC021306 mRNA. Translation: AAH21306.1.
Y12462 Genomic DNA. Translation: CAA73066.1.
IPIIPI00122399.
PIRS52417.
RefSeqNP_033175.1.
UniGeneMm.276271
Mm.440619

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteQ61543.

Proteomic databases

PRIDEQ61543.

Genome annotation databases

EnsemblENSMUSG00000003316. Mus musculus. [Contig view]
GeneID20340.
KEGGmmu:20340.

Organism-specific databases

MGIMGI:104967. Glg1.

Phylogenomic databases

HOGENOMQ61543.
HOVERGENQ61543.
OMAQ61543. EKDAHSQ.

Gene expression databases

ArrayExpressQ61543.
BgeeQ61543.
CleanExMM_GLG1.
GermOnlineENSMUSG00000003316. Mus musculus.

Family and domain databases

InterProIPR017873. Cys-rich_GLG1_repeat.
IPR001893. Cys_rich_FGFR.
[Graphical view]
PfamPF00839. Cys_rich_FGFR. 15 hits.
[Graphical view]
PROSITEPS51289. GLG1_C_RICH. 16 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio298161.
SOURCESearch...

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Entry information

Entry nameGSLG1_MOUSE
AccessionPrimary (citable) accession number: Q61543
Secondary accession number(s): Q9QZ40
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents