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Q61539

- ERR2_MOUSE

UniProt

Q61539 - ERR2_MOUSE

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Protein

Steroid hormone receptor ERR2

Gene

Esrrb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Nuclear receptor, may regulate ESR1 transcriptional activity. Induces the expression of PERM1 in the skeletal muscle By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei185 – 1851Important for stabilizing DNA-bindingBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi100 – 18687Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri103 – 12321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri139 – 16325NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II distal enhancer sequence-specific DNA binding Source: BHF-UCL
  2. sequence-specific DNA binding Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. steroid binding Source: InterPro
  5. steroid hormone receptor activity Source: InterPro
  6. transcription coactivator activity Source: BHF-UCL
  7. transcription factor binding Source: BHF-UCL
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. embryonic placenta development Source: MGI
  2. in utero embryonic development Source: MGI
  3. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  4. regulation of transcription, DNA-templated Source: UniProtKB
  5. stem cell maintenance Source: MGI
  6. transcription, DNA-templated Source: UniProtKB-KW
  7. trophectodermal cell proliferation Source: MGI
  8. trophectodermal cellular morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid hormone receptor ERR2
Alternative name(s):
Estrogen receptor-like 2
Estrogen-related receptor beta
Short name:
ERR-beta
Nuclear receptor subfamily 3 group B member 2
Gene namesi
Name:Esrrb
Synonyms:Err-2, Err2, Nr3b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1346832. Esrrb.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Steroid hormone receptor ERR2PRO_0000053663Add
BLAST

Post-translational modificationi

Acetylated by PCAF/KAT2 (in vitro).By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ61539.

PTM databases

PhosphoSiteiQ61539.

Expressioni

Gene expression databases

CleanExiMM_ESRRB.
ExpressionAtlasiQ61539. baseline and differential.
GenevestigatoriQ61539.

Interactioni

Subunit structurei

Binds DNA as a monomer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Mta2Q9R1902EBI-2312731,EBI-904134
Nr0b1Q610662EBI-2312731,EBI-2312665
Tfcp2l1Q3UNW54EBI-2312731,EBI-5691372

Protein-protein interaction databases

DIPiDIP-46110N.
IntActiQ61539. 9 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ61539.
SMRiQ61539. Positions 97-433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri103 – 12321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri139 – 16325NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG282629.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000233467.
HOVERGENiHBG108344.
InParanoidiQ61539.
KOiK08553.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61539-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSEDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGIALS
60 70 80 90 100
THANGLDSPP MFAGAGLGGN PCRKSYEDCT SGIMEDSAIK CEYMLNAIPK
110 120 130 140 150
RLCLVCGDIA SGYHYGVASC EACKAFFKRT IQGNIEYNCP ATNECEITKR
160 170 180 190 200
RRKSCQACRF MKCLKVGMLK EGVRLDRVRG GRQKYKRRLD SENSPYLNLP
210 220 230 240 250
ISPPAKKPLT KIVSNLLGVE QDKLYAMPPN DIPEGDIKAL TTLCELADRE
260 270 280 290 300
LVFLINWAKH IPGFPSLTLG DQMSLLQSAW MEILILGIVY RSLPYDDKLA
310 320 330 340 350
YAEDYIMDEE HSRLVGLLDL YRAILQLVRR YKKLKVEKEE FMILKALALA
360 370 380 390 400
NSDSMYIENL EAVQKLQDLL HEALQDYELS QRHEEPRRAG KLLLTLPLLR
410 420 430
QTAAKAVQHF YSVKLQGKVP MHKLFLEMLE AKV
Length:433
Mass (Da):48,328
Last modified:October 3, 2012 - v2
Checksum:i1A0383E7E2ED8BF3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti394 – 3941L → W in CAA61755. (PubMed:8652414)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89594 mRNA. Translation: CAA61755.1.
S82458 mRNA. Translation: AAB37687.1.
AK052256 mRNA. Translation: BAC34898.1.
AC126685 Genomic DNA. No translation available.
AC132189 Genomic DNA. No translation available.
BC132595 mRNA. Translation: AAI32596.2.
BC132597 mRNA. Translation: AAI32598.2.
PIRiS58087.
RefSeqiNP_001152972.1. NM_001159500.1.
NP_036064.3. NM_011934.4.
UniGeneiMm.235550.

Genome annotation databases

EnsembliENSMUST00000021680; ENSMUSP00000021680; ENSMUSG00000021255.
ENSMUST00000167891; ENSMUSP00000131335; ENSMUSG00000021255.
GeneIDi26380.
KEGGimmu:26380.
UCSCiuc007ohw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89594 mRNA. Translation: CAA61755.1 .
S82458 mRNA. Translation: AAB37687.1 .
AK052256 mRNA. Translation: BAC34898.1 .
AC126685 Genomic DNA. No translation available.
AC132189 Genomic DNA. No translation available.
BC132595 mRNA. Translation: AAI32596.2 .
BC132597 mRNA. Translation: AAI32598.2 .
PIRi S58087.
RefSeqi NP_001152972.1. NM_001159500.1.
NP_036064.3. NM_011934.4.
UniGenei Mm.235550.

3D structure databases

ProteinModelPortali Q61539.
SMRi Q61539. Positions 97-433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-46110N.
IntActi Q61539. 9 interactions.

PTM databases

PhosphoSitei Q61539.

Proteomic databases

PRIDEi Q61539.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021680 ; ENSMUSP00000021680 ; ENSMUSG00000021255 .
ENSMUST00000167891 ; ENSMUSP00000131335 ; ENSMUSG00000021255 .
GeneIDi 26380.
KEGGi mmu:26380.
UCSCi uc007ohw.2. mouse.

Organism-specific databases

CTDi 2103.
MGIi MGI:1346832. Esrrb.

Phylogenomic databases

eggNOGi NOG282629.
GeneTreei ENSGT00760000118887.
HOGENOMi HOG000233467.
HOVERGENi HBG108344.
InParanoidi Q61539.
KOi K08553.

Miscellaneous databases

NextBioi 304293.
PROi Q61539.
SOURCEi Search...

Gene expression databases

CleanExi MM_ESRRB.
ExpressionAtlasi Q61539. baseline and differential.
Genevestigatori Q61539.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PIRSFi PIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis."
    Pettersson K., Svensson K., Mattsson R., Carlsson B., Ohlsson R., Berkenstam A.
    Mech. Dev. 54:211-223(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiERR2_MOUSE
AccessioniPrimary (citable) accession number: Q61539
Secondary accession number(s): A2RTQ7
, O09067, O09146, Q8C7A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3