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Protein

StAR-related lipid transfer protein 3

Gene

Stard3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • lipid transport Source: UniProtKB-KW
  • progesterone biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Steroidogenesis, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
StAR-related lipid transfer protein 3
Alternative name(s):
Protein ES 64
Protein MLN 64
START domain-containing protein 3
Short name:
StARD3
Gene namesi
Name:Stard3
Synonyms:Es64, Mln64
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1929618. Stard3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252CytoplasmicSequence analysisAdd
BLAST
Transmembranei53 – 7321HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini74 – 9522ExtracellularSequence analysisAdd
BLAST
Transmembranei96 – 11621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini117 – 1215CytoplasmicSequence analysis
Transmembranei122 – 14221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini143 – 1497ExtracellularSequence analysis
Transmembranei150 – 17021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini171 – 446276CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: MGI
  • endosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: MGI
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446StAR-related lipid transfer protein 3PRO_0000220654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei210 – 2101PhosphoserineCombined sources
Modified residuei218 – 2181PhosphoserineCombined sources
Modified residuei222 – 2221PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ61542.
MaxQBiQ61542.
PaxDbiQ61542.
PRIDEiQ61542.

PTM databases

iPTMnetiQ61542.
PhosphoSiteiQ61542.

Expressioni

Gene expression databases

BgeeiQ61542.
CleanExiMM_STARD3.
ExpressionAtlasiQ61542. baseline and differential.
GenevisibleiQ61542. MM.

Interactioni

Subunit structurei

Can form homodimers. Interacts with STARD3NL (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018311.

Structurei

3D structure databases

ProteinModelPortaliQ61542.
SMRiQ61542. Positions 231-444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 218172MENTALPROSITE-ProRule annotationAdd
BLAST
Domaini231 – 444214STARTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MENTAL domain.PROSITE-ProRule annotation
Contains 1 START domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000015362.
HOVERGENiHBG052482.
InParanoidiQ61542.
OMAiCTFIWVL.
OrthoDBiEOG74FF0Z.
PhylomeDBiQ61542.
TreeFamiTF313869.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR019498. MENTAL.
IPR000799. StAR-like.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF10457. MENTAL. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
PRINTSiPR00978. STARPROTEIN.
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS51439. MENTAL. 1 hit.
PS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRPGDLAC DLERSLPALA SLGTSLSHSQ SLSSHFIPPP LEKRRAISDV
60 70 80 90 100
RRTFCLFVTF DLLFISLLWI IELNTNTGIR KNLEQEVIHY SFQSSFFDIF
110 120 130 140 150
VLAFFRFSGL LLGYAVLRLQ HWWVIAVTTL VSSAFLIVKV ILSELLSKGA
160 170 180 190 200
FGYLLPIVSF VLAWLETWFL DFKVLPQEAE EERWYLAAQA AVARGPLLFS
210 220 230 240 250
GALSEGQFYS PPESFAGSDN ESDEEVTGKK SFSAQEREYI RQGKEATAVV
260 270 280 290 300
DQILAQEENW KFERSNEYGD TVYTIEVPFH GKTFILKTFL PCPAELVYQE
310 320 330 340 350
VILQPERMVL WNKTVTACQI LQRVEDNTLV SYDVSSGAAG GVVSPRDFVN
360 370 380 390 400
VRRIERRRDR YLSSGIATTH CSKPPTHKYV RGENGPGGFI VLKSANNPRV
410 420 430 440
CTFVWILNTD LKGRLPRYLI HQSLGATMFE FAFHLRQRVG ELGARA
Length:446
Mass (Da):50,470
Last modified:November 1, 1996 - v1
Checksum:iDBF4359604F3E1E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82457 mRNA. Translation: CAA57834.1.
BC003313 mRNA. Translation: AAH03313.1.
CCDSiCCDS25345.1.
RefSeqiNP_067522.1. NM_021547.3.
XP_006533959.1. XM_006533896.2.
UniGeneiMm.265546.
Mm.489827.

Genome annotation databases

EnsembliENSMUST00000018311; ENSMUSP00000018311; ENSMUSG00000018167.
GeneIDi59045.
KEGGimmu:59045.
UCSCiuc007lgc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82457 mRNA. Translation: CAA57834.1.
BC003313 mRNA. Translation: AAH03313.1.
CCDSiCCDS25345.1.
RefSeqiNP_067522.1. NM_021547.3.
XP_006533959.1. XM_006533896.2.
UniGeneiMm.265546.
Mm.489827.

3D structure databases

ProteinModelPortaliQ61542.
SMRiQ61542. Positions 231-444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018311.

PTM databases

iPTMnetiQ61542.
PhosphoSiteiQ61542.

Proteomic databases

EPDiQ61542.
MaxQBiQ61542.
PaxDbiQ61542.
PRIDEiQ61542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018311; ENSMUSP00000018311; ENSMUSG00000018167.
GeneIDi59045.
KEGGimmu:59045.
UCSCiuc007lgc.2. mouse.

Organism-specific databases

CTDi10948.
MGIiMGI:1929618. Stard3.

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000015362.
HOVERGENiHBG052482.
InParanoidiQ61542.
OMAiCTFIWVL.
OrthoDBiEOG74FF0Z.
PhylomeDBiQ61542.
TreeFamiTF313869.

Miscellaneous databases

NextBioi314666.
PROiQ61542.
SOURCEiSearch...

Gene expression databases

BgeeiQ61542.
CleanExiMM_STARD3.
ExpressionAtlasiQ61542. baseline and differential.
GenevisibleiQ61542. MM.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR019498. MENTAL.
IPR000799. StAR-like.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF10457. MENTAL. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
PRINTSiPR00978. STARPROTEIN.
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS51439. MENTAL. 1 hit.
PS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17."
    Tomasetto C.L., Regnier C.H., Moog-Lutz C., Mattei M.-G., Chenard M.-P., Lidereau R., Basset P., Rio M.-C.
    Genomics 28:367-376(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210; SER-218 AND SER-222, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen and Testis.

Entry informationi

Entry nameiSTAR3_MOUSE
AccessioniPrimary (citable) accession number: Q61542
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.