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Q61539

- ERR2_MOUSE

UniProt

Q61539 - ERR2_MOUSE

Protein

Steroid hormone receptor ERR2

Gene

Esrrb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Nuclear receptor, may regulate ESR1 transcriptional activity. Induces the expression of PERM1 in the skeletal muscle By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei185 – 1851Important for stabilizing DNA-bindingBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi100 – 18687Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri103 – 12321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 16325NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: BHF-UCL
    3. sequence-specific DNA binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: InterPro
    5. steroid binding Source: InterPro
    6. steroid hormone receptor activity Source: InterPro
    7. transcription coactivator activity Source: BHF-UCL
    8. transcription factor binding Source: BHF-UCL
    9. zinc ion binding Source: InterPro

    GO - Biological processi

    1. embryonic placenta development Source: MGI
    2. in utero embryonic development Source: MGI
    3. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    4. regulation of transcription, DNA-templated Source: UniProtKB
    5. stem cell maintenance Source: MGI
    6. transcription, DNA-templated Source: UniProtKB-KW
    7. trophectodermal cell proliferation Source: MGI
    8. trophectodermal cellular morphogenesis Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Steroid hormone receptor ERR2
    Alternative name(s):
    Estrogen receptor-like 2
    Estrogen-related receptor beta
    Short name:
    ERR-beta
    Nuclear receptor subfamily 3 group B member 2
    Gene namesi
    Name:Esrrb
    Synonyms:Err-2, Err2, Nr3b2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1346832. Esrrb.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Steroid hormone receptor ERR2PRO_0000053663Add
    BLAST

    Post-translational modificationi

    Acetylated by PCAF/KAT2 (in vitro).By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ61539.

    PTM databases

    PhosphoSiteiQ61539.

    Expressioni

    Gene expression databases

    CleanExiMM_ESRRB.
    GenevestigatoriQ61539.

    Interactioni

    Subunit structurei

    Binds DNA as a monomer.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Mta2Q9R1902EBI-2312731,EBI-904134
    Nr0b1Q610662EBI-2312731,EBI-2312665
    Tfcp2l1Q3UNW54EBI-2312731,EBI-5691372

    Protein-protein interaction databases

    DIPiDIP-46110N.
    IntActiQ61539. 9 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61539.
    SMRiQ61539. Positions 97-433.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri103 – 12321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 16325NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG282629.
    GeneTreeiENSGT00730000110346.
    HOGENOMiHOG000233467.
    HOVERGENiHBG108344.
    InParanoidiQ61539.
    KOiK08553.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR027289. Oest-rel_rcp.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002527. ER-like_NR. 1 hit.
    PIRSF500939. ERR1-2-3. 1 hit.
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61539-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSEDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGIALS    50
    THANGLDSPP MFAGAGLGGN PCRKSYEDCT SGIMEDSAIK CEYMLNAIPK 100
    RLCLVCGDIA SGYHYGVASC EACKAFFKRT IQGNIEYNCP ATNECEITKR 150
    RRKSCQACRF MKCLKVGMLK EGVRLDRVRG GRQKYKRRLD SENSPYLNLP 200
    ISPPAKKPLT KIVSNLLGVE QDKLYAMPPN DIPEGDIKAL TTLCELADRE 250
    LVFLINWAKH IPGFPSLTLG DQMSLLQSAW MEILILGIVY RSLPYDDKLA 300
    YAEDYIMDEE HSRLVGLLDL YRAILQLVRR YKKLKVEKEE FMILKALALA 350
    NSDSMYIENL EAVQKLQDLL HEALQDYELS QRHEEPRRAG KLLLTLPLLR 400
    QTAAKAVQHF YSVKLQGKVP MHKLFLEMLE AKV 433
    Length:433
    Mass (Da):48,328
    Last modified:October 3, 2012 - v2
    Checksum:i1A0383E7E2ED8BF3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti394 – 3941L → W in CAA61755. (PubMed:8652414)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89594 mRNA. Translation: CAA61755.1.
    S82458 mRNA. Translation: AAB37687.1.
    AK052256 mRNA. Translation: BAC34898.1.
    AC126685 Genomic DNA. No translation available.
    AC132189 Genomic DNA. No translation available.
    BC132595 mRNA. Translation: AAI32596.2.
    BC132597 mRNA. Translation: AAI32598.2.
    PIRiS58087.
    RefSeqiNP_001152972.1. NM_001159500.1.
    NP_036064.3. NM_011934.4.
    UniGeneiMm.235550.

    Genome annotation databases

    EnsembliENSMUST00000021680; ENSMUSP00000021680; ENSMUSG00000021255.
    ENSMUST00000167891; ENSMUSP00000131335; ENSMUSG00000021255.
    GeneIDi26380.
    KEGGimmu:26380.
    UCSCiuc007ohw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89594 mRNA. Translation: CAA61755.1 .
    S82458 mRNA. Translation: AAB37687.1 .
    AK052256 mRNA. Translation: BAC34898.1 .
    AC126685 Genomic DNA. No translation available.
    AC132189 Genomic DNA. No translation available.
    BC132595 mRNA. Translation: AAI32596.2 .
    BC132597 mRNA. Translation: AAI32598.2 .
    PIRi S58087.
    RefSeqi NP_001152972.1. NM_001159500.1.
    NP_036064.3. NM_011934.4.
    UniGenei Mm.235550.

    3D structure databases

    ProteinModelPortali Q61539.
    SMRi Q61539. Positions 97-433.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-46110N.
    IntActi Q61539. 9 interactions.

    PTM databases

    PhosphoSitei Q61539.

    Proteomic databases

    PRIDEi Q61539.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021680 ; ENSMUSP00000021680 ; ENSMUSG00000021255 .
    ENSMUST00000167891 ; ENSMUSP00000131335 ; ENSMUSG00000021255 .
    GeneIDi 26380.
    KEGGi mmu:26380.
    UCSCi uc007ohw.2. mouse.

    Organism-specific databases

    CTDi 2103.
    MGIi MGI:1346832. Esrrb.

    Phylogenomic databases

    eggNOGi NOG282629.
    GeneTreei ENSGT00730000110346.
    HOGENOMi HOG000233467.
    HOVERGENi HBG108344.
    InParanoidi Q61539.
    KOi K08553.

    Miscellaneous databases

    NextBioi 304293.
    PROi Q61539.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_ESRRB.
    Genevestigatori Q61539.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR027289. Oest-rel_rcp.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002527. ER-like_NR. 1 hit.
    PIRSF500939. ERR1-2-3. 1 hit.
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis."
      Pettersson K., Svensson K., Mattsson R., Carlsson B., Ohlsson R., Berkenstam A.
      Mech. Dev. 54:211-223(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiERR2_MOUSE
    AccessioniPrimary (citable) accession number: Q61539
    Secondary accession number(s): A2RTQ7
    , O09067, O09146, Q8C7A6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3