Golgi apparatus protein 1 precursor

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Q61543 (GSLG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Golgi apparatus protein 1

Alternative name(s):
E-selectin ligand 1
Short name=ESL-1
Short name=Selel
Golgi sialoglycoprotein MG-160

Gene names

Name:	Glg1
Synonyms:	Esl1, Mg160, Selel

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1175 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds fibroblast growth factor By similarity. Binds E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
Subcellular location	Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note: Golgi and microvilli on the cell surface. Ref.4
Tissue specificity	Widely expressed; found in myeloid cells, fibroblasts, colon carcinoma, endothelioma, teratocarcinoma, lymphoma, myeloma.
Post-translational modification	Fucosylation is essential for binding to E-selectin. Contains sialic acid residues By similarity.
Sequence similarities	Contains 16 Cys-rich GLG1 repeats.

Ontologies

Keywords
Cellular component	Cell membrane Golgi apparatus Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Sialic acid
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	bone morphogenesis Inferred from mutant phenotype. Source: MGI negative regulation of protein processing Inferred from mutant phenotype. Source: MGI negative regulation of transforming growth factor beta receptor signaling pathway Inferred from mutant phenotype. Source: MGI regulation of chondrocyte differentiation Inferred from mutant phenotype. Source: MGI
Cellular component	Golgi membrane Inferred from direct assay. Source: MGI extracellular matrix Inferred from direct assay. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 27

Potential

Chain

28 – 1175

1148

Golgi apparatus protein 1

PRO_0000011121

Regions

Topological domain

28 – 1141

1114

Extracellular Potential

Transmembrane

1142 – 1162

Helical; Potential

Topological domain

1163 – 1175

Cytoplasmic Potential

Repeat

112 – 145

Cys-rich GLG1 1

Repeat

146 – 208

Cys-rich GLG1 2

Repeat

211 – 274

Cys-rich GLG1 3

Repeat

282 – 342

Cys-rich GLG1 4

Repeat

343 – 409

Cys-rich GLG1 5

Repeat

410 – 469

Cys-rich GLG1 6

Repeat

471 – 533

Cys-rich GLG1 7

Repeat

534 – 600

Cys-rich GLG1 8

Repeat

605 – 664

Cys-rich GLG1 9

Repeat

666 – 724

Cys-rich GLG1 10

Repeat

725 – 784

Cys-rich GLG1 11

Repeat

792 – 852

Cys-rich GLG1 12

Repeat

854 – 907

Cys-rich GLG1 13

Repeat

908 – 975

Cys-rich GLG1 14

Repeat

976 – 1031

Cys-rich GLG1 15

Repeat

1037 – 1097

Cys-rich GLG1 16

Compositional bias

46 – 51

Poly-Gly

Compositional bias

66 – 70

Poly-Gln

Compositional bias

74 – 82

Poly-Gln

Amino acid modifications

Glycosylation

161

N-linked (GlcNAc...) Ref.5

Glycosylation

206

N-linked (GlcNAc...) Ref.6

Glycosylation

577

N-linked (GlcNAc...) Potential

Glycosylation

673

N-linked (GlcNAc...) Ref.5

Glycosylation

782

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q61543 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 105835DD38C7338B
Show »

FASTA

1,175

133,734

        10         20         30         40         50         60 
MAVCGRVRGM FRLSAALPLL LLAAAGAQNG HGQGQGPGTN FGPFPGQGGG GSPAGQQPPQ 

        70         80         90        100        110        120 
QPQLSQQQQQ PPPQQQQQQQ QQSLFAAGGL PARRGGAGPG GTGGGWKLAE EESCREDVTR 

       130        140        150        160        170        180 
VCPKHTWSNN LAVLECLQDV REPENEISSD CNHLLWNYKL NLTTDPKFES VAREVCKSTI 

       190        200        210        220        230        240 
SEIKECAEEP VGKGYMVSCL VDHRGNITEY QCHQYITKMT AIIFSDYRLI CGFMDDCKND 

       250        260        270        280        290        300 
INLLKCGSIR LGEKDAHSQG EVVSCLEKGL VKEAEEKEPK IQVSELCKKA ILRVAELSSD 

       310        320        330        340        350        360 
DFHLDRHLYF ACRDDRERFC ENTQAGEGRV YKCLFNHKFE ESMSEKCREA LTTRQKLIAQ 

       370        380        390        400        410        420 
DYKVSYSLAK SCKSDLKKYR CNVENLPRSR EARLSYLLMC LESAVHRGRQ VSSECQGEML 

       430        440        450        460        470        480 
DYRRMLMEDF SLSPEIILSC RGEIEHHCSG LHRKGRTLHC LMKVVRGEKG NLGMNCQQAL 

       490        500        510        520        530        540 
QTLIQETDPG ADYRIDRALN EACESVIQTA CKHIRSGDPM ILSCLMEHLY TEKMVEDCEH 

       550        560        570        580        590        600 
RLLELQYFIS RDWKLDPVLY RKCQGDASRL CHTHGWNETS ELMPPGAVFS CLYRHAYRTE 

       610        620        630        640        650        660 
EQGRRLSREC RAEVQRILHQ RAMDVKLDPA LQDKCLIDLG KWCSEKTETG QELECLQDHL 

       670        680        690        700        710        720 
DDLAVECRDI VGNLTELESE DIQIEALLMR ACEPIIQNFC HDVADNQIDS GDLMECLIQN 

       730        740        750        760        770        780 
KHQKDMNEKC AIGVTHFQLV QMKDFRFSYK FKMACKEDVL KLCPNIKKKV DVVICLSTTV 

       790        800        810        820        830        840 
RNDTLQEAKE HRVSLKCRKQ LRVEELEMTE DIRLEPDLYE ACKSDIKNYC STVQYGNAQI 

       850        860        870        880        890        900 
IECLKENKKQ LSTRCHQKVF KLQETEMMDP ELDYTLMRVC KQMIKRFCPE ADSKTMLQCL 

       910        920        930        940        950        960 
KQNKNSELMD PKCKQMITKR QITQNTDYRL NPVLRKACKA DIPKFCHGIL TKAKDDSELE 

       970        980        990       1000       1010       1020 
GQVISCLKLR YADQRLSSDC EDQIRIIIQE SALDYRLDPQ LQLHCSDEIA NLCAEEAAAQ 

      1030       1040       1050       1060       1070       1080 
EQTGQVEECL KVNLLKIKTE LCKKEVLNML KESKADIFVD PVLHTACALD IKHHCAAITP 

      1090       1100       1110       1120       1130       1140 
GRGRQMSCLM EALEDKRVRL QPECKKRLND RIEMWSYAAK VAPADGFSDL AMQVMTSPSK 

      1150       1160       1170 
NYILSVISGS ICILFLIGLM CGRITKRVTR ELKDR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor." Steegmaier M., Levinovitz A., Isenmann S., Borges E., Lenter M., Kocher H.P., Kleuser B., Vestweber D. Nature 373:615-620(1995) [PubMed: 7531823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 255-266; 357-363; 636-641 AND 744-750. Tissue: Neutrophil.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney.
[3]	"Structure of the murine E-selectin ligand 1 (ESL-1) gene and assignment to chromosome 8." Willmroth F., Beaudet A.L. Mamm. Genome 10:1085-1088(1999) [PubMed: 10556428] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 1-138. Strain: 129/Sv. Tissue: Embryonic stem cell.
[4]	"The E-selectin-ligand ESL-1 is located in the Golgi as well as on microvilli on the cell surface." Steegmaier M., Borges E., Berger J., Schwarz H., Vestweber D. J. Cell Sci. 110:687-694(1997) [PubMed: 9099943] [Abstract] Cited for: SUBCELLULAR LOCATION.
[5]	"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation." Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B. Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed: 19656770] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-161 AND ASN-673, MASS SPECTROMETRY. Tissue: Myoblast.
[6]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-206, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X84037 mRNA. Translation: CAA58855.1. BC021306 mRNA. Translation: AAH21306.1. Y12462 Genomic DNA. Translation: CAA73066.1.
IPI	IPI00122399.
PIR	S52417.
RefSeq	NP_033175.1. NM_009149.2.
UniGene	Mm.276271. Mm.440619.
3D structure databases
ProteinModelPortal	Q61543.
ModBase	Search...
Protein-protein interaction databases
STRING	Q61543.
PTM databases
PhosphoSite	Q61543.
Proteomic databases
PRIDE	Q61543.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000169020; ENSMUSP00000131355; ENSMUSG00000003316.
GeneID	20340.
KEGG	mmu:20340.
Organism-specific databases
CTD	2734.
MGI	MGI:104967. Glg1.
Phylogenomic databases
HOGENOM	HBG358482.
HOVERGEN	HBG051850.
InParanoid	Q61543.
OMA	EKDAHSQ.
OrthoDB	EOG4JWVCP.
PhylomeDB	Q61543.
Gene expression databases
ArrayExpress	Q61543.
Bgee	Q61543.
CleanEx	MM_GLG1.
Genevestigator	Q61543.
GermOnline	ENSMUSG00000003316. Mus musculus.
Family and domain databases
InterPro	IPR001893. Cys-rich_GLG1_repeat. IPR017873. Cys-rich_GLG1_repeat_euk. [Graphical view]
KO	K06816.
Pfam	PF00839. Cys_rich_FGFR. 15 hits. [Graphical view]
PROSITE	PS51289. GLG1_C_RICH. 16 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	298161.
SOURCE	Search...

Entry information

Entry name

GSLG1_MOUSE

Accession

Primary (citable) accession number: Q61543
Secondary accession number(s): Q9QZ40

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents