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Q61539 (ERR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Steroid hormone receptor ERR2
Alternative name(s):
Estrogen receptor-like 2
Estrogen-related receptor beta
Short name=ERR-beta
Nuclear receptor subfamily 3 group B member 2
Gene names
Name:Esrrb
Synonyms:Err-2, Err2, Nr3b2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nuclear receptor, may regulate ESR1 transcriptional activity. Induces the expression of PERM1 in the skeletal muscle By similarity.

Subunit structure

Binds DNA as a monomer By similarity.

Subcellular location

Nucleus By similarity.

Post-translational modification

Acetylated by PCAF/KAT2 (in vitro) By similarity.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR3 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionReceptor
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processembryonic placenta development

Inferred from mutant phenotype PubMed 9285590. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 9285590. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 18662995. Source: BHF-UCL

regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

stem cell maintenance

Inferred from mutant phenotype PubMed 16518401PubMed 16767105PubMed 20720539. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

trophectodermal cell proliferation

Inferred from mutant phenotype PubMed 9285590. Source: MGI

trophectodermal cellular morphogenesis

Inferred from mutant phenotype PubMed 9285590. Source: MGI

   Cellular_componentnucleus

Inferred from direct assay PubMed 18662995. Source: BHF-UCL

   Molecular_functionRNA polymerase II distal enhancer sequence-specific DNA binding

Inferred from direct assay PubMed 18662995. Source: BHF-UCL

sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

steroid binding

Inferred from electronic annotation. Source: InterPro

steroid hormone receptor activity

Inferred from electronic annotation. Source: InterPro

transcription coactivator activity

Inferred from direct assay PubMed 18662995. Source: BHF-UCL

transcription factor binding

Inferred from physical interaction PubMed 18662995. Source: BHF-UCL

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Steroid hormone receptor ERR2
PRO_0000053663

Regions

DNA binding100 – 18687Nuclear receptor
Zinc finger103 – 12321NR C4-type
Zinc finger139 – 16325NR C4-type

Sites

Site1851Important for stabilizing DNA-binding By similarity

Experimental info

Sequence conflict3941L → W in CAA61755. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61539 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 1A0383E7E2ED8BF3

FASTA43348,328
        10         20         30         40         50         60 
MSSEDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGIALS THANGLDSPP 

        70         80         90        100        110        120 
MFAGAGLGGN PCRKSYEDCT SGIMEDSAIK CEYMLNAIPK RLCLVCGDIA SGYHYGVASC 

       130        140        150        160        170        180 
EACKAFFKRT IQGNIEYNCP ATNECEITKR RRKSCQACRF MKCLKVGMLK EGVRLDRVRG 

       190        200        210        220        230        240 
GRQKYKRRLD SENSPYLNLP ISPPAKKPLT KIVSNLLGVE QDKLYAMPPN DIPEGDIKAL 

       250        260        270        280        290        300 
TTLCELADRE LVFLINWAKH IPGFPSLTLG DQMSLLQSAW MEILILGIVY RSLPYDDKLA 

       310        320        330        340        350        360 
YAEDYIMDEE HSRLVGLLDL YRAILQLVRR YKKLKVEKEE FMILKALALA NSDSMYIENL 

       370        380        390        400        410        420 
EAVQKLQDLL HEALQDYELS QRHEEPRRAG KLLLTLPLLR QTAAKAVQHF YSVKLQGKVP 

       430 
MHKLFLEMLE AKV 

« Hide

References

« Hide 'large scale' references
[1]"Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis."
Pettersson K., Svensson K., Mattsson R., Carlsson B., Ohlsson R., Berkenstam A.
Mech. Dev. 54:211-223(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Heart.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X89594 mRNA. Translation: CAA61755.1.
S82458 mRNA. Translation: AAB37687.1.
AK052256 mRNA. Translation: BAC34898.1.
AC126685 Genomic DNA. No translation available.
AC132189 Genomic DNA. No translation available.
BC132595 mRNA. Translation: AAI32596.2.
BC132597 mRNA. Translation: AAI32598.2.
PIRS58087.
RefSeqNP_001152972.1. NM_001159500.1.
NP_036064.3. NM_011934.4.
UniGeneMm.235550.

3D structure databases

ProteinModelPortalQ61539.
SMRQ61539. Positions 97-433.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-46110N.
IntActQ61539. 9 interactions.

PTM databases

PhosphoSiteQ61539.

Proteomic databases

PRIDEQ61539.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021680; ENSMUSP00000021680; ENSMUSG00000021255.
ENSMUST00000167891; ENSMUSP00000131335; ENSMUSG00000021255.
GeneID26380.
KEGGmmu:26380.
UCSCuc007ohw.2. mouse.

Organism-specific databases

CTD2103.
MGIMGI:1346832. Esrrb.

Phylogenomic databases

eggNOGNOG282629.
GeneTreeENSGT00730000110346.
HOGENOMHOG000233467.
HOVERGENHBG108344.
InParanoidQ61539.
KOK08553.

Gene expression databases

CleanExMM_ESRRB.
GenevestigatorQ61539.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio304293.
PROQ61539.
SOURCESearch...

Entry information

Entry nameERR2_MOUSE
AccessionPrimary (citable) accession number: Q61539
Secondary accession number(s): A2RTQ7 expand/collapse secondary AC list , O09067, O09146, Q8C7A6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2012
Last modified: April 16, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot