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Q61542 (STAR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
StAR-related lipid transfer protein 3
Alternative name(s):
Protein ES 64
Protein MLN 64
START domain-containing protein 3
Short name=StARD3
Gene names
Name:Stard3
Synonyms:Es64, Mln64
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain By similarity.

Subunit structure

Can form homodimers. Interacts with STARD3NL By similarity.

Subcellular location

Late endosome membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Contains 1 MENTAL domain.

Contains 1 START domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446StAR-related lipid transfer protein 3
PRO_0000220654

Regions

Topological domain1 – 5252Cytoplasmic Potential
Transmembrane53 – 7321Helical; Potential
Topological domain74 – 9522Extracellular Potential
Transmembrane96 – 11621Helical; Potential
Topological domain117 – 1215Cytoplasmic Potential
Transmembrane122 – 14221Helical; Potential
Topological domain143 – 1497Extracellular Potential
Transmembrane150 – 17021Helical; Potential
Topological domain171 – 446276Cytoplasmic Potential
Domain47 – 218172MENTAL
Domain231 – 444214START

Amino acid modifications

Modified residue2101Phosphoserine Ref.3
Modified residue2141Phosphoserine Ref.3
Modified residue2181Phosphoserine Ref.3
Modified residue2221Phosphoserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q61542 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: DBF4359604F3E1E2

FASTA44650,470
        10         20         30         40         50         60 
MSKRPGDLAC DLERSLPALA SLGTSLSHSQ SLSSHFIPPP LEKRRAISDV RRTFCLFVTF 

        70         80         90        100        110        120 
DLLFISLLWI IELNTNTGIR KNLEQEVIHY SFQSSFFDIF VLAFFRFSGL LLGYAVLRLQ 

       130        140        150        160        170        180 
HWWVIAVTTL VSSAFLIVKV ILSELLSKGA FGYLLPIVSF VLAWLETWFL DFKVLPQEAE 

       190        200        210        220        230        240 
EERWYLAAQA AVARGPLLFS GALSEGQFYS PPESFAGSDN ESDEEVTGKK SFSAQEREYI 

       250        260        270        280        290        300 
RQGKEATAVV DQILAQEENW KFERSNEYGD TVYTIEVPFH GKTFILKTFL PCPAELVYQE 

       310        320        330        340        350        360 
VILQPERMVL WNKTVTACQI LQRVEDNTLV SYDVSSGAAG GVVSPRDFVN VRRIERRRDR 

       370        380        390        400        410        420 
YLSSGIATTH CSKPPTHKYV RGENGPGGFI VLKSANNPRV CTFVWILNTD LKGRLPRYLI 

       430        440 
HQSLGATMFE FAFHLRQRVG ELGARA

« Hide

References

« Hide 'large scale' references
[1]"Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17."
Tomasetto C.L., Regnier C.H., Moog-Lutz C., Mattei M.-G., Chenard M.-P., Lidereau R., Basset P., Rio M.-C.
Genomics 28:367-376(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[3]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210; SER-214; SER-218 AND SER-222, MASS SPECTROMETRY.
Tissue: Macrophage.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X82457 mRNA. Translation: CAA57834.1.
BC003313 mRNA. Translation: AAH03313.1.
IPIIPI00122397.
RefSeqNP_067522.1. NM_021547.3.
UniGeneMm.265546.
Mm.489827.

3D structure databases

ProteinModelPortalQ61542.
SMRQ61542. Positions 231-444.
ModBaseSearch...

PTM databases

PhosphoSiteQ61542.

Proteomic databases

PaxDbQ61542.
PRIDEQ61542.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000018311; ENSMUSP00000018311; ENSMUSG00000018167.
GeneID59045.
KEGGmmu:59045.

Organism-specific databases

CTD10948.
MGIMGI:1929618. Stard3.

Phylogenomic databases

eggNOGNOG242039.
GeneTreeENSGT00530000063139.
HOGENOMHOG000015362.
HOVERGENHBG052482.
InParanoidQ61542.
OMAVISPRDF.
OrthoDBEOG4KSPJV.

Gene expression databases

ArrayExpressQ61542.
BgeeQ61542.
CleanExMM_STARD3.
GenevestigatorQ61542.
GermOnlineENSMUSG00000018167. Mus musculus.

Family and domain databases

Gene3D3.30.530.20. 1 hit.
InterProIPR019498. MENTAL.
IPR000799. StAR.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamPF10457. MENTAL. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
PRINTSPR00978. STARPROTEIN.
SMARTSM00234. START. 1 hit.
[Graphical view]
PROSITEPS51439. MENTAL. 1 hit.
PS50848. START. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio314666.
SOURCESearch...

Entry information

Entry nameSTAR3_MOUSE
AccessionPrimary (citable) accession number: Q61542
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents