SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q61539

- ERR2_MOUSE

UniProt

Q61539 - ERR2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Steroid hormone receptor ERR2
Gene
Esrrb, Err-2, Err2, Nr3b2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nuclear receptor, may regulate ESR1 transcriptional activity. Induces the expression of PERM1 in the skeletal muscle By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei185 – 1851Important for stabilizing DNA-binding By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi100 – 18687Nuclear receptor
Add
BLAST
Zinc fingeri103 – 12321NR C4-type
Add
BLAST
Zinc fingeri139 – 16325NR C4-type
Add
BLAST

GO - Molecular functioni

  1. RNA polymerase II distal enhancer sequence-specific DNA binding Source: BHF-UCL
  2. protein binding Source: IntAct
  3. sequence-specific DNA binding Source: UniProtKB
  4. sequence-specific DNA binding transcription factor activity Source: InterPro
  5. steroid binding Source: InterPro
  6. steroid hormone receptor activity Source: InterPro
  7. transcription coactivator activity Source: BHF-UCL
  8. transcription factor binding Source: BHF-UCL
  9. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. embryonic placenta development Source: MGI
  2. in utero embryonic development Source: MGI
  3. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  4. regulation of transcription, DNA-templated Source: UniProtKB
  5. stem cell maintenance Source: MGI
  6. transcription, DNA-templated Source: UniProtKB-KW
  7. trophectodermal cell proliferation Source: MGI
  8. trophectodermal cellular morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid hormone receptor ERR2
Alternative name(s):
Estrogen receptor-like 2
Estrogen-related receptor beta
Short name:
ERR-beta
Nuclear receptor subfamily 3 group B member 2
Gene namesi
Name:Esrrb
Synonyms:Err-2, Err2, Nr3b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1346832. Esrrb.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Steroid hormone receptor ERR2
PRO_0000053663Add
BLAST

Post-translational modificationi

Acetylated by PCAF/KAT2 (in vitro) By similarity.

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ61539.

PTM databases

PhosphoSiteiQ61539.

Expressioni

Gene expression databases

CleanExiMM_ESRRB.
GenevestigatoriQ61539.

Interactioni

Subunit structurei

Binds DNA as a monomer By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Mta2Q9R1902EBI-2312731,EBI-904134
Nr0b1Q610662EBI-2312731,EBI-2312665
Tfcp2l1Q3UNW54EBI-2312731,EBI-5691372

Protein-protein interaction databases

DIPiDIP-46110N.
IntActiQ61539. 9 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ61539.
SMRiQ61539. Positions 97-433.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG282629.
GeneTreeiENSGT00730000110346.
HOGENOMiHOG000233467.
HOVERGENiHBG108344.
InParanoidiQ61539.
KOiK08553.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61539-1 [UniParc]FASTAAdd to Basket

« Hide

MSSEDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGIALS    50
THANGLDSPP MFAGAGLGGN PCRKSYEDCT SGIMEDSAIK CEYMLNAIPK 100
RLCLVCGDIA SGYHYGVASC EACKAFFKRT IQGNIEYNCP ATNECEITKR 150
RRKSCQACRF MKCLKVGMLK EGVRLDRVRG GRQKYKRRLD SENSPYLNLP 200
ISPPAKKPLT KIVSNLLGVE QDKLYAMPPN DIPEGDIKAL TTLCELADRE 250
LVFLINWAKH IPGFPSLTLG DQMSLLQSAW MEILILGIVY RSLPYDDKLA 300
YAEDYIMDEE HSRLVGLLDL YRAILQLVRR YKKLKVEKEE FMILKALALA 350
NSDSMYIENL EAVQKLQDLL HEALQDYELS QRHEEPRRAG KLLLTLPLLR 400
QTAAKAVQHF YSVKLQGKVP MHKLFLEMLE AKV 433
Length:433
Mass (Da):48,328
Last modified:October 3, 2012 - v2
Checksum:i1A0383E7E2ED8BF3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti394 – 3941L → W in CAA61755. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89594 mRNA. Translation: CAA61755.1.
S82458 mRNA. Translation: AAB37687.1.
AK052256 mRNA. Translation: BAC34898.1.
AC126685 Genomic DNA. No translation available.
AC132189 Genomic DNA. No translation available.
BC132595 mRNA. Translation: AAI32596.2.
BC132597 mRNA. Translation: AAI32598.2.
PIRiS58087.
RefSeqiNP_001152972.1. NM_001159500.1.
NP_036064.3. NM_011934.4.
UniGeneiMm.235550.

Genome annotation databases

EnsembliENSMUST00000021680; ENSMUSP00000021680; ENSMUSG00000021255.
ENSMUST00000167891; ENSMUSP00000131335; ENSMUSG00000021255.
GeneIDi26380.
KEGGimmu:26380.
UCSCiuc007ohw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89594 mRNA. Translation: CAA61755.1 .
S82458 mRNA. Translation: AAB37687.1 .
AK052256 mRNA. Translation: BAC34898.1 .
AC126685 Genomic DNA. No translation available.
AC132189 Genomic DNA. No translation available.
BC132595 mRNA. Translation: AAI32596.2 .
BC132597 mRNA. Translation: AAI32598.2 .
PIRi S58087.
RefSeqi NP_001152972.1. NM_001159500.1.
NP_036064.3. NM_011934.4.
UniGenei Mm.235550.

3D structure databases

ProteinModelPortali Q61539.
SMRi Q61539. Positions 97-433.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-46110N.
IntActi Q61539. 9 interactions.

PTM databases

PhosphoSitei Q61539.

Proteomic databases

PRIDEi Q61539.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021680 ; ENSMUSP00000021680 ; ENSMUSG00000021255 .
ENSMUST00000167891 ; ENSMUSP00000131335 ; ENSMUSG00000021255 .
GeneIDi 26380.
KEGGi mmu:26380.
UCSCi uc007ohw.2. mouse.

Organism-specific databases

CTDi 2103.
MGIi MGI:1346832. Esrrb.

Phylogenomic databases

eggNOGi NOG282629.
GeneTreei ENSGT00730000110346.
HOGENOMi HOG000233467.
HOVERGENi HBG108344.
InParanoidi Q61539.
KOi K08553.

Miscellaneous databases

NextBioi 304293.
PROi Q61539.
SOURCEi Search...

Gene expression databases

CleanExi MM_ESRRB.
Genevestigatori Q61539.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PIRSFi PIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis."
    Pettersson K., Svensson K., Mattsson R., Carlsson B., Ohlsson R., Berkenstam A.
    Mech. Dev. 54:211-223(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiERR2_MOUSE
AccessioniPrimary (citable) accession number: Q61539
Secondary accession number(s): A2RTQ7
, O09067, O09146, Q8C7A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2012
Last modified: June 11, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi